43 Matching Annotations
  1. Last 7 days
    1. Mitotic ER exit site dissociation is mediated by TANGO1 phosphorylation with CK1

      Substrate: TANGO1 (Q5JRA6)

    2. Here, we showed that TANGO1 is phosphorylated by casein kinase 1 (CK1) during mitosis

      Substrate: TANGO1 (Q5JRA6)<br/>Kinase: casein kinase 1 (CK1) (Q8N752)

    3. Interestingly, the interaction with Sec16 was abrogated by phosphorylation of TANGO1, leading to dissociation of the ER exit sites

      Substrate: TANGO1 (Q5JRA6)

    4. Maeda et al. report that casein kinase 1 phosphorylates TANGO1 to abrogate the interaction with Sec16, causing ER exit site dissociation during mitosis

      Substrate: TANGO1 (Q5JRA6)<br/>Kinase: casein kinase 1 (Q8N752)

    1. NEK10 loss increases cellular proliferation through modulation of the p53-dependent transcriptional output, by directly phosphorylating p53 on Y327, revealing NEK10’s unexpected substrate specificity

      Substrate: p53 (P04637)<br/>Kinase: NEK10 (Q6ZWH5)<br/>Site: Y327

    2. Here, we describe a function for NEK10 in the regulation of p53 transcriptional activity through tyrosine phosphorylation

      Substrate: p53 (P04637)<br/>Site: tyrosine

    3. NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity

      Substrate: p53 (P04637)<br/>Kinase: NEK10 (Q6ZWH5)<br/>Site: tyrosine

  2. Aug 2019
    1. The brewery issued the voluntary recall after three bottles of the brew exploded, WTVR reports. No injuries or formal complaints have reportedly been filed in connection with the beer, however.While the bottles may be at risk, the beer itself is apparently safe to drink. The problem appears to stem completely from the continued fermentation causing pressure to build up inside the bottle.

      Brewery

    1. Log In has a new look. This is the right place to Log In to the VR you know and love, now known as VerticalResponse Classic.
    1. Central African Republic (CNN) — There’s nothing secret about Russia’s presence in the Central African Republic. The streets are plastered with propaganda posters proclaiming “Russia: hand in hand with your army!” A local radio station churns out Russian ballads and language lessons. New recruits to the army are being trained in Russian, using Russian weapons.

      Putin

    1. The surprise outcome in Argentina’s primary vote roiled the nation’s financial markets, sending the S&P Merval Index plunging 48% in dollar terms.That marked the second-biggest one-day rout on any of the 94 stock exchanges tracked by Bloomberg going back to 1950. Sri Lanka’s bourse tumbled more than 60% in June 1989 as the nation was engulfed in a civil war.

      Argentina

    1. It states later: “Take action with us. Fight back against anti-Semitism. Demand Reps. Omar and Tlaib be removed from the committees and censured.”

      Test4

  3. Jul 2019
  4. May 2019
    1. However, unlike insulin signaling, UNC-43 phosphorylates and activates DAF-16, thus promoting its nuclear localization. The phosphorylation of DAF-16 at S286 by UNC-43 is removed by TAX-6•CNB-1, leading to DAF-16 inactivation.

      Kinase: UNC-43 (O62305) <br /> Substrate: DAF-16 (O16850) <br /> Site: Ser-286

    2. DAF-16 is phosphorylated by the AKT kinases, preventing its nuclear translocation.

      Kinase: AKT kinases <br /> Substrate: DAF-16 (O16850) <br />

  5. Mar 2019
  6. Aug 2018
    1. Contributions to the practice and theory of teaching and learning literature, including publications in peer-reviewed and professional journals, conference publications, book chapters, textbooks and open education repositories/resources.

      P&T language supporting Open activities

  7. Jul 2018
    1. I think this paper and these data could be extremely useful for psychologists, but I also think this paper needs at least one more analysis: estimating effect sizes by research area, controlling for publication bias.

      It's very hard to interpret these estimates given good evidence and arguments that researchers and journals select for p < .05. I think it's safe to assume that all these estimates reported in this preprint are bigger than the true averages (Simonsohn, Nelson, & Simmons, 2014).

