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IVs: previously institutionalized children, biologically raised children. DVs: brain activity, trait anxiety.

H1: aversive learning will be supported by a more distributed, adult-like set of brain regions in PI youth relative to comparison youth.

H2: altered amygdala-hippocampal-mPFC function during aversive learning will predict reduced anxiety among PI youth.

RQ2: do differences in aversive learning partially explain the association between early institutionalization and anxiety?

RQ1: does early adversity, in the form of prior institutionalization, alter neurobiology of aversive learning during human development?

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Another application of peptide chemistry, Unsing those to target virus helical coils (a way to interrup PPIs). In this case they use helical peptides to bind virus helixes with high affinity (I wonder if we can use this to make libraries of helical stappled peptides and improve binding efficiency as well)

I'm reminded of a reference recently to Republicans being upset that poor people of color would "waste" their money on frivolities like manicures and fake fingernails instead of on food or other necessities. How might this tie into the argument made in this book?

Previous research has found that barrel cortex NMDAR activation was required to initiate plasticity after learning a somatosensory task, but that barrel cortex mGluR activation was required to initiate plasticity after re-practicing that same task. The current study hypothesized that a similar phenomenon occurred with plasticity after learning a fear task in the hippocampus, and its results support this assertion.

Previous research has found that piriform cortex NMDAR activation was required for initial learning of an olfactory discrimination task, but piriform cortex neuron intrinsic excitability increase and synaptic NMDAR subunit composition alteration was required for subsequent learning of the same task. The current study hypothesized that a similar phenomenon occurred in the hippocampus with spatial/contextual learning, and its results support this assertion.

Blocking neuronal excitability or the reactivation of excitable neurons may reduce NMDAR-independent learning, and NMDAR-independent learning may persist over time before eventually disappearing. Recent study results support these assertions.

Two conditions must be met to conclude that hippocampal NMDAR activation is not required for subsequent memory formation: animals must form a new memory during training and not simply generalize from previous experiences, and NMDAR-independent memories must depend on the hippocampus. The current study found that both of these conditions were met, suggesting that hippocampal NMDAR activation is in fact not required for subsequent memory formation.

Hippocampal NMDAR activation is only required for initial memories to be formed, since subsequent memories can be formed in the presence of hippocampal NMDAR antagonists. Prior NMDAR-dependent learning has to be of a similar task for later NMDAR-independent learning to occur.

Some forms of hippocampal LTP that do not require NMDAR activation require the activation of metabotropic glutamate receptors (mGluRs) instead. The current study aimed to see if that was the case through the use of bioassays of animal models.

It is possible that initial learning increases intrinsic excitability, which allows subsequently learned information to be encoded by plasticity mechanisms that don't involve the activation of NMDARs. The current study aimed to see if this was the case using bioassays of animal models.

We know from psychology that previous experiences impact how individuals learn, but we don't know much about the neurobiological mechanisms underlying this process. This is because we've only been able to experiment in lab settings that may not accurately reflect nature.

In various animal models, NMDA receptors have been found to activate when something is initially being learned, but not when it is subsequently being practiced or built upon.

(Gadamer 2004).

All intellectual endeavors start from a preexisting set of ideas. These can then be built upon to create new concepts which then influence the original starting point and may continue ever expanding with further thought.

Ahrens argues that most writing advice goes against the idea of the hermeneutic circle and pretends as if the writer is starting with a blank page. This can prefigure some of the stress and difficulty Ernest Hemingway spoke of when he compared writing to "facing the white bull which is paper with no words on it."

While it can be convenient to think of the idea of tabula rasa, in practice it really doesn't exist. As a result the zettelkasten more readily shows its value in the writing process.

If the best ideas are the ones we haven't anticipated, how are we defining "best"? Most surprising from an information theoretic perspective? One which creates new frontiers of change? One which subsumes or abstracts prior ideas within it? Others?

The important part of permanent notes are generating your own ideas and connecting (linking them densely) into your note system. The linking part is important and can be the part that most using digital systems forget to do. In paper zettelkasten, one was forced to create the first link by placing the note into the system for the first time. This can specifically be seen in Niklas Luhmann's example where a note became a new area of its own or, far more likely, it was linked to prior ideas.

