316 Matching Annotations
  1. Last 7 days
  2. Feb 2025
    1. Disease: Von-willebrand Disorder Type 2B, Noncanonical

      Patient: 55 YO, Italian male

      Note: these heterozygous variants are in cis mutations

      Variant1: VWF NM_000552.5 c.2771G>A p.(R924Q), in exon 21, D'D3 domain affected

      Variant2: VWF NM_000552.5 c.6532G>T p.(A2178S), in exon 37, D4 domain affected

      Phenotypes: Mucosal and cutaneous bleeding, low VWF antigent and VWF activity, mild thrombocytopenia, increased ristocetin-induced platelet aggregation, deficiency in high-molecular-weight multimers. Epistaxis, repeated GI bleeding, easy bruising, ISTH BAT score of 7.

      Note: Proband initially diagnosed with VWD type 1 in 2010 but later re-diagnosed as VWD-Type 2.

      Family: No reported family history of bleeding, parents unable to be included in family work-up as they were deceased by time of study. Paternity test was performed for family, parental link established. Patient's daughter does not present the same mutation noted in proband but has heterozygous polymorphic variant inherited from mother which is: VWF NM_000552.5 c.3379C>T p.(P1127S), in exon 25. Daughter did not show menorrhagia or hemorrhagic disorder except for large hematoma on the thigh after trauma of moderate intensity.

      Molecular workup: Paternity test, Sanger-sequencing to validate genetic variants, multimer analysis with electrophoresis, platelet aggregation analysis with Ristocetin, electron micrographs to observe conformation differences.

      Prediction workup: Structural analysis with I-TASSER modeling program to identify perturbed structure. A2178S is predicted as tolerated in all in-silico systems used.

      Database Information: Effect of the R924Q mutation is noted in literature database but has contradicting reports of effects altering VWF levels. Some studies do report it as a polymorphic variant

      Variant is present in dbSNP database (rs33978901). MAF in European population 0.01< MAF< 0.02

      Effect of A2178S variant is present in dbSNP database (rs34230288), MAF = 0.02 in European population.

  3. Jan 2025
    1. Disease for patient 1: Von Willebrand Disease Type1, transmitter VWD-type 3

      Disease for patient 2: Von Willebrand Disease Type 3

      Patient1: 90 YO female (Afro-Caribbean)

      Patient2: 40 YO female (Afro-Caribbean)

      Notes multiple variants in the VWF gene but have focused on variants in the D4 domain. However cannot discount the impact of some other variants.

      Variant 1: VWF NM_000552.5: c.6647del p.(Cys2216Phefs*9), results in VWF protein missing D4 domain and C-terminal end of molecule

      Phenotype patient 1: Reduced VWF levels in VWF:Ag, VWF:ristocetin cofactor, FVIII:C, FVIII(VWF:FVIIIB). Bleeding score 0, required Helixate treatment before and after receiving surgery.

      Variant 2: VWF NM_000552.5: c.6432dup p.(Pro2145Thrfs*5)

      Three sequence variations in family study showed other variants highlighted p.(Cys1149Arg) and p.(Pro2145Thrfs*5) are not on the same allele.

      Does have other variants in VWF but they are stated by authors to not be detrimental. p.(Val510=) is noted to be potentially deleterious.

      Phenotype patient 2: severely reduced VWF levels, absence of multimers, bleeding score 32, epistaxis, bruising, oral cavity bleeding, prolonged bleeding from minor wounds, menorrhagia, hemarthrosis, ankle arthropathy.

      Suggests premature termination codons in these variants may lead to NMD but that this mechanism was found to be PTC position-dependent. Degradation was not 100% and need to perform cellular experiments.

    1. inode71 1 point2 points3 points 13 hours ago (1 child)Which city? I’m in LA so if it’s northern OC I’m interested.
  4. Dec 2024
    1. Disease: Von-willebrand Disorder Type 3

      Patient: 26 yo, female

      Variant: VWF NM_000552.5 c:997+118 T>G g.(6073501 A>C), homozygous, intronic

      Phenotypes: No detectable VWF in plasma, early onset bleeding complications, epistaxis, easy bruising, bleeding following injury, menorrhagia, iron-deficient anemia

      Note: underwent prophylaxis replacement therapy, on-demand antihemorrhagic treatments, oral contraceptives, and replacement therapy.

      Family: not mentioned

      Predictions:

      VEP SpliceAI tool predicted variant likely deleterious (delta score 0.95)

      Used Polyphen-2 and SIFT which determined pathogenic likelihood.

