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  1. Last 7 days
    1. With that in mind, I'm trying something new, the guided tour for Mu. Ironically, it atomizes my previous docs by linking repeatedly into anchors in the middle of pages. Proceed if you dare.

      The current incarnation of the tutorial (https://raw.githubusercontent.com/akkartik/mu/7195a5e88e7657b380c0b410c8701792a5ebad72/tutorial/index.md) starts by describing "Prerequisites[:] You will need[...]", and then goes on to list several things, including various software packages—assuming a Linux system, etc.

      This is the idea I'm trying to get across with the self-containedness I've been pursuing (if not with triple scripts then at least with LP docs).

      That prerequisites list should be able to replace with two requirements, i.e.:

      "You will need: (1) this document, and (2) the ability to read it (assuming you have an appropriate viewer [which in 2021 is nowhere close to the kind of ask of the old world])"

    1. Discussion, revision and decision


      Discussion and Revision


      Author

      Reviewer 1 (Takehiko Ogawa, Yokohama City University, ogawa@yokohama-cu.ac.jp ):

      We had already suggested in the "Limitations" section on page 10 of the manuscript-PDF testis transplantation experiments to test biological functionality for future studies: https://www.biorxiv.org/content/10.1101/2021.10.12.464060v1.full.pdf

      However, these experiments will require new cell lines, new funding, more resources, more logistics, and new ethics approval which we are considering for future studies. We believe that the observations described in our manuscript are valuable to the scientific community and are a basis to conduct further studies.


      Reviewer 2 (Dr. Pradeep G Kumar, Rajiv Gandhi Centre for Biotechnology, and kumarp@rgcb.res.in )

      There are no line numbers in the manuscript-PDF but the pages are numbered: https://www.biorxiv.org/content/10.1101/2021.10.12.464060v1.full.pdf Since the pages of the manuscript-PDF are numbered, we think that citation of the manuscript is unproblematic. The text of the manuscript has been checked by multiple experienced authors and found not to require the suggested changes.

    1. On one side of the world were people whose relationship with the liv-ing world was shaped by Skywoman, who created a garden for the

      well-being of all. On the other side was another woman with a garden and a tree. But for tasting its fruit, she was banished from the garden and the gates clanged shut behind her. That mother of men was made to wander in the wilderness and earn her bread by the sweat of her brow, not by filling her mouth with the sweet juicy fruits that bend the branches low. In order to eat, she was instructed to subdue the wilder-ness into which she was cast.

      Its amazing how two origin stories with such similarities lead us to such different cultures and civilizations. The founder effects can be incredibly powerful.

    2. Our elders say that ceremonies are the way we “remember to remember,”

      The Western word "ceremony" is certainly not the best word for describing these traditions. It has too much baggage and hidden meaning with religious overtones. It's a close-enough word to convey some meaning to those who don't have the cultural background to understand the underlying orality and memory culture. It is one of those words that gets "lost in translation" because of the dramatic differences in culture and contextual collapse.

      Most Western-based anthropology presumes a Western idea of "religion" and impinges it upon oral cultures. I would maintain that what we would call their "religion" is really an oral-based mnemonic tradition that creates the power of their culture through knowledge. The West mistakes this for superstitious religious practices, but primarily because we can't see (or have never been shown) the larger structures behind what is going on. Our hubris and lack of respect (the evils of the scala naturae) has prevented us from listening and gaining entrance to this knowledge.

      I think that the archaeological ideas of cultish practices or ritual and religion are all more likely better viewed as oral practices of mnemonic tradition. To see this more easily compare the Western idea of the memory palace with the Australian indigenous idea of songline.

    1. Discussion, revision and decision


      Revision


      Author

      The objective of the paper was not to address a research question but to report on a more recent set of PubMed retractions due to insufficient/old information available in the papers published on this subject(PubMed, not WoS retracted articles). One of the initial objectives was to analyze the dynamic of image related retractions(a relatively new subject), a subject for which the information is at least scarce if non existing. We have also studied the impact of retracted research via two citations databases (Google Scholar and Dimensions) and tried to represent the variability of this impact when the author country is being considered. At this time, the paper is the second biggest serie of PubMed retracted articles.

      There was an error from our part, thank you very much for pointing this.

      We have revised the article and added the informations related to previous research on this subject. Thank you so much for this suggestion.

    1. Sustainability window analysis is based on the advanced sustainability analysis (ASA) approach. The ASA approach was developed in Finland Futures Research Centre [31,32,33] providing a general framework for analyzing sustainability.

