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  1. Last 7 days
    1. Cephalosporins or extended-spectrum penicillins are commonly used (eg, cephalexin, 0.5 g orally four times daily for 7–10 days; see Table 35–6). Trimethoprim-sulfamethoxazole (two double-strength tablets orally twice daily for 7–10 days) should be considered when there is concern that the pathogen is MRSA (see Tables 35–5 and 35–6). Vancomycin, 15 mg/kg intravenously every 12 hours, is used for patients with signs of a systemic inflammatory response.

      cephalexin, dicloxacillin, penicillin VK, amoxicillin/clavulanate, or clindamycin (for penicillin-allergic patients). [1-2] These beta-lactam antibiotics provide excellent coverage against streptococci and methicillin-susceptible S. aureus (MSSA

    1. Urgent treatment for neoplasm consists of (1) cautious use of intravenous diuretics and (2) mediastinal irradiation, starting within 24 hours, with a treatment plan designed to give a high daily dose of radiation but a short total course of therapy to rapidly shrink the local tumor. Intensive radiation therapy combined with chemotherapy will palliate the process in up to 90% of patients. In patients with a subacute presentation, radiation therapy alone usually suffices. Chemotherapy is added if lymphoma or small-cell carcinoma is diagnosed

      endovascular stenting emerging as first-line therapy for rapid symptom relief, while definitive treatment targets the underlying cause

      Glucocorticoids (dexamethasone 4 mg every 6 hours) are commonly prescribed but lack robust supporting data; they may be more beneficial in lymphoma or thymoma and as prophylaxis against radiation-induced edema. [2-4] Importantly, SVC syndrome is no longer considered a medical emergency except in rare cases with life-threatening cerebral edema, laryngeal edema, or altered mental status. When thrombosis is present, catheter-directed thrombolysis or aspiration thrombectomy should be performed within 2-5 days of symptom onset before thrombus organization occurs. [3] The role of long-term anticoagulation after stenting remains unclear, though it is standard when significant thrombosis is present The American College of Chest Physicians recommends obtaining histologic diagnosis before treatment in suspected lung cancer cases, as stenting does not interfere with tissue diagnosis. [2] For small cell lung cancer (SCLC), chemotherapy alone is recommended as first-line treatment given rapid response rates. [2] For non-small cell lung cancer (NSCLC), radiation therapy and/or stent insertion are recommended, with response rates of 59% for chemotherapy and 63% for radiation therapy. [2] Patients with chemotherapy- or radiation-refractory disease should receive vascular stents For device-related thrombosis (catheters, pacemakers), catheter removal should be considered in conjunction with anticoagulation. [4] Endovascular therapy is first-line for device-related obstruction, while surgical bypass may be preferred for mediastinal fibrosis. [7] Both approaches show good mid-term patency, though secondary interventions are common (approximately 27-28%

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    1. Treatment of superficial vein reflux (see Varicose Veins, above) has been shown to decrease the recurrence rate of venous ulcers. Where there is substantial obstruction of the femoral or popliteal deep venous system, superficial varicosities supply the venous return and should not be removed.

      Failure of venous insufficiency ulcerations to heal is most often due to inconsistent use of first-line treatment methods. Ongoing control of edema is essential to prevent recurrent ulceration; the use of compression stockings following ulcer healing is critical, with recurrence rates 2–20 times higher if compression stockings are not used

      Duplex ultrasound evaluation should assess blood flow direction, venous reflux, and venous obstruction, and include examination of the deep venous system, great saphenous vein (GSV), small saphenous vein (SSV) and its thigh extension (Giacomini vein), accessory saphenous veins, and perforating veins. Venography is recommended primarily in patients with post-thrombotic disease, especially when intervention is planned, as it provides greater anatomic detail than duplex ultrasonograph The examination also identifies patterns of disease that have treatment implications. Axial reflux is defined as uninterrupted retrograde flow from groin to calf and can occur in either superficial or deep systems. [4] Junctional reflux is limited to the saphenofemoral or saphenopopliteal junction, while segmental reflux occurs in a portion of a truncal vein. [4] Understanding whether reflux originates from superficial junctions versus deep venous incompetence fundamentally changes treatment planning, as superficial disease is amenable to ablation while deep disease typically requires conservative management Management of secondary varicose veins from post-thrombotic syndrome (PTS) is fundamentally different and more challenging. Compression therapy, lifestyle modifications, and symptom management form the cornerstone of PTS treatment. [4-8] Elastic compression stockings (20-30 mm Hg), leg elevation, weight loss, and exercise constitute the primary therapeutic approach Endovascular interventions for PTS—including percutaneous transluminal venoplasty and stenting—are reserved for select patients with significant iliofemoral obstruction who have failed conservative management. [7] These procedures require careful patient selection and standardized criteria. The role of superficial venous ablation in PTS patients with concomitant superficial reflux remains controversial and should be approached cautiously, as the underlying deep venous pathology may limit benefit

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    1. Briefing : Le traitement judiciaire des violences sexuelles incestueuses sur mineurs

      Ce document synthétise les témoignages et analyses fournis par les représentants des syndicats de la magistrature (USM, Syndicat de la Magistrature, Unité Magistrat) lors de leur audition devant la commission d'enquête de l'Assemblée nationale.

      Résumé exécutif

      L'institution judiciaire française traverse une crise structurelle profonde qui entrave le traitement efficace des violences sexuelles incestueuses.

      Malgré une libération de la parole et une augmentation des signalements, la réponse judiciaire reste marquée par un taux de classement sans suite alarmant (environ 70 % à 80 % dans les affaires de viols sur mineurs) et des délais de traitement inacceptables pouvant dépasser un an et demi entre le signalement et les premières mesures de garde à vue.

      Les principaux points de blocage identifiés sont :

      • Un manque criant de moyens humains et matériels : La France dispose de deux à quatre fois moins de magistrats et procureurs que la moyenne européenne, entraînant une gestion des flux au détriment de la qualité.

      • Une faillite de la chaîne de protection : Les enquêtes sont ralenties par le sous-effectif des brigades spécialisées et la pénurie d'experts psychiatres qualifiés.

      • Un besoin de réforme des outils civils : Les syndicats plaident pour un renforcement de l'ordonnance de protection, gérée par le juge aux affaires familiales (JAF), pour protéger l'enfant dès la phase de soupçon.

      • Le poids du passé : Le traumatisme de l'affaire d'Outreau continue d'influencer la perception de la parole de l'enfant, oscillant entre déni et suspicion.

      --------------------------------------------------------------------------------

      1. Une institution sous tension : le constat des moyens

      L'analyse des syndicats souligne un décalage majeur entre les attentes sociétales et la réalité budgétaire de la justice.

      Déficit de personnel et comparaison européenne

      Le système judiciaire français est sous-dimensionné par rapport à ses voisins européens (chiffres de la CEPEJ) :

      | Catégorie | France (pour 100 000 hab.) | Moyenne Européenne | | --- | --- | --- | | Procureurs | 3,2 | 12,2 | | Juges | 11,3 | 21,9 |

      Il manquerait environ 20 000 magistrats pour assurer une justice de qualité, alors que seulement 8 500 sont actuellement en poste.

      Conséquences sur les enquêtes

      Le manque d'enquêteurs spécialisés crée des stocks de dossiers "morts".

      • À Nantes, 500 dossiers étaient en attente en mars 2024 avec seulement 9 enquêteurs.

      • À Paris, le délai entre un signalement et une garde à vue est estimé entre 12 et 18 mois.

      • La priorité est souvent donnée à la délinquance de voie publique (opérations "place nette") au détriment des enquêtes complexes sur l'inceste qui exigent du temps (auditions multiples, perquisitions informatiques).

      Obsolescence des outils informatiques

      Les magistrats travaillent encore en "silos".

      Le logiciel des juges des enfants (non "webisé") ne permet pas de savoir si un parent fait l'objet d'une procédure dans une autre juridiction.

      L'absence d'interopérabilité entre le civil et le pénal freine la circulation des informations cruciales pour la protection des mineurs.

      --------------------------------------------------------------------------------

      2. La parole de l'enfant et l'expertise judiciaire

      Le traitement de la parole de l'enfant reste le point le plus critique de la procédure.