      Neural Network Splicing, Alternative Splice Site Predictor, plug-in MaxEnt(For 5' donor site) of Human Splicing Finder all concur this variant can create a new donor splice site in intron 8. Contains premature stop codon and susceptible to NMD.

      Functional work:

      qRT-PCR performed to identify levels of VWF in IP-derived endothelial cells.

      histochemical immunostaining for IP-derived endothelial cells confirm no VWF production, only a residual amount present. Suggests leaky mutation.

      performed RNA sequencing to assess co-regulated gene networks

    1. Disease: Von-willebrand Disorder Type 2M

      Patient1: 13 YO male

      Patient2: 16 YO female

      Note they are siblings

      Variant: VWF NM_000552.5: c.5192C>T p.(Ser1731Leu), heterozygous variant, in A3 domain in exon 30

      Phenotype patient 1: several bleedings after tosillectomy, recurrent epistaxis, decreased VWF:CB ratio, decreased VWF:CB/VWF:Ag ratio

      Phenotype patient 2: menorrhagia, intermittent gum bleeding, easy bruising, decreased VWF:CB ratio, decreased VWF:CB/VWF:Ag ratio

      For both patients: VWF:CB ratio corresponds to collagen type 1, multimer analysis was normal, VWF:Ag, VWF:Ac, and factor VIII activity was normal.

      Family: Not listed

      Present in dbSNP (rs764077750)

      Present in gnomAD, rare MAF (ALL: 0.0012%)

      Predictions:

      SIFT- predicted deleterious (Score 0.01, median 3.34)

      MutationTaster- Predicted disease causing (probability score 1)

      PolyPhen2- Predicted probably damaging (Score 0.983)

      CADD score- 26.5

      Authors mention similar AA substitutions at the p.1731 position which leads to reduced binding of VWF to collagen in other patients.

      Authors also cite a functional human cell experiment in COS7 cell line which resulted in functional VWF defect.

      Authors conclude this novel variant as likely pathogenic.

    1. endomorph body type = good weight gainers = bad weight losers.<br /> thats the whole secret of the "fat acceptance" tragedy / comedy.

  5. Nov 2024
    1. The store offers maintenance and repair lessons to the public (including Philadelphia school students). The shop hosts poetry nights, open mics, comedy shows and other events. It even offers typewriters to public places such as bookstores, libraries and coffeeshops to bring the machines back into the collective consciousness.
    1. Disorder studied: Type 1 von Willebrand disease (T1-VWD).

      Type of study: Translational

      Model organism: Mouse (inbred strains) Obtained from Jackson Laboratory

      Analyses:

      VWF plasma protein quantitation (ELISA)

      Hertiability calculations

      PCR genotyping

      QTL analysis

      Allele-specific primer extension analysis

      Results:

      Identified new modifier of VWF known as (Mvwf5). Also found two loci unliked to Vwf known as (Mvwf6-7)

      Mice with this variant displayed statistically significant decrease in VWF levels, recapitulating the decreasing patterns displayed in humans.

      However, another strain of inbred mice with a different mutation did not show an age-dependent decrease in VWF. Suggests strain-specific differences in regulation of VWF levels over time.

      Mvwf5 is a cis-regulatory variant altering Vwf mRNA expression.

      This is a natural variant of the Vwf allele among inbred strains of mice. Found this variant causes elevation in steady-state levels of Vwf mRNA.

      Authors state findings show equivalent of of type 1 VWD is remarkably common in mice and humans. ALso state the Mvwf1 analysis in wild mouse populations suggest this locus is under selective pressure.

      Of the 5 potential modifier loci identified, 3 display conservation of synteny with potential human modifier loci.

    1. On most real life projects, the speed of development is easily worth an occasional corner case bug with an unexpected nil value … except when it isn’t.

      speed of development vs. safety

    1. If you've been dreaming of plunging into this profession, consider the success of Paul Lundy, who took over Bremerton Office Machine Company from nonagenarian Bob Montgomery; or Antony Valoppi, creator of Portland's Type Space, which combines a traditional typewriter shop with a cultural center; or Trevor Brumfield, a young man in his late twenties who has quickly built Dayton's TB Writers Plus into a busy enterprise.
  6. Oct 2024
    1. Typewriter Basics: Carriage Locks by [[Sarah Everett]] of [[Just My Typewriter]]

      Sarah describes having a common spacebar issue when repairing a typewriter, bending the spacebar down which causes the machine not to work/advance as a result when it's put back into the typewriter shell.

      Sarah also shows some type bar benders, but doesn't demonstrate how she (or her father) used them to do the repair.

