39 Matching Annotations
  1. Last 7 days
    1. if the magnetic tape remains tightly wound, you can’t read the information on the cassette. Epigenetics works by unspooling the tape, or not, to control which genetic instructions are carried out. In epigenetic inheritance, the DNA code is not altered, but access to it is.

      An interesting way to describe epigenetics. It is like magnetic tape on a cassette, you have to unwind it to be able to read its content. Epigenetics, by analogy would be controlling the spooling of the DNA for accessibility.

  2. Nov 2020
    1. Genomics

      The study of whole genomes of the organisms and incorporates elements from genetics. The genomics uses a combo of DNA, DNA sequencing, and bioinformatics to sequence, assembly, and analyze the structure and the function of the genomes.

    1. histone acetylation

      Allows for DNA binding proteins to interact with sites to activate gene transcription and alters the accessibility of chromatin.

    1. transcriptionalleve

      This is the process of a complementary mRNA copy of a single gene on the DNA that is created in the nucleus. The mRNA is smaller than the DNA so it can carry the genetic code into the ribosome and into the cytoplasm that enables the protein creation.

    1. reading fram

      The reading frame is the way of dividing each sequence of nucleotides in the DNA or RNA molecule into a set of consecutive, non-overlapping triplets.

    1. Single-strand binding proteins

      These bind to single-stranded regions of the DNA and during DNA replication they bind to newly formed DNA strands. They help keep the DNA strands in place as a framework for new DNA synthesis.

    1. Tumor suppressor genes

      These are genes that slow down cell division, repair DNA errors, and/or tell cells to terminate. If these Tumor Suppressor Genes fail to function properly, they go rouge and become cancer cells.

  3. Oct 2020
  4. Jul 2020
  5. Jun 2020
  6. May 2020
  7. Jan 2020
    1. generally accepted extinction coefficients for nucleic acids are: • Double-stranded DNA: 50 • Single-stranded DNA: 33 • RNA: 40
  8. Nov 2018
  9. Sep 2018
  10. Jul 2018
    1. repeat expansion at IIL1 leads to increased accumulation of 24-nt siRNAs in a temperature-dependent manner that correlates with the iil phenotype. We show that DCL3 and other components of the RNA-dependent DNA methylation (RdDM) pathway are essential for this siRNA-directed epigenetic gene silencing
  11. Apr 2018
  12. Mar 2018
    1. Excessive mutation will often stop a gene from working, yet somehow the sand rat’s genes manage to still fulfil their roles despite radical change to the DNA sequence. This is a very difficult task for genes. It’s like winning Countdown using only vowels.

      This will change everything.

    1. "Interestingly, though our results are preliminary, there are no major traces of genetic ancestry in these early inhabitants of Bavaria that might have come from soldiers of the Roman army,"
  13. Jan 2018
    1. A resource for the allele-specific analysis of DNA methylation at multiple genomically imprinted loci in mice
  14. Dec 2017
  15. Jul 2017
    1. global dye-bias equalization step to control for the different average intensities in the red and green channels. This procedure scales the background-corrected intensities, dividing by the average intensity of the positive control probes in the same channel, red or green, and multiplying by the average intensity of all positive controls in a reference array.
  16. Jan 2017
  17. Nov 2016
    1. Two new molecular catalysts of water oxidation have been synthesized by a team of brilliant scientists from the U.S. Department of Energy’s Brookhaven National Laboratory. These new molecular catalysts – complexes of ruthenium which are surrounded by the binding molecules, and they contain phosphonate groups.

  18. Mar 2016
  19. Feb 2015
    1. tests

      (We should be thinking...)

      What kinds of "tests"? When?

      The answers are available in the Cease and Desist letters and later in the article -- DNA Barcoding.