      La formation des acteurs

      Bien que la formation initiale à l'École Nationale de la Magistrature (ENM) intègre des modules sur les violences sexuelles (auditions filmées, protocoles NI-CHD), la formation continue est souvent délaissée par les magistrats en raison d'une charge de travail excessive.

      • Statistique clé : 60 % des auditions de mineurs victimes ne sont toujours pas réalisées par des enquêteurs formés.

      La crise de l'expertise

      Le recours aux experts psychiatres et psychologues est décrit comme une "misère".

      • Pénurie : Certaines cours d'appel n'ont aucun pédopsychiatre inscrit.

      • Qualité variable : Des expertises cruciales tiennent parfois sur une seule page.

      • Délais : Une demande de contre-expertise peut rallonger la procédure de 18 mois à 2 ans.- Coût : La faible rémunération des experts dissuade les professionnels les plus qualifiés de travailler pour la justice.

      Le traumatisme d'Outreau

      L'affaire d'Outreau est citée comme une "régression fatale".

      Elle a instauré un climat de suspicion systématique envers la parole de l'enfant, poussant certains magistrats à exiger des preuves matérielles impossibles à obtenir dans des dossiers d'inceste (souvent "parole contre parole").

      --------------------------------------------------------------------------------

      3. Propositions de réformes et débats juridiques

      Les syndicats proposent plusieurs leviers pour améliorer la protection et le jugement.

      Élargissement du cadre légal

      • Définition de l'inceste : Unanimité sur l'intégration des cousins et cousines dans la définition légale.

      • Ordonnance de protection : Proposition de calquer l'ordonnance de protection des enfants sur celle des violences conjugales.

      Elle permettrait au JAF de statuer en 6 jours sur la suspension de l'autorité parentale sur la base de la "vraisemblance" des faits, sans attendre la preuve pénale.

      Opposition au "Plaider-coupable" criminel

      Le projet de loi visant à instaurer un "plaider-coupable" pour les crimes (dont les viols incestueux) rencontre une vive opposition :

      • Risque d'une justice "expéditive" et dégradée.

      • Nécessité de l'audience publique pour poser l'interdit social.

      • Doute sur la réalité de la reconnaissance des faits par les auteurs (souvent assortie d'une minimisation du type "elle était d'accord").

      La question de l'imprescriptibilité

      La majorité des intervenants est défavorable à l'imprescriptibilité.

      L'argument principal est que cela "vend du rêve" aux victimes : plus le temps passe, plus les preuves se dégradent, rendant la condamnation quasi impossible et le procès déceptif.

      Le Syndrome d'Aliénation Parentale (SAP)

      Unité Magistrat et le Syndicat de la Magistrature alertent sur la persistance de ce concept "pseudo-scientifique".

      Utilisé pour discréditer les mères protectrices en les accusant d'instrumentaliser l'enfant, le SAP contribuerait à masquer les situations réelles d'inceste.

      --------------------------------------------------------------------------------

      4. Dysfonctionnements systémiques et protection de l'enfant

      Le classement "21" (infraction insuffisamment caractérisée)

      Ce motif de classement est majoritaire.

      Les syndicats précisent qu'un classement ne signifie pas que les faits n'ont pas eu lieu, mais que l'enquête n'a pas permis de réunir des preuves suffisantes pour un procès pénal.

      Cela crée un sentiment de déni violent pour l'enfant.

      La non-représentation d'enfant (NRE)

      Le Syndicat de la Magistrature prône la dépénalisation de ce délit, souvent utilisé contre les mères qui refusent de confier leur enfant à un père suspecté de violences.

      Actuellement, 83 % des personnes condamnées pour NRE sont des mères.

      Manque de coordination "Transversalité"

      Le besoin d'un "référent inceste" en juridiction est évoqué, mais la multiplication des casquettes de "référent" (VIF, mineurs, etc.) sans moyens dédiés est jugée inefficace.

      La priorité doit être la circulation fluide des dossiers entre le procureur, le juge des enfants et le juge aux affaires familiales.

      --------------------------------------------------------------------------------

      Citations clés

      « La justice n'est pas réparée [...]. Elle a besoin de cap clair quant aux priorités, car tout ne peut pas être prioritaire. » — Ludovic Fria (USM)

      « Un classement ne signifie pas que des faits n'ont pas existé. C'est une vérité judiciaire, pas une vérité absolue. » — Ségolène Marquet (SM)

      « Nous sommes obligés de prioriser les urgences entre elles. C'est compliqué quand on reçoit les victimes et qu'on leur dit : "Votre dossier n'a pas avancé car les enquêteurs ont 15 commissions rogatoires avant la vôtre". » — Stéphanie Caprin (USM)

      « L'inceste est le tabou par excellence. Ce n'est pas un crime comme un autre. » — Béatrice Brugère (Unité Magistrat)

    1. Briefing : Traitement judiciaire et médical des violences sexuelles incestueuses

      Ce document de synthèse analyse les témoignages et expertises présentés devant la commission d'enquête parlementaire relative au traitement judiciaire des viols et agressions sexuelles incestueuses sur mineurs.

      Il compile les observations de trois experts pédopsychiatres : les docteurs Maurice Berger, Françoise Fericelli et Myriam Pieron-Bertier.

      Résumé exécutif

      L'analyse des sources révèle une crise systémique dans la protection de l'enfance face à l'inceste en France.

      Les points critiques identifiés sont les suivants :

      • Terrorisation du corps médical : Les médecins hésitent à signaler les soupçons d'inceste par crainte de sanctions disciplinaires systématiques de la part du Conseil de l'Ordre des médecins (CNOM), souvent à la suite de plaintes déposées par les agresseurs présumés.

      • Infiltration d'idéologies non scientifiques : Le "Syndrome d'Aliénation Parentale" (SAP), bien qu'exclu des classifications internationales (DSM-5, CIM-11), continue d'influencer massivement les experts et les magistrats, conduisant à discréditer la parole de l'enfant et du parent protecteur.

      • Carence d'expertise spécialisée : Les expertises judiciaires sont trop souvent confiées à des psychiatres d'adultes sans formation en clinique de l'enfant, menant à des évaluations superficielles, voire traumatisantes.

      • Déni spécifique chez le nourrisson : Il existe un déni massif concernant les agressions sexuelles sur les enfants de moins de trois ans, malgré une sémiologie clinique et psychosomatique précise.

      • L'idéologie du "lien à tout prix" : La priorité donnée au maintien des liens familiaux et à la coparentalité, même en présence de violences avérées, met les enfants en danger immédiat de réexposition traumatique.

      --------------------------------------------------------------------------------

      1. Obstacles au signalement et rôle du Conseil de l'Ordre des médecins

      Le système actuel entrave la détection précoce de l'inceste en raison de la vulnérabilité juridique des médecins signalants.

      La "profession terrorisée"

      • Les médecins libéraux (généralistes, pédiatres) sont les plus exposés aux attaques du Conseil de l'Ordre lorsqu'ils rédigent un certificat ou un signalement.

      • Même l'utilisation des modèles officiels fournis par le CNOM ne garantit aucune immunité.

      Un médecin a été condamné à 15 jours d'interdiction d'exercer malgré la validation préalable de son écrit par le président de son conseil départemental.

      • Conséquence : Le taux de signalements provenant des médecins est alarmant (entre 1 % et 2 % selon les chiffres récents de l'UMJ de l'Hôtel-Dieu).

      Nécessité d'une réforme structurelle

      • Limitation du pouvoir disciplinaire : Les experts préconisent que le CNOM perde son pouvoir de sanction dans les affaires de signalements concernant les enfants, s'inspirant des modèles suisse ou anglais où ces questions relèvent d'instances mixtes incluant des magistrats et des représentants de la société civile.

      • Sécurisation juridique : L'obligation de signalement ne peut être envisagée sans une protection préalable et absolue du médecin contre les poursuites ordinales (Préconisation 17 de la Civise).

      --------------------------------------------------------------------------------

      2. Défaillances et normes de l'expertise judiciaire

      L'expertise est le pivot de la décision judiciaire, mais sa qualité est jugée erratique et souvent insuffisante.

