- Oct 2024
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Local file Local file
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I feela great relief. I feel thankful to her. She has died that I may live.
Irony and displays the woman vs woman thing -- but also irony that people find escape in death.
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- Sep 2024
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hypothes.is hypothes.is
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I tell you, Zeus with all his arrogance will be brought low. He is already 69 planning the marriage that will throw him from his omnipotence into oblivion. The curse his father, Kronos, spoke when he was driven from his ancient throne will be fulfilled then.
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URL
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- Aug 2024
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www.sciencedaily.com www.sciencedaily.com
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for - climate change impacts - marine life - citizen-science - potential project - climate departure - ocean heating impacts - marine life - marine migration - migrating species face collapse - migration to escape warming oceans - population collapse
main research findings - Study involved 146 species of temperate or subpolar fish and 2,572 time series - Extremely fast moving species (17km/year) showed large declines in population while - fish that did not shift showed negligible decline - Those on the northernmost edge experienced the largest declines - There is speculation that the fastest moving ones are the also the one's with the least evolutionary adaptations for new environments
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- Feb 2024
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docdrop.org docdrop.org
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Résumé de la vidéo [00:00:00][^1^][1] - [00:24:40][^2^][2]:
La vidéo présente une conférence sur l'innovation dans l'éducation, organisée par l'INSEP. Les intervenants discutent de l'importance de l'innovation pédagogique et de son intégration dans la formation des enseignants.
Points forts: + [00:00:00][^3^][3] Introduction de la conférence * Présentation des rencontres de l'innovation + [00:03:33][^4^][4] L'importance de l'innovation * L'innovation alimente la formation et la recherche + [00:07:00][^5^][5] La création d'une communauté * Développer une culture de l'innovation chez les étudiants + [00:09:00][^6^][6] Le service d'innovation pédagogique * Présentation du service et de son rôle + [00:11:43][^7^][7] Les objectifs de l'innovation * Éveiller la créativité et accompagner la création de dispositifs pédagogiques + [00:17:01][^8^][8] Les types d'innovation * Différence entre innovation incrémentale et de rupture
Résumé vidéo [00:24:44][^1^][1] - [00:49:46][^2^][2]: La vidéo présente une discussion sur l'innovation pédagogique et le rôle du mini-lab dans la création de ressources éducatives. Elle met en lumière l'importance de la collaboration, de la créativité et de l'expérimentation dans le développement de méthodes d'enseignement innovantes.
Points forts: + [00:24:44][^3^][3] Introduction aux contreparties * Formation requise * Création de dispositifs + [00:26:48][^4^][4] Mission de création de ressources * Développement d'escape games * Réappropriation par les visiteurs + [00:29:48][^5^][5] Bilan des accompagnements * Soutien individuel et en groupe * Projets avec divers partenaires + [00:35:42][^6^][6] Perspectives et enjeux * Capitalisation des productions * Renforcement du lien innovation-recherche
Résumé de la vidéo 00:49:48 - 01:11:08: La vidéo présente un projet éducatif innovant utilisant le kamishibai, un théâtre de bois japonais, pour encourager l'expression orale des élèves. Le projet intègre la technologie avec des cartes mécaniques et une Raspberry Pi pour créer un mur d'expression interactif sans nécessiter d'ordinateur ou de connexion internet.
Points forts: + [00:49:48][^1^][1] Introduction du kamishibai * Théâtre de bois pour l'expression * Collaboration avec le mini Lab + [00:53:00][^2^][2] Application en mathématiques * Utilisation d'un escape game pédagogique * Amélioration de l'engagement des étudiants + [00:57:00][^3^][3] Avantages du module * Motivation et implication accrues * Développement de compétences diverses + [01:07:23][^4^][4] Escape game en mathématiques * Facilité de mise en œuvre * Changement d'attitude des étudiants
Résumé de la vidéo [01:11:10][^1^][1] - [01:34:07][^2^][2]:
Cette vidéo présente une table ronde sur l'innovation pédagogique, abordant des sujets tels que la création d'un escape game éducatif, les défis de l'innovation, et l'importance de l'adaptation et de la réflexion dans l'enseignement.
