real-world-application #question How can gene therapies be used to combat these imperfections in mutated genomes? What are some other ways of curing cancer involving the genome?

Real world significance

https://diggingthedigital.com/hoe-werkt-het-maken-van-een-idee-notitie/

Frank calls out what he considers a good example of actual note taking practice rather than the more often seen talk about note taking theory. The example in question is Forrest Perry's YouTube video #9 Zettelkasten: from source card to idea card.

real world assets for collateral diversification?

Devirisifaction can mitigate future attacks of this nature

This is similar to the IndieWeb and web standards ideas of looking back at history to see the actual patterns of work that were beneficial.

Link to: - https://hypothes.is/a/HhAj3r1bEeyw9h_Pa4QNrA

This feels like an underlying and underpinning principle of how the IndieWeb which focuses on working real world examples which are able to build up more complex systems instead of theoretical architecture astronomy which goes no where.

Reference: John Gall (1975) Systemantics: How Systems Really Work and How They Fail p. 71

Deepti Gurdasani. (2022, January 10). Lots of people dismissing links between COVID-19 and all-cause diabetes. An association that’s been shown in multiple studies- whether this increase is due to more diabetes or SARS2 precipitating diabetic keto-acidosis allowing these to be diagnosed is not known. A brief look👇 [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1480546865812840450

Broadfoot, M. (n.d.). Masks Protect Schoolkids from COVID despite What Antiscience Politicians Claim. Scientific American. Retrieved January 23, 2022, from https://www.scientificamerican.com/article/masks-protect-schoolkids-from-covid-despite-what-antiscience-politicians-claim/

Olson, S. M., Newhams, M. M., Halasa, N. B., Price, A. M., Boom, J. A., Sahni, L. C., Pannaraj, P. S., Irby, K., Walker, T. C., Schwartz, S. P., Maddux, A. B., Mack, E. H., Bradford, T. T., Schuster, J. E., Nofziger, R. A., Cameron, M. A., Chiotos, K., Cullimore, M. L., Gertz, S. J., … Randolph, A. G. (2022). Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents. New England Journal of Medicine, 0(0), null. https://doi.org/10.1056/NEJMoa2117995

Tseng, H. F., Ackerson, B. K., Luo, Y., Sy, L. S., Talarico, C., Tian, Y., Bruxvoort, K., Tupert, J. E., Florea, A., Ku, J. H., Lee, G. S., Choi, S. K., Takhar, H. S., Aragones, M., & Qian, L. (2022). Effectiveness of mRNA-1273 against SARS-CoV-2 omicron and delta variants (p. 2022.01.07.22268919). https://doi.org/10.1101/2022.01.07.22268919

Simon, M. A., Luginbuhl, R. D., & Parker, R. (2021). Reduced Incidence of Long-COVID Symptoms Related to Administration of COVID-19 Vaccines Both Before COVID-19 Diagnosis and Up to 12 Weeks After (p. 2021.11.17.21263608). https://doi.org/10.1101/2021.11.17.21263608

Racine, N., Madigan, S., Cardinal, S., Hartwick, C., Leslie, M., Motz, M., & Pepler, D. (2021). Community-Based Research: Perspectives of Psychology Researchers and Community Partners. PsyArXiv. https://doi.org/10.31234/osf.io/cxrmt

The Design Problem

Three diagrams will explain the lack of social engagement in design. If (in Figure 1) we equate the triangle with a design problem, we readily see that industry and its designers are concerned only with the tiny top portion, without addressing themselves to real needs.

(Design for the Real World, 2019. Page 57.)

The other two figures merely change the caption for the figure.

• Figure 1: The Design Problem
• Figure 2: A Country
• Figure 3: The World

Edge Effects

It was in the Design Science Studio that I learned about edge effects.

Yesterday, I was thinking about how my life embodies the concept of edge effects. That same day, a book was delivered to our door, Design for the Real World by Victor Papanek.

Today, I was reading these words:

Design for the Real World

Design for Survival and Survival through Design: A Summation

Integrated, comprehensive, anticipatory design is the act of planning and shaping carried on across the various disciplines, an act continuously carried on at interfaces between them.

Victor Papanek goes on to say:

It is at the border of different techniques or disciplines that most new discoveries are made and most action is inaugurated. It is when two differing areas of knowledge are brought into contact with one another that… a new science may come into being.

(Page 323)

Exiles and Emigrés

The Bauhaus spread its ideas because it existed at the boundaries, the avant-garde, the edges of what was thought to be possible, especially as a socialist utopian idea found its way to a capitalist industrial-military complex, where the concept of modernism was co-opted and colonized by globalizing economic forces beyond the control of the individual. Design was the virus that propagated around the world through the vehicle of corporate globalization.

That same design ethic is infecting corporations with a conscience, with empathy, with a process that begins with listening to people. Design is the virus that can spread the values of unconditional love throughout the body of neoliberal capitalism.

Design for the Real World

You have to make up your mind either to make sense or to make money, if you want to be a designer.