    1. ROYAL KMM Replacing Type Bar Link Remove Arm Repaired Typewriter by [[Phoenix Typewriter]]

      This is roughly what I expected to be the case. I've got to shift the fulcrum pivot wire so I can reattach my Q and @ on a Royal KMG.

      Roughly similar to Gerren's video on swapping out typefaces, but with a slightly different technique for speed of doing that. See: https://hypothes.is/a/I_-9rBV2Ee-eMotzy9_Z-Q

    1. Usually the keys on most typewriters are friction fit on and come off pretty easily. The tougher part is that the slugs are soldered onto the typebars, so you'll need to remove them and swap them with a soldering arm. Even if you have the soldering tools, the more trying part is aligning them properly when putting them back on. Many old school shops have/had custom jigs made for properly aligning slugs when soldering them on.

      If you don't have the tools, patience or facility, this is usually something best left to your favorite shop: https://site.xavier.edu/polt/typewriters/tw-repair.html


      reply to u/fontinalispluma at https://old.reddit.com/r/typewriters/comments/1gb3dwc/change_the_keys_and_type_slugs/

    1. Dolettersin alinesometimesstart nicely,thenrundownhill?Thiscan’thappenifyouuse theline-spacinglever,insteadofrollingthepaper throughwiththecylinderknob.Inthelatter case, the rollerthatlocksthespacingofthe linesmaycometorest on topofaratchettooth,insteadofsettlingbetweentwoofthem.Whenthemachinestarts, thevibration graduallyjarsthecylinderarounduntilitreachesitsnormal position—droppinglettersasitturns.
    2. Check the alignment of the type by striking eachcharacter between the straight-sided letter "N"
    3. Cakedinkmayberemovedwithtypeputty,alcohol,carbontetrachloride,oroneoftheproprietarydry-cleaningfluids,appliedwithabrush.Pressthetypeputtyontothetype,peelitoff,andthecakedinkcomeswithit.Ifyouusealiquid,firstliftthetypeandputpaperunderitto prevent dirt from dripping into the machine. When using type-cleaning fluid, be sure toWipe the type dry with a cloth before using the place paper under type to prevent dirt frommachine again.

      dry cleaning solvents in 1941 were likely Varsol or Stoddard's Formula.

      compare to trichloroethane<br /> https://hypothes.is/a/EyBIAFXAEe-AcP-Atlj_aQ

      Note discontinuation of carbon tetrachloride<br /> https://hypothes.is/a/bfdi_I90Ee-OQLN0HpsE7Q

    1. https://en.wikipedia.org/wiki/Carbon_tetrachloride

      Carbon tetrachloride or carbon tet is a non-flammable, dense, colorless liquid which was often used as a cleaning agent in the mid 1900s, but was phased out due to safety and environmental concerns. High exposure can affect the central nervous system and cause damage to the liver and kidneys. Prolonged exposure can be fatal.

    1. Hints for a Happy Typewriter<br /> Bryan Kravitz, Nancy Gorrell, 1983<br /> https://typewriterdatabase.com/1983-Hints4HappyTypewriter.index.manual

      Some good, basic home care and use from 1983. Home mechanics in 2024 are probably capable of a bit more without the backstop of a typewriter mechanic.

      This guide suggest the use of solvents like alcohol or trichloroethane for cleaning type slugs and internals. Note that trichloroethane manufacture and use has diminished significantly since 1996 when it was identified by the Montreal Protocol as a contributor to ozone depletion.

    1. When doing type alignment, Duane Jensen was taught to use an old/used ribbon instead of a new, wet/dark ribbon for better performance in testing. New ribbons don't show the differences as well.

      He's noticed that ribbon from Around the Office are dreadful.

    1. Advanced Typing: Duplicating and Manuscript. Vol. MN-1512d, 1943. https://www.youtube.com/watch?v=7ve5JnTUzvo.

      Stencils

      Before writing stencils, be sure to clean your type. (Don't use liquid solvent.)

      Be sure to place the cushion sheet properly behind the stencil.

      Place the paper bail rollers at the extreme left and right of the stencil to prevent them from marking the master.

      For errors, rub individual characters separately with a burnisher using a circular motion.

      Hectograph masters, Hectograph ribbon (ditto ribbon)

      Wax pencils

      Typefaces

      20% more type on a page with elite than 10 inch pica.

      Pica allows approximately 26-40 lines on standard letterhead giving 300-450 words to a page.

