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  1. Dec 2021
    1. Another record day for cases in the U.K yesterday. One of the worst Christmas presents we could have received. Please look after each other as well as you can this festive season.
    1. 2021-12-26

    2. Trisha Greenhalgh. (2021, December 27). This is nothing short of scandalous. Unless and until those leading the public health response acknowledge the AIRBORNE nature of the virus and give transmission mitigation advice commensurate with how airborne viruses spread, we will be yo-yoing from wave to wave ad infinitum. [Tweet]. @trishgreenhalgh. https://twitter.com/trishgreenhalgh/status/1475502337594646528

    3. Picture says a lot
    1. 2021-12-27

    2. Trisha Greenhalgh. (2021, December 27). This is nothing short of scandalous. Unless and until those leading the public health response acknowledge the AIRBORNE nature of the virus and give transmission mitigation advice commensurate with how airborne viruses spread, we will be yo-yoing from wave to wave ad infinitum. [Tweet]. @trishgreenhalgh. https://twitter.com/trishgreenhalgh/status/1475502337594646528

    3. This is nothing short of scandalous. Unless and until those leading the public health response acknowledge the AIRBORNE nature of the virus and give transmission mitigation advice commensurate with how airborne viruses spread, we will be yo-yoing from wave to wave ad infinitum.
    1. 2021-12-17

    2. Sefik, E., Israelow, B., Mirza, H., Zhao, J., Qu, R., Kaffe, E., Song, E., Halene, S., Meffre, E., Kluger, Y., Nussenzweig, M., Wilen, C. B., Iwasaki, A., & Flavell, R. A. (2021). A humanized mouse model of chronic COVID-19. Nature Biotechnology, 1–15. https://doi.org/10.1038/s41587-021-01155-4

    3. 10.1038/s41587-021-01155-4
    4. Coronavirus disease 2019 (COVID-19) is an infectious disease that can present as an uncontrolled, hyperactive immune response, causing severe immunological injury. Existing rodent models do not recapitulate the sustained immunopathology of patients with severe disease. Here we describe a humanized mouse model of COVID-19 that uses adeno-associated virus to deliver human ACE2 to the lungs of humanized MISTRG6 mice. This model recapitulates innate and adaptive human immune responses to severe acute respiratory syndrome coronavirus 2 infection up to 28 days after infection, with key features of chronic COVID-19, including weight loss, persistent viral RNA, lung pathology with fibrosis, a human inflammatory macrophage response, a persistent interferon-stimulated gene signature and T cell lymphopenia. We used this model to study two therapeutics on immunopathology, patient-derived antibodies and steroids and found that the same inflammatory macrophages crucial to containing early infection later drove immunopathology. This model will enable evaluation of COVID-19 disease mechanisms and treatments.
    5. A humanized mouse model of chronic COVID-19
    1. 2021-12-18

    2. ReconfigBehSci. (2021, December 18). One thing I keep coming back to in my thoughts is the formerly respected scientists who completely lost their way in this pandemic. Is there something we could be teaching young researchers that would help minimise this in future? Are there norms of science we could strengthen? [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1472172123829456897

    3. one thing I keep coming back to in my thoughts is the formerly respected scientists who completely lost their way in this pandemic. Is there something we could be teaching young researchers that would help minimise this in future? Are there norms of science we could strengthen?
    1. 2021-12-19

    2. Far-right lures recruits using COVID-19 conspiracy theories, alongside misogyny, anti-Semitism, and Islamophobia, says study. (n.d.). Retrieved December 21, 2021, from https://ca.movies.yahoo.com/far-lures-recruits-using-covid-134548878.html

    3. Far-right groups on Telegram have been using COVID-19 conspiracy theories to recruit new members.This finding comes from a study by the Institute of Strategic Dialogue, based in London.Far-right groups have mobilized emotions around COVID-19 restrictions and vaccinations.
    4. Far-right lures recruits using COVID-19 conspiracy theories, alongside misogyny, anti-Semitism, and Islamophobia, says study
    1. 2021-12-20

    2. Travelling Tabby. (2021, December 20). Https://travellingtabby.com/scotland-coronavirus-tracker/ There were over 6,700 new cases reported today, which is one of the highest days we’ve had. And a positivity rate of over 15% too, which is the joint highest we’ve had since reporting began. #covid19scotland #coronavirusscotland #DailyCovidUpdate https://t.co/ZvrVGc2J3I [Tweet]. @TravellingTabby. https://twitter.com/TravellingTabby/status/1472952525544255489