      Les lacunes de la pratique actuelle

      • Absence de spécialisation : Des psychiatres d'adultes expertisent des enfants sans maîtriser le développement psycho-affectif spécifique à chaque âge.

      • Conditions inadaptées : Entretiens trop courts (parfois 10 minutes), absence de matériel de jeu ou de dessin, et réception des enfants à des heures inappropriées (sieste, soirée).

      • Manquements méthodologiques : Défaut d'observation des interactions parent-enfant (diades), omission de la lecture du carnet de santé et absence de contact avec les professionnels suivant l'enfant (enseignants, éducateurs).

      Les critères d'une expertise de qualité

      Une expertise rigoureuse devrait répondre aux standards suivants :

      • Durée : Entre 12 et 25 heures de travail effectif pour une évaluation complète de la famille.

      • Méthodologie : Analyse clinique, utilisation de protocoles validés (NICHD/Nich pour l'audition, SVA pour la crédibilité des déclarations).

      • Formation : Exigence d'une pratique clinique de 5 à 10 ans en pédopsychiatrie avant l'inscription sur les listes d'experts.

      --------------------------------------------------------------------------------

      3. L'influence du "Syndrome d'Aliénation Parentale" (SAP)

      Le SAP est décrit comme un "fourre-tout conceptuel" utilisé stratégiquement par les agresseurs pour obtenir l'impunité.

      Un outil de disqualification

      • Lorsqu'un enfant dénonce un inceste dans un contexte de séparation, l'agresseur accuse fréquemment la mère d'être "aliénante" ou "fusionnelle".

      • Cette rhétorique conduit à une inversion accusatoire : la détresse normale d'un parent protecteur est pathologisée et utilisée pour justifier le transfert de la garde à l'agresseur présumé.

      Une infiltration institutionnelle

      • Bien que rejeté par l'OMS et le Parlement européen, le lobby du SAP a infiltré les manuels scolaires et a longtemps été enseigné à l'École Nationale de la Magistrature (ENM).

      • Les experts soulignent que la "mère fusionnelle" est souvent une mère parfaitement adaptée aux besoins de protection d'un enfant traumatisé.

      --------------------------------------------------------------------------------

      4. Clinique de l'inceste chez le nourrisson (0-3 ans)

      Les agressions sur les très jeunes enfants constituent un angle mort majeur du système judiciaire.

      Sémiologie spécifique

      L'inceste chez le bébé se manifeste par des signes cliniques précis que les experts non formés ignorent :

      • Troubles psychosomatiques : Eczéma brutal, infections vulvovaginales ou angines à répétition, béance anale ou vaginale.

      • Troubles du comportement : Masturbation compulsive, phobie des soins d'hygiène (change, douche), agitation extrême (souvent confondue avec un TDH) ou retrait relationnel massif.

      • Données probantes : Le carnet de santé est un document biographique crucial qui révèle souvent des ruptures de courbes de croissance ou des hospitalisations suspectes.

      La fiabilité de la parole précoce

      • Les enfants de 2 ou 3 ans "ne mentent pas" car ils n'ont aucune connaissance préalable de la sexualité adulte.

      • Leur vocabulaire est spécifique (ex: "manger le pipi" pour désigner des actes sexuels oraux).

      Ignorer ces propos au motif de "l'âge de raison" (7 ans) est une erreur scientifique.

      --------------------------------------------------------------------------------

      5. Conséquences judiciaires et "Idéologie du lien"

      La justice française est critiquée pour son attachement dogmatique au maintien du lien biologique, même au détriment de la sécurité de l'enfant.

      La réexposition traumatique

      • Visites médiatisées : Le maintien de contacts en présence de professionnels est souvent inefficace pour protéger l'enfant du retraumatisme.

      Des cas de viols ont été signalés lors de ces rencontres.

      • Syndrome de Stockholm : Le fait qu'un enfant se précipite vers son parent agresseur au tribunal ne prouve pas l'absence de violences, mais témoigne d'un mécanisme de survie et d'emprise.

      Statistiques et faits saillants

      | Catégorie | Donnée statistique | | --- | --- | | Profil des agresseurs | 94-96 % d'hommes (pères, oncles, grands-parents) ; 4-6 % de femmes. | | Risque corrélé | 6,5 fois plus de risques d'inceste dans les foyers marqués par des violences conjugales. | | Crédibilité | Les fausses allégations volontaires représentent seulement 0,5 % à 6 % des cas. | | Rétractations | 22 % des enfants se rétractent par peur, mais 93 % d'entre eux reviennent ensuite sur leur rétractation. | | Démographie médicale | Environ 600 pédopsychiatres en France, moyenne d'âge de 62 ans. |

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      6. Préconisations concrètes

      Pour remédier à ces dysfonctionnements, les experts proposent :

      • Réforme de la déontologie : Sortir les signalements d'enfants de la compétence disciplinaire du Conseil de l'Ordre.

      • Spécialisation des experts : Réserver les expertises de mineurs aux seuls professionnels justifiant d'une pratique clinique longue auprès des enfants (minimum 5 ans).

      • Formation à l'ENM : Remplacer les enseignements basés sur le SAP par des modules sur la victimologie et le psychotraumatisme de l'enfant.

      • Application des protocoles SVA/Nich : Généraliser ces outils de validation scientifique pour limiter l'arbitraire de l'expert.

      • Remise en cause du lien absolu : Reconnaître juridiquement l'existence de "disparentalités définitives" et suspendre tout droit de visite dès lors que la santé psychique de l'enfant est gravement compromise.

  2. Mar 2026
    1. Aortic dissection typically presents acutely with sudden, severe tearing chest or back pain, often described as lancinating in quality. [5-6] Approximately 50% of patients with thoracic aortic aneurysm may progress to dissection without timely intervention. [5] In contrast, thoracic aortic aneurysm is usually asymptomatic and discovered incidentally during physical examination or imaging for other indications. [5]

  3. Jul 2025
    1. How can you tell when someone has real potential in pure mathematics?

      question by u/OkGreen7335 at https://reddit.com/r/math/comments/1m0qe7f/how_can_you_tell_when_someone_has_real_potential/

      The same way the music teacher in Liverpool who had half of The Beatles in his elementary school music class knew they had music potential—you can't possibly.

      Potential is by definition the unknown part. The rest of it is interest, desire, enthusiasm, and time working at the thing itself over long periods which slowly unleashes that potential. You don't know until you try, so quit worrying about it and enjoy the area, even if it's just as a hobby you do on the side. There are garage bands that hustle on the side, why can't you be a garage mathematician?!?

      Most of the smart, talented university professors in mathematics are there because they had the passion and (often had the luxury to) spend the time. Nurture your own passions and those of your students and encourage them to spend the time.

      How many parents unabashedly encourage their kids to become international superstar musicians? I'll bet The Beatles' parents didn't. I'll also bet that number is close to the numbers of parents who encourage their kids to do the same thing in math.

  4. May 2025
  5. Apr 2025
    1. “The China Syndrome,” a 2011 paper on the impact of trade withChina by a powerful troika of economists—David Autor, David Dorn,and Gordon Hanson—underscored what is going on. The empiricalstudy is particularly significant because it marks a shift in consensusthinking in the academy. In the debate about the causes of growingincome inequality, American economists have tended to opt fortechnology as the driving force. But, drawing on detailed data fromlocal labor markets in the United States, the authors of “The ChinaSyndrome” argue that globalization, and in particular trade with themighty Middle Kingdom, are today also having a huge impact onAmerican blue-collar workers: “Conservatively, it explains one-quarterof the contemporaneous aggregate decline in U.S. manufacturingemployment.”

      Autor, David H., David Dorn, and Gordon H. Hanson. “The China Syndrome: Local Labor Market Effects of Import Competition in the United States.” American Economic Review 103, no. 6 (October 2013): 2121–68. https://doi.org/10.1257/aer.103.6.2121.