Points forts: + [01:11:10][^3^][3] L'escape game éducatif * Discussion sur la conception et l'adaptabilité + [01:11:43][^4^][4] Défis de l'innovation * Accepter l'inconnu et gérer l'imprévu + [01:12:23][^5^][5] Importance de l'adaptation * Réflexion sur l'usage du numérique en éducation + [01:18:26][^6^][6] Réflexions finales * Contributions au domaine de l'éducation et remerciements
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gusandco.net gusandco.net
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guide étape par étape pour créer le meilleur Escape Game éducatif.
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docdrop.org docdrop.org
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Pour échanger avec Aurélie Canizares le mardi 12 mars 2024 à 12h30, inscriptions ici : https://comprendreleseleves.ensfea.fr...
Intervenant : Aurélie Canizares, maître de conférences en numérique éducatif
Résumé : Nous nous intéressons aux stratégies de traitement des informations développées par les élèves dans le cadre d’un escape game pédagogique numérique. Dans ce type de jeu où la contrainte temporelle est particulièrement forte, ces dernières relèvent-elles de stratégies pour apprendre ou de stratégies pour gagner ? Un escape game pédagogique est-il compatible avec la construction de connaissances ? Autant de questions auxquelles nous tenterons de répondre en nous appuyant sur un jeu portant sur l’évaluation de la qualité de l’information auquel ont participé des étudiants de BTSA. Transcription
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- Nov 2023
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docdrop.org docdrop.org
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what I talk about is reaching what I call uh escape velocity from modernity just like reaching escape velocity from the gravity of Earth if if you're trying to get to the moon and you 00:51:45 don't reach escape velocity gravity will bring you back through the atmosphere and kill you in the process
- for: meme - escape velocity from modernity
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- Nov 2022
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www.autohotkey.com www.autohotkey.com
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Page: Escape Sequences
I was looking for documentation on escaped characters.
This was because Auto Hotkey threw an error when I used
<%* %>as an option for the text insert script. It said the illegal character was*but really what was happening was that the unquoted text%* %was treated like a variable since%is used to enclose variables in Auto Hotkey. The solution was to escape the percent sign with one left back tick.
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- Aug 2022
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assets.publishing.service.gov.uk assets.publishing.service.gov.uk
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SARS-CoV-2 variants of concern and variants under investigation. (2021). 45.
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twitter.com twitter.com
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ReconfigBehSci. (2021, December 22). RT @chrischirp: Positivity rising steeply too—There are definitely many more people we aren’t catching https://t.co/4xDPwYQtrx [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1473695678610214927
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twitter.com twitter.com
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ReconfigBehSci. (2021, November 26). RT @HZiauddeen: 🧵 COVID-19 & B.1.1.529: A chance for govt & others to change their mind and their approach? While we are still gathering d… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1464200877888184324
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twitter.com twitter.com
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ReconfigBehSci. (2021, November 26). RT @PeterHotez: …this info is more relevant than immune escape. For instance the B.1.351 from ZA last year never really took off. So transm… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1464240155070447632
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- Mar 2022
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www-nature-com.proxy-ub.rug.nl www-nature-com.proxy-ub.rug.nl
