123 Matching Annotations
  1. Last 7 days
    1. However, its tails are thicker than the normal distribution’s, meaning observations are more likely to fall beyond two standard deviations from the mean than under the normal distribution.

      This is what Dr. Herring meant by "fatter tails."

      Below is why.

  2. Aug 2022
  3. Jun 2022
    1. In the 1920s and ’30s, the NRA was at the forefront of legislative efforts to enact gun control. The organization’s president at the time was Karl T. Frederick, a Princeton- and Harvard-educated lawyer known as “the best shot in America”—a title he earned by winning three gold medals in pistol-shooting at the 1920 Summer Olympic Games. As a special consultant to the National Conference of Commissioners on Uniform State Laws, Frederick helped draft the Uniform Firearms Act, a model of state-level gun-control legislation.
  4. May 2022
    1. DICER1 syndrome encompasses a variety of benign and malignant manifestations including multinodular goitre

      Gene: DICER1 PMCID: PMC8451242 PMID: 34552563 Pathogenic Inheritance Pattern: Autosomal Dominant MultipleDiseaseEntities Disease Entity: DICER1 syndrome, multinodular goitre, cystic nephroma, anaplastic renal sarcoma, Wilms tumour, differentiated thyroid carcinoma, gynandroblastoma, ciliary body medulloepithelioma, embryonal rhabdomyosarcoma, pineoblastoma, pituitary blastoma, kidney cyst, pulmonary cyst, Sertoli-Leydig Cell Tumor. Mutation: Germline MultipleGeneVariants Variant & Clinvar IDs: c.3452_3453del (485534), c.316del (no ClinVar ID), c.171_172insAC (no ClinVar ID), c.3434del (no ClinVar ID), c.988C>T (933007), c.5388dup (no ClinVar ID) Zygosity: None provided. Case: At time of operation, the goitre patients living in Denmark were ages 21, 12, 21, 8, 14, and 16. Four underwent total thyroidectomies, and two underwent partial thyroidectomies. The patient originally aged 21 previously had a kidney cyst at age 14 and a pulmonary cyst at an unknown age. The patient aged 14 at time of partial thyroidectomy later manifested a Sertoli-Leydig Cell Tumor at age 15. All six patients were female. CasePresentingHPO: None provided. CasePreviousTesting: thyroidectomy gnomAD: ENSG00000100697.10, https://gnomad.broadinstitute.org/gene/ENSG00000100697 Mutation Type: Frameshift, Nonsense

    1. DICER1 syndrome is an autosomal-dominant, pleiotropic, tumor-predisposition disorder arising from pathogenic germline variants in DICER1, which encodes an endoribonuclease integral to processing microRNAs (1).

      Gene Name: DICER1 PMCID: PMC5443331 PMID: 28323992 HGNCID: not found Inheritance Pattern: autosomal dominant Disease Entity: thyroid cancer and familial multinodular doiter Mutation: germline loss-of-function mutation Zygosity: not provided Variant: c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.1870C>T; p.Arg624a, c.3726C>A; p.Tyr1242a, c.3675C>G; p.Tyr1225a, c.3675C>G; p.Tyr1225a Family Information: 145 individuals with a DICER1 germline mutation and 135 controls from 48 families Case: family members used; both males and females used and no significant differences seen among sex; ages range from 20-40 with carriers being significantly younger than controls; no significant differences seen among ethnicity but participants located from the US, UK, and Great Britain CasePresentingHPOs: thyroid cancer or MNG diagnosis common to those with a DICER! mutation but with no chemotherapy or radiation treatment yet CasePreviousTesting: tested levels of thyroid-stimulating hormone, thyroxine, thyroxine-binding globulin, and serum albumin; thyroid palpation; thyroid ultrasound; Sanger or next-generation sequencing assays gnomAD: n/a Mutation Type: missense

  5. Apr 2022
    1. Payne, R. P., Longet, S., Austin, J. A., Skelly, D. T., Dejnirattisai, W., Adele, S., Meardon, N., Faustini, S., Al-Taei, S., Moore, S. C., Tipton, T., Hering, L. M., Angyal, A., Brown, R., Nicols, A. R., Gillson, N., Dobson, S. L., Amini, A., Supasa, P., … Zawia, A. A. T. (2021). Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine. Cell, 184(23), 5699-5714.e11. https://doi.org/10.1016/j.cell.2021.10.011

