We have demonstrated that small RNAs can tightly repress their target genes when their synthesis rate is smaller than some threshold, but have little or no effect when the synthesis rate is much larger than that threshold

In particular, small RNAs are shown to establish a threshold for the expression of their target, providing safety mechanism against random fluctuations and transient signals. The threshold level is set by the transcription rate of the small RNA and can thus be modulated dynamically to reflect changing environmental conditions.

in the absence of tamoxifen, it exhibits some activity

strong promoters capable of driving expression of microbial opsins or fluorescent proteins in specific populations can exhibit leaky expression elsewhere. This low-level leak may be virtually undetectable as light responsiveness or fluorescence but can be a serious issue when expressing Cre recombinase.

it can be useful for reducing leaky expression of toxic proteins

We report the construction of a family of vectors that contain a reengineered lacIq-lac promoter-operator complex in which cloned genes are strongly repressed in the absence of inducer.

While these techniques offer good repression, they exhibit leakiness that precludes the gene of interest from being completely turned off

Here we combined RNA-seq with an in vivo assay to identify the major transcriptional changes that occur in Escherichia coli when inducible synthetic constructs are expressed.

n they will share similar genes, but it 18is the phenotype –upon which selection acts –which is crucia

Censure

controllers that speak regular MIDI and MPE

Massive mining of publicly available RNA-seq data from human and mouse

repeat expansion at IIL1 leads to increased accumulation of 24-nt siRNAs in a temperature-dependent manner that correlates with the iil phenotype. We show that DCL3 and other components of the RNA-dependent DNA methylation (RdDM) pathway are essential for this siRNA-directed epigenetic gene silencing

Different sets of ESR1 polymorphisms were associated with cognitive decline from CDR 0 to 0.5 and CDR 0.5 to 1. ESR1 polymorphisms (rs3853248, rs22334693 [ESR1+397], rs9340799 [ESR1+351], rs9397456, rs1801132 [ESR1+975], rs2179922, rs932477, and rs9341016) were associated with the deterioration of episodic memory among subjects with baseline CDR 0, indicating these polymorphisms might be markers for episodic memory decline at an earlier stage

p(HGNC:ESR1) hasVariant g(dbSNP:rs3853248)
p(HGNC:ESR1) hasVariant g(dbSNP:rs22334693)
p(HGNC:ESR1) hasVariant g(dbSNP:rs9340799)
p(HGNC:ESR1) hasVariant g(dbSNP:rs9397456)
p(HGNC:ESR1) hasVariant g(dbSNP:rs1801132)
p(HGNC:ESR1) hasVariant g(dbSNP:rs2179922)
p(HGNC:ESR1) hasVariant g(dbSNP:rs932477)
p(HGNC:ESR1) hasVariant g(dbSNP:rs9341016)

a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs3853248)
a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs22334693)
a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs9340799)
a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs9397456)
a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs1801132)
a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs2179922)
a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs932477)
a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs9341016)

Although we observed no association between rs3785883 or rs1868402 alone and change in CDR-sb (P > .10), there was a significant association between a combined genotype model and change in CDR-sb: carriers of the high-risk genotypes at both loci progressed >2.9 times faster than noncarriers (P = .015)

g(dbSNP:rs1868402) cnc a(CTO:"Clinical_Dementia_Rating_Scale-sum_of_boxes")
g(dbSNP:rs3785883) cnc a(CTO:"Clinical_Dementia_Rating_Scale-sum_of_boxes")
composite(g(dbSNP:rs1868402),g(dbSNP:rs3785883)) pos a(CTO:"Clinical_Dementia_Rating_Scale-sum_of_boxes")

novel method developed within the MAQC-III project utilizing the expression distributions, corrected for noise and batch effects, and assisted by random resampling, to compute DEG scores related to the Wilcoxon U test (Magic, see Additional file 1: Supplementary Note 2)

Robust enumeration of cell subsets from tissue expression profiles

Gene Set Enrichment Analysis Made Simple

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse

.

strings $PWD/bin/myapp | egrep '\.gcda$'

The ISMARA client

ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs

Anyone working with the latest generation of MIDI musical instruments – like the Eigenharp, LinnStrument, ROLI Seaboard, Haken Continuum and the Madrona Soundplane – has probably encountered the work of Belgium-based programmer & electronic musician Geert Bevin.

audience's attention with an unusually striking expression

riting as an art, not as a method of self-expression.