      One approach to estimating "selection bias adjusted" effects would be to estimate the effect size for each research area using the code provided in the p-curve effect size paper supplements (http://www.p-curve.com/Supplement/). You could estimate confidence intervals or percentiles using bootstrapping procedures or write code to estimate the lower and upper bounds using the same methods to estimate the average effect.

      This approach assumes the p-values all test the hypothesis of interest and don't suffer from unique selection biases (see Selecting p Values in Simonsohn, Nelson, & Simmons, 2014, p. 540).

      Hope this helps make the paper better!

  8. Jun 2018
  9. Feb 2018
  10. jaredgardner.org jaredgardner.org
    1. I also find the line "And death shall be no more, comma, Death thou shalt die" to also be very important. With death often being viewed as the ultimate end, it is interesting to think of death also dying (perhaps indication of an afterlife?)

    2. I find this line ironic when he states "I am waiting for the moment when someone asks me this questions and I am dead. I'm a little sorry I'll miss that". It is already bad enough when people ask those with chronic diseases how they are doing because everyone already knows the answer.

    1. n the process of trying to assess Huntington’s views, it occurred to me that what is happening globally today resembles European experience in the Renaissance and Reformation era.

      Similar point argued by Ian Goldin and Chris Kutarna in Age of Discovery: Navigating the Risks and Rewards of Our New Renaissance.

  11. May 2017
    1. ($20*3)-($20*3*.1) = $54

      10% of $2000(cost of camer) * 3days = Rental Price

      Rental Price - Commission = Rental Made This guy totally forgot taxes here.... :)

      54$ for 3 days 365 days a year about 50 % usage so roughly 180 days. $54 for 3 days $? for 180 days = $3240 about 740$ profit per year for a $2000 investment if he's 50% utilized over the year.

      Camera's Man this guy needed to crunch some more numbers. Camera's have compatibility issues....

  12. Apr 2017
    1. abriel no longer wanted to live outside.He knew he had a room and a bed of his own in the tall building.So he stood up, with Spaghetti under his chin, and went inside to show his kitten where they would live together

      HE WANAS BELUNG yaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

    1. Guest Interviews

      I thought we categorized these already on the google doc? OR would you like me to choose 5 for each? #phoebechange

  13. Jan 2017
  14. Dec 2016
  15. Aug 2016
    1. Student Task

      Use the below sources: video, website, and essay to gather information on both of the Emancipation Proclamations. Once you have gathered information, read through each document once and then go back and annotate one part of each document. You should have two annotations when complete.

      Questions that can be answered with annotations:

      ●Which Republican goals were served by each paragraph?

      ● Why is the president authorized to do this?

      ● What should the President have replied to critics who warned him that this document would 1) anger the border states or southern unionists, and 2) undermine prosecution of the war?

      ●What differences are there in the two documents?

      https://www.youtube.com/watch?v=05GVVw7008M&list=PLVggCKD8PzewikRabpcuKeW7ENokjpx-W&index=19

      Emancipation Proclamation 1863 (http://housedivided.dickinson.edu/)

      Emancipation Essay

  16. Mar 2016
  17. Feb 2016
    1. Cocoa beans can be 4 percent moldy or insect infested, but only 6 percent moldy and insect infested. More than 10 milligrams of “mammalian excreta” is permitted per pound of cocoa beans.

      Sounds good

  18. Nov 2015
    1. This freshness not only affects the taste of your food, but the nutritional value which declines with time

      the health benefits of the movements is greater than eating processed food.

    2. Because the produce will be handled less, locally grown fruit does not have to be “rugged” or to stand up to the rigors of shipping

      meaning that the food will not be damaged if it is not shipped from a long distance.

  19. Oct 2015
    1. it tells us little about sales of actual ebooks

      Or about the broader context for reading. Often strikes me that we still take the “book” concept as a given. Texts come in many forms but we’re stuck with this model of packaging texts by length. Much of literary postmodernism had to do with breaking free of those boundaries on our thinking. But eBooks often reproduce the linearity and boundedness of pre-hypertext “books”. Landow’s book was first published in 1991. What happened in the last 25 years?

  20. Jul 2015
    1. Davis, Allison P. "Sheila Heti on Drinking Her Way to a Child's-Eye View" from Department of Corrections in The Cut July 16, 2015 annotation as a correction to existing online resources such as Wikipedia