536 Matching Annotations
  1. Nov 2024
    1. Disease: N/A, variant present in F12 gene

      Patient: 36 yo, Female, Saudi descent

      Variant:F12 NC_000005.9:g.176,830,269 G>A; p.Gly506Asp Homozygous mutation, exon 12 Located in peptidase S1 domain of F12

      Family:

      Consanguineous family history (parents first-degree cousins)

      No family history of bleeding or thrombosis

      Phenotypes:

      Significantly high activated partial thromboplastin time

      No history of bleeding during deliveries or tooth extractions

      No history of thrombosis or skin manifestations

      On no medications, physical examination unremarkable

      Factor assays and VWF tests within normal ranges except Factor XII (Severely deficient)

      variant is proposed to be deleterious but there is insufficient evidence to support this claim.

  2. Oct 2024
    1. An interesting heuristic I came up with is that we should install 1 kWh of batteries for every kilowattpeak (kWp) of solar panels. On average solar panels will output around 20% of their rated peak power worldwide (see table). A good rule of thumb is that you want a minimum of 5 hours of storage in the future renewable grid. Five times 20% is 100%, hence 1 kWh of batteries for 1 kWp of solar panels.

      This shows the Germany having only 11-12% capacity factor for solar? I assumed it was close to Spain's figure

  3. May 2024
    1. One way in which students report experiencing the social presenceof an instructor is the immediacy of response and type of feedbackreceived

      feedback - social presence

  4. Jul 2023
    1. ```idl dictionary NavigatorUABrandVersion { DOMString brand; DOMString version; };

      dictionary UADataValues { DOMString architecture; DOMString bitness; sequence<NavigatorUABrandVersion> brands; DOMString formFactor; sequence<NavigatorUABrandVersion> fullVersionList; DOMString model; boolean mobile; DOMString platform; DOMString platformVersion; DOMString uaFullVersion; // deprecated in favor of fullVersionList boolean wow64; };

      dictionary UALowEntropyJSON { sequence<NavigatorUABrandVersion> brands; boolean mobile; DOMString platform; };

      [Exposed=(Window,Worker)] interface NavigatorUAData { readonly attribute FrozenArray<NavigatorUABrandVersion> brands; readonly attribute boolean mobile; readonly attribute DOMString platform; Promise<UADataValues> getHighEntropyValues (sequence<DOMString> hints ); UALowEntropyJSON toJSON (); };

      interface mixin NavigatorUA { [SecureContext] readonly attribute NavigatorUAData userAgentData ; };

      Navigator includes NavigatorUA; WorkerNavigator includes NavigatorUA; ```

  5. May 2023
    1. “Multi-factor authentication needs multi-factor enrollment,” noted Taku. It shouldn’t have been possible to enroll just using a stolen password. He listed numerous possibilities, among them credentials handed out in person, a one-time password, or a PIN sent to the employee’s registered email or mobile.
  6. Apr 2023
    1. Whereas U2F only supports multi-factor mode, having been designed to strengthen existing username/password-based login flows, FIDO2 adds support for single-factor mode.
  7. Mar 2023
    1. If you can unlink your address from a locked out account and then link it to a new account and add new 2FA factors to new account, and basically set it up again to be a replacement nearly identical to the original... how is that any different / more secure than just using a "reset account" feature that resets the original account (removes 2FA)?

      We're still back to the recurring original problem with account security where the security of your account comes down to the security of your linked e-mail account.

    1. Most platforms that require OTP verification for ensuring security are targeted at the mobile phone only. But some payment gaterways send OTP to email address also simultaneously to doubly ensure that you get the OTP and that you have requested the OTP. There could be some delay in SMS or email reaching you. Many OTPs are time restricted - you have to use them quickly.
  8. Jan 2023
  9. Dec 2022
    1. It is crucial to establish the key feedbacks regulating, or destabilizing, each safety variable, and how they interact on different timescales. To quantitatively assess and combine these feedbacks, an established but under-used approach of calculating and combining feedback “gain” factors (Lashof, 1989) can provide a useful framework.

      !- Feedback Gain Factors : used to assess and combine feedbacks - this helps establish the key feedbacks regulating or destabilizing safety variables

    1. the risk that I see is the more people and the more countries and governments that recognize the logic of this, the sooner there's 00:36:07 a phase shift that actually mortally wounds the super organism, and then the complexity and financial supports that we have for all of our nations kind of unravel before we're able to do the important work.

      !- transition : risk factor - financial system unravels prematurely and capital for transition becomes scarce

  10. Aug 2022
    1. We want to use the Doorkeeper gem to implement an OAuth provider in our app. However, we use 2 factor auth in the login process, so we need a way to modify the password grant to accept email, password and a 2fa token (and respond with an appropriate error if the 2fa token is required and missing).
    1. Gilbert, P. B., Montefiori, D. C., McDermott, A., Fong, Y., Benkeser, D. C., Deng, W., Zhou, H., Houchens, C. R., Martins, K., Jayashankar, L., Castellino, F., Flach, B., Lin, B. C., O’Connell, S., McDanal, C., Eaton, A., Sarzotti-Kelsoe, M., Lu, Y., Yu, C., … Teams, U. S. G. (USG)/CoVPN B. (2021). Immune Correlates Analysis of the mRNA-1273 COVID-19 Vaccine Efficacy Trial. MedRxiv, 2021.08.09.21261290. https://doi.org/10.1101/2021.08.09.21261290

  11. Jun 2022
    1. Users often forget to save their recovery codes when enabling 2FA. If you added an SSH key to your GitLab account, you can generate a new set of recovery codes with SSH:
  12. May 2022
    1. The advantage of ocean currents is their stability. They flow with little fluctuation in speed and direction, giving them a capacity factor — a measure of how often the system is generating — of 50-70%, compared with around 29% for onshore wind and 15% for solar.