    1. Edward Nirenberg 🇺🇦 [@ENirenberg]. (2021, November 30). This is also not limited to the vaccine- any infection we encounter will do the same thing. It’s how we evolved to get around a massive genetic and bioenergetic challenge and it’s brilliant and it’s happening all the time regardless of any vaccines we get. [Tweet]. Twitter. https://twitter.com/ENirenberg/status/1465698637434933254

    1. In this case, for a test to be statistically significant, p-value must be lower than 0.05.

      statistical significance should be less than 5%

      tf your confidence that the results are not due to chance is 95%

    1. We are 99% confident that the true average “attitude” difference betweenliving environments is between 1.32 and 7.88. At a significance level of 0.01we can say that living in a minority environment is associated with higherscore

      99% confident that the true average (result) is between these two numbers;

      at 1% (0.01) significance, we can scientifically assume there is a causal relationship

  6. Mar 2022
    1. Bellesi, S., Metafuni, E., Hohaus, S., Maiolo, E., Marchionni, F., D’Innocenzo, S., La Sorda, M., Ferraironi, M., Ramundo, F., Fantoni, M., Murri, R., Cingolani, A., Sica, S., Gasbarrini, A., Sanguinetti, M., Chiusolo, P., & De Stefano, V. (2020). Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients. British Journal of Haematology, 191(2), 207–211. https://doi.org/10.1111/bjh.17034

    1. Eric Topol. (2022, February 28). A multimodal #AI study of ~54 million blood cells from Covid patients @YaleMedicine for predicting mortality risk highlights protective T cell role (not TH17), poor outcomes of granulocytes, monocytes, and has 83% accuracy https://nature.com/articles/s41587-021-01186-x @NatureBiotech @KrishnaswamyLab https://t.co/V32Kq0Q5ez [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1498373229097799680

  7. Feb 2022
  8. Jan 2022
    1. Paolucci, S., Cassaniti, I., Novazzi, F., Fiorina, L., Piralla, A., Comolli, G., Bruno, R., Maserati, R., Gulminetti, R., Novati, S., Mojoli, F., Baldanti, F., Bruno, R., Mondelli, M., Brunetti, E., Matteo, A. D., Seminari, E., Maiocchi, L., Zuccaro, V., … Ferrari, A. (2021). EBV DNA increase in COVID-19 patients with impaired lymphocyte subpopulation count. International Journal of Infectious Diseases, 104, 315–319. https://doi.org/10.1016/j.ijid.2020.12.051

    1. Townsend, L., Dyer, A. H., Naughton, A., Kiersey, R., Holden, D., Gardiner, M., Dowds, J., O’Brien, K., Bannan, C., Nadarajan, P., Dunne, J., Martin-Loeches, I., Fallon, P. G., Bergin, C., O’Farrelly, C., Cheallaigh, C. N., Bourke, N. M., & Conlon, N. (2021). Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health. Frontiers in Immunology, 12. https://www.frontiersin.org/article/10.3389/fimmu.2021.676932

    1. In his article, Gorbachev says that perestroika was meant for the people and that its goal was to emancipate human beings to give people ownership of their lives and of their country. This stood out to me because the believed it was right to give people freedom which is a great point.

  9. Dec 2021
    1. Heitmann, J. S., Bilich, T., Tandler, C., Nelde, A., Maringer, Y., Marconato, M., Reusch, J., Jäger, S., Denk, M., Richter, M., Anton, L., Weber, L. M., Roerden, M., Bauer, J., Rieth, J., Wacker, M., Hörber, S., Peter, A., Meisner, C., … Walz, J. S. (2021). A COVID-19 peptide vaccine for the induction of SARS-CoV-2 T cell immunity. Nature, 1–9. https://doi.org/10.1038/s41586-021-04232-5

  10. Nov 2021
    1. I have used the Oxford text of T. W. Allen, 2nd edition, and followed itexcept in a very few places

      The source of the translation of the Odyssey by Richmond Lattimore is the 2nd edition of the Oxford text of T. W. Allen.