      Special characters: - o for degrees ' and " for feet and inches or minutes and seconds along with superscript - division: - backspace colon - pound sterling: L backspace f - exclamation point: period backspace ' - equal sign: hyphen backspace variable hyphen - paragraph mark: P backspace I

      proofreaders' marks<br /> # followed by a number is used to mean insert that number of spaces

      Centering timestamp 19:37

    1. Basic Typing: Machine Operation. 16 mm. Vol. MN-1512b, 1943. https://www.youtube.com/watch?v=b-REJEArnjE.

      Type pacer timestamp 4:12

      "Your head is the most important part of your typing." - Lenore Fenton

      "Your typewriter does exactly what you make it do, but it does no more" - Lenore Fenton <br /> This is very similar to quotes about computer programs at the end of the 20th century too.

      The touch characteristics for the manual, the noiseless, and the electric are all slightly different.

    1. 1962 Vintage IBM Typewriter Training Film IBM Selectric Proper Typing Procedures, w/ Bud McDole by [[Computer History Archives Project]]

      Right at the Typewriter. 16 mm. San Francisco, CA: KQED, 1962. https://www.youtube.com/watch?v=sPfHAW_OfGo.

      On manual typewriters one "snaps" the keys while on an electric keyboard one "taps" the keys for maximum speed and accuracy.

      Overview of functionality of an IBM typewriter.

      To add longevity to one's carbon papers they should be rotated both top to bottom and front to back within one's packs.

      Use plastic type cleaner, meant for cleaning type slugs, to clean the excess ink from a typewriter. Form it into a point and press it to the letter to erase several times. Then erase with eraser shield and eraser.

      To type to the very bottom of the page, particularly with a carbon pack, to prevent slippage at the bottom, insert a "trailer sheet" about halfway down the first page. Insert it at the back of the pack just behind the original and between the first carbon sheet.

      For typing small sheets of paper (index cards) fold a pleat into a regular sheet of paper and use the lip to hold the smaller sheet you're typing on.

      To more quickly type envelopes, do the first then reverse the platen so that only about an inch of the top of the envelope is visible. Then insert the next envelope behind the first and continue reversing the platen. This will allow the finished envelopes to stack at the paper table and speed the threading and typing of envelopes in rapid succession.

      Use of the divots on the typing guide for making horizontal or vertical lines while moving the carriage or rotating the platen respectively.

      How to change the typeball and the ribbon cartridge on the IBM selectric.

    1. Disease: Von Willebrand Disease (VWD) type 1

      Patient(s): 13 yo, female and 14 yo, female, both Italian

      Variant: VWF NM_000552.5: c.820A>C p. (Thr274Pro)

      Dominant negative effect

      Heterozygous carrier

      Variant located in the D1 domain on VWF

      Phenotypes:

      heterozygous carriers have no bleeding history

      reduced VWF levels compatible with diagnosis of VWD type 1

      increased FVIII:C/VWF:Ag ratio, suggests reduced VWF synthesis/secretion as possible phathophysiological mechanism

      Normal VWFpp/VWF:Ag ratio

      Modest alteration of multimeric pattern in plasma and platelet multimers

      plasma VWF showed slight increase of LMWM and decrease of IMWM and HMWM

      Platelet VWF showed quantitative decrease of IMWM, HMWM, and UL multimers

      In silico analysis:

      SIFT, ALIGN, GVD Polyphen 2.0, SNP&GO, Mutation Taster, Pmut all suggest damaging consequences.

      PROVEAN and Effect suggest neutral effect

      according to ACMG guidelines this variant was classified as pathogenic

    1. The 2024 Phoenix Type-In by [[Joe Van Cleave]]

      Platen shrinkage

      • most typewriters are 6 lines per inch
      • 6.5 lines per inch based on actual measurement per JVC on one of his machines
      • 2mm shrinkage??
      • Per Bob/Typewriter Muse 1.1

      Bob had a machine that was supposed to be 1.27 but was measured at 1.259 when pulled off. So shrinkage of platens can be roughly fifteen hundredths of an inch (0.015" or about 0.4mm)

      Bob at Typewriter Muse custom tunes platens to the typewriter. Only place doing platens outside of JJ Short.

      JVC's partner took him to the Phoenix Type-in for her birthday.

      Bill Wahl of Mesa Typewriter Exchange

      grandfather started in the 40s<br /> bill started in 73<br /> part time help to 92 and now by himself<br /> does his benchwork after hours and chats during the day

      Ted Munk

      adding machine database consideration

      looking for service manuals for: - royal portables 50-59<br /> - skyriter 40s / 50s<br /> - sm9 service manual

      Royal Mercury manual is a clear, well-written manual. The Smith-Corona series 5 typewriter manuals are great too, though a bit more dense.