— R. Buckminster Fuller

(Page 86)

Design for the Real World

by Victor Papanek

Papanek on the Bauhaus

Many of the “sane design” or “design reform” movements of the time, such as those engendered by the writings and teachings of William Morris in England and Elbert Hubbard in the United States, were rooted in a sort of Luddite antimachine philosophy. By contrast Frank Llloyd Wright said as early as 1894 that “the machine is here to stay” and that the designer should “use this normal tool of civilization to best advantage instead of prostituting it as he has hitherto done in reproducing with murderous ubiquity forms born of other times and other conditions which it can only serve to destroy.” Yet designers of the last century were either perpetrators of voluptuous Victorian-Baroque or members of an artsy-craftsy clique who were dismayed by machine technology. The work of the Kunstgewerbeschule in Austria and the German Werkbund anticipated things to come, but it was not until Walter Gropius founded the German Bauhaus in 1919 that an uneasy marriage between art and machine was achieved.

No design school in history had greater influence in shaping taste and design than the Bauhaus. It was the first school to consider design a vital part of the production process rather than “applied art” or “industrial arts.” It became the first international forum on design because it drew its faculty and students from all over the world, and its influence traveled as these people later founded design offices and schools in many countries. Almost every major design school in the United States today still uses the basic foundation course developed by the Bauhaus. It made good sense in 1919 to let a German 19-year-old experiment with drill press and circular saw, welding torch and lathe, so that he might “experience the interaction between tool and material.” Today the same method is an anachronism, for an American teenager has spent much of his life in a machine-dominated society (and cumulatively probably a great deal of time lying under various automobiles, souping them up). For a student whose American design school slavishly imitates teaching patterns developed by the Bauhaus, computer sciences and electronics and plastics technology and cybernetics and bionics simply do not exist. The courses the Bauhaus developed were excellent for their time and place (telesis), but American schools following this pattern in the eighties are perpetuating design infantilism.

The Bauhaus was in a sense a nonadaptive mutation in design, for the genes contributing to its convergence characteristics were badly chosen. In boldface type, it announced its manifesto: “Architects, sculptors, painters, we must all turn to the crafts.… Let us create a new guild of craftsmen!” The heavy emphasis on interaction between crafts, art, and design turned out to be a blind alley. The inherent nihilism of the pictorial arts of the post-World War I period had little to contribute that would be useful to the average, or even to the discriminating, consumer. The paintings of Kandinsky, Klee, Feininger, et al., on the other hand, had no connection whatsoever with the anemic elegance some designers imposed on products.

(Pages 30-31)

Victor Papanek’s book includes an introduction written by R. Buckminster Fuller, Carbondale, Illinois. (Sadly, the Thames & Hudson 2019 Third Edition does not include this introduction. Monoskop has preserved this text as a PDF file of images. I have transcribed a portion here.)

Ingale, M., & Shekatkar, S. M. (2020). Resource dependency and survivability in complex networks. Physical Review E, 102(6), 062304. https://doi.org/10.1103/PhysRevE.102.062304

Prof. Christina Pagel. (2021, May 17). this is important because it means that lab based studies looking at this tell you meaningful things about real world efficacy—And the lab based studies are much quicker than real world ones. [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1394276693335019525

Westgate, Erin, Nick Buttrick, Yijun Lin, and Gaelle Milad El Helou. ‘Pandemic Boredom: Predicting Boredom and Its Consequences during Self-Isolation and Quarantine’. PsyArXiv, 11 May 2021. https://doi.org/10.31234/osf.io/78kma.

Quillien, Tadeg, and Michael Barlev. ‘Causal Judgment in the Wild: Evidence from the 2020 US Presidential Election’. PsyArXiv, 7 April 2021. https://doi.org/10.31234/osf.io/7w9re.

Dikker, S. (2020, June 15). Out of the lab: Crowdsourcing neuroscience during real-world social interactions. Neurosync-2020. https://www.youtube.com/watch?v=XE1XcSNWDQc

Argument Quality in Real World Argumentation. (2020). Trends in Cognitive Sciences, 24(5), 363–374. https://doi.org/10.1016/j.tics.2020.01.004

Gollwitzer, A., Martel, C., Marshall, J., Höhs, J. M., & Bargh, J. A. (2020, May 5). Connecting Self-Reported Social Distancing to Real-World Behavior at the Individual and U.S. State Level. https://doi.org/10.31234/osf.io/kvnwp

One teacher's experience using slack, referencing what things were like before using it and after; contains many ideas on how about how to maximize Slack (3/5)

One instructor's use of Slack, comparing and contrasting other LMS (but he used Canvas); good basic breakdown of the conversational tools and samples of how hey can be used; This is a great primer of Slack's use in the classroom (5/5)

Use of Slack in a FACE-TO-FACE class and how much it increased interaction; brings up a point that concerns me and that's what happens when the instructor/TA appear to be available 24/7 given the nature of Slack; good exploration of motivating students to use it (4/5)

Just a political science professor's thoughts on using Slack in his class; points out how it can be useful (1/5)

big data solutions for cardiovascular and oncological research.

To fully grasp someone's culture, you would have to learn the meanings of real world objects such as love, marriage, animals etc. of that culture