Imagine an associate with a photographic memory and excellent pattern recognition who digested and analyzed millions of cases. Would you want that associate working for you for less than the price of one typical billable hour every month?

We long ago admitted that we’re poor at scheduling, so we have roosters; sundials; calendars; clocks; sand timers; and those restaurant staff who question my integrity, interrupting me with a phone call under the premise of “confirming” that I’ll stick to my word regarding my reservation.

A closely-related failing to scheduling is our failure to remember, so humans are very willing to save information on their computers for later.

sequential lineage tracing studies aimed at unraveling the relationships between cellular precursors and mature cell types

His answer is that our creative minds are being strengthened rather than atrophied by the ability to interact easily with the Web and Wikipedia. “Not only has transactive memory not hurt us,” he writes, “it’s allowed us to perform at higher levels, accomplishing acts of reasoning that are impossible for us alone.”

Socrates and his prediction that writing would destroy the Greek tradition of dialectic. Socrates’ primary concern was that people would write things down instead of remembering them. “This discovery of yours will create forgetfulness in the learners’ souls, because they will not use their memories,” Plato quotes him as saying. “They will trust to the external written characters and not remember of themselves.”

It is challenging to study how pneumococci control virulence factor expression, because cues of natural environments and the presence of an immune system are difficult to simulate in vitro

With this approach, neurons that show E-SARE–driven expression in response to stimuli are permanently labeled by the fluorescent protein during the time window specified by the drug

Expression of a drug-inducible Cre recombinase downstream of E-SARE enabled imaging of neuronal populations that respond to monocular visual stimulation and tracking of their long-distance thalamocortical projections in living mice

The feedback loop permits sustained induction of recombinant proteins without massive quantities of inducer.

in the absence of tamoxifen, it exhibits some activity

A technique common in rodents is the use of Cre recombinase lines that are inducible at specific developmental time points (Figure 3b). The most common form of inducible Cre is CreERT2, which contains a modified estrogen receptor binding domain that prevents Cre from entering the nucleus in the absence of a ligand

strong promoters capable of driving expression of microbial opsins or fluorescent proteins in specific populations can exhibit leaky expression elsewhere. This low-level leak may be virtually undetectable as light responsiveness or fluorescence but can be a serious issue when expressing Cre recombinase.

creating improved technologies for large-scale recordings of neural activity in the live brain is a crucial goal in neuroscience

new toolkits for chronic labeling of active ensembles will provide a much awaited experimental basis to interrogate various aspects of neuronal circuits underlying long-term plastic changes of the brain, such as during nervous system development, during establishment of long-lasting remote memory over months, or in association with age-related neuronal changes over several years.

new direction of functional labeling involves conversion of transient expression from activity-dependent promoters into a permanent labeling based on tamoxifen-dependent recombinases

This gene fusion approach will allow us to assay the induction of gene expression in as few as one cell

recording past events, to study localization of single-cell transcriptional events within the gut

Now we can ask, ‘Have I seen iron at some threshold?’ ‘Have I seen some nitrate?’ And have every microbe write it down. As one thinks about long-term incubation, this is a really powerful tool, because even six months later we can pull out the DNA and see what happened.”

Growth history influences starvation-induced expression of uspA, grpE, and rpoS and subsequent cryotolerance in Escherichia coli O157:H7

in E. coli a form of ‘memory’ of past phosphate limitation leads to a faster response to successive periods of phosphate limitation, and that this faster response may be survival enhancing

Researchers could use the method to study poorly-understood aspects of the sulfur cycle or bacterial methane production

these technologies all require destruction of samples and prevent us from analyzing dynamic changes in molecular profiles, phenotypes, and behaviors of individual cells in a complex system

Live cell imaging is capable of analyzing spatiotemporal dynamics of molecules and cells with fluorescent proteins or probes, but only for a limited number of objects, which can be observed by microscopy

The psychological Interpretation according to which the “I” has something ‘in the memory’ [“im Gedächtnis”] is at bottom a way of alluding to the existentially constitutive state of Being-in-the-world.