    3. https://travellingtabby.com/scotland-coronavirus-tracker/… There were over 6,700 new cases reported today, which is one of the highest days we've had. And a positivity rate of over 15% too, which is the joint highest we've had since reporting began. #covid19scotland #coronavirusscotland #DailyCovidUpdate
    1. 2021-12-20

    2. Colin Davis. (2021, December 20). Update for 20th Dec. The trend line still reflects 1.8 day doubling (it’s 1.7 days if we look at just the last week). Today’s number is down, but I wouldn’t read too much into that at this point. Https://t.co/kOCjxhRbop [Tweet]. @ProfColinDavis. https://twitter.com/ProfColinDavis/status/1472969632705392640

    3. Update for 20th Dec. The trend line still reflects 1.8 day doubling (it's 1.7 days if we look at just the last week). Today's number is down, but I wouldn't read too much into that at this point.
    1. 2021-12-07

    2. ReconfigBehSci. (2021, December 7). Given an estimate whereby the average person knows ca. 600 people, assuming 50% vaxxed, the average person would know 8 people who died of the vaccine. It is hard to believe numeracy is so low that people cannot see how crazy these “statistics” are... [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1468163579069280258

    3. Given an estimate whereby the average person knows ca. 600 people, assuming 50% vaxxed, the average person would know 8 people who died of the vaccine. It is hard to believe numeracy is so low that people cannot see how crazy these "statistics" are...
    1. 2021-11-26

    2. Arieh Kovler. (2021, November 26). Israel has identified four cases of the B.1.1.529 variant, all recent travellers. One case, a 32-year-old woman returning from South Africa, was triple vaccinated with Pfizer and had her 3rd dose just two months ago. [Tweet]. @ariehkovler. https://twitter.com/ariehkovler/status/1464190991204859919

    3. Update: only one of these four is a fully confirmed case of Omicron. The other three (plus three more) are suspected cases, but their viral loads are too low now to confirm fully. Which itself might be a good sign?
    4. As this thread is being shared to support all sorts of different views, here's my spotters' guide to Covid conspiracy theorists
    5. Clarification here: No reports IF they had symptoms or not. I'm not saying for sure that they are asymptomatic.
    6. On the one hand, B.1.1.529 became the dominant variant in SA frighteningly quickly; on the other, it did so from a very low base number of cases, which makes it easier to be dominant in percentage terms.
    7. Tiny sample size of course, very early days, etc. We still no next to nothing about this variant.
    8. No reports yet if these people are suffering from any symptoms at all; all travelers are screened with PCR tests on arrival, which is how they were identified.
    9. Another, a hotel worker from Malawi, had her second dose of AZ in mid-July. A third had her second J&J dose two months ago.
    10. Israel has identified four cases of the B.1.1.529 variant, all recent travellers. One case, a 32-year-old woman returning from South Africa, was triple vaccinated with Pfizer and had her 3rd dose just two months ago.
    1. 2021-12-17

    2. Novavax and Serum Institute of India Announce World Health Organization Grants Emergency Use Listing for NVX-CoV2373 COVID-19 Vaccine—Dec 17, 2021. (n.d.). Retrieved December 18, 2021, from https://ir.novavax.com/2021-12-17-Novavax-and-Serum-Institute-of-India-Announce-World-Health-Organization-Grants-Emergency-Use-Listing-for-NVX-CoV2373-COVID-19-Vaccine?sf156899079=1

    3. First EUL granted by WHO for a protein-based COVID-19 vaccine EUL vaccine manufactured and marketed by SII as COVOVAX™ WHO EUL for Nuvaxovid™ currently under assessment; will be completed following European Medicines Agency (EMA) review
    4. Novavax and Serum Institute of India Announce World Health Organization Grants Emergency Use Listing for NVX-CoV2373 COVID-19 Vaccine
    1. 2021-12-16

    2. Courtney, D. S., & Bliuc, A.-M. (2021). Antecedents of Vaccine Hesitancy in WEIRD and East Asian Contexts. Frontiers in Psychology, 12, 5873. https://doi.org/10.3389/fpsyg.2021.747721