Chapter 12 SELF-EXPRESSION & THE MENTAL ENVIRONMENT

Affiliations— memberships, formal and informal, in online communities centeredaround various forms of media, such as Friendster, Facebook, message boards,metagaming, game clans, or MySpace).Expressions— producing new creative forms, such as digital sampling, skinning andmodding, fan videomaking, fan fiction writing, zines, mash-ups).Collaborative Problem-solving— working together in teams, formal and informal,to complete tasks and develop new knowledge (such as through Wikipedia, alternativereality gaming, spoiling).Circulations — Shaping the flow of media (such as podcasting, blogging).

all Desire to express in Words that Idea, without the consciousness of My Will being theOne and Only source of Inspiration, is futile. Likewise, all desire to express that Idea in livingacts, without losing all consciousness of your human personality -- of your personal part in theacts, and centering your self wholly in Me, -- is vain and fruitless and will end only in failure,disappointment and humiliation

In time will the Great Awakening come-- that all Words are but Symbols of One Idea, and allIdeas of whatsoever nature are but phases of One Idea, My Idea of My Self in Expression,

In the Impersonal there is no use or necessity for words. Ideas alone exist and express. Theysimply Are, for they are the expression of the various phases of My Be-ing.But in this Dream condition, where every expression in these early stages of outer being had tohave a form and substance that could be heard, seen, felt, smelled or tasted, in order that itsmeaning could be clearly apprehended, there naturally had to be provided organisms capable ofbeing used for the double purpose of expression and of understanding what was expressed

n Your search for the most favorable conditions for the manifestation of Your particularattributes, You gradually spread over the face of the Earth, each containing many words, and allborn of Desire in the human mind to express in Earthly terms the infinite phases of My Idea eversurging within.The more the human mind strove thus to express " in Words" My Idea, the greater and moreabject the failure

I, by so doing, provide My Idea with a suitableform for Earthly expression, -- I gave you the power to express Your Self, through a definiteorganism, by means of words

And so I Spake the Word, and drove You out of the Garden of Eden, and clothed You with a"coat of skin," or, in other words, with flesh, the same as other animals. For now, in order thatYou might enter into the heart of Earth conditions, into the real Earth, the Earth of My Idea, --not the one of your Dream, -- so as to quicken My Idea therein into active life expression, You,My Attribute, had to have an organism and a covering appropriate to the conditions in whichYou were to manifest in your Dream

Thus was born Your human personality, and since its birth have I impelled You to nourish,support and strengthen it, by filling You with longings, hopes, ambitions, and aspirations, withall the various manifestations of Desire; which are but the human phases of My Will, operatingin the preparation and development of a medium capable of expressing perfectly My Attributeson Earth

29Now, perhaps, you can see why this all had to be, why You (Humanity) had to leave the Edenicstate of Impersonal Consciousness and lose Your Self wholly in the Earth illusions of this DreamWorld, in order to be able to create a body and develop in it a personal or self consciousnesscapable of fully expressing My Perfection.

And finally the necessity of Desire casting its complete spell over You (Humanity), that YourCelestial or Impersonal nature might be kept deep in sleep; until, in your Dream, by the free butignorant use of My Will, You could taste and fully eat of the fruit of the so-called Tree ofKnowledge of Good and Evil, and through the eating could learn properly to discriminate andknow its fruit for what it really is; and thus acquire the strength to use the knowledge thus gainedwisely and perfectly in the expression of My Idea onl

And the wisdom of having this influence, through the Serpent of Selfishness (the shape I causedit to assume in your mind), first generate in the passive, feeling, receptive part of You -- Desire,the mortal agent of My Will, which was to supply the motives and the power for the further andcomplete expression of My Attributes on Earth

This, then, was the first condition into which You awakened when You entered into Earthexpression, and is what is called the Edenic state or dwelling in the Garden of Eden.This Edenic state represents the Celestial phase of Impersonal Consciousness, or that state inwhich You were still consciously One with Me, though now confined in a mortal medium ofexpression