  6. Nov 2024
    1. I'm reminded of poor online friend Jack Baty who can never seem to settle on a PKM approach, oscillating between 5 or so over the years, including publishing platforms/blogs. It's easy to reply "Don't! There's no greener grass on any side." But that also misses the point, I believe, when in the end one just wants to explore and tinker. And not get stuff done all the time. All that being said, I believe there's hope in simplicity of a Zettelkasten, but maybe that's not what is being searched for 😅

      via [[Christian Tietze]] at https://forum.zettelkasten.de/discussion/comment/22076/#Comment_22076

      There's tremendous value in keeping a single zettelkasten store of knowledge. Spreading it out only dilutes things and can prevent building. Shiny object syndrome can be a problem as it's often splitting the stores of information and silo-ing them from each other. Unless the shiny object can do something radically different or has a dramatic affordance it's really only a distraction.

      But still, sometime the search for either simpler or better serves other needs...

  7. Oct 2024
  8. Jul 2024
    1. metabolic syndrome

      for - health - insulin resistance - metabolic syndrome

      health - insulin resistance - metabolic syndrome - When your mitochondria doesn't work, it results in insulin resistance - Metabolic syndrome includes an enormous variety of the major diseases afflicting modernity - up to 75% of the diseases that affect modern humans and - up to 75% of today's health care costs - and includes - type 2 diabetes - hypertension - dyslipidemia - cardiovascular disease - cancer - dementia - fatty liver disease - pollycystic ovarian disease - (he didn't include strokes here but he mentions throughout his talk)

  9. May 2024
    1. I should have learned to do what he’d have done. Shrugged myshoulders—and been okay with pre-come. But that wasn’t me. It wouldnever have occurred to me to say, So what if he saw? Now he knows

      Juxtaposition with the fear of expressing one's identity (Elio) and the carefree nature of Oliver, who is honest about his body whereas Elio feels shameful with the honesty of his body's expression of identity.

  10. Apr 2024

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  11. Mar 2024
    1. Frequent re- arrangements are a distinct disadvantage,for with every change the filer loses much time in becoming familiaragain with the new positions.

      While Kaiser recommends against the need to re-arrange physical cards from one drawer to another, which creates the need to refamiliarize oneself with their new locations, the same idea applies to switching from one digital note taking application to another as a similar switch of user interface functionality may cause additional overhead and stress thereby preventing quick use of the system itself.

    2. It is there-fore to be expected that the initial cost of the card system is nota fair criterion of its cost when in working order.

      Setting up and learning a note taking or card index system has a reasonably large up-front cost, but learning it well and being able to rely on it over long periods of time will eventually reap larger and cheaper long-term outcomes and benefits.

      Unless changing systems creates dramatically larger improvements, the cost of change will surely swamp the benefits making the switch useless. This advice given by Kaiser is still as true today as it was in 1908, we tend not to think about the efficiency as much now as he may have then however and fall trap to shiny object syndrome.

  12. Dec 2023
      • for: plan B, climate futures, dystopian future, civilization collapse

      • title: If We’ve Lost the Climate War, What’s Plan B?

      • subtitle: Why a carbon tax won’t save us, and what’s next.
      • author: Crawford Kilian
      • date: Nov 22, 2023

      • summary

        • a good article that shows the complexity and unpredictability of a collapse scenario and system justification theory, which sounds like the boiling frog syndrome
  13. Sep 2023
    1. I’ve been flitting around loads of note taking platforms - each time, I bask in the glory of a new tool then about 3-4 weeks later I’m done.The one lasting tool is Roam, which I still like despite it being tossed aside by many for other tools. I use TickTick for my task management.I’ve recently returned to journaling or writing things down for that I’ve done and what I want to achieve. I still have an online and mobile task list but I really find writing useful for reflecting.Getting into Zettkekasten, I’m about to use a paper card based approach to do a spell of studying. Im looking forward to the analogue experience but almost feel like I’m being disloyal to the modern digital way. I’m looking forward to seeing if this method helps digest the learning and seeing where this takes me.

      reply to u/FilterGrad6 at https://www.reddit.com/r/Zettelkasten/comments/16iwdep/newbie/

      Digital is just a tool. Why necessarily chose it over analog unless you can specifically identify affordances which dramatically improve your experience or output?

      As you've discovered, shiny object syndrome may prevent you from collecting enough into one place to be truly useful and valuable. Pick one that seems to work for you and build from there.

      If paper was good enough for the practices and outputs of Carl Linnaeus, Konrad Gessner, Gottfried Wilhelm Leibnitz, John Locke, Hans Blumenberg, Roland Barthes, Beatrice Webb, Jacques Barzun, Niklas Luhmann, Gertrud Bauer, Marcel Mauss, Phyllis Diller, and so many others is there any reason it shouldn't work just as effectively for your work?

  14. Aug 2023
    1. Does anyone has it’s Zettelkasten in Google Docs, Microsoft Word or Plain Tex (without a hood app like obsidian or The Archive)? .t3_15fjb97._2FCtq-QzlfuN-SwVMUZMM3 { --postTitle-VisitedLinkColor: #9b9b9b; --postTitleLink-VisitedLinkColor: #9b9b9b; --postBodyLink-VisitedLinkColor: #989898; }

      reply to u/Efficient_Earth_8773 at https://www.reddit.com/r/Zettelkasten/comments/15fjb97/does_anyone_has_its_zettelkasten_in_google_docs/

      Experimenting can be interesting. I've tried using spreadsheet software like Google Sheets or Excel which can be simple and useful methods that don't lose significant functionality. I did separate sheets for zettels, sources, and the index. Each zettel had it's own row with with a number, title, contents, and a link to a source as well as the index.

      Google Docs might be reasonably doable, but the linking portion may be one of the more difficult affordances to accomplish easily or in a very user-centric fashion. It is doable though: https://support.google.com/docs/answer/45893?hl=en&co=GENIE.Platform%3DDesktop, and one might even mix Google Docs with Google Sheets? I could see Sheets being useful for creating an index and or sources while Docs could be used for individual notes as well. It's all about affordances and ease of use. Text is a major portion of having and maintaining a zettelkasten, so by this logic anything that will allow that could potentially be used as a zettelkasten. However, it helps to think about how one will use it in practice on a day-to-day basis. How hard will it be to create links? Search it? How hard will it be when you've got thousands of "slips"? How much time will these things take as it scales up in size?

      A paper-based example: One of the reasons that many pen and paper users only write on one side of their index cards is that it saves the time of needing to take cards out and check if they do or don't have writing on the back or remembering where something is when it was written on the back of a card. It's a lot easier to tip through your collection if they're written only on the front. If you use an alternate application/software what will all these daily functions look like compounded over time? Does the software make things simpler and easier or will it make them be more difficult or take more time? And is that difficulty and time useful or not to your particular practice? Historian and author David McCullough prefers a manual typewriter over computers with keyboards specifically because it forces him to slow down and take his time. Another affordance to consider is how much or little work one may need to put into using it from a linking (or not) perspective. Using paper forces one to create a minimum of at least one link (made by the simple fact of filing it next to another) while other methods like Obsidian allow you to too easily take notes and place them into an infinitely growing pile of orphaned notes. Is it then more work to create discrete links later when you've lost the context and threads of potential arguments you might make? Will your specific method help you to regularly review through old notes? How hard will it be to mix things up for creativity's sake? How easy/difficult will it be to use your notes for writing/creating new material, if you intend to use it for that?

      Think about how and why you'd want to use it and which affordances you really want/need. Then the only way to tell is to try it out for a bit and see how one likes/doesn't like a particular method and whether or not it helps to motivate you in your work. If you don't like the look of an application and it makes you not want to use it regularly, that obviously is a deal breaker. One might also think about how difficult/easy import/export might be if they intend to hop from one application to another. Finally, switching applications every few months can be self-defeating, so beware of this potential downfall as you make what will eventually need to be your ultimate choice. Beware of shiny object syndrome or software that ceases updating in just a few years without easy export.

  15. May 2023
    1. I used Apple Notes, Evernote, Roam, Obsidian, Bear, Notion, Anki, RemNote, the Archive and a few others. I was pondering about different note types, fleeting, permanent, different organisational systems, hierarchical, non-hierarchical, you know the deal. I often felt lost about what to takes notes on and what not to take notes on.

      Example of someone falling prey to shiny object syndrome, switching tools incessantly, then focusing on too many of the wrong things/minutiae and getting lost in the shuffle.