    3. 10.3389/fpsyg.2021.747721
    4. Following decreasing vaccination rates over the last two decades, understanding the roots of vaccine hesitancy has become a public health priority. Vaccine hesitancy is linked to scientifically unfounded fears around the MMR vaccine and autism which are often fuelled by misinformation spread on social media. To counteract the effects of misinformation about vaccines and in particular the falling vaccination rates, much research has focused on identifying the antecedents of vaccine hesitancy. As antecedents of vaccine hesitancy are contextually dependent, a one-size-fits-all approach is unlikely to be successful in non-WEIRD (Western, Educated, Industrialised, Rich, and Democratic) populations, and even in certain (non-typical) WEIRD sub-populations. Successful interventions to reduce vaccine hesitancy must be based on understanding of the specific context. To identify potential contextual differences in the antecedents of vaccine hesitancy, we review research from three non-WEIRD populations in East Asia, and three WEIRD sub-populations. We find that regardless of the context, mistrust seems to be the key factor leading to vaccine hesitancy. However, the object of mistrust varies across WEIRD and non-WEIRD populations, and across WEIRD subgroups suggesting that effective science communication must be mindful of these differences.
    5. Antecedents of Vaccine Hesitancy in WEIRD and East Asian Contexts
    1. 2021-12-13

    2. Man whose wife won a lawsuit to treat his COVID-19 with ivermectin has died. (n.d.). Retrieved December 17, 2021, from https://ca.news.yahoo.com/man-whose-wife-won-lawsuit-203019784.html

    3. Keith Smith, whose wife had gone to court to have his COVID-19 infection treated with ivermectin, died Sunday evening, a week after he received his first dose of the controversial drug.
    4. Man whose wife won a lawsuit to treat his COVID-19 with ivermectin has died {"longForm":{"weekday":"short","day":"numeric","hour":"numeric","hourCycle":"h12","minute":"2-digit","month":"long","year":"numeric"},"shortForm":{"day":"numeric","month":"long","year":"numeric"}} {"videoDockingCfg":{"enableOnMuted":true,"enableOnScrollDown":true,"enableOnScrollUp":false,"fadeInAnimation":true,"height":225,"positionBottom":0,"positionLeft":-1,"positionRight":20,"positionTop":-1,"showInfoCard":false,"width":400,"threshold":10}} {"twitter":{"timeout":5000}} Read full article
    1. 2021-12-16

    2. Kim Willsher. (2021, December 16). Let’s try again...new “drastic” regulations for anyone planning to come to France from UK. There must be a “compelling” reason. This does not include tourism or business French nationals/residents can return but must have a negative Covid test within 24hrs before departure. 1/2 [Tweet]. @kimwillsher1. https://twitter.com/kimwillsher1/status/1471401803828764682

    3. *Returning French nationals/residents must register (guessing this is similar to UK "locator" form) and isolate for 7 days "in a place of their choice". This can be reduced to 48hrs if they take another Covid test that is negative. 2/2
    4. Let's try again...new "drastic" regulations for anyone planning to come to France from UK. *There must be a "compelling" reason. This does not include tourism or business *French nationals/residents can return but must have a negative Covid test within 24hrs before departure. 1/2
    1. 2021-12-17

    2. Tom Moultrie. (2021, December 17). A 1-figure Gauteng update, bringing in data through Wednesday 15/12 (PCR only; by date of collection). The turn continues. On similar metrics (not shown) ALL northern provinces (NW, GT, MP, LP) seem to have now turned. Https://t.co/6Bh3kZsooK [Tweet]. @tomtom_m. https://twitter.com/tomtom_m/status/1471723711287996416

    3. A 1-figure Gauteng update, bringing in data through Wednesday 15/12 (PCR only; by date of collection). The turn continues. On similar metrics (not shown) ALL northern provinces (NW, GT, MP, LP) seem to have now turned.
    1. 2021-12-16

    2. Jay Varma. (2021, December 16). Um, we’ve never seen this before in #NYC. Test positivity doubling in three days 12/9—3.9% 12/10—4.2% 12/11—6.4% 12/12—7.8% Note: Test % is only for PCR & NYC does more per capita daily than most places ~67K PCR/day + 19K [reported] antigen over past few days (1/2) https://t.co/PhxsZq55jn [Tweet]. @DrJayVarma. https://twitter.com/DrJayVarma/status/1471485885447389186