  11. Sep 2021
    1. John Burn-Murdoch. (2021, August 23). NEW: in the last couple of weeks there have a lot of new studies out assessing vaccine efficacy, many of which have touched on the question of waning immunity. Unsurprisingly, these have prompted a lot of questions. Time for a thread to summarise what we do and don’t know: [Tweet]. @jburnmurdoch. https://twitter.com/jburnmurdoch/status/1429878189011111936

  12. Jul 2021
  13. Jun 2021
    1. Parry, H. M., Tut, G., Faustini, S., Stephens, C., Saunders, P., Bentley, C., Hilyard, K., Brown, K., Amirthalingam, G., Charlton, S., Leung, S., Chiplin, E., Coombes, N. S., Bewley, K. R., Penn, E. J., Rowe, C., Otter, A., Watts, R., D’Arcangelo, S., … Moss, P. (2021). BNT162b2 Vaccination in People Over 80 Years of Age Induces Strong Humoral Immune Responses with Cross Neutralisation of P.1 Brazilian Variant. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3816840

  14. May 2021
  15. Apr 2021
  16. Mar 2021
    1. In the late 1960s and early ’70s, he liked to tweak his critics by wearing a T-shirt that read “Minor Regional Novelist.”

      I want a shirt like this!

    1. Buss, Lewis F., Carlos A. Prete, Claudia M. M. Abrahim, Alfredo Mendrone, Tassila Salomon, Cesar de Almeida-Neto, Rafael F. O. França, et al. ‘Three-Quarters Attack Rate of SARS-CoV-2 in the Brazilian Amazon during a Largely Unmitigated Epidemic’. Science 371, no. 6526 (15 January 2021): 288–92. https://doi.org/10.1126/science.abe9728.

  17. Feb 2021
    1. When T-Cells are activated they release cytokines (yes, that cytokine), which trigger additional T-Cells to be made, which then release even more cytokines. One type of T-cells that are created are called cytotoxic T-cells. Cytotoxic T-cells are the cells that are able to roam the body and mercy kill infected cells who are chemically calling out to be killed and ideally to stop the increased production of viruses like COVID-19.
  18. Jan 2021
    1. Learners’ practices, for example, should develop from low-level procedures such as sharing initial ideas to mid-level comparing and evaluatingsequences and eventually toward high-level challenging/debating and synthesizingroutines.

      The surface to in-depth learning. Related to Expansive framing written by Andrews et al.

    2. identify invariant (i.e., constant) characteristics of subsequent transfer domains

      The "bone" of the body. In the design of social annotation activities, what are the bones?

  19. Dec 2020
  20. www.investopedia.com www.investopedia.com
    1. Essentially, a t-test allows us to compare the average values of the two data sets and determine if they came from the same population.

      Comparing datasets to see if they came from the same population.

  21. Oct 2020
  22. Sep 2020
    1. Come, Shamhat, 1 will fix your destiny,

      It shows the confident.

    2. [who] knew ... , was wise in all matters!

      Was the author meant Gilgamesh?

    1. Le Bert, N., Tan, A. T., Kunasegaran, K., Tham, C. Y. L., Hafezi, M., Chia, A., Chng, M. H. Y., Lin, M., Tan, N., Linster, M., Chia, W. N., Chen, M. I.-C., Wang, L.-F., Ooi, E. E., Kalimuddin, S., Tambyah, P. A., Low, J. G.-H., Tan, Y.-J., & Bertoletti, A. (2020). SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. Nature, 584(7821), 457–462. https://doi.org/10.1038/s41586-020-2550-z

  23. Aug 2020
    1. Mateus, J., Grifoni, A., Tarke, A., Sidney, J., Ramirez, S. I., Dan, J. M., Burger, Z. C., Rawlings, S. A., Smith, D. M., Phillips, E., Mallal, S., Lammers, M., Rubiro, P., Quiambao, L., Sutherland, A., Yu, E. D., Antunes, R. da S., Greenbaum, J., Frazier, A., … Weiskopf, D. (2020). Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science. https://doi.org/10.1126/science.abd3871