      Don't get caught up into this. Understand the basics of types of notes, but don't focus on them. Let them just be. Does what you've written remind you of the end goal?

  16. Apr 2023
    1. AnthonyJohn @AnthonyJohn@pkm.socialDo you ever get the feeling that you're in an abusive relationship is note taking apps. I've used then all and in my pursuit for perfection have achieved absolutely nothing. This is the subject of my next long-form essay. subscribe for free at http://notentirelyboring.com to read it first. (And you'll also get a weekly newsletter thats not entirely boring)#PKM #NoteTaking #Obsidian #RoamResearch #Logseq #BearApr 20, 2023, 24:40

      reply to @AnthonyJohn@pkm.social at https://mastodon.social/@AnthonyJohn@pkm.social/110230007393359308

      Perfectionism and Shiny object syndrome are frequently undiagnosed diseases. Are you sure it's not preventing you from building critical mass in one place to actually accomplish your goals? Can't wait to see the essay.

      syndication link

    1. “I wrote 86 episodes of ‘The West Wing,’ and every single time I finished one, I’d be happy for five minutes before it just meant that I haven’t started the next one yet, and I never thought I would be able to write the next one. Ever.”

      I'm reminded a bit of Dale Keiger's mention of Mark Strand having this same feeling after writing a poem.

      https://hypothes.is/a/e8L5wuJlEe29ii_FcRhu4g

  17. Mar 2023
    1. Another way to widen the pool of stakeholders is for government regulators to get into the game, indirectly representing the will of a larger electorate through their interventions.

      This is certainly "a way", but history has shown, particularly in the United States, that government regulation is unlikely to get involved at all until it's far too late, if at all. Typically they're only regulating not only after maturity, but only when massive failure may cause issues for the wealthy and then the "regulation" is to bail them out.

      Suggesting this here is so pie-in-the sky that it only creates a false hope (hope washing?) for the powerless. Is this sort of hope washing a recurring part of

  18. Feb 2023
    1. Stop Procrastinating With Note-Taking Apps Like Obsidian, Roam, Logseq https://www.youtube.com/watch?v=baKCC2uTbRc by Sam Matla

      sophisticated procrastination - tweaking one's system(s) or workflow with the anticipation it will help them in the long run when it is generally almost always make-work which helps them feel smart and/or productive. Having measurable results which can be used against specific goals will help weed this problem out.

    1. I got rid of most of the features after I realized that they are redundant or a just plain harmful when they slowed me down.

      Many long time practitioners of note taking methods, particularly in the present environment enamored with shiny object syndrome, will advise to keep one's system as simple as possible. Sascha Fast has specifically said, "I got rid of most of the features after I realized that they are redundant or a (sic) just plain harmful when they slowed me down."

    1. According to Shulman, "Cargo-cult is a belief that mock airplanes made of manure and straw-bale may summon the real airplanes who bring canned beef. Reverse cargo-cult is used by the political elites in countries lagging behind who proclaim that, in the developed world, airplanes are also made of manure and straw-bale, and there is also a shortage of canned beef."[29]

      "Екатерина Шульман: Практический Нострадамус, или 12 умственных привычек, которые мешают нам предвидеть будущее". vedomosti/ (in Russian). Retrieved 24 June 2021.


      A Note on the Cargo Cult of Zettelkasten

      Modern cargo cults can be seen in many technology and productivity spaces where people are pulled in by exaggerated (or sometimes even real claims) of productivity or the general "magic" of a technology or method.

      An example is Niklas Luhmann's use of his zettelkasten which has created a cargo cult of zettelkasten aspirants and users who read one or more of the short one page blog posts about his unreasonable productivity and try to mimic it without understanding the system, how it works, or how to make it work for them. They often spend several months collecting notes, and following the motions, but don't realize the promised gains and may eventually give up, sometimes in shame (or as so-called "rubbish men") while watching others still touting its use.

      To prevent one's indoctrination into the zettelkasten cult, I'll make a few recommendations:

      Distance yourself from the one or two page blog posts or the breathless YouTube delineations. Ask yourself very pointedly: what you hope to get out of such a process? What's your goal? Does that goal align with others' prior uses and their outcomes?

      Be careful of the productivity gurus who are selling expensive courses and whose focus may not necessarily be on your particular goals. Some are selling very pointed courses, which is good, while others are selling products which may be so broad that they'll be sure to have some success stories, but their hodge-podge mixture of methods won't suit your particular purpose, or worse, you'll have to experiment with pieces of their courses to discover what may suit your modes of working and hope they'll suffice in the long run. Some are selling other productivity solutions for task management like getting things done (GTD) or bullet journals, which can be a whole other cargo cults in and of themselves. Don't conflate these![^1] The only thing worse than being in a cargo cult is being in multiple at the same time.

      If you go the digital route, be extremely wary of shiny object syndrome. Everyone has a favorite tool and will advocate that it's the one you should be using. (Often their method of use will dictate how much they love it potentially over and above the affordances of the tool itself.) All of these tools can be endlessly configured, tweaked, or extended with plugins or third party services. Everyone wants to show you their workflow and set up, lots of which is based on large amounts of work and experimentation. Ignore 99.999% of this. Most tools are converging to a similar feature set, so pick a reasonable one that seems like it'll be around in 5 years (and which has export, just in case). Try out the very basic features for several months before you change anything. Don't add endless plugins and widgets. You're ultimately using a digital tool to recreate the functionality of index cards, a pencil, and a box. How complicated should this really be? Do you need to spend hundreds of hours tweaking your system to save yourself a few minutes a year? Be aware that far too many people touting the system and marketers talking about the tools are missing several thousands of years of uses of some of these basic literacy-based technologies. Don't join their island cult, but instead figure out how the visiting culture has been doing this for ages.[^2] Recall Will Hunting's admonition against cargo cults in education: “You wasted $150,000 on an education you coulda got for $1.50 in late fees at the public library.”[^3]

      Most people ultimately realize that the output of their own thinking is only as good as the inputs they're consuming. Leverage this from the moment you begin and ignore the short bite-sized advice for longer form or older advice from those with experience. You're much more likely to get more long term value out of reading Umberto Eco or Mortimer J. Adler & Charles van Doren[^4] than you are an equivalent amount of time reading blog posts, watching YouTube videos, or trolling social media like Reddit and Twitter.

      Realize that reaching your goal is going to take honest-to-goodness actual work, though there is potential for fun. No matter how shiny or optimized your system, you've still got to do the daily work of reading, watching, listening and using it to create anything. Focus on this daily work and don't get sidetracked by the minutiae of trying to shave off just a few more seconds.[^5] In short, don't get caught up in the "productivity porn" of it all. Even the high priest at whose altar they worship once wrote on a slip he filed:

      "A ghost in the note card index? Spectators visit [my office to see my notes] and they get to see everything and nothing all at once. Ultimately, like having watched a porn movie, their disappointment is correspondingly high." —Niklas Luhmann. <small>“Geist im Kasten?” ZKII 9/8,3. Niklas Luhmann-Archiv. Accessed December 10, 2021. https://niklas-luhmann-archiv.de/bestand/zettelkasten/zettel/ZK_2_NB_9-8-3_V. (Personal translation from German with context added.)</small>


      [^1] Aldrich, Chris. “Zettelkasten Overreach.” BoffoSocko (blog), February 5, 2022. https://boffosocko.com/2022/02/05/zettelkasten-overreach/.

      [^2]: Blair, Ann M. Too Much to Know: Managing Scholarly Information before the Modern Age. Yale University Press, 2010. https://yalebooks.yale.edu/book/9780300165395/too-much-know.

      [^3]: Good Will Hunting. Miramax, Lawrence Bender Productions, 1998.

      [^4]: Adler, Mortimer J., and Charles Van Doren. How to Read a Book: The Classic Guide to Intelligent Reading. Revised and Updated edition. 1940. Reprint, New York: Simon & Schuster, 1972.

      [^5]: Munroe, Randall. “Is It Worth the Time?” Web comic. xkcd, April 29, 2013. https://xkcd.com/1205/.


      Recommended resources

      Choose only one of the following and remember you may not need to read the entire work:

      Ahrens, Sönke. How to Take Smart Notes: One Simple Technique to Boost Writing, Learning and Thinking – for Students, Academics and Nonfiction Book Writers. Create Space, 2017.