Thus were now manifest all the various mediums for the Earth expression of My Idea; and You,being one of My Attributes, naturally had dominion over all of these mediums, or possessed thepower of utilizing any or all of them, if necessary, for the full and complete expression of Your --My Attributes -- powers and possibilities.In this manner and for this reason alone did You and Your Brothers and Sisters come into humanexpression. While in human form yet Your expression was so entirely Impersonal, that, thoughself-conscious, you still looked wholly to Me within for inspiration and guidance

Shall I explain further? -- That the quickening power within My Idea (your Soul) proceeded toattract to it the various elements of life substance (dust), and, atom by atom, and cell by cell, indue course of time, to mold and shape each into substantial reality, after the pattern of theThought Image composing your Soul Body, thus forming an Earthly outer covering, as it were, --until finally your mortal form actually became manifest to the psychic sense, if not yet to what iscalled the physical sense. Whereupon, all being now prepared for this cyclic moment, You, MyAttribute, breathed into and then through its nostrils (from within) the breath of life, and Youthen made your first appearance of Earth as a human being-- a living Soul (My Idea now able toexpress consciously through a suitable Earth medium), containing within your Self all of MyAttributes, all of My Powers and all of My Possibilities

So now we have, --First, I AM, expressing as You, one of My Divine Attributes;Second, My Idea of You, one of My Attributes, expressing in Earth conditions -- or Your Soul;Third, My Imaged Thought of You, forming the Temple of Your Soul -- or Your Soul Body inwhich You dwell.These three make up the Divine or Impersonal part of You, the Immortal Three-in-One -- You,My latent yet completely formulated thought, shaped in My Image and Likeness, as yetunquickened, and therefore having no connection with your human personality, which has notyet been born

26This Temple, being in My Image and Likeness, and composed of My Thought Substance,surrounding and clothing My Idea, is consequently your Real body. It is therefore indestructible,immortal, perfect. It is My complete, imagined (imaged in) Thought, containing My LivingEssence, awaiting the time when it can come into outer expression and take on material form

So it was then that the first tendency to think yourself as separate from Me was born. Thecomplete consciousness of separation did not become established until long after.In the beginning, when You thus first entered into Earth expression, obeying the impulse I hadsent forth through My concentrated Thought, You, one of My Attributes, surrounded or clothedYour Self with My Idea of My Self in expression as the particular Attribute You represented.You being the animating Force of that Idea.In other words, My Idea of My Self expressing that particular Attribute then became the Soul ofYour particular expression. But that Idea or Soul is not You, remember, for You are really a partof Me, being My Self in expression through the medium of that particular Attribute.Having clothed Your Self with My Idea, this Idea then, through the necessity of Its be-ing,immediately began to attract to Itself the necessary Thought Substance requisite for theexpression of that particular Attribute, and to build and shape it into My Image and Likeness. Itthus became a Holy Temple, filled with My living Presence, because inhabited by You, one ofMy Divine Attributes

saw You in perfect expression, even as I see You now -- the Real You, an Attribute of My Self-- perfect.For in Reality You are an Angel of Light, one of My Thought Rays, an Attribute of My Being,ensouled in Earth conditions, with no other purpose (which is no purpose at all, but a necessity ofMy Being) but the final complete expression of My Idea.

But there yet remained the final and culminating medium of expression.Up to this point, while each perfectly expressed some phase of My Nature, yet all existingmediums and avenues were unconscious of Me, and were mediums of expression only as a wireis a medium for conducting heat, light and power.The conditions were ripe, however, for the creation of mediums through which My DivineAttributes could find conscious expression, conscious not only of their relationship to Me, but oftheir ability and power to express My Idea.It was at this moment in Time that You and Your Brothers and Sisters were born into existenceas human expressions, coming into manifestation as you did, similarly with all other mediums, inresponse to My concentrated Thought, in which I saw all the infinite variety of My Attributes inactual expression in entitized forms, each manifesting in predominance some particular phase ofMy Being, and each conscious of Me, Its Creator and Expressor