By linking the idea to others within the system, it becomes more likely that the idea can have additional multiple contexts where it might be used and improve the fact that context shifts will prove more insight in the future.

Additional links to subject headings, tags, categories, or other forms of taxonomy will also help to make sure the note isn't lost completely into the system. Links to the bibliographical references within the system are helpful as well, especially for later citation. Keep in mind that these categories and reference links aren't nearly as valuable as the other primary idea links.

One can surely collect ideas and facts into their system, but these aren't as important or as interesting as one's own ideas and the things that are sparked and generated by them.

Asking questions in permanent notes can be valuable as they can become the context for new research, projects, and writing. Open questions can be incredibly valuable for one's thinking and explorations.

Collecting thoughts is great, but there is more value in linking them, encouraging them to have sex, and making new and more exciting ideas.

Cross reference: Matt Ridley's When Ideas Have Sex https://www.ted.com/talks/matt_ridley_when_ideas_have_sex

It should be recognized that these basic note types are very different than the digital garden framing of 📤 (seedbox), 🌱 (seedling), 🪴 (sapling), 🌲 (evergreen), etc. which are another measure of the growth and expansion of not just one particular idea but potentially multiple ideas over time. These are a project management sort of tool for focusing on the growth of ideas. Within some tools, one might also use graph views and interconnectedness as means of charting this same sort of growth.

Sönke Ahrens' framing of fleeting note, literature note, and permanent note are a value assignation to the types of each of these notes with respect to generating new ideas and writing.

topic sentence

FBOE is a reliable correlate, but not predictor, of same sex attraction in men (more older brothers, but not more older sisters).

Many questions remain about how sexual orientation develops, despite how much research has been done into the topic. These studies cannot infer causality between the phenomena studied and the development of sexual orientation, however, this does not erase the possibility that they may contribute to the development of sexual orientation in some way (albeit indirectly). Overall, it seems like biology and prenatal hormone exposure do play a significant role in the development of sexual orientation in both men and women.

We couldn't do this ourselves, but we might be able to write a proposal to do this with CCRC. It would be really interesting to explore whether we could track FFN providers using CCR&R level admin data. Churn? Movement into and out of licensing systems?

A study that examined the co-occurrence of sexual orientation biomarkers in adult men found that they don't significantly co-occur, but that the FBOE is the most accurate predictor of homosexuality in men.

The study that supports FBOE also supports that a maternal immune mechanism underlies FBOE. In addition, it provides evidence that a male specific protein may be important in the development of sexual orientation and in neurological functioning associated with forming social connections (including sexual ones).

A study found that mothers of gay sons had higher rates of antibodies to male-specific proteins expressed in the fetal brain than mothers of heterosexual sons, suggesting that the immune response to these proteins during pregnancy was greater in mothers of gay sons than in mothers of heterosexual sons (supports FBOE).

The study that supports FBOE had reliable methods, so the significance of its results should be trusted.

FBOE is biological in nature (non-biological older brothers do not contribute to the effect). Basically, male fetuses have proteins on the Y chromosome called HY antigens that mothers develop more antibodies to with each subsequent pregnancy. These antibodies are theorized to alter the function of proteins in areas of the brain that are relevant to the development of sexual attraction, leading to the incidence of homosexuality. So, the more sons a mother has (and the more antibodies she has), the more likely she is to have a son who is homosexual.

A study supported the idea that sexual orientation was a polygenic (controlled by multiple genes) characteristic in male and female homosexuals, as it was associated with the location of multiple specific SNPs. In homosexual men, one of these SNPs was located near a gene that regulates olfactory functioning (which may be tied to sexuality/sexual orientation), and one of them was located near a gene that regulates reproductive functioning and development. The study had a flawed methodology.

A study showed that male homosexuality may be associated with the location of specific SNPs, but the study's sample size wasn't large enough to make any definitive conclusions.

Booming time to start a plastic surgeon affiliate marketing business targeted at frequent Zoom callers!

what is agent of destiny

Anklet

• Like, Lord of the rings (Ring)
• Kannagi can be speculated as Kali for beheaded North indian kings

Example of non-Europeans being considered the sons of Ham, in this case by an incredibly learned and influential Roman Catholic scholar.

• OK: tools for register, but NEED "THE TOOL" for searching and RECOVER these data!