      Brian Goode and Christy organized this year's Phoenix Type-In.

    1. this article reveals howcommon themes are being discursively constructed in relation to the future of public libraries,maker cultures, and informal learning. The analysis highlights tensions and questions thatemerge through the discursive construction of making, makers, and makerspaces in the field oflibrary and information studies. The article employs discourse analysis to examine professionallibrary journal articles and blog posts published from 2011–14 that focus on makerspaces inpublic libraries.

      This section of the abstract highlights that the article is a literature review that will be looking at other published articles on Maker education

    Tags

    Annotators

    1. Disease: Von-willebrand Disorder, type 1

      Patient 1 Variant: VWF NM_000552.5: c.4135C>T p.(Arg1379Cys) Exon 28

      Family: History not mentioned

      Patient 1 phenotype: near normal VWF:Ag and WVF:RCo levels RIPA within normal range Platelet VWF levels were normal normal pattern for multimeric analysis of plasma Slightly reduced VWF levels

      In silico predictions available:

      I-Mutant 3.0 value = -1.36 PYMOL prediction = substitution of ARG 1379 with a cysteine results in the loss of hydrogen bonds with Lys1407 and Lys1408, predicted change in secondary structure of A1 domain

  7. Sep 2024
    1. heterozygous c.G380A variant in GP1BA (NM_000173.7) (Figure 1B), resulting in a missense substitution of an arginine with a glutamine at position 127

      Disease: platelet-type von Willebrand disease (PT-VWD)

      Patient: 14 yo, Male

      Variant: GP1BA NM_000173.7:c.389G>A p.(Arg127Gln), Heterozygous, Gain-of-Function (GOF)

      Located in LRR5 domain of GP1BA

      Family: Mother did not refer any bleeding symptoms (variant absent in mother) Father not available for collection of clinical history or platelet function testing

    1. Type-in activities:<br /> - learning about typewriters, both using and how they work;<br /> - demonstrations of typewriter maintenance, cleaning, how to change a ribbon, and small repairs for common problems - typewriter tool showcases - what tools might you need to maintain, clean, and repair your typewriter? - lots of machines to try out, which might best suit your writing style, and typing touch? If you don't have a typewriter, this is a great way to try some out before buying your first one - typewriter purchasing and collecting advice - encouraging typing as a distraction and screen-free writing tool - writing (fiction, non-fiction, poetry) along with potential writing prompts (this could dovetail in with other library-related writing endeavors); - A group story: A single typewriter is reserved to one side upon which each participant can contribute by typing a single sentence to create a collaborative/group story "exquisite corpse"-style; - typewriter art and arttyping - Speed typing contest (with small prizes) - We'll bring stationery (paper, envelopes, stamps) to encourage participants to type letters to friends or family (bring an address for someone you'd like to write to); - typewriter swap and sale (optional depending on the venue's perspective; sales are not the primary purpose here) - typewriter repairs using 3D printing or designing replacement parts (if the venue can support this) - typewriter handicrafts (typewriter covers and sewing/repairing cases) - typewriter resources (repair shops, where to find ribbon, how old is my machine?, et al.) - a possible typewriter mystery game? - share stories - encourage community

      For a local library-specific type in:<br /> - library card applications which can be typewritten for potential patrons who don't have a library card - typewriter books (particularly if hosted at a library; place a hold on several typewriter-related books which attendees can browse through at the event and check out afterward) - 3D printing typewriter keys, spare parts; design of replacement parts for 3D printing

      Attendees are encouraged to bring one (or many more of their own favorite manual typewriters) to use, showcase, or demonstrate to others, but having your own typewriter is NOT a requirement for attendance.

    1. Joe Van Cleave hypothesizes that the slightly blurry and/or ghosting letters on typewriters may be the result of the typebar just hitting the typing guide and moving slightly as they do thereby creating issues with the type clarity.

      https://youtu.be/GpLpTkhSGWc?si=MFmshF-LPPa1CyUP&t=1190

    1. I visited the Supply Sergeant store on Hollywood Blvd yesterday, and for $15 they were selling a "regulator bag." This was 11 3/4" x 11 3/4" x 3". Perfect for carrying a Hermes Baby/Rocket! Here is another, but more expensive: https://www.akona.com/products/product?productId=11406

      u/pbasch is in the LA area

  8. Aug 2024
    1. Cleaning Type Slugs Fast ! Removing Clogged Dirty Ink Typewriter Service How to Shine Those Faces by [[Phoenix Typewriter]]

      Duane cleans type slugs by draping the typewriter with cloths and then using a metal bristle brush and lacquer thinner. Small picks or an X-Acto knife can help to remove gunk from the interiors of the closed letters.