Yet that Desire you feel in you is from Me, because it is born of My Idea, which I implanted inyour mind only that It might come forth into expression through you. Indeed, whatever youdesire is I, knocking at the door of your mind, announcing My Purpose of manifesting My Self inyou or through you in the particular form indicated by that Desire.What is called Desire in human personalities, is but the necessary Action of My Will pushingforth the expression of My Idea into outer Manifestation or Being.What to you would seem to be in Me a desire for expression, is but the Necessity of My Idea ofMy Self to Be, or Express Itself

Expressing what?What else could I express, if I AM All that Is, but My Self?You cannot yet see or comprehend when I inspire you with an Idea.Therefore, if I AM All there is, that Idea, which is direct from Me, must be part of or a phase ofMy Self in Being or Expression.Any Idea, once born within the realm of My Mind, as has been shown, immediately becomes aReality, for in the Eternality of My Being Time is not. With you, however, an Idea first createsDesire, a desire to express that Idea; then Desire compels Thinking, Thinking causes Action, andAction produces Results -- the Idea in actual outer manifestation.In Reality I have no Desire, for I AM All Things, and All Things are of Me. I need only to thinkand Speak the Word to produce results

Now, My Consciousness is the inner essence of all Space and all Life. It is the real Substance ofMy All-comprehending and All-including Mind, whose informing and vitalizing Center iseverywhere and Its limit and circumference nowhere. Within the realm of My Mind alone I liveand move and have My Being. It both contains and fills all things, and Its every vibration andmanifestation is but the expression of some phase of My Be-ing.Be-ing is ex-pressing or out-pressing. You cannot imagine be-ing without expression. Therefore,I, All that Is, AM expressing, constantly and continuously expressing

You have been told that the Earth and all things belonging to it are but the outer manifestationsof My Idea, which is now in the process of being thought into perfect expression.You have been shown that My Idea is responsible for all created things, and that It is both theCause and the Reason for all manifestations, yourself and your brothers and sisters included, allof which have been thought into existence by Me, the One Original Thinker and Creator

Just so will I develop and unfold all My mediums of expression, which shall finally, unitedly andcompletely picture forth My Idea from out their souls, in all the glory of Its perfection.At present these mediums are of such nature that they require many languages of many types,from the simplest to the most complex, composed of almost an infinite number of Words, toexpress My Idea.But when I shall have completely thought out My Idea, or shall have perfected My manymediums of expression, then shall My Idea shine forth in every Word, each, in fact, being aperfect part or phase of My Idea, all so chosen and arranged that they will really be as one Word,radiating the sublime significance of My Meaning.Then shall all languages have melted, merged, into one language, and all words into One Word;for all mediums shall have become One flesh, the now perfected medium for the completeexpression in One Word of My Idea, -- My SELF.Then shall My SELF, now capable of being expressed by these perfected Words, shine throughIts medium of expression, -- through the personalities, their bodies, minds and intellects; and theWord shall have become flesh, or shall BE the flesh

The Word that was in the beginning and that was with Me was then not only an Idea, but It wasMy Idea of My Self IN EXPRESSION in a new state or condition, which you call Earth life.This Idea was I, My Self, because It was part of Me, being as yet latent and unmanifest withinMe; for It was of the substance and essence of My BE-ing, which is Itself an Idea, the OneOriginal Idea.All things were made by Me by the vitalized action of this, My Idea, being thought and spokeninto expression; and nothing has been or ever can be expressed in Earth life without having MyIdea as the primary and fundamental cause and principle of its being.This, My Idea, therefore, is now in the process of unfoldment or of being thought into outerexpression -- some call it evolution -- just as is the flower when the bud puts forth from the stalkand finally opens into the blossom, obeying the urge to express My Idea hidden within its soul

You shall learn herein how My Word was in the beginning, how It was with Me, and how It wasI, My Self; how all things were made by Me and by My Word, and that without Me and MyWord was nothing made that now exists.Now, a word to the human understanding is a symbol of an Idea; that is, it stands for, embodies,and represents an Idea.You are a Word, a symbol of an Idea, if you can see it. So is a diamond, a violet, a horse.When you can discern the idea back of the symbol, then you know the soul or the reality of themanifestation appearing as a man, a diamond, a horse, a violet.Hence, a word, as used in the above quotation, means an Idea, an Idea latent and unmanifest,however, waiting to be expressed, or thought and spoken forth, in some form or another