Some of this critique relates to my classification about the sorts of notes that one takes. Some are more important or valuable than others.

Some are for recall and later memory, some may be collection of ideas, but the highest seems to be linking different ideas and contexts together to create completely new and innovative ideas. If one is simply collecting sententiae and spewing them back out in reasonable contexts, this isn't as powerful as nurturing one's ideas to have sex.

Cross reference origin in

Seneca (2006) Epistles 66-92. With an English translation by Richard G. Gummere. Cambridge, MA: Harvard University Press (Loeb Classical Library), 277-285.

There's an interesting analogy between Niklas Luhmann's zettelkasten numbering system and the early street address system in Vienna. Just as people (often) have a fixed address, they're able to leave it temporarily and mix with other people before going back home every night. The same is true with his index cards. Without the ability to remove cards and remix them in various orders, the system has far less complexity and simultaneously far less value.

Link to reference of street addressing systems of Vienna quoted by Markus Krajewski in (chapter 3 of) Paper Machines.

Both the stability and the occasional complexity of the system give it tremendous value.

How is this linked to the idea that some of the most interesting things within systems happen at the edges of the system which have the most complexity? Cards that sit idly have less value for their stability while cards at the edges that move around the most and interact with other cards and ideas provide the most value.

Graph this out on a multi-axis drawing. Is the relationship linear, non-linear, exponential? What is the relationship of this movement to the links between cards? Is it essentially the same (particularly in digital settings) as movement?

Are links (and the active creation thereof) between cards the equivalent of communication?

https://us.makerscabinet.com/products/ferrule

What a beautiful looking instrument!

Nationalistic, racial, and cultural blinders have led us to posit broadly accepted (positive) ideas like democracy as having developed and grown out of Western ideas rather than attributing them to historical cultures and societies all over the world.

Any serious historical or other academic work should include a conversation with the body of other scholarship with which argues for or against.

Comparing and contrasting one idea with another is crucial for any sort of advancement.

let's change to wiki structure, instead "linear" text

I wonder how you might build pricate modules for the web. The most common solution we have to this currently is the SAAS model. This model does work generally well, like Auth0 for auth, Vercel for deployment, Stripe for payments. There are many more micro-saas companies that solve for more niche problems like Onfido for ID verification.

I think the concern here is the amount of flexibility expected by most developers on the web. In Game Development people are much more invested in their tools. An Unreal Engine developer likely has no reason to ever leave unless they change jobs significantly. Really, this is similar to React. Which is why we are seeing frameworks built entirely around this like Remix and Next. Is this such a bad system?

It seems like a No-Code solution really could just build on top of these frameworks and take advantage of their existing patterns for uniformity.

Atomizing projects and research ideas is very similar to the idea of the atomic note.

If useful things can be turned into re-usable building blocks, then it can be easier to build and design larger and more complex systems out of them.

likely attested elsewhere, but he credits https://www.inkandswitch.com/muse/

via Jess Martin https://jessmart.in/

Much the same way printing was automated with Johannes Gutenberg's moveable type invention, the writing of longer pieces may be automated with moveable ideas. Ideas written down on slips (index cards) can be moved around easily and re-used as necessary in composing longer articles.

discrimination everywhere against race and skin color

racism and discrimination in the military.

I would also like to talk about bathroom we have bathrooms for women bathrooms for men. But we don’t have bathrooms for People of the Transgender community and we also don’t have private feeding places for people who have baby. There is a free hands free sanitary napkins mishen in one of the bathrooms. It should be in all of the women’s and non gender bathrooms. This is also a right and for people who are having a hard time in school more homework help in all departments tutors. Also preparing us for the future and giving us more of an option for a gap year instead of pushing us out of the nest. Sometimes we are not ready for jobs.

Software as a service, or SaaS, is one of the most promising business models in 2021. It’s popular among entrepreneurs, investors, and customers alike. Learn about the most promising ideas you can tap into to build your own SaaS startup and make it successful.

When reading and taking notes, one should have a reason or purpose in mind and endeavor to stick to it. While you're absorbing what the writer has written, allow the unnecessary portions with respect to your goal flow through the sieve of your mind and only catch and annotate the portions which supplement your end goal. Keep and elaborate on these.