      Include this in a comparative analysis of other methodologies such as Hoornweg, Hachaichi, R3.0 Thresholds and Allocations, etc.

  2. Nov 2021
    1. Looking for a property?

      Do you want to buy property in India? Are you looking for best-in-class residential and commercial properties for sale in Delhi NCR, Lucknow, Pune, Mumbai, Bangalore, Gurgaon, and Noida? Well, you have landed in the correct place.

    1. ignores

      Critiques community economic development's focus on local empowerment. Advances the argument that a local focus divorced from the broader political economy cannot tackle the larger governance and economic forces that create inequality, especially due to concentrated poverty in some jurisdictions that leaves local governments under-resourced due to a meager tax base.

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    1. My UIs are data/store driven. The UI is just a way to visualize the data. Your data could flow through all of of the extensions and the extensions can make decisions (e.g. setting visible to false). Like middlewares in a Connect/Express/Polka app. And the UI doesn't even know about all this, it just updates with the current state and makes sure it's consistent.
    1. I think it’s a good idea to have a fall break. Also a mental day. But the mental day has to be productive. A roundtable discussion is a really good idea. Maybe even some group therapy sessions if that’s even a thing. And with students with disabilities. We should also have classes that talk about serious subjects. And also give The students with disabilities a chance to air their grievances. And also have teachers explain to them what’s going on and how they can make a change. Or have some additional counseling. Maybe we can even have a way to make sure everybody is safe both physically mentally. And educationally. Students with disabilities have a right to. It’s harder for students is with mental challenges to grasp at serious subject. Maybe we should have a class maybe at the Achieve center like a roundtable class or a class and teaching us how to be more resilient. How to deal with trauma and PTSD and she CPTSD.

    1. 2018wave of ICILS (International Computer and Information Literacy Study)

      2018 wave of ICILS (International Computer and Information Literacy Study)

    2. Special EducationalNeeds and /or Disabilities (SEND):

      Special Educational Needs and /or Disabilities (SEND):

    3. Guarantee access to internet and availability of computers, laptops, or tablets:access to the internet at a decent speed and to proper ICT tools are basicprerequisites for any online teaching and learning strategy.

      ICT Information and Communication Technology

    4. TALIS(Teaching and Learning International Survey)

      TALIS

      (Teaching and Learning International Survey)

    5. The experience from EDT raises pedagogical and organizational questions.

      like in Finland, but technological

    6. Distant and Remote Communication

      Distant and Remote Communication

    7. structure of the measurement and analysis
      1. Findings, solutions and good practices in regard of online learning during the pandemic. mixed method approach
      • collect data through surveying students each week
      • analyze quantitative data using ANOVA
      • compare results to the analysis from qualitative data triangulation: quantitative, qualitative data and literature
    1. I think the reason that all the spiritual traditions have got this concept of "we are all connected inside of it" is because the societies that actually deeply adopt this idea are the ones that over time deepen their level of consideration, deepen their level of expression, deepen their level of understanding for each other. 00:16:40 This is the reason that this idea pops up over and over at the core of spiritual traditions. And I hope through this talk you see that the reason that it appears at the core of science is it's actually something that is just literally true of the physical universe at every single level of organization and every single manifestation of matter, energy, and life.

      This is a good alignment showing that at the deepest level, the fundamental aspiration and values of science and religion are the same: interconnectedness.

    1. How people use to write was on Papyrus which was made out of hands and other natural things you find in nature. People also wrote with black and red ink. And they would make those into scrolls. What is papyrus?

    1. There was no ancient poet called “Homer,” he argued. Nor were the poems attributed to him “written” by any single individual. Rather, they were the product of a centuries-long tradition of poet-performers.

      Are there possibly any physical artifacts in physical archaeology that may fit into the structure of the thesis made by Lynne Kelly in Knowledge and Power in Prehistoric Societies?

      What would we be looking for? Small mnemonic devices? Menhir? Standing stones? Wooden or stone circles? Other examples of extended ekphrasis similar to that of the shield of Achilles?

      cf: Expanding Ekphrasis to the Broader Field of Mnemotechny: or How the Shield of Achilles Relates to a Towel, Car, and Water Buffalo

  3. Oct 2021
    1. Unfortunately, if the location to which you wish to move the text is off-screen, you may have to use some other mechanism to find the target location
    1. Around @0:25:52

      Krouse: Another subset of "shit just works" would be—

      Leung:"No installation required"?