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Routes of cell entryEndocytosis is a key mechanism driving EV entry into cells. Mammalian cells depend on a diversity of endocytic mechanisms that occur concurrently, including clathrin-dependent and clathrin–independent mechanisms as well as macropinocytosis. Specialized phagocytic cells are furthermore capable of ingesting other cells and/or particles via phagocytosis. Interestingly, all of these different endocytic mechanisms have been implicated in EV internalization, which is likely a result of the large diversity of EV donor and recipient cell pairs that have been reported, as reviewed in5. The mechanism of internalization may be relevant to the fate of EVs and their cargo. For example, when studying EV-mediated small RNA delivery, a poor correlation between EV/small RNA uptake efficiency and functional small RNA transfer (assessed via target gene knockdown) was observed among different cell types, including phagocytic Kupffer cells75. It is thus tempting to speculate that different EV internalization mechanisms may lead to different functional outcomes: degradation versus functional transfer of EV cargo.Intracellular trafficking and signallingIn general, endocytosis in mammalian cells leads to internalization of cargo from the plasma membrane, and transport from early endosomes to either recycling endosomes through which the cargo is recycled back to the plasma membrane, or to late endosomes and finally lysosomes where it is degraded. EVs seem to follow a similar path, with evidence suggesting that EVs, or at least the dyes or labels that are used to visualize them, eventually end up in lysosomes69,76. Accumulation of EVs in lysosomes may also reflect the final destination of EVs that have signalled at the surface of the recipient cells. While lysosomes are often seen as sites for breaking down biomolecules (and therefore considered non-functional EV destinations), increasing evidence suggests they also function in various cellular processes such as plasma membrane homeostasis, signalling and energy metabolism. Indeed, lysosomal catabolism of EVs by endothelial cells has been suggested to provide these cells with trophic support59. Thus, lysosomes may serve as a site of functionality for EVs, and may not be simply a compartment for their destruction.At the same time, there is overwhelming evidence that EVs are capable of transferring their luminal cargo, including RNA, into the cytosol of recipient cells, which indicates that EVs are capable of escaping the endolysosomal pathway. How EVs induce such endosomal escape is largely unknown, however there is some evidence that this occurs through EVs fusing with late endosomal membranes77,78, potentially triggered by acidification along the endolysosomal axis79,80. Whether there are intrinsic differences in EV subtypes which are destined for lysosomal degradation or cargo release through fusion, or whether EV fate is dictated by the characteristics of the recipient cell remains unknown
Endocytosis, lysosomes, degradation, lysosomal escape
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- Feb 2022
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assets.publishing.service.gov.uk assets.publishing.service.gov.uk
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Academics: Viral Evolution Scenarios, 10 February 2022. (n.d.). GOV.UK. Retrieved February 14, 2022, from https://www.gov.uk/government/publications/academics-viral-evolution-scenarios-10-february-2022
Tags
- severity
- protection
- testing
- surveillance
- variant
- vaccine
- infection
- viral evolution
- COVID-19
- immunity
- antiviral drug resistance
- UK
- lang:en
- prediction
- antigenic escape
- therapeutic
- is:report
- vaccination
- scenario
- transmissibility
- vaccine efficacy
- heterogeneity
- immune escape
- waning immunity
Annotators
URL
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www.youtube.com www.youtube.com
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American Medical Association (AMA). (2021, December 6). Peter Hotez, MD, PhD, on the omicron variant and Delta winter surge | COVID-19 Update for Dec. 6, 20. https://www.youtube.com/watch?v=WnfpC1_N2Mg
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- Jan 2022
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www.imperial.ac.uk www.imperial.ac.uk
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Omicron largely evades immunity from past infection or two vaccine doses | Imperial News | Imperial College London. (n.d.). Imperial News. Retrieved January 12, 2022, from https://www.imperial.ac.uk/news/232698/omicron-largely-evades-immunity-from-past/
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www.medrxiv.org www.medrxiv.org
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Tseng, H. F., Ackerson, B. K., Luo, Y., Sy, L. S., Talarico, C., Tian, Y., Bruxvoort, K., Tupert, J. E., Florea, A., Ku, J. H., Lee, G. S., Choi, S. K., Takhar, H. S., Aragones, M., & Qian, L. (2022). Effectiveness of mRNA-1273 against SARS-CoV-2 omicron and delta variants (p. 2022.01.07.22268919). https://doi.org/10.1101/2022.01.07.22268919