Man, then, is only the organism I AM thus preparing through which to manifest the perfection ofMy Idea. He provides the personality, with its body, mind and intellect, through which I canexpress this Idea perfectly, the physical brain with which I can think and speak It into outermanifestation.I plant in man's brain an Idea -- any idea. That idea would grow, mature and speedily ripen intocomplete outer fruition or manifestation, -- if man only would let it, would give his mind and allits thoughts, his heart and all its desires wholly over to Me, and let Me come forth as the perfectfulfillment of that Idea

I, the Creator, AM the Original THINKER, the One and Only THINKER.First know that.As previously stated, man does not think. It is I Who think through his organism. Man believeshe thinks, but before he has awakened to a realization of Me within he only takes the thoughts Iattract to or inspire in his mind, and, mistaking their real meaning and purpose, places a personalconstruction upon them and, through the selfish desires thus aroused, creates for himself all histroubles and brings upon himself all his woes.These apparent mistakes, misconstructions and interferences of man are in reality only theobstacles in his way to be overcome, that he may, through the overcoming, finally develop abody and mind strong and clean and capable enough to express perfectly and consciously thisIdea of Mine eternally working within his Soul.

finally how to control and utilizeyour desires so that they will always serve YOU, instead of your being a slave to them.You have within you all possibilities. For I AM there. My Idea must express, and It must expressthrough you. It will express itself perfectly --- if you but let it; if you will only still your humanmind, put aside all personal ideas, beliefs and opinions, and let if flow forth. All you need to dois to turn within to Me, and let Me direct your thinking and your desires, let Me express whateverI will, you personally accepting and doing what I desire you to do. Then will your desires cometrue, your life become one grand harmony, your world a heaven and your self one with My Self.When you have begun to realize this and have glimpsed somewhat of its inner meaning, then youwill be ready to grasp the real import of what follo

When you can once realize this and can know that I AM Consciousness within you is one withthe consciousness of all animate and inanimate matter, and that Its will is one with your will,which is My Will, and that all your desires are My Desires, then will you begin to know and feelMe within, and will acknowledge the Power and Glory of My Idea, which is eternally expressingItself Impersonally through you.But it is first wholly necessary that you learn HOW to think, how to know Your thoughts, thosedirected by Me, from the thoughts of others;

This is the plan and process of all true thinking, and therefore of all Creation.Listen! You have now and always have had, through this power of thinking, dominion over allthe kingdoms of the Earth. If you but know it. You have now, this moment, only to Think andSPEAK THE WORD, -- realizing your power, and that I, God, your Omniscient, Omnipresent,Omnipotent Self, will bring about the results, -- and the waiting consciousness of the invisiblecells of all matter upon which your will and attention become focused, -- which waitingconsciousness is My consciousness, remember, -- will begin immediately to obey and do exactlyaccording to the image or plans you have prepared by you thinking.For all things are made by the Word, and without the Word was not anything made that wasmade.

19So much for the relation. Now for the process of realization.In accordance with the definiteness with which the picture of the Idea is held in the mind, and theextent to which the Idea possesses the personality, does its creative Power, impelled by Desire,proceed with Its work. This It does by compelling the mortal mind to think out or to imagine(image in), or, in other words, to build mental forms into which I can pour, as into a vacuum, theImpersonal, elemental, vital substance of the Idea. When the Word is spoken, either silently oraudibly, consciously or unconsciously, this substance at once begins to materialize Itself, by firstdirecting and controlling the consciousness and all the activities of both mind and body, and ofall minds and all bodies connected with or related to the Idea, -- for remember, all consciousness,and all minds and all bodies are Mine, and are not separated but are One and wholly Impersonal,-- and then so attracting, directing, shaping and molding conditions, things and events that,sooner or later, the Idea actually comes forth into definite, tangible manifestation.So it is that every thing, every condition, every event that ever transpired, was first an Idea in themind. It was by desiring, by thinking, and by speaking forth the Word, that these ideas came intovisible manifestation.