    1. Ferretti, A. P., Kula, T., Wang, Y., Nguyen, D. M., Weinheimer, A., Dunlap, G. S., Xu, Q., Nabilsi, N., Perullo, C. R., Cristofaro, A. W., Whitton, H. J., Virbasius, A., Olivier, K. J., Baiamonte, L. B., Alistar, A. T., Whitman, E. D., Bertino, S. A., Chattopadhyay, S., & MacBeath, G. (2020). COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2. MedRxiv, 2020.07.24.20161653. https://doi.org/10.1101/2020.07.24.20161653

  24. Jun 2020
  25. May 2020
    1. Grifoni, A., Weiskopf, D., Ramirez, S. I., Mateus, J., Dan, J. M., Moderbacher, C. R., Rawlings, S. A., Sutherland, A., Premkumar, L., Jadi, R. S., Marrama, D., de Silva, A. M., Frazier, A., Carlin, A., Greenbaum, J. A., Peters, B., Krammer, F., Smith, D. M., Crotty, S., & Sette, A. (2020). Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals. Cell, S0092867420306103. https://doi.org/10.1016/j.cell.2020.05.015

  26. Apr 2020
  27. Dec 2019
    1. On-Demand T-shirt Printing - A New Business Idea To Lead the Market

      On-demand t-shirt printing is the best business you can have these days. With innovating business ideas and perfect marketing strategies, you can make your business successful in lesser time.

    1. Best Freelancing Websites for Graphic Designers [Top 5]

      Today designers can build their careers easily in the graphics design field if they follow proper path and focus. There are many graphics designing companies and websites that hire graphic designers as remote or inhouse to work for them.

  28. Oct 2019
    1. Let's make the example even easier. function convertDate<T extends string | undefined>(isoDate?: string): T { return undefined } 'undefined' is assignable to the constraint of type 'T' Means: What you return in the function (undefined), matches the constraints of your generic type parameter T (extends string | undefined). , but 'T' could be instantiated with a different subtype of constraint 'string | undefined'. Means: TypeScript does not consider that as safe. What if you defined your function like this at compile time: // expects string return type according to generics // but you return undefined in function body const res = convertDate<string>("2019-08-16T16:48:33Z") Then according to your signature, you expect the return type to be string. But at runtime that is not the case! This discrepancy that T can be instantiated with a different subtype (here string) than you return in the function (undefined) is expressed with the TypeScript error.
    1. In the body of the function you have no control over the instantiation by the calling context, so we have to treat things of type T as opaque boxes and say you can't assign to it. A common mistake or misunderstanding was to constraint a type parameter and then assign to its constraint, for example: function f<T extends boolean>(x: T) { x = true; } f<false>(false); This is still incorrect because the constraint only restricts the upper bound, it does not tell you how precise T may really be.
  29. Feb 2019
    1. he names of simple ideas tlie least doubtful. c8. Fr

      So, Locke is trying to establish somewhat of a hierarchy of language based in clarity. Names of simple substances are closest to the Truth of the substance. "Philosophical" words are furthest from Truth because what the concepts/things they represent are most difficult to nail down. I wonder, then, if we can translate this to exploring the human--do we have a hierarchy of understanding? Or a hierarchy of Truest representation?

    2. no-body having an authority to establish the precise signification of words,

      While Locke seems to favor the capital T Truth, he here says that nobody is the authority on it.

    3. certain and undoubted

      "Certain and undoubted" brings to mind the classical sense of logos, where it's meaning isn't logic or reasoning (as we tend to think of it now) but is more about the commonly accepted truth. It's a truth that people believe--but that doesn't make it correct. Locke undoubtedly is not intending this meaning but is instead calling for an objective Truth.

    4. nonrelativistic view of knowledge.

      Objective knowledge of Truth

    5. incomplete or inaccurate idea

      Incomplete or inaccurate according to whom? Some objective Truth?

    1. Among athousand different opinions which different menmay entenain of the same subject, there is one,and but one, that is just and true;

      Aaaand there we have it, the rejection of relativism that was also in Locke. "Come, John! There is one Truth and we must seek it out!"

    1. indb-•i' putablc truth

      The belief in capital T truth strikes again. For the Greeks, search for Truth was under the purview of the philosophers; here, it's sought by practitioners of science. Interesting parallels between scientists and philosophers.

  30. Jan 2019
    1. where no clear 1ruth was availahlc

      When there's no Truth (in subjective situations), rhetoric comes to the rescue.