      Allosso, Dan, and S. F. Allosso. How to Make Notes and Write. Minnesota State Pressbooks, 2022. https://minnstate.pressbooks.pub/write/.

      Bernstein, Mark. Tinderbox: The Tinderbox Way. 3rd ed. Watertown, MA: Eastgate Systems, Inc., 2017. http://www.eastgate.com/Tinderbox/TinderboxWay/index.html.

      Dow, Earle Wilbur. Principles of a Note-System for Historical Studies. New York: Century Company, 1924.

      Eco, Umberto. How to Write a Thesis. Translated by Caterina Mongiat Farina and Geoff Farina. 1977. Reprint, Cambridge, MA, USA: MIT Press, 2015. https://mitpress.mit.edu/books/how-write-thesis.

      Gessner, Konrad. Pandectarum Sive Partitionum Universalium. 1st Edition. Zurich: Christoph Froschauer, 1548.

      Goutor, Jacques. The Card-File System of Note-Taking. Approaching Ontario’s Past 3. Toronto: Ontario Historical Society, 1980. http://archive.org/details/cardfilesystemof0000gout.

      Sertillanges, Antonin Gilbert, and Mary Ryan. The Intellectual Life: Its Spirit, Conditions, Methods. First English Edition, Fifth printing. 1921. Reprint, Westminster, MD: The Newman Press, 1960. http://archive.org/details/a.d.sertillangestheintellectuallife.

      Webb, Sidney, and Beatrice Webb. Methods of Social Study. London; New York: Longmans, Green & Co., 1932. http://archive.org/details/b31357891.

      Weinberg, Gerald M. Weinberg on Writing: The Fieldstone Method. New York, N.Y: Dorset House, 2005.

  19. Dec 2022
    1. So I’ve started a routine where every few years, I block out a couple of days to sit down and review all my idea tools—and other rituals of how I structure my creative thinking— to see if there's something that can be improved upon.

      As a strategy for avoiding shiny object syndrome, one can make a routine of making a "creative inventory" of one's tools.

      There is generally a high switching cost, so tools need to be an order of magnitude more useful, beneficial, or even fun to make it worthwhile.

    2. In my line of work as a writer, there’s a near endless stream of new applications coming out that touch different stages in my workflow: e-book readers, notetaking apps, tools for managing PDFs, word processors, bibliographic databases. The problem is that it’s very tricky to switch horses midstream with these kinds of tools, which means you have a natural tendency to get locked into a particular configuration, potentially missing out on better approaches.

      Steven Johnson indicates that it can be difficult to change workflows, tools, apps, etc.

    1. There are different kinds of information, some of which don't make sense being recorded at all. I was struggling with what to record and what not to record for a long time. For example, I took notes on programming syntax that are just useless (most of these things can be googled in seconds and they are usually decently documented already).

      How was this not obvious from the jump? Was the author of the essay so distracted by shiny object syndrome they failed to see the obvious?

      It's like taking notes in a language class... the goal is to read and write with fluency, so you practice these things regularly and gain fluency over time. Taking notes about the grammar and syntax of a language is highly unlikely to get you to fluency. Note taking is the wrong tool for a number of processes and the user should very quickly get a gut feeling for what's useful and what is not.

      This author obviously missed the boat here.

    2. But then life went on and nothing really happened.

      https://www.reddit.com/r/Zettelkasten/comments/zl2hwh/is_the_concept_of_personal_knowledge_management/

      This essay seems to be more about shiny object syndrome. The writer doesn't seem to realize any problems they've created. Way too much digging into tools and processes. Note the switching and trying out dozens of applications. (Dear god, why??!!) Also looks like a lot of collecting digitally for no clear goal. As a result of this sort of process it appears that many of the usual affordances were completely blocked, unrealized, and thus useless.

      No clear goal in mind for anything other than a nebulous being "better".

      One goal was to "retain what I read", but nothing was actively used toward this stated goal. Notes can help a little, but one would need mnemonic methods and possibly spaced repetition neither of which was mentioned.

      A list of specific building blocks within the methods and expected outcomes would have helped this person (and likely others), but to my knowledge this doesn't exist as a thing yet though bits and pieces are obviously floating around.<br /> TK: building blocks of note taking

      Evidence here for what we'll call the "perfect system fallacy", an illness which often goes hand in hand with "shiny object syndrome".

      Too many systems bound together will create so much immediate complexity that there isn't any chance for future complexity or emergence as the proximal system is doomed to failure. One should instead strive for immediate and excessive simplicity which might then build with time, use, and practice into something more rich and complex. This idea seems to be either completely missed or lost in the online literature and especially the blogosphere and social media.


      people had come up with solutions Sadly, despite thousands of variations on some patterns, people don't seem to be able to settle on either "one solution" or their "own solution" and in trying to do everything all at once they become lost, set adrift, and lose focus on any particular thing they've got as their own goal.

      In this particular instance, "retaining what they read" was totally ignored. Worse, they didn't seem to ever review over their notes of what they read.


      I was pondering about different note types, fleeting, permanent, different organisational systems, hierarchical, non-hierarchical, you know the deal.

      Why worry about all the types of notes?! This is the problem with these multi-various definitions and types. They end up confusing people without giving them clear cut use cases and methods by which to use them. They get lost in definitional overload and aren't connecting the names with actual use cases and affordances.


      I often felt lost about what to takes notes on and what not to take notes on.

      Why? Most sources seem to have reasonable guidance on this. Make notes on things that interest you, things which surprise you.

      They seem to have gotten lost in all the other moving pieces. Perhaps advice on this should come first, again in the middle, and a third time at the end of these processes.

      I'm curious how deeply they read sources and which sources they read to come to these conclusions? Did they read a lot of one page blog posts with summarizations or did they read book length works by Ahrens, Forte, Allosso, Scheper, et al? Or did they read all of these and watch lots of crazy videos as well. Doing it "all" will likely lead into the shiny object syndrome as well.

      This seems to outline a list of specifically what not to do and how not to approach these systems and "popular" blog posts that are an inch deep and a mile wide rather than some which have more depth.

      Worst of all, I spent so much time taking notes and figuring out a personal knowledge management system that I neglected the things I actually wanted to learn about. And even though I kind of always knew this, I kept falling into the same trap.

      Definitely a symptom of shiny object syndrome!

  20. Nov 2022
    1. I'm pretty much done thinking about "tools for thought". It quickly becomes an infinity of navel gazing and a complete waste of time. It's an easy topic for budding "influencers" because you don't actually need to know anything. All they need is to spend some time with a new bit of software and tell people how they should use it and the next thing you know they're selling an online course via their budding YouTube channel.

      scathing, but broadly true...

  21. Oct 2022
  22. Aug 2022
    1. Since 2016, American diplomats in Cuba, Russia, China and elsewhere have experienced "Havana Syndrome," associated with mysterious neurological and brain injuries thought to be inflicted by unknown high-powered microwave or targeted sonic energy systems. Sound wave transmitters are not only psychologically toxic but can cause pain and dizziness, burns, irreversible damage to inner ears and possibly neurological and internal injuries.
  23. Jul 2022
    1. Harold Jarche looked at his most visited blog postings over the years, and concludes his blog conforms to Sturgeon’s Revelation that 90% of everything is crap. I recognise much of what Harold writes. I suspect this is also what feeds impostor syndrome. You see the very mixed bag of results from your own efforts, and how most of it is ‘crap’. The few ‘hits’ for which you get positive feedback are then either ‘luck’ or should be normal, not sparse. Others of course forget most if not all of your less stellar products and remember mostly the ones that stood out. Only you are in a position to compare what others respond to with your internal perspective.

      The cumulative effect of one's perception of Sturgeon's law may be a driving force underlying imposter syndrome.

      While one see's the entirety of their own creation process and realizes that only a small fraction of it is truly useful, it's much harder seeing only the finished product of others. The impression one is left with by availability heuristic is that there are thousands of geniuses in the world with excellent, refined products or ideas while one's own contribution is miniscule in comparison.


      Contrast this with Matt Ridley's broad perspective in The Rational Optimist which shows the power of cumulative breeding and evolution of ideas. One person can make their own stone hand axe, but no one person can make their own toaster oven or computer mouse alone.