      Krouse: Yeah. "No installation required". [...] as I was just telling you, I spent the last, like... I spent 5 hours over the last two days installing... trying to install software to get something to run. And it's just ridiculous to have to spend hours and hours. If you want to get Xcode to run, it takes— first of all you need a Mac, which is crazy, and then second of all it takes, depending on your internet connection, it could take you a whole day just to get up and running. Why isn't it xcode.com/create?

    1. From paper to block and ink we are now learning about the printing press. The best invention at the time because you can create a news paper. And now printers are becoming obsolete and so is the news paper now a news paper is on line.

  4. bafybeiery76ov25qa7hpadaiziuwhebaefhpxzzx6t6rchn7b37krzgroi.ipfs.dweb.link bafybeiery76ov25qa7hpadaiziuwhebaefhpxzzx6t6rchn7b37krzgroi.ipfs.dweb.link
    1. A final cluster gathers lenses that explore phenomena that are arguably more elastic and withthe potential to both indirectly maintain and explicitly reject and reshape existing norms. Many ofthe topics addressed here can be appropriately characterized as bottom-up, with strong and highlydiverse cultural foundations.

      The bottom-up nature of this cluster makes it the focus area for civil society movements, inner transformation approaches and cultural methodologies. Changing the mindset or paradigm from which the system arises is the most powerful place to intervene in a system as Donella Meadows pointed out decades ago in her research on system leverage points: https://donellameadows.org/archives/leverage-points-places-to-intervene-in-a-system/

      The Stop Reset Go initiative is focused on this thematic lens, bottom-up, rapid whole system change, with Deep Humanity as the open-source praxis to address the needed shift in worldview. One of the Deep Humanity programs is based on addressing the psychological deficits of the wealthy, and transforming them into heroes for the transition, by redirecting their WEALTH-to-WELLth.

    2. Yet, these lenses also point to the power of ideas, to how people can thrive beyonddominant norms, and to the possibility of rapid cultural change in societies—all forms of trans-formation reminiscent of the mythological phoenix born from the ashes of its predecessor. It isconceivable that this cluster could begin to redefine the boundaries of analysis that inform the En-abler cluster, which in turn has the potential to erode the legitimacy of the Davos cluster. The veryearly signs of such disruption are evident in some of the following sections and are subsequentlyelaborated in the latter part of the discussion.

      This passage pays homage to Donella Meadows, who identified the shift in mindset or paradigm that supports the system as the top leverage point. If we can shift this mindset in sufficient number of people, it can shift the thinking of the Enabler Cluster identified in the paper. A social tipping point strategy can be adopted to help this to happen quickly. This strategy is being developed by Stop Reset Go and other civil society actors.

    1. I no longer know how it works. I don't care to maintain it. It needs big changes to handle something like embedding a Jupyter notebook. And it depends on Python 2.6(!).With hundreds of pages, and its own custom URL layout that I don't want to break, I dread migrating
    1. To date, there is no single accounting of how much money flowed from the slave economy into coffers of American higher education. But Wilder says most American colleges founded before the Civil War relied on money derived from slavery. He suspects that many institutions are reluctant to examine this past. "There's not a lot of upside for them. You know these aren't great fundraising stories," Wilder says. Some people say that institutions must do more than make apologies and rename buildings. They insist that scholarships and other forms of monetary reparations are due. And others argue that whatever colleges and universities are doing to acknowledge their slave-holding past — a campus memorial to slaves, for example — is motivated by public relations and does nothing to ameliorate the legacy of slavery and systemic inequality. Brown University was the first to confront its ties to slavery in a major way. In 2003, Brown president Ruth Simmons appointed a commission to investigate. "What better way to teach our students about ethical conduct than to show ourselves to be open to the truth, and to tell the full story?" she says.

      This is important research to do so as not to conveniently forget the past. If all were equal today, that would have happened as the proper outcome of proactive, widespread and impactful recognition of the injustice of the past. Inequality has persisted, transmuted into structural inequality, especially manifesting in economic legacy of inherited wealth. It could be interpreted as unconducive for fundraising, but so can opaqueness of a proactive strategy.

    2. "The story of the American college is largely the story of the rise of the slave economy in the Atlantic world," says Craig Steven Wilder, a historian at MIT and author of "Ebony and Ivy: Race, Slavery, and the Troubled History of America's Universities."

      In this way, the past seeps into the present. This is a literal example of the legacy of structural inequality.

    1. When the Western world accepted Christianity, Caesar conquered; and the received text of Western theology was edited by his lawyers.… The brief Galilean vision of humility flickered throughout the ages, uncertainly.

      On the Homebrewed Christianity podcast, Tripp Fuller quotes Process and Reality by Alfred North Whitehead in a conversation with Brian McLaren (22:20).