A few days after your reading and annotating, go back through your notes with a keen eye toward expanding on those important things to your goal or interests and set aside (or even discard) all the other less interesting pieces.

Naturally there are other pieces which may be important for remembering the shape of the things you read or facts which you've highlighted and want to remember or memorize. Save these things also in a separate space from the bigger ideas you're working on creating. They're useful, but of an entirely different nature than the ideas.

Two broad different types of notes:

• facts to remember
• ideas which can have sex with other ideas

Cái này mua cho con bé chơi được đấy. Nó khá vô hại. Để hôm nào tim trên Shopee.

Ideas work best when linked to related ideas.

https://glendalecitygovernmentwatch.org/2021/09/09/an-open-letter-to-mike-mohill/

https://outlooknewspapers.com/blog/2020/09/19/council-condemns-glendales-past-racism/

"Very fine" is a dog whistle statement here created by Donald J. Trump and indicates his approval of white power. See also:

• https://www.washingtonpost.com/politics/2020/05/08/very-fine-people-charlottesville-who-were-they-2/
• https://www.politifact.com/article/2019/apr/26/context-trumps-very-fine-people-both-sides-remarks/
• https://www.youtube.com/watch?v=JmaZR8E12bs

https://pluralistic.net/2021/09/29/jubilance/

The conviction that leads to investments needs to be checked if it is grounded in truth

Ideas lead to investing, both need infrastructure. The quality of these three factors are interlinked, defending on each other

This is an interesting framing in hindsight, because it makes the question sound simple despite the fact that the easiest and kindest answer is simply to do the work oneself. Weren't these the sort of pull yourself up by the bootstrap sort of folks?

(I'm using the problematic phrase pull yourself up by the bootstraps with derision here.)

Here I feel compelled to revisit an earlier quote:

One slave trader, John Newton (who later became an antislavery leader), wrote about the people of what is now Sierra Leone:

The state of slavery, among these wild barbarous people, as we esteem them, is much milder than in our colonies

Which was really the more barbarous culture?

Given the word barbarous here, I wonder if, on the whole, cultures viewed from outside of one's own culture are more often seen for the worst of their traits rather than the best or even just the average traits?

With limited experience and exposure, what qualifies one correspondent to stereotype an entire culture? Is the lack of alternate and likely better information reason enough for the viewing culture to completely condemn the external culture? (Assuredly not...)

I like the framing of this.

While Europeans used the fact that slavery existed in Africa to justify their own use of Africans as slaves, the concept of slavery in Africa was akin to the idea of serfs in Europe. These slaves/serfs in Africa certainly had hard and difficult lives, but they did have some rights and freedoms not granted to American slaves in any form.

In the next paragraphs, it turns out that there isn't laziness, but misaligned incentives. The lifeways of the people involved were not those of the writer who jumped to conclusions about the people who were different from him.

In generalizations supported by another study of Mexican labour conditions, Wilbert Moore remarks: "Work is almost always task-orientated in non-industrial societies ... and ... it may be appropriate to tie wages to tasks and not directly to time in newly developing areas".

When comparing and contrasting cultures, empathy for each and their particular incentives must be taken into account.

This is particularly important as he's spent a dozen pages talking about how poorly the English dealt with industrialization over centuries themselves. How quickly we forget.

Perhaps this is some of the value behind the ability to resort index cards within a zettelkasten over the prior staticness of the commonplace tradition? The ideas aren't anchored to the page, but can be moved around, rearranged.

https://www.youtube.com/watch?v=0nyIy_TX4wk

An excellent video. Going to have to watch it a few more times to absorb more.

https://youtu.be/qYsMtroVLeA?t=287

The big thing that I want to talk about here is out groups. This is a phenomenon that we that we see, which is that it's very very easy for people to decide that someone else is not like them they're different and they should be shunned and talked about.

This is the minimal group paradigm. Thanks to Rashmi for giving that term. [It] says the smallest possible difference will be magnified into in group and an outgroup. Kevin Marks, Web 2.0 Expo NY 09: "...New Words You Need to Know to Understand the Web"

Perhaps we can decrease the levels of fear and racism in our society by tummelling? By bringing in outsiders, treating them with dignity and respect within your own group of friends, you can help to normalize their presence by decreasing the irrational fears that others have built up and carry with them about these supposed outsiders.