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www.nature.com www.nature.com
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Carreño, J. M., Alshammary, H., Tcheou, J., Singh, G., Raskin, A., Kawabata, H., Sominsky, L., Clark, J., Adelsberg, D. C., Bielak, D., Gonzalez-Reiche, A. S., Dambrauskas, N., Vigdorovich, V., Group, P. S., Srivastava, K., Sather, D. N., Sordillo, E. M., Bajic, G., van Bakel, H., … Krammer, F. (2021). Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron. Nature. https://doi.org/10.1038/d41586-021-03846-z
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- Dec 2021
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scape.enepe.fr scape.enepe.fr
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Annotators
URL
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www.theguardian.com www.theguardian.com
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Devlin, H., & Kollewe, J. (2021, November 26). BioNTech says it could tweak Covid vaccine in 100 days if needed. The Guardian. https://www.theguardian.com/society/2021/nov/26/biontech-says-it-could-tweak-covid-vaccine-in-100-days-if-needed
Tags
- science
- clinical trials
- research
- protection
- is:news
- variant
- variant-specific booster
- vaccine
- escape variant
- Pfizer
- BioNTech
- COVID-19
- immunity
- effectiveness
- lang:en
- spike protein
- transmissibility
- mutation
- Omicron
- booster
- development
Annotators
URL
theguardian.com/society/2021/nov/26/biontech-says-it-could-tweak-covid-vaccine-in-100-days-if-needed -
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twitter.com twitter.comTwitter1
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Kristian G. Andersen on Twitter. (n.d.). Twitter. Retrieved 3 December 2021, from https://twitter.com/K_G_Andersen/status/1465822536629821442
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- Nov 2021
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jamanetwork.com jamanetwork.com
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It remains unclear whether the reduction in the neutralization sensitivity of the N501Y.V2 strain to vaccine-induced antibodies is enough to seriously reduce vaccine efficacy. First, mRNA vaccines also induce virus-specific helper T cells and cytotoxic T cells, both of which might be involved in protection against challenge. Also, the mRNA vaccines, in particular, induce such a strong NAb response that there could be enough “spare capacity” to deal with reductions in the sensitivity of the variant to NAbs. In other words, N501Y.V2 (and the related virus from Brazil) may be less sensitive to NAbs, but not to an extent that will cause widespread vaccine failure.
Variants that show reduced sensitivity to NAbs don't necessarily mean mRNA vaccine failure
New variants may emerge that show reduced sensitivity to NAbs.
This may not result in vaccine failure because:
- The mRNA vaccines induce such a strong NAb response, there will be enough spare capacity to deal with the virus.
- The mRNA vaccines also induce other virus specific protection such as helper T cells and cytotoxic T cells, which may not be affected by the reduction in NAb sensitivity.
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- Oct 2021
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Orent 10.28.2021, W. (2021, October 28). Why I Still Believe Covid-19 Could Not Have Originated in a Lab. Undark Magazine. https://undark.org/2021/10/28/opinion-why-covid-19-could-not-have-originated-in-a-lab/
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www.nature.com www.nature.com
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Waltz, E. (2021). COVID vaccine makers brace for a variant worse than Delta. Nature, d41586-021-02854–3. https://doi.org/10.1038/d41586-021-02854-3
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- Jul 2021
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www.medrxiv.org www.medrxiv.org
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Surprisingly, we found that the decreased in neutralization of B.1.351 strains was similar to that of distantly related coronaviruses, namely, SARS-CoV (43.8-fold for BNT162b2 and 33.5-fold for mRNA-1273) and WIV1-CoV (44.3-fold for BNT162b2 and 26.5-fold for mRNA-1273), suggesting that a relatively small number of mutations can medicate potent escape from vaccine-induced neutralizing antibody responses. These substantial differences in neutralization could not be explained by differences in spike protein expression (Figure S4B) nor in the amount of pseudovirus used in the assay (Figure S4C).