      Link to: - lone genius myth (eg. Einstein's special relativity did not spring fully formed from the head of Zeus, there was a long train of work and thought which we don't see the context of)

    1. As the Intergovernmental Panel on Climate Change says in its October 2018 report, keeping global warming below 1.5 C “is possible within the laws of chemistry and physics” but will require “unprecedented changes” before 2030.

      The increasingly dire warnings of scientists are unfortunately increasingly normalized as the unintended consequences of media on human evolutionary propensity to adapt to environmental challenges - the so called "Boiling Frog Syndrome".

  24. May 2022
    1. Common Pitfalls to Avoid When Choosing Your App

      What are the common pitfalls when choosing a note taking application or platform?

      Own your data

      Prefer note taking systems that don't rely on a company's long term existence. While Evernote or OneNote have been around for a while, there's nothing to say they'll be around forever or even your entire lifetime. That shiny new startup note taking company may not gain traction in the market and exist in two years. If your notes are trapped inside a company's infrastructure and aren't exportable to another location, you're simply dead in the water. Make sure you have a method to be able to export and own the raw data of your notes.

      Test driving many

      and not choosing or sticking with one (or even a few)<br /> Don't get stunned into inaction by the number of choices.

      Shiny object syndrome

      is the situation where people focus all attention on something that is new, current or trendy, yet drop this as soon as something new takes its place.<br /> There will always be new and perhaps interesting note taking applications. Some may look fun and you'll be tempted to try them out and fragment your notes. Don't waste your time unless the benefits are manifestly clear and the pathway to exporting your notes is simple and easy. Otherwise you'll spend all your time importing/exporting and managing your notes and not taking and using them. Paper and pencil has been around for centuries and they work, so at a minimum do this. True innovation in this space is exceedingly rare, and even small affordances like the ability to have [[wikilinks]] and/or bi-directional links may save a few seconds here and there, in the long run these can still be done manually and having a system far exceeds the value of having the best system.

      (Relate this to the same effect in the blogosphere of people switching CMSes and software and never actually writing content on their website. The purpose of the tool is using it and not collecting all the tools as a distraction for not using them. Remember which problem you're attempting to solve.)

      Future needs and whataboutisms

      Surely there will be future innovations in the note taking space or you may find some niche need that your current system doesn't solve. Given the maturity of the space even in a pen and paper world, this will be rare. Don't worry inordinately about the future, imitate what has worked for large numbers of people in the past and move forward from there.

      Others? Probably...

    1. software engineers who do web development are by far among the worst at actually evaluating solutions based on their engineering merit

      There's plenty of irrationality to be found in opposing camps, too. I won't say that it's actually worse (because it's not), but it's definitely a lot more annoying, because it usually also carries overtones that there's a sort of well-informed moral and technological high ground—when it turns out it's usually just a bunch of second panel thinkers who themselves don't even understand computers (incl. compilers, system software, etc.) very well.

      This is what makes it hard to have discussions about reforming the practices in mainstream Web development. The Web devs are doing awful things, but at least ~half of the criticism that these devs are actually exposed to ends up being junk because lots of the critics unfortunately just have no fucking idea what they're talking about and are nowhere near the high ground they think they're standing on—often taking things for granted that just don't make sense when actually considered in terms of the technological uppercrust that they hope to invoke. Just a kneejerk "browser = bad" association from people who can't meaningfully distinguish between JS (the language), browser APIs, and the NPM corpus (though most NPM programmers are usually guilty of exactly the same...).

      It's a very "the enemy of my enemy is not my friend" sort of thing.

    1. DICER1 syndrome is an autosomal-dominant,pleiotropic, tumor-predisposition disorder arisingfrom pathogenic germline variants in DICER1, whichencodes an endoribonuclease integral to processingmicroRNAs

      DICER1 is the gene name. PubMed ID, HGCNCID, and Variant: I can't find Inheritance Pattern: autosomal-dominant The disease entity: DICER1 syndrome The type of mutation: germline. Zygosity: not known. Family Information: a family was used, DICER1 carriers, and non DICER1 variant used, some of the family members had tumors from DICER1 Case Information: mean age is 34, the range of age is 18.6 to 43 years, male, and female used, ethnicity can't find Case Presenting HPO: cancer testing, chemotherapy, radiotherapy gnomeAD: 9.2,8.3.2 Mutation type: Pleiotropic, loss of function, missense

  25. Apr 2022
    1. DICER1 syndrome is a rare genetic disorder that predisposes individuals to multiple cancer types

      GeneName: DICER1 PMID (PubMed ID): 29762508 HGNCID: Unavailable Inheritance Pattern: Autosomal Dominant Disease Entity: cancer, rare genetic disorder, pleuroplumonary blastomas, cystic nephroma, rhabdomyosarcoma, multinodular goiter, thyroid cancer, overian Sertoli-Leydig cell tumors, and other meoplasias Mutations: Germline mutations or Somatic mutations Zygosity: Heterozygosity Variant: unregistered Family Information: Cystic nephromas has been reported in approximately 12% of children with pleuripulmonary blastomas or those with a family member with cystic nephroma. Patient with two DICER1 mutations and several of his family members shared these mutations. All members developed a least one type of tumor with differing origins. The patient was an 11-year old boy with a rare Hodgkin lymphoma with DICER1 in 2016. (c.5299delC and c.4616C>T).

  26. Feb 2022
    1. These study guides, which neglect everything before a writingassignment is given, are a little bit like financial advisors who discusshow 65-year-olds can save for retirement. At this point you would bebetter off curbing your enthusiasm (which is exactly what one of themost often sold study guides in Germany recommends: first, loweryour expectations on quality and insight).

      A side benefit of a growing set of notes as an academic is that one has a visible repository of knowledge and ideas as well as fascinating questions which, while they may reveal how much one doesn't know, it will make it apparent how much one does know and thereby mitigate one's feelings of imposter syndrome.

    2. Good students, on the other hand, constantly raise the bar forthemselves as they focus on what they haven’t learned andmastered yet. This is why high achievers who have had a taste ofthe vast amount of knowledge out there are likely to suffer from whatpsychologists call imposter syndrome, the feeling that you are notreally up to the job, even though, of all people, they are (Clance andImes 1978; Brems et al. 1994).

      He's saying here that smart, high achievers are more likely to suffer from imposter syndrome specifically because they've read more broadly and know what they're doing.

      Does the psychology research indicate this? Is there a higher incidence of imposter syndrome at the higher end of the spectrum in part because ones' knowledge of the Known Unknown Framework is dramatically expanded?

      Look into these sources for more detail on this question.

    1. Deepti Gurdasani. (2022, January 29). Going to say this again because it’s important. Case-control studies to determine prevalence of long COVID are completely flawed science, but are often presented as being scientifically robust. This is not how we can define clinical syndromes or their prevalence! A thread. [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1487366920508694529

  27. Jan 2022
  28. Dec 2021
    1. Among the most eloquent commentaries on this wholephenomenon is to be found in a private letter written by BenjaminFranklin to a friend:When an Indian Child has been brought up among us,taught our language and habituated to our Customs, yet ifhe goes to see his relations and make one Indian Ramblewith them there is no persuading him ever to return, andthat this is not natural merely as Indians, but as men, isplain from this, that when white persons of either sexhave been taken prisoner young by the Indians, and livedawhile among them, tho’ ransomed by their Friends, andtreated with all imaginable tenderness to prevail withthem to stay among the English, yet in a Short time theybecome disgusted with our manner of life, and the careand pains that are necessary to support it, and take thefirst opportunity of escaping again into the Woods, fromwhence there is no reclaiming them. One instance Iremember to have heard, where the person was to bebrought home to possess a good Estate; but finding somecare necessary to keep it together, he relinquished it to ayounger brother, reserving to himself nothing but a gunand match-Coat, with which he took his way again to theWilderness.30

      Franklin, Benjamin. 1961 [1753]. Letter to Peter Collinson, 9 May 1753. In Leonard W. Labaree (ed.), The Papers of Benjamin Franklin. New Haven, CT and London: Yale University Press, vol. 4, pp. 481–3.