      Have other coastal countries other than Japan explored the capacity factor for tidal energy of the currents off their shoreline? Are other currents as promising as the Kuroshio current?

    1. Manton says owning your domain so you can move your content without breaking URLs is owning your content, whereas I believe if your content still lives on someone else's server, and requires them to run the server and run their code so you can access your content, it's not really yours at all, as they could remove your access at any time.

      This is a slippery slope problem, but people are certainly capable of taking positions along a broad spectrum here.

      The one thing I might worry about--particularly given micro.blog's--size is the relative bus factor of one represented by Manton himself. If something were to happen to him, what recourse has he built into make sure that people could export their data easily and leave the service if the worst were to come to happen? Is that documented somewhere?

      Aside from this the service has one of the most reasonable turn-key solutions for domain and data ownership I've seen out there without running all of your own infrastructure.

  13. Apr 2022
  14. Mar 2022
  15. Jan 2022
    1. Riepenhausen, A., Veer, I., Wackerhagen, C., Reppmann, Z. C., Köber, G., Ayuso-Mateos, J.-L., Bögemann, S., Corrao, G., Felez-Nobrega, M., Abad, J. M. H., Hermans, E., Leeuwen, J. van, Lieb, P. D. K., Lorant, V., Mary-Krause, M., Mediavilla, R., Melchior, M., Mittendorfer-Rutz, E., Compagnoni, M. M., … Walter, H. (2021). Coping with COVID: Risk and Resilience Factors for Mental Health in a German Representative Panel Study. PsyArXiv. https://doi.org/10.31234/osf.io/fjqpb

  16. Nov 2021
  17. Oct 2021
    1. Personality traits are understood as patterns of thought, feeling, and behaviour that are relatively enduring across an individual’s life span.

      Q:: What is a personality trait?<br> A::

  18. Sep 2021
  19. Aug 2021
  20. Jul 2021
  21. Jun 2021
    1. We should think about the number of simultaneous connections (peak and average) and the message rate/payload size. I think, the threshold to start thinking about AnyCable (instead of just Action Cable) is somewhere between 500 and 1000 connections on average or 5k-10k during peak hours.
      • number of simultaneous connections (peak and average)

      • the message rate/payload size.

  22. May 2021
    1. oceans warm
    2. more saline
    3. climatechange
    4. salinity
    5. pH
    6. tem-perature
    7. salinity
    8. pH
    9. Changes in tem-perature
    10. salinity
    11. warming
    12. acidification
    13. acidification
    14. warming
    15. rapid climate change
    16. climate change
    17. ocean temperatures
    18. salinity
    19. pH
    20. oftemperature
    21. increased air temperature
    22. altering climate conditions
    23. Increases in salinity
    24. evaporation35
    25. estuarine acidification
    26. estuarine acidification
    27. degree of warming
    28. temperatures
    29. increase pH
    30. acidified
    31. acidification
    32. acidification
    33. pHdeclines
    1. acidifi-cation
    2. warming
    3. increases in temperature
    4. acidification
    5. ocean warming
    6. warming
    7. acidification
    8. increasing ocean temperature
    9. ocean acidification
    10. Oceanwarming
    11. acidification
    12. ocean warming
    13. elevated temperature
    14. Warming
    15. increase in sea-water temperature
    16. acidification
    17. ocean warming
    18. acidification
    19. ocean warming
    20. acidification
    21. warming
    22. Warming
    23. ocean warming
    24. Climate change
    25. climate change
    26. acidification
    27. ocean warming
    28. increase in ocean temperature

    Tags

    Annotators

    1. salinity increase
    2. low salinities
    3. salinity
    4. salinity
    5. f global warming
    6. temperature
    7. high CO2 concen-tration
    8. CO2 levels were increased
    9. rising atmospheric CO2.
    10. t CO2 enrichment
    11. changes of atmospheric CO2
    12. hange in the atmospheric CO2 l
    13. obal temperature rise
    14. temperature
    15. temperature increases
    16. chang-ing temperature
    17. increased temperature,
    18. temperature
    19. s dramatic temperatureperturbations
    20. induced climatechange
    21. level of salinit
    22. climatechange
    23. mean global temperature increases
    24. increase in mean global temperature
    25. higher temperatures
    26. temperature
    27. global warming
    28. Global climate h
    29. global climate chang
    30. atmospheric carbon dioxide concentra-tion
    31. temperature
    32. emporal fluctuations
    33. climatic changes
    1. temperature
    2. salinity
    3. rough salinity climate
    4. oxygen
    5. temperature
    6. salinity
    7. fluctuating salinities
    8. higher salinities
    9. low salinities
    10. salinity
    11. salinity
    12. salinity conditions
    13. light
    14. oxygen
    15. temperature
    16. salinities.
    17. salinities
    18. salinity
    19. effects of salinity
    20. salinity levels
    21. normal salinities
    22. reduced both in sub- and supranormal salin- ities
    23. increased both in sub- and supranormal salinities
    24. reduced in supranormal salinities
    25. increased in subnormal salinities
    26. salinity
    27. salinity conditions
    28. criticall~ low temperature conditions.
    29. low or high salinities
    30. temperature
    31. salinity
    32. salinities
    33. Salinity
    34. salinity-temperature
    35. salinity
    36. salinity
    37. salinity
    38. reduced salinity
    39. temperature
    40. salinity
    41. decrease in normal habitat salin- ity
    42. salinity
    43. salinity
    44. salinity
    45. lower and upper limiting salinities
    46. temperature
    47. salinity
    48. salinity
    49. salinity
    50. salinity of estuaries
    51. s a 1 in i t y
    52. temperature conditions