      When the Western world accepted Christianity, Caesar conquered; and the received text of Western theology was edited by his lawyers. The code of Justinian and the theology of Justinian are two volumes expressing one movement of the human spirit. The brief Galilean vision of humility flickered throughout the ages, uncertainly. In the official formulation of the religion it has assumed the trivial form of the mere attribution to the Jews that they cherished a misconception about their Messiah. But the deeper idolatry, of the fashioning of God in the image of the Egyptian, Persian, and Roman imperial rulers, was retained. The Church gave unto God the attributes which belonged exclusively to Caesar.

      Whitehead, Alfred North. Process and Reality (Gifford Lectures Delivered in the University of Edinburgh During the Session 1927-28) (p. 342). Free Press. Kindle Edition.

    1. In some cases, our use of cellphone cameras has the potential to liberate us when directed at the state, subjecting the powerful and privileged to forms of accountability that they’re not used to. That’s been made plain by the significant role of cellphone video in the movement against police brutality

      This topic of cellphone cameras relates perfectly to my social justice topic. Before, cellphones the only way to record police brutality was by word of mouth.

    2. But as we surveil each other in profoundly coercive ways, we also risk — as is often the case with informal forms of power — replicating the coercive power of the state itself. Surveillance disciplines our behavior, as any minority who’s passed through a security checkpoint in America can tell you in detail. It creates certain behaviors by design, most notably compliance, the willingness to do anything to avoid being hurt.

      In reference to social justice, we surveil each other in ways, such as police brutality. Before there was cell phones to record violent behavior, it was their word against the public and no one believed them..

    1. Coronavirus Pandemic Data Explorer. (n.d.). Our World in Data. Retrieved March 3, 2021, from https://ourworldindata.org/coronavirus-data-explorer

      is:webpage lang:en COVID-19 graph case death Germany Sweden UK Afghanistan Africa Albania Algeria Andorra Angola Anguilla Antigua Barbuda Argentina Armenia Asia Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia Bosnia Herzegovina Botswana Brazil Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Colombia Comoros Congo Costa Rica Cote d'ivoire Croatia Cuba Cyprus Czechia Democratic Republic of Congo Denmark Djobouti Dominica Dominician Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Eswatini Ethiopia Europe Europian Union Faeroe Islands Falkland Islands Fiji Finland France Gabon Gambia Georgia Ghana Gibraltar Greece Greenland Grenada Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Honduras Hong Kong Hungary Iceland India Indonesia Iran Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kosovo Kuwait Kyrgyzstan Laos Latvia Lebanon Lesotho Liberia Libya Liechtenstein Lithuania Luxembourg Macao Madagascar Malawi Malaysia Maldives Mali Malta Mashall Islands Mauritania Mauritius Mexico Micronesia Moldova Monaco Mongolia Montenegro Morocco Mozambique Myanmar Namibia Nepal Netherlands New Zealand Nicaragua Niger Nigeria North America North Macedonia Northern Cyprus Norway Oceania Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philipines Poland Portugal Qatar Romania Russia Rwanda Saint Helena Saint Kitts and Nevis Saint Lucia Saint Vincent Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Slovakia Slovenia Solomon Islands Somalia South Africa South America South Korea South Sudan Spain Sri Lanka Sudan Suriname Switzerland Syria Taiwan Tajikistan Tanzania Thailand Timor Togo Trinidad Tobago Tunisia Turkey Turks and Caicos Islands Uganda Ukraine United Arab Emirates USA Uruguay Uzbekistan Vanuatu Vatican Venezuela Vietnam World Yemen Zambia Zimbabwe test vaccine chart map table data case fatality rate mortality

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  5. Sep 2021
    1. Frank Wilhot's: "Conservatism consists of exactly one proposition, to wit: There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect." https://crookedtimber.org/2018/03/21/liberals-against-progressives/
    2. Libertarianism is notionally grounded in the idea of self-determination and personal responsibility, but in practice, powerful libertarians routinely trade off (others') freedom for (their own) tax savings.

      An intriguing thesis.

      Too often we trade away others' freedom(s) for small benefits to ourselves. This pattern has got to stop. The system should be closed in such a manner that the small trade-offs are balanced out across all of society.

      Cory Doctorow also highlights the recent Texas abortion law which targets abortion providers. Rich Republicans who have backed this law will still have the power and flexibility to drive or fly to another state for their abortions when desired. There are no consequences for them because they're not in a closed system. If abortions were illegal everywhere and anyone getting one were to be prosecuted regardless of where they got their abortion, then the system would be more "closed" and without loopholes they could use. As a result, laws like this would never be passed because they would apply equally to those who were making them. Legislators and judges should think more about walking a mile (or a lifetime) in another person's shoes more often.