    3. This is #SARSCoV2 evading both vaccine & virus induced immunity *against infection* unlike any variant before. That's only explanation for dramatic jump in positivity. Consensus for now (but subject to change) is that immunity *against severe disease* should be far better. (2/2)
    4. Um, we've never seen this before in #NYC. Test positivity doubling in three days 12/9 - 3.9% 12/10 - 4.2% 12/11 - 6.4% 12/12 - 7.8% Note: Test % is only for PCR & NYC does more per capita daily than most places ~67K PCR/day + 19K [reported] antigen over past few days (1/2)
    1. 2020-11-28

    2. Eric Topol. (2020, November 28). This will go down in history as one of science and medical research’s greatest achievements. Perhaps the most impressive. I put together a preliminary timeline of some key milestones to show how several years of work were compressed into months. Https://t.co/BPcaZwDFkl [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1332771238771630080

    3. 4. Whose idea was OWS and when did it kick in? Peter Marks @US_FDA https://nytimes.com/2020/11/21/us/politics/coronavirus-vaccine.html?searchResultPosition=1… @SharonLNYT It was announced May 15th https://defense.gov/Explore/Spotlight/Coronavirus/Operation-Warp-Speed/
    4. 3. The 5 days from sequencing the virus to design of an mRNA vaccine, relayed by Tony Fauci in our conversation https://twitter.com/EricTopol/status/1284503783045623809… @Medscape
    5. 2. 3 scientists led the way Katalin Karikó, worked on a mRNA vaccine for ~30 years, was demoted from @PennMedicine d/t losing her grants, went to @moderna_tx https://statnews.com/2020/11/10/the-story-of-mrna-how-a-once-dismissed-idea-became-a-leading-technology-in-the-covid-vaccine-race/… and the husband and wife team @BioNTech_Group https://nytimes.com/2020/11/10/business/biontech-covid-vaccine.html…
    6. There are several points noteworthy related to this timeline: 1. Moderna had a head-start, so why didn't their Phase 3 trial finish first? Part of #OperationWarpSpeed (OWS), they were requested to slow down enrollment to get better minority representation https://nytimes.com/2020/11/21/us/politics/coronavirus-vaccine.html?searchResultPosition=1
    7. This will go down in history as one of science and medical research's greatest achievements. Perhaps the most impressive. I put together a preliminary timeline of some key milestones to show how several years of work were compressed into months.
    1. 2021-12-08

    2. Wilhelm, A., Widera, M., Grikscheit, K., Toptan, T., Schenk, B., Pallas, C., Metzler, M., Kohmer, N., Hoehl, S., Helfritz, F. A., Wolf, T., Goetsch, U., & Ciesek, S. (2021). Reduced Neutralization of SARS-CoV-2 Omicron Variant by Vaccine Sera and monoclonal antibodies (p. 2021.12.07.21267432). https://doi.org/10.1101/2021.12.07.21267432

    3. 10.1101/2021.12.07.21267432
    4. Due to numerous mutations in the spike protein, the SARS-CoV-2 variant of concern Omicron (B.1.1.529) raises serious concerns since it may significantly limit the antibody-mediated neutralization and increase the risk of reinfections. While a rapid increase in the number of cases is being reported worldwide, until now there has been uncertainty about the efficacy of vaccinations and monoclonal antibodies. Our in vitro findings using authentic SARS-CoV-2 variants indicate that in contrast to the currently circulating Delta variant, the neutralization efficacy of vaccine-elicited sera against Omicron was severely reduced highlighting T-cell mediated immunity as essential barrier to prevent severe COVID-19. Since SARS-CoV-2 Omicron was resistant to casirivimab and imdevimab, genotyping of SARS-CoV-2 may be needed before initiating mAb treatment. Variant-specific vaccines and mAb agents may be required to treat COVID-19 due to Omicron and other emerging variants of concern.
    5. Reduced Neutralization of SARS-CoV-2 Omicron Variant by Vaccine Sera and monoclonal antibodies
    1. 2021-12-16

    2. Theo Sanderson. (2021, December 16). 71.9% of cases in London with specimens from 13 December were Omicron. Overall London cases are already reaching the maximum values ever seen in the pandemic. Https://t.co/CJF5kQqBpl [Tweet]. @theosanderson. https://twitter.com/theosanderson/status/1471537690650812420

    3. 71.9% of cases in London with specimens from 13 December were Omicron. Overall London cases are already reaching the maximum values ever seen in the pandemic.