Could this suggest that the Beta (B.1.351) variant is more similar to SARS-CoV-1? Should more variants evolve in this direction, could its behavior go beyond escape to full ADE?
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URL
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- Jun 2021
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yellowrabbit.gitlab.io yellowrabbit.gitlab.io
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Arteck HB030 Keyboard and Normal Escape
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- Feb 2021
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twitter.com twitter.com
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Eric Feigl-Ding. (2020, December 6). HUMAN➡️MINKS➡️HUMAN transmission on mink farms in NL. 68% of the tested farm workers and/or contacts had evidence of #SARSCoV2 infection. The coronavirus mutated & even evolved within minks before transmitted back to humans—& keeps #COVID19 perpetuating. Https://t.co/5ARZ6Pq5mO https://t.co/fhrQC9ZVDo [Tweet]. @DrEricDing. https://twitter.com/DrEricDing/status/1335419078446551041
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When employees correctly conclude that a state-ment is bullshit, they may react in a number ofdifferent ways. To illustrate these reactions, wedraw onHirschman’s (1970)exit,voice,loyaltyframework, which he initially formulated to illus-trate how employees react to organizations indecline or when the sky was falling. Scholars lateraddedneglect(Farrell, 1983; Withey & Cooper,1989) and successfully applied the framework tohelp understand employees’ responses to negativeworkplace experiences (Rusbult, Farrell, Rogers, &Mainous, 1988; Turnley & Feldman, 1999). Weapply this framework here to employees’ reactionsto bullshit.When employees act by exiting, they are tryingto escape from the bullshit and the bullshitter.This can involve quitting the organization orseeking a transfer to a different unit of the orga-nization so as to avoid the influence of the bull-shitter. Exiting is a likely reaction when employeesare so appalled by the bullshit that they cannotstay with the organization or unit, or when theyare already disillusioned, and the bullshit (possiblythe latest bout in a stream of bullshit) is the laststraw. For exiting to happen, employee dissatis-faction with the situation must rise to such a levelthat the disadvantages of remaining and facingbullshit in the workplace are greater than thedisadvantages of leaving. Or alternatively, thepersonal costs of leaving should be low enoughrelative to the costs of the two other responses inwhich workers remain and either contest thebullshit (i.e., voice) or disengage from the work-place bullshit (i.e., neglect).
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2019.trailblazer.to 2019.trailblazer.to
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note that TRB source code modifications are not proprietary
In other words, you can build on this software in your proprietary software but can't change the Trailblazer source unless you're willing to contribute it back.
loophole: I wonder if this will actually just push people to move their code -- which at the core is/would be a direction modification to the source code - out to a separate module. That's so easy to do with Ruby, so this restriction hardly seems like it would have any effect on encouraging contributions.
Tags
- well-written
- reminder
- LGPL
- open-source software: not contributing new code back to project
- annotation meta: may need new tag
- wording designed to be more palatable/pleasing/inoffensive
- good point
- proprietary software
- neutral/dispassionate/impartial/objective wording
- loophole/escape hatch
- software licensing
Annotators
URL
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- Dec 2020
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github.com github.com
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it can be difficult or verbose to accomplish some things like animations in React, especially without libraries, and high-performance React animation libraries often bail out of its rendering cycle to manipulate the DOM directly.
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React abstracts the DOM with functionally pure declarative rendering and provides escape hatches back to mutable imperative DOM land. This is a profound philosophical difference that Rich gave a talk about.
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- Nov 2020
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github.com github.com
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You can either use require to bypass typescript special import.
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- Oct 2020
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icla2020b.jonreeve.com icla2020b.jonreeve.com
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little freaks, little inspirations, little melting dreams
An incredibly genius way of describing pastries instead of saying something like "unique, masterfully made, but a little melty". I take from this that the pastries (perhaps like the place that the characters are in and the world in which the girl inhabits) represent some kind of glamorous, overwhelming, but ultimately shallow and meaningless escape.