      For lack of a better term let's use the idea of "political calculus" to describe this. Calculus is the mathematical study of small changes. So a small change to an individual isn't a big thing, but in the aggregate it can have profound and destructive effects on large swaths of the people.

      In large part, this is how institutionalized and structural racism flourishes. We take small bites of powerless individuals which in aggregate causes far more harm.

      This is all closely related to the idea of "privatizing profits and socializing losses".

    1. c. 19, s. 700

      Jobs, Growth and Long-term Prosperity Act, SC 2012, c 19, s. 700:

      • removed the previous s. 2(2)
      • replaced it with: "(2) Unless otherwise indicated, references in this Act to “this Act” include regulations made under it and instructions given under subsection 14.1(1)."
    1. Thomas Edison creating motion pictures not because of a contest. But he created short films using other investors from France ideas and created a studio called the black Moria

    2. You need to pay to get in the crystal palace to see all that Paris has to offer. The crystal palace was a museum or movie theater

    3. Don’t sit to close to the television. The old way of thinking and now to much screen time can have an effect on your mental health.

    1. After ablation, we observed a 95% reduction in time spent exploring the open arm of the EPM and a 57% increase in duration of the immobility time in the FST

      These findings validate the effectiveness of TH-IR ablation by 6-OHDA, as a decrease in time spent in the open arm of the EPM is associated with increased anxiety, and an increase in immobility time in the FST is associated with a depressed state. These results are not surprising as it is expected that a halt in the synthesis of dopamine (the feel-good transmitter) would increase anxiety and depression.

    2. Long-day exposure produced the opposite effects

      For rats, nocturnal mammals, increased photoperiod exposure is a stressor. Consequently, in both the EPM and FST, rats exhibit more depressive/anxious behaviors following long photoperiod exposure. In the EPM test, these rats spend less time in the open arm, and in the FST, they give up swimming and become almost immobile much sooner than the control group. For the short-day exposure group, the rats have more open arm activity, and in the FST persevere for longer, indicating reduced anxiety relative to the control group.

    3. Assays of CRF in the CSF and corticosterone in the plasma confirmed this to be the case (Fig. 4D).

      Panel D of Figure 4 shows that CSF levels of CRF and plasma levels of corticosterone significantly decrease following short photoperiod exposure. In panel B, short photoperiod exposure results in elevated coexpression of D2R and SST2/4R. These findings support the hypothesis that increased coexpression of D2R and SST2/4R has inhibitory effects on CRF neurons of the third ventricle.

    4. These results demonstrate that transmitter respecification is not achieved by translation from preexisting transcripts and involves de novo induction of TH or SST mRNA

      The experimenters' measurements of mRNA expression are used to determine whether transmitter respecification is resulting from new transcription or preexisting transcription. If transmitter respecification is resulting from preexisting transcripts, TH and SST mRNA would already be present in the cytosol and only following exposure to a certain photoperiod condition, translational machinery would translate that existing mRNA. Thus, if the source is preexisting mRNA, then we should not observe TH and SST mRNA counts follow numbers of TH and SST neurons, and instead mRNA levels should be unchanged. The fact that the experimenters are observing that mRNA levels follow TH and SST neuron count demonstrates that the photoperiod exposure condition is inducing de novo transcription, rather than direct translation of preexisting transcripts.

    5. Newly expressing TH-IR neurons induced through short-day photoperiod exposure coexpressed additional dopaminergic markers (3), VMAT2 (fig. S6), and the dopamine transporter, DAT (fig. S7).

      Because one role of VMAT2 is to package dopamine from the cytosol into synaptic vesicles for their release from the neuron, VMAT2 serves as a marker for the presence of dopamine. In addition to VMAT2 expression, the expression of the dopamine transporter, DAT, was also observed. Altogether, these findings serve as evidence that the newly expressed TH-IR neurons, induced by short-day photoperiod exposure, are indeed synthesizing dopamine.

    6. The number of intracellular SST-IR storage vesicles depended on photoperiod light-cycle duration

      Panel D is consistent with the findings in Panel B and Panel C, which also demonstrate an increase in SST expression following increase day exposure.