  9. Jul 2024
    1. Joe Van Cleave shows how to raise/lower individual type slugs by bending the typebars, particularly the ones out toward the end, without using custom typewriter repair tools.

      time stamp 19:25

    1. Two "5" keys (?!?) (SC Poweriter)

      reply to u/Deep-Seaworthiness48 at https://www.reddit.com/r/typewriters/comments/1e5gh4p/two_5_keys_sc_poweriter/

      SMC Typewriter from late 60s/early 70s with a pound/5 key in the !/1 position whose 5 is duplicated in the usual %/5 position

      Things like that happened on alternate language/region typewriters. I've got a Dutch keyboard layout that repeats a % symbol twice.

      It's likely that the pound symbol was needed/required so they pulled one from a pre-existing typeslug and key cap on a keyboard where the £/5 key was common and replaced the 1/! which in the era was widely known could be done by alternate means (aka lower case 'l' and '.' backspace '''.

      The value of the £ was more important to the typist and because of typeface manufacture was probably easier to do in the £/5 existing combination from something like the English No. 1028, International No. 1060 keyboard, the Brazilian No. 1065, or the Danish No. 1047 all of which paired the £/5. See also: https://munk.org/typecast/2023/02/03/1954-smith-corona-scm-typewriter-type-styles-and-keyboards-catalog/

      Off hand, I don't see another S-C keyboard combination from that time period that had a £ paired with any other glyph/character. In the "change-a-type" time period they likely wouldn't have done a custom black key for the £/5 when they were already manufacturing one in a matching white. If they didn't also swap out the key at the far right end of that bank, I would expect it to be a standard black '+/=' key cap and slug.

    1. ribbon carrier (vibrator) not moving

      reply to u/67comet at https://www.reddit.com/r/typewriters/comments/1e4hu0s/smith_corona_electra_120_ribbon_carrier_not_moving/

      That piece is called a ribbon vibrator which moves the ribbon up and down. They generally operate on gravity and as a result they need to be clean and free from oil, gunk, hair, dust, etc. Usually they slide up and down freely. There's a colloquial saying in the typewriter space that "A typewriter isn't really broken unless it's clean and broken."

      Occasionally ribbon vibrators can become bent which makes them inoperable and this can be remedied with some light forming (bending) with an appropriate screwdriver or needle nosed plier. You can search YouTube and you'll find a variety of videos for cleaning and forming these back into shape so that they slide cleanly.

      As for your missing 1/! slug, it's unlikely that you'll find someone selling just the slug itself and then you'll need to solder it on perfectly and/or adjust it slightly with appropriate tools to get the right alignment. Far better is to check around with repair shops that might have the same or similar machines which they're parting out and then you could request one. Your best bet is to purchase the entire typebar and slug assembly from a donor machine which you can then swap out into your machine and skip the soldering. For this https://www.youtube.com/watch?v=pFMu6dUROGA can give you tips.

      To find donor machines, try repair shops on this list: https://site.xavier.edu/polt/typewriters/tw-repair.html

  10. Jun 2024
  11. May 2024
    1. Bruder, Jessica. “Click, Clack, Ding! Sigh ...” The New York Times, March 30, 2011, sec. Fashion. https://www.nytimes.com/2011/03/31/fashion/31Typewriter.html.

    2. “Like a jam session for people who like typewriters,” said Michael McGettigan, 56, a local bike shop owner who came up with the idea. “You had unions do sit-ins and hippies do be-ins, so I thought, ‘We’ll do a type-in.’ ”
    1. Notable is the fact that no top-level type fields exist in an ACDC. This is because the Schema, s, field itself is the type field for the ACDC and its parts
    1. The term "Type-Out" was coined by Tom at Cambridge Typewriter in MA to refer to the practice of having a Type-In outside in the sunshine. The first such Type-Out was held in front of Cambridge Typewriter on Oct 22, 2011.
    1. One of the first thing I noticed was the rubber on this foot was sticking. This is the resting spot for the basket shift. Moving it up or down will adjust where the lower case letters strike the platen. I removed the old sticky rubber. There are two adjustments here, you can’t see the other one, but it’s looks the same. One is for lower case letters the other is for upper case. This is called the “on feet” adjustment. If you ever have the top of an upper case letter not imprinting or not level with the lower case letters, look at this adjustment. A good way to tell is to type HhHh, and see if the bottoms of the letters line up.
  12. Apr 2024
  13. Mar 2024
    1. https://archive.org/details/run-de-1986-10/page/120/mode/2up