      Is Stockholm syndrome a temporary or permanent condition? Likely that it's not permanent and that basic lifeways may win out in a switch of lifeways.

    2. The colonial history of Northand South America is full of accounts of settlers, captured oradopted by indigenous societies, being given the choice of wherethey wished to stay and almost invariably choosing to stay with thelatter.

      How is this to be interpreted against the idea of Stockholm syndrome, a condition in which hostages develop a psychological bond with their captors during captivity?

      Were these people actually captives? Could there have been an effect beyond the idea of one way of life being better than another? Are there example in the other direction?

      There's the example in Chagnon's Science paper (1998: 990) in which the nursing student wanted Western culture to visit his Yanomami peoples.

      There are also numerous examples of indigenous Americans being captured by Americans and forced to live a life they didn't want to or choose.

  29. Nov 2021
  30. Oct 2021
  31. Sep 2021
  32. Jul 2021
  33. Jun 2021
    1. Mike: That was going on high school. I think it was my freshman year, because like I said man, it's just all these things that happen to you, there's just only so much you could take to where you're like, "You know what? Eff it." You're just done with everybody and you're just like, "You know what? If life paid me back like this, then why should I care?" You know what I mean? And it makes me feel like inferior at times.Mike: So yeah, I feel like it was around my freshman year, everything started going downhill, because I used to be in events, classes, and all my teachers loved me. I would have conversations like this with my teachers and they'd be amazed sometimes like, "Wow, this kid has so much insight. So much to talk about." And they would always encourage me, but the thing about it is I wouldn't feel like that.

      Time in the US, School, High School, Struggling/ Suspension/ Dropping Out

  34. May 2021
    1. I have received a lot of positive feedback for noting my epistemic status and effort at the top of my posts. This is hilarious, because I originally started using these as a hack in order to publish half-baked ideas that I'd otherwise not feel comfortable sharing.

      This is an interesting hack for getting one to hit the publish button.

      I wonder if people have renamed the "publish" button in their CMS to make hitting it easier?

      My own anecdotal evidence is that hitting it often can certainly make it seem trivial, particularly if one is posting their status updates to their site along with everything else.

      <small><cite class='h-cite via'> <span class='p-author h-card'>Maggie Appleton</span> in A Brief History & Ethos of the Digital Garden (<time class='dt-published'>05/28/2021 18:08:16</time>)</cite></small>

  35. Apr 2021
  36. Mar 2021
    1. People diagnosed with REM sleep behaviour syndrome have an increased risk of developing Parkinson's disease.

      According to this statement, those who are diagnosed with RME sleep behavior syndrome have an increased risk of developing Parkinson’s disease. A number of questions arise from this statement.

      • What are the characteristics of REM sleep behavior syndrome? How does it manifest itself? How often does it manifest itself? Do those individuals in which it manifests itself more frequently have an increased chance of developing Parkinson’s disease?
      • What is the neurological mechanism that is causing REM sleep behavior syndrome? Is the mechanism that is causing this the actual cause of the reduction of dopamine production that is characteristic of Parkinson’s disease?
  37. Feb 2021
  38. Oct 2020
    1. The solution to imposter syndrome is to see that you are one. When I first wrote about how useful it is to remember that everyone is totally just winging it, all the time, we hadn’t yet entered the current era of leaderly incompetence (Brexit, Trump, coronavirus). Now, it’s harder to ignore. But the lesson to be drawn isn’t that we’re doomed to chaos. It’s that you – unconfident, self-conscious, all-too-aware-of-your-flaws – potentially have as much to contribute to your field, or the world, as anyone else.
  39. Aug 2020
    1. Consiglio, C. R., Cotugno, N., Sardh, F., Pou, C., Amodio, D., Zicari, S., Ruggiero, A., Pascucci, G. R., Rodriguez, L., Santilli, V., Tan, Z., Eriksson, D., Wang, J., Lakshmikanth, T., Marchesi, A., Lakshmikanth, T., Campana, A., Villani, A., Rossi, P., … Brodin, P. (2020). The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19. MedRxiv, 2020.07.08.20148353. https://doi.org/10.1101/2020.07.08.20148353

    1. Chen, Y., Yang, W.-H., Huang, L.-M., Wang, Y.-C., Yang, C.-S., Liu, Y.-L., Hou, M.-H., Tsai, C.-L., Chou, Y.-Z., Huang, B.-Y., Hung, C.-F., Hung, Y.-L., Chen, J.-S., Chiang, Y.-P., Cho, D.-Y., Jeng, L.-B., Tsai, C.-H., & Hung, M.-C. (2020). Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 main protease by tafenoquine in vitro. BioRxiv, 2020.08.14.250258. https://doi.org/10.1101/2020.08.14.250258

  40. Jul 2020
  41. Jun 2020
  42. May 2020
  43. Apr 2020
  44. Feb 2020
  45. Apr 2019
  46. Oct 2018
    1. Low BP was more prevalent in subjects with upper airway resistance syndrome (UARS) (23%) than in subjects with obstructive sleep apnea syndrome (OSAS) (0.06%), parasomnia (0.7%), restless leg syndrome (0.9%), or psychological insomnia (0.9%).

      That's an extremely high rate of hypotension in UARS. This may be what I have. If UARS causes hypotension, then sleep apnea (SA) may be different because of its link to obesity.

  47. Feb 2017
  48. Oct 2016
  49. May 2016
    1. Slower metabolisms were not the only reason the contestants regained weight, though. They constantly battled hunger, cravings and binges. The investigators found at least one reason: plummeting levels of leptin. The contestants started out with normal levels of leptin. By the season’s finale, they had almost no leptin at all, which would have made them ravenous all the time. As their weight returned, their leptin levels drifted up again, but only to about half of what they had been when the season began, the researchers found, thus helping to explain their urges to eat.Leptin is just one of a cluster of hormones that control hunger, and although Dr. Hall and his colleagues did not measure the rest of them, another group of researchers, in a different project, did. In a one-year study funded by Australia’s National Health and Medical Research Council, Dr. Joseph Proietto of the University of Melbourne and his colleagues recruited 50 overweight people who agreed to consume just 550 calories a day for eight or nine weeks. They lost an average of nearly 30 pounds, but over the next year, the pounds started coming back.
  50. Aug 2015
    1. Here, on page 2, a study on infrasound conducted by Mr. Richard James is referenced. Mr. Richard James references Nina Pierpont's "Wind Turbine Syndrome" in articles he has written, namely "Wind Turbine Infra and Low-Frequency Sound: Warning Signs That Were Not Heard," see this link. Wind turbine syndrome is not a real medical syndrome, see this link and this link. In fact, Mr. Richard James and his methodologies for measuring sound has been discredited in a Michigan court, see Rick James – A Technical Discussion of His Deposition and Testimony in the Spencer / Kobetz Lawsuit.

      On page 7, we learn that Mr. Richard James trained a field technician to set up sound measuring equipment at a dozen homes within the Shirley Wind Farm. It's unclear if Mr. Richard James was present to ensure set up and staging of equipment was per professional protocol. The trained field technician is stated to live within the Shirley Wind Farm. Mr. Richard James also collected weather data using a website called wonderground.com [sic]. Note that the field technician didn't record weather data via actual observation while domiciled within the Shirley Wind Farm. Also to consider is the likelihood of gaps in the collection of data, "On many occasions, there was an observer recording the events of the turbines..." This sounds fuzzy. Brings doubt to the reliability of collected data.

      On page 13, the Brown County Board of health declares the Shirley Wind Farm a human health hazard.

      As a result of Brown County's declaration, the Governor of Wisconsin will spend $250,000 to study health effects of wind power.

  51. May 2015
    1. When we trivialize learning something new for other people, it sends a message. “This is easy. You should know how to do this. Why don’t you?” It’s demoralizing. If you see someone else struggling, let them know it will be okay and that you’ve been there too. It’s reassuring, as a beginner, to hear that the thing that feels so impossible will one day feel easy.
    2. For me, the feeling went away after I realized, like the Director of Photography, that no one else knew what to do either. I also started to listen to conference talks on my way into work as a way of improving and read a few books in my spare time. I talked to my friends about how I felt and asked for advice.