The genetic/epigenetic relation is a dimension of différance qua the history of life. The question then is that of a specification of différance differing and deferred, of the possibility of such specification, if it is true that Leroi-Gourhan’s major point consists in putting into question a clear break between the animal and the human. His way of broaching this problem brings him back, in the final analysis, to the heart of a simple opposition, albeit one shifted to the also quite traditional level of faber/sapiens. He is brought back in the same stroke (the coup of the second origin) to the metaphysics of an opposition between the inside and the outside, the before and the after, of the animal human and the spiritual human, and so on. We are trying to preserve and to broach the aporetic impossibility of simply opposing the interior to the exterior in speaking of an instrumental maieutics that alone permits an understanding of how tools do not derive from a creation or from a consciousness present to itself, master of matter, but pursue a process engaged long before the rupture yet nevertheless constitute a rupture— a new organization of différance, a différance of différance. Now, if the central concept is in fact that of epiphylogenetic memory, allowing for both the contestation of oppositions and the description and preservation of differentiations, it does not seem to us to have any equivalent in grammatological deconstructions. We shall develop this question further on the level of linear writing. Without such a concept, it seems to us impossible to specify the différance, differing and deferring, with respect to différance in general qua the history of life in general, or to say what the human is or is not. We are left: with the ambiguity of the invention of the human, that is, of the subject of the verb “to invent,” that which holds together the who and the what, as being that which binds them while separating them; this is, then, différance— this double movement, this intersection of reflection, this reflecting whereby the who and the what are constituted as the twin faces of the same phenomenon.

a high-fidelity memory device might allow researchers to identify cell populations responsive to specific events and track their progression through the cellular response

suggested that low basal expression coupled with switch-like activation is required to maintain memory; growth rate was also found to significantly impact memory loop protein sustainability following cell division.

Transcripts with more polyadenylation are more likely to be translated compared to those without

bistable autoregulatory transcriptional feedback

using recombinases can be challenging because their reactions are slow (requiring 2–6 h) and often generate mixed populations when targeting a multicopy plasmid

This supplemented the individual's memory and ability to visualize. (We are not concerned here with the value derived from human cooperation made possible by speech and writing, both forms of external symbol manipulation. We speak of the manual means of making graphical representations of symbols—

symbolic portrayal

they are not meant to be substituted for a recollection that may fail. They constitute, rather, a material and a framework for exercises to be carried out frequently: reading, rereading, meditating, conversing with oneself and with others.

notebooks serving as memory aids. Their use as books of life, as guides for conduct

Our extensions also have implications for theories ontrust.

Therefore, training should focus on learning how toquickly recognize volunteers’ volition in participating inan emergent group, the tasks they might engage in, andthe support they might need to carry out those tasks.Such training could also help people to recognize thebenefits and dangers of generalized trust. It could alsohelp people to quickly evolve a coordination mecha-nism that does not rely on what people know, but oncompiling and communicating a narrative of the actionsthat volunteers take, so that others are able to assess forthemselves what actions they could take to help.

ur examination suggests that by expandingthe context in which TMS theory is applied to includeemergent response groups, insights can be gained intotheir internal dynamics. The three indicators of the levelof development of a TMS provide a useful frameworkfor organizing these insights in the exhibit.

The urgency of time may make it too onerous forthe extra effort of articulating actions as they are beingperformed, yet most emergency response requires somecommunication.

Explicitly articulated narratives mayalso make clearer that multiple sequences of actions maybe occurring simultaneously, thus resolving role conflictsby allowing multiple ways to accomplish a task

Emergent response groups may also use a mechanismof creating a community narrative (Boland and Tenkasi1995), which is a running narrative of the actions takenand not taken, the decisions made, and the theories inuse. Narratives do not represent a single shared under-standing of a domain; rather they represent the mul-tiplicity of events and actions a community is taking,as members are taking them. Narratives may be articu-lated explicitly or understood implicitly.

Whenemergent response groups first come together, membersare likely not to ask one another about who knows what;instead, they are likely to ask about what is knownabout the situation and about the actions taken thus far(Dyer and Shafer 2003, Hale et al. 2005). The cogni-tive structure that they develop for the group centersnot around people, but on action-based scenarios thateither have been or might be carried out. These scenariosinclude decisions, actions, knowledge, events, and feed-back (Vera and Crossan 2005).

On the surface, the lack of sta-ble membership suggests that a shared mental modelmay not be viable or even desired in emergent responsegroups. Time may be too precious to seek consensus onevents and actions, and agreements may make the groupless flexible to accommodate to changing inputs.

hus, we believe challenges occur in all three indica-tors of the level of development of a TMS—expertisespecialization, credibility, and expertise coordination—requiring a need to consider extending theorizing abouteach indicator for emergent response groups.

Moreland and Argote(2003) suggest that the dynamic conditions under whichthese groups form and work together are likely to havenegative effects on the development of transactive mem-ory.

