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  1. Last 7 days
  2. Jan 2021
  3. Nov 2020
    1. To test that hypothesis, the researchers genetically modified H3 histones in rats by replacing the amino acid that dopamine attaches to with a different one it doesn’t react with. This stops dopaminylation from occurring. Withdrawal from cocaine is associated with changes in the readout of hundreds of genes involved in rewiring neural circuits and altering synaptic connections, but in the rats whose dopaminylation was prevented, these changes were suppressed. Moreover, neural impulse firing in VTA neurons was reduced, and they released less dopamine, showing that these genetic changes were indeed affecting the brain’s reward circuit operation. This might account for why people with substance use disorder crave drugs that boost dopamine levels in the brain during withdrawal. Finally, in subsequent tests, the genetically modified rats exhibited much less cocaine-seeking behavior

      Rats were genetically modified to decrease dopaminylation (modifying M3 so dopamine couldn't attach). This correlated to the Ventral Tegmental Area firing less (less cocaine impulse) and released less dopamine. This showed that these changes to H3, and subsequently the dopaminylation, did impact brain's reward circuit operation.

  4. Oct 2020
    1. Mikhail Gershovich - Vocat (@mgershovich)
    2. Michael Berman - California State University Channel Islands (@amichaelberman)
    3. Rolin Moe - Pepperdine (@RMoeJo)

      A bit curious that for a reclaim the web event around DoOO that he highlights their Twitter presence rather than their own websites. Potentially for lack of notifications/webmention functionality?

    4. Chris Mattia - California State University Channel Islands (@cmmattia)
  5. Sep 2020
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  10. Dec 2019
    1. "Social Equity Applicant" means an applicant that is an Illinois resident that meets one of the following criteria:        (1) an applicant with at least 51% ownership and     control by one or more individuals who have resided for at least 5 of the preceding 10 years in a Disproportionately Impacted Area;         (2) an applicant with at least 51% ownership and     control by one or more individuals who:             (i) have been arrested for, convicted of, or         adjudicated delinquent for any offense that is eligible for expungement under this Act; or             (ii) is a member of an impacted family;        (3) for applicants with a minimum of 10 full-time     employees, an applicant with at least 51% of current employees who:            (i) currently reside in a Disproportionately         Impacted Area; or            (ii) have been arrested for, convicted of, or         adjudicated delinquent for any offense that is eligible for expungement under this Act or member of an impacted family.

      Applicants for social equity measures must be majority owners or employ at least 10 full-time employs that qualify. Qualifications include living in an area that was over policed during the war on drugs. Family members of those incarcerated for a marijuana offense are also eligible, along with the individual.

  11. Jul 2019
    1. Java program to calculate area of a circle
    2. Java program to calculate area of rectangle
    3. Java program to calculate area of circle using method
    4. Calculate area of rectangle using class in java
    5. Calculate area of rectangle using default constructor in java
    6. Calculate area of rectangle using parameterised constructor in java
    7. Calculate area of rectangle using constructor overloading in java
  12. Jan 2019
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  17. Nov 2017
  18. May 2017
  19. enst31501sp2017.courses.bucknell.edu enst31501sp2017.courses.bucknell.edu
    1. 1002 area

      This map shows a more detailed version of the 1002 area, located in the north section of the Arctic National Wildlife Refuge. This map also shows the location of the Native property that is at risk of being drilled.

      USGS. "Arctic National Wildlife Refuge, 1002 Area, Petroleum Assessment, 1998, Including Economic Analysis." USGS: Science for a Changing World. Accessed April 28, 2017.

  20. Nov 2016
    1. Heminger estimated that it would take “over a million” new housing units “to make a dent in the shortfall.” The real challenge, he said, is “to fit that growth in the communities we cherish,” adding, in a non sequitur: “We need to change what the Bay Area looks like.”

      That's not a non-sequitur at all. If you build a bunch of things, it will change the landscape.

      This statement was totally on point and to the point: defending "neighborhood character", as more conservative voices often do, is at odds with major development.

    2. Strictly speaking, this is true. No jurisdiction can be legally compelled to designate a Priority Development Area. The region’s 191 PDAs were all nominated by local jurisdictions. San Francisco’s PDAs were unanimously approved by the Board of Supervisors in 2007.

      And yet, earlier in this article, the process is criticized for being undemocratic. Which is it, dude?

  21. Sep 2016
  22. online.salempress.com.lacademy.idm.oclc.org online.salempress.com.lacademy.idm.oclc.org
    1. Land Area: 20,721 square kilometers (8,000 square miles)

      This is really small compared to the united states land area. The land area for the united states is 3.806 Million Square Miles