      "RUN – Unabhängiges Commodore Computermagazin", Ausgabe 10/Oktober 1986, which has a hexdump code listing of a C64 Zettelkasten

      ᔥ[Michael Gisiger[]] in mastodon: (@gisiger@nerdculture.de)

      Lust auf #Retrocomputing und #PKM mit einem #Zettelkasten? Bitte schön, in der Oktober-Ausgabe 1986 des #Commodore Magazins RUN findet sich ein Listing für den #C64 dazu. Viel Spass beim Abtippen 😅

      https://archive.org/details/run-de-1986-10/page/120/mode/2up

      See additional conversation at: https://www.reddit.com/r/c64/comments/1bg0ja1/does_anyone_have_the_zettelkasten_program_from/?utm_source=share&utm_medium=web2x&context=3

    1. taste. its a matter of taste, aka personality type.<br /> some people see life as a game of patience, they seek security, stability, monotony, linearity.<br /> some people see life as a game of luck, they seek freedom, dynamics, variation, chaos.

  14. Feb 2024
  15. Jan 2024
    1. 1:10:00 identity politics: the only stable "identity" is personality type, which is inborn and constant for life.<br /> my heresy: i found a hypothesis for the question: how must we connect different personality types to create stable groups?<br /> "the system" likes my work so much, they are threatening to bust my door, steal my stuff, and throw me in jail for five years, as a punishment for publishing my radical answer to the question: who are my friends?<br /> my book: pallas. who are my friends. group composition by personality type

  16. Dec 2023
    1. The thing most obvious about the type systems of Java, C, C++, Pascal, and many other widely-used “industry” languages is not that they are statically typed, but that they are explicitly typed.In other words, they require lots of type declarations. (In the world of less explicitly typed languages, where these declarations are optional, they are often called “type annotations”.) This has nothing to do with static types. continued
  17. Nov 2023
    1. blah. this surveillance system is one big personality test.<br /> the problem is, they do not want a balance of all personality types or "natural order",<br /> but they do a one-sided selection by personality type.<br /> aka socialdarwinism, socialism, survival of the social, social credit score, civilization, high culture, progress, "made order", human laws, human rights, humanism, ...

  18. Oct 2023
  19. Sep 2023
    1. A record can be viewed as the computer analog of a mathematical tuple, although a tuple may or may not be considered a record, and vice versa, depending on conventions and the specific programming language.
    2. An object in object-oriented language is essentially a record that contains procedures specialized to handle that record; and object types are an elaboration of record types. Indeed, in most object-oriented languages, records are just special cases of objects, and are known as plain old data structures (PODSs), to contrast with objects that use OO features.
    3. A record type is a data type that describes such values and variables.
    4. In type theory, product types (with no field names) are generally preferred due to their simplicity
    1. Most typed functional programming languages implement tuples directly as product types
    1. Modules do not add anything to the global (window) scope. Modules always are in strict mode. Loading the same module twice in the same file will have no effect, as modules are only executed once. Modules require a server environment.
  20. Jun 2023
  21. May 2023
    1. Emphasizing lifetime-polymorphism can also make type inference untenable, a design choice that wouldn’t fit OCaml.

      References or sources? Why? Presumably there's some research into this?

    1. Typewriter Cleaning and Repair Basics #2 Type Bars, Case, and Crinkle Finish

      https://www.youtube.com/watch?v=82O_iUAI5og


      Segment comb cleaning - isopropyl alcohol (gentler solvent) - odorless mineral spirits - Lacquer thinner (maybe a bit too aggressive) - naphtha (lighter fluid) take care for flammability and ventilation

      Work solvent into bearing between type bar and segment comb. To dry things out one can used compressed air when done or just air dry.

      If sticking keys not due to being gummed up, bend portions slightly for better alighment.

      Do not lubricate the segment comb.

      Only lubricate the carriage rails when necessary.

      Exterior cleaning

      Brass bristle or nylon bristle brushes (toothbrushes) can be used to clean the exterior of the typewriter and/or cases with mild detergents or other solvents. Depending on the finish, try the brush and solvent on a small portion to determine colorfastness and potential scratching first.

  22. Apr 2023
  23. Mar 2023
  24. Feb 2023
    1. [Episode!]! represents an array of Episode objects. Since it is also non-nullable, you can always expect an array (with zero or more items) when you query the appearsIn field. And since Episode! is also non-nullable, you can always expect every item of the array to be an Episode object.

      Note that this still allows an empty array, []. It only disallows: null and [null].

