28 Matching Annotations
  1. Last 7 days
    1. In an observational study of 14 patients, no subjects developed any cardiac or skeletal disease after receiving doses from 25- to 150mcg over a two-year period.41

      Note that the high dose was because they were increasing the dose based on symptoms. That is to say, as the thyroid gland produced less thyroid hormone, they increased liothyronine dose to compensate.

    1. The substitution of l-T3 for l-T4 at equivalent doses (relative to the pituitary) reduced body weight and resulted in greater thyroid hormone action on the lipid metabolism, without detected differences in cardiovascular function or insulin sensitivity.

      This implies that T4 and T3 are not identical, but I want to check the study further to see if half-life comes into play. The T3 group could theoretically have higher daily thyroidergic exposure, but maintain TSH because they experience a daily dip. Multiple dosing at least partly solves this issue. Controlled release tablets would be ideal.

  2. Jan 2020
    1. At the final study visit, subjects were asked whether they thought their L-T4 doses at the end of the study were higher, lower, or unchanged from the start of the study and which of the two doses they preferred. Subjects were not able to accurately ascertain changes in L-T4 doses (P = 0.54)

      The study does not provide enough information to determine whether this is meaningful. It appears to be meaningless. If they had used a crossover design, then this might be useful.

  3. Dec 2019
    1. The sodium-restricted diet group received a regimen aiming a maximum intake of 3 g of sodium per day (equivalent to 7.5 g of sodium chloride).

      That sounds incredibly high to me. 3000 mg is the absolute maximum intake that could ever be considered 'low' sodium. Under 1500 is usually considered ideal. Would, then, a diet aiming for half the sodium be twice as effective?

  4. Nov 2019
    1. between 535 and 900 kcal, depending on age, sex, weight, and height (16).

      In other words, it was isocaloric between the two groups, in that similar subjects were fed similar calories.

    1. Personally, I have eaten and will continue to eat the Impossible Burger. I often lean more towards the “ends justify the means” side of the philosophical spectrum, and for me, this falls into that category. Pat Brown, Impossible Foods’ founder and CEO, has been vegetarian for four decades and vegan (if the vegan police are still letting him call himself that) for 14 years. I’ve read his statement on the issue, and while I still have no idea what I would have done in his situation, I fully understand how he arrived at the difficult conclusion that he needed to allow the testing.

      This isn't spot on for me, but pretty close.

  5. Oct 2019
  6. Feb 2019
    1. It’s simply better to link directly to your related content in a meaningful context, than to use a generic related posts box somewhere else on your page.
    1. Without this, men fill one another's heads with noise and sounds;

      Alluding to the Transactional Model of Communication, noise can external (e.g. words, sounds) or internal (e.g. anxiety, distraction). Noise is a barrier to clear communication, which in this sense, inhibits the progression of knowledge.

  7. Nov 2018
  8. Apr 2017
    1. Ethnic identity is twin skin to linguistic identity

      One could see this with how she writes in this very text. Alternating between English and Spanish phrases and sentences, mixing and matching the words a la Spanglish - her twin identity emerges within in the very text.

  9. Jan 2017
    1. Out of the night

      Can you find the contrasting images? Imagery are the larger impression built up from individual images. What kinds of contrasting imagery do you find here?

  10. Sep 2015
    1. gravitoinertial ambiguity

      I had to find other references for this phenomenon. The wikipedia page on Einstein's equivalency principle was helpful. As was this pdf with merfeld and zupan Until there is information from other sensory systems, fluid movement in otolith organs cannot disambiguate between a head tilt or a head acceleration.

  11. Sep 2013
    1. From this definition of happiness it follows that its constituent parts are: -- good birth, plenty of friends, good friends, wealth, good children, plenty of children, a happy old age, also such bodily excellences as health, beauty, strength, large stature, athletic powers, together with fame, honour, good luck, and virtue. A man cannot fail to be completely independent if he possesses these internal and these external goods; for besides these there are no others to have.

      What is happiness?

    1. He must, therefore, know how many different forms of constitution there are; under what conditions each of these will prosper and by what internal developments or external attacks each of them tends to be destroyed. When I speak of destruction through internal developments I refer to the fact that all constitutions, except the best one of all, are destroyed both by not being pushed far enough and by being pushed too far.