Research on TMS has identified three indicators of thelevel of development of a TMS (Lewis 2003, Morelandand Argote 2003):1.Memory (or expertise) specialization:the tendencyfor groups to delegate responsibility and to specialize indifferent aspects of the task;2.Credibility:beliefs about the reliability of mem-bers’ expertise; and3.Task (or expertise) coordination:the ability of teammembers to coordinate their work efficiently based ontheir knowledge of who knows what in the group.The greater the presence of each indicator, the more de-veloped the TMS and the more valuable the TMS is forefficiently coordinating the actions of group members.

A TMS can be thoughtof as a network of interconnected individual memorysystems and the transfer of knowledge among them(Wegner 1995). Individuals who are part of a TMSassume responsibility for different knowledge domains,and rely on one another to access each other’s expertiseacross domains. Expertise is defined in the TMS litera-ture to broadly include the know-what, know-how, andknow-why of a knowledge domain (Quinn et al. 1996),what Blackler (1995) refers to as embodied competen-cies. Expertise specialization, then, reduces the cognitiveload of each individual and the amount of redundantknowledge in the group, while collectively providingthe dyad or group access to a larger pool of knowl-edge. What makes transactive memory transactive arethe communications (called transactions) among individ-uals that make possible the codifying, storing, retrieving,and updating of information from individual memorysystems. For transactive memory to function effectively,individuals must have a shared conceptualization of whoknows what in the group.

TMS theory, a theoryof group-level cognition, explains how people in collec-tives learn, store, use, and coordinate their knowledge toaccomplish individual, group, and organizational goals.It is a theory about how people in relationships, groups,and organizations learn who knows what, and use thatknowledge to decide who will do what, resulting in moreefficient and effective individual and collective perfor-mance.

Alzheimer's disease (AD) is not normally diagnosed until later in life, although evidence suggests that the disease starts at a much earlier age. Risk factors for AD, such as diabetes, hypertension and obesity, are known to have their affects during mid-life, though events very early in life, including maternal over-nutrition, can predispose offspring to develop these conditions. This study tested whether over-nutrition during pregnancy and lactation affected the development of AD in offspring, using a transgenic AD mouse model. Female triple-transgenic AD dam mice (3xTgAD) were exposed to a high-fat (60% energy from fat) or control diet during pregnancy and lactation. After weaning (at 3 weeks of age), female offspring were placed on a control diet and monitored up until 12 months of age during which time behavioural tests were performed. A transient increase in body weight was observed in 4-week-old offspring 3xTgAD mice from dams fed a high-fat diet. However, by 5 weeks of age the body weight of 3xTgAD mice from the maternal high-fat fed group was no different when compared to control-fed mice. A maternal high-fat diet led to a significant impairment in memory in 2- and 12-month-old 3xTgAD offspring mice when compared to offspring from control fed dams. These effects of a maternal high-fat diet on memory were accompanied by a significant increase (50%) in the number of tau positive neurones in the hippocampus. These data demonstrate that a high-fat diet during pregnancy and lactation increases memory impairments in female 3xTgAD mice and suggest that early life events during development might influence the onset and progression of AD later in life.

the Dr. Memory directory inside your profile directory

The fact that stimuli that have high association values are easily learned and remembered means that it is easier to learn new meanings for stimuli that already have multiple meanings;

it is much easier to remember places, objects, or rooms in a building by name than by number, because names have higher association values than numbers.

How to Determine the Amount of RAM Slots In Use?

all his memories of the days when Odette had been in love with him, which he had succeeded, up till that evening, in keeping invisible in the depths of his being, deceived by this sudden reflection of a season of love, whose sun, they supposed, had dawned again, had awakened from their slumber, had taken wing and risen to sing maddeningly in his ears, without pity for his present desolation, the forgotten strains of happiness.

Some people think that these system calls are a good way to improve the performance of a high-performance process on a system. A common use case I’ve seen in the real world is to try to call mlockall() on a program that’s supposed to running with very high performance. The reasoning is that if the program is paged out to disk, that will reduce performance; therefore mlockall() will improve things.If you try to actually use mlockall() in this way you might run into some difficulties because most systems have a very low default ulimit on the number of pages a process can lock. With some twiddling of the default ulimits you can get this working, but perhaps it’s worth considering why the default ulimits are so low in the first place.