    1. If you want a workaround for the case where you can't just replace key with a string literal, you could write your own user-defined type guard function called hasProp(obj, prop). The implementation would just return prop in obj, but its type signature explicitly says that a true result should cause obj to be narrowed to just those union members with a key of type prop: function hasProp<T extends object, K extends PropertyKey>( obj: T, prop: K ): obj is Extract<T, { [P in K]?: any }> { return prop in obj; } and then in your function, replace key in a with hasProp(a, key): function f3(a: A) { const key = 'b'; if (hasProp(a, key)) { return a[key]; // okay } return 42; }
  25. Dec 2022
    1. type switches

      type switch 是一种固定的格式吗?还是基于 switch 条件控制的?

      A type switch is a construct ``` func do(i interface{}) { switch v := i.(type): case int:

      case string:

      default:

      } ```

    2. Type switches

      type switch 是一种固定的格式吗?还是基于 switch 条件控制的? A type switch is a construct ``` func do(i interface{}) { switch v := i.(type): case int:

      case string:

      default:

      } ```

    1. in this moment Chris and the deer have their owncoagulation: fusing into one “buck” (and obviously Peele was playing uponthis terminology associated with the Black male slave), they jointly chargeand kill their enemy. Together, the “vermin” strike back
    2. Chris makes use of thedead deer; another (more mystical) analysis could posit that the deer takesrevenge on the hunter, using Chris’s body as a vehicle
    3. First, the conflation of the deerwith the devaluation of Black life nods to the long-standing tradition of usinganimals to speak back to the power structures upheld by plantation slaveryin the form of animal folktales. And second, this deer comes roaring back tolife. He gets his revenge on the family that made his noble head into a trophy.The taxidermied deer is a speaking animal that has a kind of second life, andthere are multiple ways we might read its importance in Chris’s escape

      back to life, revenge, trophy, head, speaking animal with second life, the deer also fights back

    4. the deer strikes back
    5. Like the trickster tales discussed above, the films we are lookingat here do not make animals the focal point, but use them as a means of“thinking with” humans.
    6. The trickster is an animal low on the peckingorder (like a rabbit) who finds himself in a jam and must use his wits, charms,and other skill sets to outfox his more powerful enemies. He is an animalsurrogate that speaks softly of strategies for resistance
    7. Wagner emphasizes thatsuch animal tales often provided coded ways of imparting strategies forresistance and that this story has historical connections not only to the tropeof the speaking animal from African trickster mythologies like the spiderAnansi, but also perhaps, to Aesop’s animal fable
    8. educe animals to mere metaphors, similes, or symbolsdo not seem promising for theorizing ethical recognition of actual animals.Donna Haraway, for example, criticizes philosophical texts that show a “pro-found absence of curiosity about or respect for and with actual animals,even as innumerable references to diverse animals are invoked.” 15 SusanMcHugh, meanwhile, suggests that “the aesthetic structures of metaphor,though precariously supporting the human subject, seem unable to bearanimal agency.”16 An
    9. She maybelieve the comparison reveals the moral horror of industrial animal agri-culture, but, as Bénédicte Boisseron argues, such comparisons “instrumen-talize” Blackness in a “self-serving” way, ignoring the complex and ongoingBlack struggle against dehumanizing discourses and institutions in order toframe “the animal” as “the new black.
    10. remind us of the historical reduction of the human to the status of ananimal under transatlantic slavery, but also were used as a mode of resistancefor enslaved peoples

      first half is type 1, first half is type 2

    11. Rather than viewing fables as operating with a purely substitutivelogic, where the animal stands in for the human, recent criticism explores thepossibility that the fable can imagine relationality and even allyship amongspecies
    12. lens of alliance, not solely analogy
    13. Rather, the appearance of animals in some recentfilms highlights the unequal treatment of Black lives in America in a mannerthat continues the fable tradition, and simultaneously emphasizes the human
    14. Theseworks encode various strategies of survival in an era in which Black livescontinue to be devalued
    15. Any resistance must be sanitized soas to be tolerable” for the general audience. 5 But resistance also works not bybeing sanitized, but by being hidden in plain sight, coded as symbols legibleto some but not to all. The use of animal fables has a long-standing historydating back to slavery as providing such a coded language of resistance

      get out use of deer ... chris, black resistance, fables...taxidermy hidden in plain sight, coded/only chris to understand

    16. Wagner notes that theweaker animals use their wits as a means of overcoming the unequal powerdistribution in the world they navigated

      slavery fables weak/vermin intro get out deer...wits and taxidermy