The Attack on "Critical Race Theory": What's Going on?

https://www.youtube.com/watch?v=P35YrabkpGk

Lately, a lot of people have been very upset about “critical race theory.” Back in September 2020, the former president directed federal agencies to cut funding for training programs that refer to “white privilege” or “critical race theory, declaring such programs “un-American propaganda” and “a sickness that cannot be allowed to continue.” In the last few months, at least eight states have passed legislation banning the teaching of CRT in schools and some 20 more have similar bills in the pipeline or plans to introduce them. What’s going on?

Join us for a conversation that situates the current battle about “critical race theory” in the context of a much longer war over the relationship between our racial present and racial past, and the role of culture, institutions, laws, policies and “systems” in shaping both. As members of families and communities, as adults in the lives of the children who will have to live with the consequences of these struggles, how do we understand what's at stake and how we can usefully weigh in?

Hosts: Melissa Giraud & Andrew Grant-Thomas

Guests: Shee Covarrubias, Kerry-Ann Escayg,

Some core ideas of critical race theory:

• racial realism
  • racism is normal
• interest convergence
  • racial equity only occurs when white self interest is being considered (Brown v. Board of Education as an example to portray US in a better light with respect to the Cold War)
• Whiteness as property
  • Cheryl Harris' work
  • White people have privilege in the law
  • myth of meritocracy
• Intersectionality

People would rather be spoon fed rather than do the work themselves. Sadly this is being encouraged in the media.

Short summary of CRT: How laws have been written to institutionalize racism.

Culturally Responsive Teaching (also has the initials CRT).

KAE tries to use an anti-racist critical pedagogy in her teaching.

SC: Story about a book Something Happened in Our Town (book).

• Law enforcement got upset and the school district
• Response video of threat, intimidation, emotional blackmail by local sheriff's department.
• Intent versus impact - the superintendent may not have had a bad intent when providing an apology, but the impact was painful

It's not really a battle about or against CRT, it's an attempt to further whitewash American history. (synopsis of SC)

What are you afraid of?

Sketchnoting forces students to take ideas from a lesson and turn them into their own ideas. It also forces modality shifts.

Reviewing over a lecture after the fact to create sketchnotes is incredibly similar to some of the point and purpose of Cornell Notes.

While watching: https://www.youtube.com/watch?v=UOHcWhdguIY

Sketchnotes by Chad Moore and Chris Wilson

https://vi.to/hubs/microcamp/pages/chad-moore-and-chris-wilson?v=chad-moore-and-chris-wilson&discussion=hidden&sidebar=hidden

Sketchnotes are ideas not art.

Squiggle birds - take squiggles and give them beaks, eyes, and bird feet. (Idea apparently from Austin Kleon.)

How you might take notes if you'd never been told how to.

• There is no particular app or platform that is the "right" one.

Common elements:

• Headlines and sub headlines are common
  • Elegant text / fancy text
• Icons
• containers - ways of holding information together
  • this can be explicit or via white space
• flow of information (arrows)
• arrangements or layouts of how information is displayed
  • top to bottom, circles, columns, stream of flow of ideas
• people
  • emotions, perhaps using emoji-like faces
• shadows, highlights

Icons

Simple can be better. Complexity may make understanding more difficult.

Examples

A few they pulled off of the web

Sketchnote Selfie

Goal: Create an info rich portrait with character. Portrait, name, info, location, passions, hobbies, interests, social usernames, now section, etc.

Tangentially related idea which this sparked:

Within my beyond the pale thesis, banishing people in smaller social groups is easier, but doesn't necessarily scale well.

In larger towns, cities, and even states, it may work in some of the smallest and most egregious cases like major crime or murder when carried out by the state, but what about the smaller social infractions?

Cancel culture is attempting to apply this larger social pressure to bigger public figures in ways that it traditionally has been more difficult to do. It's even more difficult in a highly networked world where globalism has taken hold.

How do we cater to the centric masses while potentially allowing some flexibility to the cultures considered at the edges? Ethics aren't universal, so there will be friction at a huge number of overlaps.

Examples:

• Paula Dean (racism), loses shows, deals, etc. but still has reach in certain sections of the country and online

This could be a fascinating discussion to take a close look at later in the book.