    7. The 43% increase and 96% decrease in TH-IR/SST-IR coexpression after short- and long-day exposure, in contrast to the balanced photoperiod, suggest that TH-IR and SST-IR neurons are recruited from a reserve pool of cells (23) that are switching transmitters

      In response to the photoperiod exposure condition, the circuit activity changes such that the neurons of the reserve pool are switching transmitters. The researchers believe that the TH-IR and SST-IR neurons are coming from this reserve pool of cells based on their finding that short-day exposure led to an increase in the recruitment of TH-IR neurons and diminishment of SST-IR neurons, while long-day exposure had the opposite effect.

    8. Double immunofluorescence revealed that different photoperiods changed the balance of dopamine and SST coexpression in neurons in the PaVN and PeVN

      The experimenters performed immunostaining for both dopamine and SST expression. Panel B depicts immunofluorescence of these transmitters in the PaVN. The first of the three images depicts the results from long day exposure; under this condition, there is an abundance of red representing an increase of SST expression and very little green indicating that there is a decrease in dopamine expression. Under short day exposure (third image), the opposite is true.

    9. TH expression did not differ from controls exposed to the 12L:12D photoperiod for 2 weeks

      Finding that the TH-IR neuron counts are reversible upon application of opposite photoperiod treatment is further evidence that sensory stimuli can induce neuroplastic changes in the already mature brain.

    10. No significant BrdU labeling was detected in the LPO, PaVN, or PeVN

      BrdU labeling did not result in significant amounts of active poliferating cells; this is an initial indication that inverse SST and dopamine expression is not due to neurogenesis.

    11. Week-long exposure to each of the different photoperiods failed to produce changes in numbers of TH-IR neurons in an adjacent nucleus, A13 (Fig. 1E and fig. S2B), which does not receive retinal input via the SCN

      In order for the dopamine alterations to be induced by changes in light exposure duration, the dopaminergic neurons must be able to receive retinal input, as is the case with the dopaminergic neurons in the hypothalmic nuclei, innervated by the retino-hypothalmic projection. If the neurotransmitter respecificaiton is indeed due to the photoperiod treatment, dopamine production at an adjacent dopamine source, which does not receive retinal input via the SCN, should be unaffected.

    12. Circadian fluctuations do not account for changes produced by different photoperiods.

      Within the three photoperiods, 19L:5D, 5L:19D, and 12L:12D, the number of TH-IR neurons are similar. Because there is a consensus within each photoperiod, this is indicating that circadian fluctuations are not contributing to neurotransmitter respecificaiton.

    13. FFN511 generated fluorescent signals in hypothalamic slices from brains of animals exposed to each of the three photoperiods. Fluorescence decreased upon KCl depolarization

      In panel C, before KCl depolarization, there is observable fluorescent signals from FFN511, indicating dopamine uptake. Upon KCl depolarization, the fluorescence is diminished; this is indicative of dopamine release. The results of panel C are consistent with panel A and B in that during the long day light condition (19 hours light, 5 hours darkness), the fluorescence signal is the lowest, which means less dopamine being taken up.

    14. Dopamine is colocalized with TH in the PaVN after exposure to each of the photoperiods. n = 5 animals for each photoperiod.

      Panel B: The fact that in all three photoperiod conditions, dopamine is colocalized with TH validates the use of TH as a marker of dopamine synthesis.

    15. Natural stimulation of other sensory modalities may cause changes in transmitter expression that regulate different behaviors.

      The researchers found that neurotransmitters are not actually fixed upon maturation, but are, in actuality, dynamic and can be affected by sensory stimuli such as longer or shorter photoperiods. Changes in transmitter expression result in behavioral changes as well. Thus, follow up research can explore what other sensory stimuli can change transmitter expression and also examine the corresponding behaviors that are regulated by those transmitters.

    16. Induction of newly dopaminergic neurons through exposure to the short-day photoperiod rescued the behavioral consequences of lesions.

      Shortening the length of daylight the rats are exposed to induced the formation of new dopaminergic neurons and thereby restored the rats' previous (normal) behaviors, i.e., the rats no longer displayed anxious and depressed behaviors.

    17. Pharmacological blockade or ablation of these dopaminergic neurons led to anxious and depressed behavior, phenocopying performance after exposure to the long-day photoperiod

      Using drugs to prevent dopamine production resulted in anxious and depressed behaviors by the rats; these same behaviors were also observed following extended day length exposure.

    18. Changes in postsynaptic dopamine receptor expression matched changes in presynaptic dopamine, whereas somatostatin receptor expression remained constant.

      When more of the neurotransmitter dopamine is produced, there is also an increase in the postsynaptic dopamine receptor. Likewise, when less dopamine is produced, it follows that there is a decreased expression of dopamine receptors. However, for somatostatin, this was not the case. Regardless of whether somatostatin production is increased or decreased, the somatostatin receptor expression is unchanged.