    1. truth and Truth,
    2. prove

      Interesting that there's this call for "proof," some form of evidence, something tangible that we can point to. Such a desire feels very objective, as though there's some Truth this proof will point to. What would such proofs be?

  31. Sep 2018
    1. rigid schedules

      Improve practices for scheduling that take into account workers needs

    2. commute

      Assessment and implementation of protective measures for long commutes particularly those linked to long hours of work to avoid safety risks

    3. share agreement

      Adoption of mechanisms like the "Fair Share Agreement" in B.C. or similar to get funds for improving infrastructure in municipalities and regions.

    4. availability of housing

      Improve the need of affordable housing in host, hub and source communities

    5. travel

      Improve information for LDLC workers about travel; assess the existing gaps to protect workers during their work related travel and develop or improve the tools for their protection

    6. information LDLC workers

      Improve information for LDLC workers about their rights related to OH&S and WC

    7. Lack of metrics

      Develop or strengthen statistical information of new industry developments, ups and downs of existing industries.

    8. welfare support

      Implement a timely response of welfare support linked to slow-downs of industries that involve numerous workers in given communities

    9. mental health and addiction services

      Assess the prevalence and incidence of mental health issues and addictions and establish sufficient services for caring and prevention. This phenomena affect workers, their families and communities.

    10. medical care

      Improve medical care infrastructure and inter-provincial agreements to be able to cover LC-LD workers and their families in source, host and hub communities in a timely manner. the improvement of such services should be flexible enough to adapt to the ups and downs of the predominant industries.

    11. environmental impacts

      Improve environmental assessments in the planning stages of industrial and housing developments in source, host and hub communities

    12. community participation

      Establishment of bodies and paths for community participation in the development of new industrial activities and the assessments of their needs imposed by the labour market linked to the industry and its ups and downs.

    13. prior preparation

      Anticipation through planning of community needs due to new developments and ups and downs of predominant industries for example mining.

    14. transportation in Greater Toronto

      Improve urban and peri-urban transportation for LC workers particularly those with low income

    15. improving infrastructure

      Improve infrastructure in the host and hub communities according to the needs imposing by industrial developments

    16. child care

      Improve child care services for LC workers particularly those with low income

    17. Child and elder care

      Improve in a timely manner services of child and elder care according to the needs imposed by the labour market (work shifts; LD-LC work).

    18. Transportation

      Improve in a timely manner transportation services according to the needs of LDLC workers taking into account those with low income.

    19. LDLC workers and their needs

      Develop or strengthen statistics regarding LDLC workers and their needs

    20. housing, infrastructure

      Anticipation to fulfill housing needs and assessment of the ups and downs of the industry that affect the housing needs. Decisions should be taken about short, medium and long term needs.

    21. infrastructure

      Timely response for the maintenance of roads and development of new routes when needed according to the traffic needs due to industrial developments and labour market that involve drive-in drive-out mobility and heavy transit during construction phase

  32. Aug 2018
    1. Contributions to the practice and theory of teaching and learning literature, including publications in peer-reviewed and professional journals, conference publications, book chapters, textbooks and open education repositories/resources.

      P&T language supporting Open activities

  33. Nov 2017
    1. Toxoplasmosis is caused by the obligate intracellular parasite, Toxoplasma gondii. Its life cycle consists of 3 forms, including an oocyst, a tissue cyst, and an active (proliferative) form.

      See also: CDC- Toxoplasmosis

      Toxoplasmosis

      Source of Infection in humans:

      1. Eating under cooked meat of animals harboring tissue cysts
      2. Consuming food or water contaminated with cat feces or by contaminated environmental samples (such as fecal-contaminated soil or changing the litter box of a pet cat)
      3. Blood transfusion or organ transplantation
      4. Transplacentally from mother to fetus

      Sources of T. gondi infection

      Life cycle of T. gondi

  34. Oct 2017
  35. May 2017
  36. Feb 2017
    1. Dinosaur 13 tells the story of a group of geologists, led by Peter Larson, who dug up the largest Tyrannosaurus Rex skeleton ever found.

      Saw her!

  37. Jan 2017
  38. Oct 2016
  39. Sep 2016
  40. Jul 2016
  41. Jun 2016