Always I AM there to pick you up, after the fall, although you do not know it at the time; firststraightening you out and then starting you onward again, by pointing out the reason for yourfall; and finally, when you are sufficiently humbled, causing you to see that these powersaccruing to you by the conscious use of My Will, My Intelligence and My Love, are allowed youonly for use in My Service, and not at all for your own personal ends.Do the cells of your body, the muscles of your arm, think to set themselves up as having aseparate will from your will, or a separate intelligence from your intelligence?No, they know no intelligence but yours, no will but yours.After a while it will be that you will realize you are only one of the cells of My Body; and thatyour will is not your will, but Mine; that what consciousness and what intelligence you have areMine wholly; and that there is no such person as you, you personally being only a physical formcontaining a human brain, which I created for the purpose of expressing in matter and Idea, acertain phase of which I could express best only in that particular form.All this may be difficult for you now to accept, and you may protest very strenuously that itcannot be, that every instinct of your nature rebels against such yielding and subordinatingyourself to an unseen and unknown power, however Impersonal or Divine.Fear not, it is only your personality that thus rebels. If you continue to follow and study MyWords, all will soon be made clear, and I will surely open up to your inner understanding manywonderful Truths that now are impossible for you to comprehend. Your Soul will rejoice singglad praises, and you will bless these words for the message they bring

I AM the Innermost, the Spirit, the animating Cause of your being, of all life, of all living things,both visible and invisible. There is nothing dead, for I, the Impersonal ONE, AM all that there is.I AM Infinite and wholly unconfined; the Universe is My Body, all the Intelligence there isemanates from My Mind, all the Love there is flows from My Heart, all the Power there is, is butMy Will in action.The threefold Force, manifesting as all Wisdom, all Love, all Power, or if you will, as Light,Heat, and Energy “ that which holds together all forms and is back of and in all expressions andphases of life, -- is but the manifestation of My Self in the act or state of Being.Nothing can Be without manifesting and expressing some phase of Me, Who AM not only theBuilder of all forms, but the Dweller in each. In the heart of each I dwell; in the heart of thehuman, in the heart of the animal, in the heart of the flower, in the heart of the stone. In the heartof each I live and move and have My Being, and from out the heart of each I send forth thatphase of Me I desire to express, and which manifests in the outer world as a stone, a flower, ananimal, a man

that which you have read has awakened a response within, and the Soul of you yearns formore, -- then you are ready for what follows.If you still question or rebel at the seeming assumption of Divine authority for what is hereinwritten, your intellect telling you it is but another attempt to beguile your mind with cunningsuggestion and subtle sophistry, -- then you will receive no benefit from these words; for theirmeaning is as yet hidden from your mortal consciousness, and My Word must come to youthrough other avenues of expression.It is well if your personality with its intellect impels you thus to question and rebel againstauthority you do not yet know to be Mine. It is really I Who cause your personality thus to rebel;for your personality with its proud sense of individuality is still needed by Me to develop a mindand body strong enough that they can perfectly express Me. Until you have become prepared toknow Me it is but natural for your personality thus to question and rebel. Once you recognize MyAuthority, that moment the undermining of the authority of the personality has begun. The daysof its dominion are numbered, and you will more and more turn to Me for help and guidance.Therefore, be not dismayed. Read on, and mayhap the recognition will come. But know that youcan read or not, as you choose; but if you do it is really I Who choose, and not you.For you, who seemingly choose not to read further, I have plans, and in due season you shalllearn that whatever you do, or like, or desire, it is I leading you through all the fallacies andillusions of the personality, that you may finally awaken to their unreality and then turn to Me asthe one and only Reality. Then these words will find a response within:

Again, the goal is to be goal-less, present in the now, so as to always be standing in support of the movement of Being and Its Intent, which is never confined to concepts, but is always absolutely expressive of original fulfillment. So, be willing to stay at the threshold, the crest of the wave—as Susan brought out this morning—that point of instability where unpredictable originality is what is happening.

You do not have to understand analytically, logically. It isn’t the understanding which is important. It is the experience of your Peace. It is the experience of your congruence. It is the experience of your Integrity—which is a feeling. And in the presence of that feeling, which is uncluttered by conflict, you are the transparency for Truth. You are “the understanding” expressed and expressing. But the understanding is not a possession. So, if you want to understand, don’t try to understand. Invite the Knowing.