    1. while the super-rich may move through through world cities, their cosmopolitan practices and lifestyles rarely break out of the exclusive transnational spaces which stand at the intersecting points of particular corporate, capital, technological, information and cultural lines of flow.

      The elites move in a world of their own. Embedded within the deteriorating spaces all around them, their privileged and exclusive spaces are like self-constructed lotus blossoms floating on a sea of muck, which their lifestyles have disproportionately helped create in the first place. The geographic juxtapostion of these two spaces is stark, as illustrated in images such as those of Cape Town’s elite neighborhoods nextdoor to crowded townships. Wealth and privilege live side by side poverty.

    1. ERP vs CRM: Which do you need?

      Both CRM and ERP systems handle contacts, companies, quotes, orders and forecasts… and they may handle line-item configuration, bundles, delivery schedules and invoices. Where does one start and the other stop? So what's the difference between erp and crm? Behold this guide for the bewildered.

    1. the following terms are from the arkansas department of health: family planning

      "prevent unwanted pregnancies" = abortion "lifestyle behaviors" = having sex "prevent unintended pregnancies" = birth control "infants born too early" = premature babies for some insane reason, all of these things are still considered taboo. the website is using euphemism (and for the infants one, orthphemism). these terms like "unwanted pregnancy" are way "softer" than saying that a woman has become pregnant and wants an abortion. they don't use abortion once on the entire website. the goal is to seem neutral and clinical, so there is no room for emotions. birth control is somehow also still considered taboo by many, so it is much easier and clinical to say "contraceptives." i think the website does an amazing job of making it very clear what family planning can do without giving the haters any room to be dumb.

      the other website, "the order of the good death," uses a lot of orthphemisms. words like "bacteria," "decomposing bodies," and "decomposition" describe exactly what is literally happening. it uses clinical words to explain what a dead body goes through during decomposition, like "autolysis" and "rigor mortis." because of my own person idealogy concerning death, i wanted to read this website and deem it dysphemistic, but i think it really is just very literal, clinical diction. the website does a really good job of ecplaining important questions that i'm sure a lot of people have who are afraid to ask. this also seems like something i would research at 3 am after skipping out on my zoloft for a few days. in that situation, i would need clear, concise answers to my questions. death is often really taboo and emotional, and the interworkings of death are something that we as a society NEVER talk about. i think this website just wanted to answer our questions.

    2. the website i used had over forty examples of grammatical errors. here are the ones i chose.

      1. "first come, first serve." this sentence sounds right when i say it, but the website says that the word is actually supposed to be "served" and not "serve." the lack of the d making it past tense makes the sentence "lose its meaning." this is obviously just verbs losing their endings, which is a sign of language change.

      2. using "me" to start a sentence. grammatically, the website says, we are supposed to list ourselves second and the other noun first. the author of this website obviously has very strict views on subject pronouns and object pronouns (blech). i think this is language becoming less formal. i think (in my world at least) language is much less written and much more frequently spoken. starting a sentence with me just makes sense to me verbally.

      3. overuse of apostrophes. the website states that the only times we are to use apostrophes are when there are missing letters or we are showing possession. in this case, "the johnson's" would be wrong, because it is neither showing possession nor is it making up for missing letters. however, again, i believe it just makes sense to a lot of us to add an apostrophe.

      my website didnt talk about this, but it felt wrong to not include the idea of subject-verb agreement a great many people i know feel much more comfortable being referred to as "they," but they should not lose their personage just because they do not want to use he/she pronouns. gendered pronouns are truly a thing of the past and "they" is just as singular as he or she.

    1. The tunnel far below represented Nevada’s latest salvo in a simmering water war: the construction of a $1.4 billion drainage hole to ensure that if the lake ever ran dry, Las Vegas could get the very last drop

      Deep Concept: Modern America is mostly corrupt from it's own creation of wealth. Wealth is power, power corrupts and absolute power corrupts absolutely! Money and wealth have completely changed the underlying foundation of America. Modern America is the corrupted result of wealth. Morality and ethics in modern American have been reshaped to "fit" European Aristocracy, ironically the same European aristocracy America fled in the Revolutionary War.

      Billions and billions of tax payer money is spent on projects that could never pass rigorous examination and best public ROI use. Political authoritative conditions rule public tax money for the benefit of a few at the expense of the many. The public "cult-like" sheep have no clue how they are being abused.