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Annotators
URL
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final-form.org final-form.org
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If you define a variable outside of your form, you can then set the value of that variable to the handleSubmit function that 🏁 React Final Form gives you, and then you can call that function from outside of the form.
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svelte.dev svelte.dev
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Generally, you should read the value of a store by subscribing to it and using the value as it changes over time. Occasionally, you may need to retrieve the value of a store to which you're not subscribed. get allows you to do so.
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psyarxiv.com psyarxiv.com
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Mendonça, Raíssa Oliveira de, Mylena Maria Ribeiro de Almeida, Talita Garcia Barroso, Normando José Queiroz Viana, and Caio Maximino. ‘COVID-19, Social Isolation, and Psychological Distress in a Brazilian Sample’. Preprint. PsyArXiv, 30 September 2020. https://doi.org/10.31234/osf.io/f942w.
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- Sep 2020
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svelte.dev svelte.dev
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export { className as class }
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Annotators
URL
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github.com github.com
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There are tools in Svelte that break this expectation to a degree, but they are a bit annoying to use, which makes it an active decision on the part of the developer. The API hints at the way we want you to do things because we feel that this will give the better experience.
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There is an escape hatch in :global() that facilitates this. It is verbose, and we are okay with that, we don't want it to be too pleasant to use. We don't want people doing this at all, but it is there when needed.
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- May 2020
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en.wikipedia.org en.wikipedia.org
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This technique may allow a developer to delay offering full support and responsibility for remaining issues.
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nypost.com nypost.com
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That’s why the escape hatch is so appealing. Self-insured companies can tailor their health benefits to meet the needs of their workers. They don’t have to pay for services their employees neither need nor want. And self-insured plans pay their own medical costs, without having to subsidize the health-care costs of other groups.
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- Jun 2017
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escapeplanltd.com escapeplanltd.com
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P.O.W camp,
We should keep a record of where and when they are set. Date, Country and specific locaiton - this one looks like its a POW camp.
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- Apr 2017
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oxford.library.emory.edu oxford.library.emory.edu
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Game Night
Oxford College Library is offering a Game Night on April 14, 2017, 7-11 pm! We hope to see you there!
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Annotators
URL
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- Mar 2017
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rhetcompnow.com rhetcompnow.com
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I am an outsider who thought that perhaps I could lay a set of parallel sidetracks next to the well-worn ones of System B, an underground railway designed to lift up, carry forward, and sustain those fleeing the plight of System B.
identity
escape
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- Jan 2017
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newrepublic.com newrepublic.com
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The paper states the prisoners are beaten with oxtails and shot “when caught in the attempt to escape” or are found “hanging in their cells.” Every prisoner knows that the report is true.
If the prisoners tried to escape or were caught escaping they were beaten and shot.
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- May 2016
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www.turnitin.com www.turnitin.com
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If Turnitin is involved in a merger, acquisition, or sale of all or a portion of its assets, you will be notified via email and/or a prominent notice on our website, of any change in ownership, uses of your personal information, and choices you may have regarding your personal information.
A. merger voids any privacy pledges. The new owner has no requirement to follow these policys.
B. The information is kept for an extended period of time. Once a teacher leaves a school district, their email will be invalid. It's a vacuous promise to say that they'll be contacted.
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- Feb 2014
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gap2.alexandriaarchive.org gap2.alexandriaarchive.org
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The Teians did the same things as the Phocaeans: when Harpagus had taken their walled city by building an earthwork, they all embarked aboard ship and sailed away for Thrace.
1.168 The Teians of the island Teos pull the same disappearing act the Phocaeans pulled in 1.164, escaping the siege of Harpagos and the Persian Army by abandoning the city to the Achaemenid general.
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So when Harpagus withdrew his army from the walls, the Phocaeans launched their fifty-oared ships
1.164 The Phocaeans escape from Harpagos and the Persian Army as the siege lines retreat.
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