You drink coffee all day long, and you smoke cigarettes right through your conversations. That is movement. It is activity—internal and external. You do not interpret it as something which could interfere with your being Centered and Listening. And yet those are activities which are not apart of the communication. You scratch your head, you shift your position for comfort, and not as part of the communication. I bring this up because you assume that the mundane movements which are not directly associated with the expression of Knowing are somehow not susceptible to Centeredness. You are comfortable when a conversation or a Workshop is occurring, because it conveys what I will call a process of education, a very specific, focused expression of love. But, you are not able to identify Centeredness with relating to Chris, or to eating dinner, or to being with friends. You do not have much basis—outside of the scope of a Workshop or of a private conversation—for being in the world from your Center. And so I point out to you that being Centered has not inhibited you from scratching your head or removing a piece of food from your tongue just a moment ago which had become lodged in your tooth, nor of drinking coffee, nor, in the case of Christopher’s coming in the room, relating to him without “teaching.”

It is absolutely correct that you are going to have to learn to be out from your Center with your eyes open. At this point, I wish to make it very clear that in spite of your experience with the bio-feedback equipment—which seemed to make it obvious that visual experience is of such a stimulating nature that it interferes with one’s being able to come out from a theta or delta frequency—the key is where you are placing your attention. The key is whether you are placing your attention at the threshold of Centeredness or at what I will call the “threshold of stimulation.” Mind you, that “threshold of stimulation” only seems to have meaning relative to a body which, in itself, has the capacity to be sensitive, the capacity to be aware—something which the body does not have, simply because it is the visibility and the tangibility of the expression of Meaning which is being experienced as a result of Knowing.

It is necessary for you not to argue against the possibility and accessibility of Guidance by assuming that certain conditions are not conducive to Listening and Hearing. One of these, of course, relates to your body, as though if you have been engaged in activity or movement, you will need to necessarily sit down and become unconscious of it. Indeed, you must rely heavily upon your experience of being centered and carrying on the activities of the Workshops. You will realize that movement of the body occurs during a Workshop—not just the movement of your lips, as is occurring at this moment—and that movement of the body is not inconsistent with being centered. Movement of the body is not, in itself, distracting to centeredness. The necessity is to give permission unconditionally. I will tell you that you can be jogging and still Hear. To be physically active does not constitute a block to Hearing. Physical activity can become part of the whole experience of centeredness and of Guidance, while not giving your focused attention to the movements, because in and of themselves they do not constitute appropriate “subject-matter,” if I can put it that way. The body, and the movements of the body, exist for the sole purpose of giving visibility and tangibility—expression—to what you find yourself Knowing as a result of Listening.

You do not know whether the observing of the events in the Mideast on TV is unworthy of your attention, but your experience of financial lack is worthy of your attention, because you grasp that they might both be of the same order of illusion. Is one or the other of them more worthy of your attention? Are they both? Or neither one? I will tell you something: If either one of them were the appropriate focus of your attention, that is what we would be talking about! But, you see, we are talking about letting go of the sidekick and its polarized, dualistic perceptions—confidences and doubts, fulfillments and lack of fulfillments—and, indeed, we are talking about anchoring yourself at Home by means of simply connecting with me, because it is literally that shift from the standpoint of the sidekick to the standpoint of your Being which separates the tares from the wheat, the illusion from the reality, the overlay of misperception from the underlying Reality which is being misperceived. Then the illusion of lack will not be present to deal with, and the experience of the Wholeness of You, the Wholeness of God’s Self-expression, will be what is being experienced.

unless it comes unasked out of your heart and your mind and your mouth and your gut, don't do it.

Seeing out from Being is that perfect Awareness which Mind experiences of its own infinite Self-expression. All that actually happens is that the illusion, or misunderstanding, caused by conceptual thinking simply evaporates. One is left with a clear view of the Actuality of one’s own Being and the Harmony of it as one’s own experience.

You don’t have control, and have never had control as a person—as a thinking mind—whereas your Being has always had complete Control in Its Self-expression. It will forever continue to do so.

The various languages placed side by side show that with words it is never a question of truth, never a question of adequate expression; otherwise, there would not be so many languages

Then why, if you call rhetoric the art which treats of discourse, and all the other arts treat of discourse, do you not call them arts of rhetoric?

a maker of rhetoricians

exhibit

The wise man, as the proverb says, is late for a fray, but not for a feast