Does this map of the world with the black burnt people in the lands to the south (which includes the idea of "below") result in future racist ideas?

This idea is a bit on the extreme side, but it does suggest that having a multi-card comparison view in a PKM system would be useful.

Drawing on Raymond Llull's combitorial memory system from the 12th century and a bit of Herman Ebbinghaus' spaced repetition (though this is also seen in earlier non-literate cultures), one could present two (or more) random atomic notes together as a way of juxtaposing disparate ideas from one's notes.

The spaced repetition of the cards would be helpful for one's long term memory of the ideas, but it could also have the secondary effect of nudging one to potentially find links or connections between the two ideas and help to spur creativity for the generation of new hybrid ideas or connection to other current ideas based on a person's changed context.

I've thought about this in the past (most likely while reading Frances Yates' Art of Memory), but don't think I've bothered to write it down (or it's hiding in untranscribed marginalia).

"Many North American music education programs exclude in vast numbers students who do not embody Euroamerican ideals. One way to begin making music education programs more socially just is to make them more inclusive. For that to happen, we need to develop programs that actively take the standpoint of the least advantaged, and work toward a common good that seeks to undermine hierarchies of advantage and disadvantage. And that, inturn, requires the ability to discuss race directly and meaningfully. Such discussions afford valuable opportunities to confront and evaluate the practical consequences of our actions as music educators. It is only through such conversations, Connell argues, that we come to understand “the real relationships and processes that generate advantage and disadvantage”(p. 125). Unfortunately, these are also conversations many white educators find uncomfortable and prefer to avoid."

I want to explore this idea a bit. Resources, citations? Which analysts?

This could be an interesting gift idea. Definitely shows someone that you were actively thinking about them for extended lengths of time while they were away.

new tag?:

• understand why it is correct

A fascinating quote in the history of the commonplace book on it's way to becoming the Memex.

https://www.valuecoders.com/blog/technology-and-apps/top-software-ideas-for-startup/

Would be interesting to run some game theoretical experiments on some of these issues.

context: https://www.nytimes.com/live/2021/03/17/us/shooting-atlanta-acworth

There's something discordant here in a scholarly article about having academic participants with names like SenorG and actualham. It's almost like a 70's farce starring truckers with bizarre CB handles. It's even more bizarre since I know some of the researchers behind these screennames.

Is the pseudonymous nature of some of these handles useful in hiding the identity of the participants and thereby forcing one to grapple only with their ideas and not the personas, histories and contexts behind them?

Definition: textual productivity

A measure of how much additional knowledge is generated by a system of ideas and thoughts interacting with each other.

I resemble this remark!

Perhaps a better framing is to not look at things from such a broad perspective, but to focus in on the smaller and more specific?

Racism is a big forest, but to really see and fix it we need to look at individual racist idea hills and plains and specific racist policy trees, plants, and shrubs.

This is great to go along with .Josh Spector how to outline a blog post

primera clase block chain

5 grandes idesas a desarollar:

1. Cripto activos: capacidad para comerciar activos digitales peer-to-peer sin pasa a traves de un banco o intermediario.

2. identidad digital: capacidad para capturar, procesar y administrar nuestros datos, caja negra digital con el fin de que no sean administrados por google,facebook,etc

3. smartcontracts: pieza de codigo que con un objetivo especifico que ejecuta un conjunto de instrucciones en blockchain (garantiza el cumplimiento contraactual y son autoejecutables

4. modelos de negocio descentralizados: sin humanos

5. libro de conocimientos: transacciones entre dispositivos, internet de las cosas

What are the main trends in medical mobile app development and how to to build a healthcare app to get the best results. We highlight the general insights of the business and technical models of mobile healthcare apps.

La invitación a un trabajo colectivo lo hace más interesante y significativo.

It may be worth it programming a bot that brings this information to wikidata

This is one of my favorite parts about my website and others supporting Webmention: the conversation is aggregated onto or more closely adjacent to the source. This helps prevent context collapse.

Has anyone made a browser tool for encouraging lateral reading? I'd love a bookmarklet that I could click to provide some highly relevant lateral reading resources for any particular page I'm on.

Another example of a scion in academia using racial ideas to launch his career to prominence.

This also provides a schism for a break between science and religion which we're still heavily dealing with in American culture.

This is a powerful example