      The authoritative abusers (politicians) follow the "mostly" corrupt American (fuck-you) form of government and individual power tactics that have been conveniently embedded in corrupt modern morality and ethics, used by corrupted lawyers and judges to codify the fundamental moral code that underpins the original American Constitution.

    1. Connect Pick and Pack Warehouse UK

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      What is Pick and Pack?

      Pick and pack is part and parcel of any warehouse operation. It’s critical when it comes to the order fulfilment process, and is essentially following a few steps, which are:

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      Next, these items are appropriately packaged, or packed, in a safe and secure manner, so nothing is damaged or lost.

      Then, the product or package is shipped to the customer.

      Simple!

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  6. Aug 2021
    1. COGNITIVE CONSEQUENCES OF FORCED COMPLIANCE

      The title of the article immediately made me think of the world we are living in now. For example it is becoming more and more evident that the country has mixed opinions on the vaccine. The government, state agencies and other public entities are requiring proof of a vaccine to even enter the premises. Some companies are offering incentives across the country to incentivize the vaccine by offering free products and discounts. To an extent from a medical perspective you want everyone as healthy as possible, but from a freedom perspective it is on the verge of violating an individual's freedom of choice through forced compliance.

    1. We found that populations of interneurons in the adult rat hypothalamus switched between dopamine and somatostatin expression in response to exposure to short- and long-day photoperiods.

      Altering the amount of time that a rat is exposed to light in a day leads to changes in the type of neurotransmitters being expressed by a set interneurons located in the hypothalamus. When the rat's daily light exposure is restricted to a shorter time frame, those interneurons favor dopamine expression. In contrast, longer daily periods of light exposure results in those same interneurons favoring somatostatin expression.

    1. There are two ways for someone to be in this quadrant. The unhealthy way, as a people pleaser, with associated resentment and chaos. In a healthy way, everything feels very clear. It’s easy to fit feedback into their mental model, and adjustments feel natural and build on what they are currently working on. This comes from having a good idea themselves about what is happening and how they think they can improve.

      good point on the people-pleaser mindset, also worth considering with ADHD/ASD employees - try and foster more curiosity than chaos

    1. Tonality refers to how our harmony affects our song's mood and vibe.

      Hmm? Again, it makes some sense in context. Yet it could lead to quite a bit of confusion. I honestly thought it was going to be about actual tonality. Yet it’s about mode, calling it tonality. Disconnecting mode and mood. It’s nice to use simple language. This isn’t that. It’s using jargon and shifting it. The technical term for that might be… obfuscation. Strange

    1. Marc Lipsitch. (2021, July 20). At the risk of boiling down too much and certainly losing some detail, one way to summarize this wonderful thread is that when we think about vaccine effectiveness, we should think of 4 key variables: 1 which vaccine, 2 age of the person, 3 how long after vax, 4 vs what outcome. [Tweet]. @mlipsitch. https://twitter.com/mlipsitch/status/1417595538632060931

    1. What we call progressconsists in coordinating ideas with realities

      "The map is not the territory" is there as a basic sentiment long before General Semantics

    1. Travel, Transportation, and Hospitality Software Development

      No matter what you want to build ― a hotel management system, ticket aggregator, travel guide app, or resort booking platform ― we’re here to help. Developing a travel solution should be as stress-free as the vacation itself. Looking for a travel app development company? We’re all ears. Drop us a line and we’ll get back to you.

    1. the logistics and freight industry is heading towards digitization in order to ease its management process. Digital transformation has come up with numerous benefits for the transportation industry. In fact, there are experts who say “Implementation of various technologies and going digital is an inevitable step in the freight industry.
  7. Jul 2021
    1. typhoid diet chart in hindi(health and disease)

      typhoid diet chart in hindi(health and disease):in this pin you can see about typhoid diet chart in hindi and food in typhoid. food should be eat and not in typhoid

    1. A word of caution first. Anyone considering a Ph.D. might not want to listen to advice from anyone with a Ph.D., us included. People with doctorates are notoriously bad at this kind of advice, often exaggerating their history into a singular universal experience.
  8. greggman.github.io greggman.github.io
    1. One other thing is that many libraries seem bloated. IMO the smaller the API the better. I don't need a library to try to do 50 things via options and configuration.
    1. Looking deeper, you can see a large amount of issues open, bugs taking months to fix, and pull requests never seem to be merged from outside contributors. Apollo seems unfocused on building the great client package the community wants.
    2. This sort of behaviour indicates to me that Apollo is using open-source merely for marketing and not to make their product better. The company wants you to get familiar with Apollo Client and then buy into their products, not truly open-source software in my opinion. This is one of the negatives of the open-core business model.