Quoting Media Theorist & philosopher Wolfgang Ernst on his concept of processual memory: “The web provides immediate feedback, turning all present data into archival entries and archival entries into data – a dynamic agency, with no delay between memory and the present. Archive and memory become meta-phorical; a function of transfer pro-cesses.”, which Ernst describes as an economy of circulation – permanent transformations and updating. There are no places of memory, Ernst states, there are simply urls. In other words; digital memory is built from its archi-tecture, it is embedded in the network and constituted from how it links from one to another.

The result of this externalization, Blair notes, is that we come to think of long-term memory as something that is stored elsewhere, in “media outside the mind.” At the same time, she writes, “notes must be rememorated or absorbed in the short-term memory at least enough to be intelligently integrated into an argument; judgment can only be applied to experiences that are present to the mind.”

required by Java

the longer must the mind be exerted in carrying forward the qualifying mem-ber ready for use.

Usually, learning immediately after training is so unstable that it can be disrupted by subsequent new learning until after passive stabilization occurs hours later

memory under the domain of rhetoric either.

memory is a link not just with earthly places but with those heavenly places where ideal fonns and true knowledge reside.

London Bridge is falling down falling down falling down

maternal lamentation

Is the internet killing our brains?

If "social memory" can be defined as "how and what social groups remember," then digital culture, as Richard Rinehart and Jon Ippolito point out, changes both the how and the what of social memory.

The term “testing” evokes a certain response from most of us: the person being tested is being evaluated on his or her knowledge or understanding of a particular area, and will be judged right or wrong, adequate or inadequate based on the performance given. This implicit definition does not reflect the settings in which the benefits of “test-enhanced learning” have been established.

Setting aside the last few minutes of a class to ask students to recall, articulate, and organize their memory of the content of the day’s class may provide significant benefits to their later memory of these topics.

This theory posits that memory has two components: storage strength and retrieval strength. Retrieval events improve storage strength, enhancing overall memory, and the effects are most pronounced at the point of forgetting—that is, retrieval at the point of forgetting has a greater impact on memory than repeated retrieval when retrieval strength is high.

L’analogico richiede una cultura del registrare e dunque uno sforzo per incidere qualcosa su pietra, argilla, papiro, pergamena o carta. Il digitale richiede una strategia del dimenticare; oggi tutto viene registrato automaticamente e ogni tanto bisogna fare uno sforzo per togliere, eliminare.

digital memory systems radically augment the scope and dura- tion of personal ritemory far beyond the lifespan of the person in question

Lethe (Leith)

FTT, as it applies to reasoning, is adapted from dual process models of human cognition. It differs from the traditional dual process model in that it makes a distinction between impulsivity and intuition—which are combined in System 1 according to traditional dual process theories—and then makes the claim that expertise and advanced cognition relies on intuition.[57] The distinction between intuition and analysis depends on what kind of representation is used to process information. The mental representations described by FTT are categorized as either gist or verbatim representations: Gist representations are bottom-line understandings of the meaning of information or experience, and are used in intuitive gist processing. Verbatim representations are the precise and detailed representations of the exact information or experience, and are used in analytic verbatim processing.

When people try to remember past events (e.g., a birthday party or the last dinner), they often commit two types of errors: errors of omission and errors of commission.

Having made these points many times in the last few years, I've realized that the fundamental problem is in the mistaken belief that the type system has anything whatsoever to do with the storage allocation strategy. It is simply false that the choice of whether to use the stack or the heap has anything fundamentally to do with the type of the thing being stored. The truth is: the choice of allocation mechanism has to do only with the known required lifetime of the storage.

Now compare this to the stack. The stack is like the heap in that it is a big block of memory with a “high water mark”. But what makes it a “stack” is that the memory on the bottom of the stack always lives longer than the memory on the top of the stack; the stack is strictly ordered. The objects that are going to die first are on the top, the objects that are going to die last are on the bottom. And with that guarantee, we know that the stack will never have holes, and therefore will not need compacting. We know that the stack memory will always be “freed” from the top, and therefore do not need a free list. We know that anything low-down on the stack is guaranteed alive, and so we do not need to mark or sweep.

When a garbage collection is performed there are three phases: mark, sweep and compact. In the “mark” phase, we assume that everything in the heap is “dead”. The CLR knows what objects were “guaranteed alive” when the collection started, so those guys are marked as alive. Everything they refer to is marked as alive, and so on, until the transitive closure of live objects are all marked. In the “sweep” phase, all the dead objects are turned into holes. In the “compact” phase, the block is reorganized so that it is one contiguous block of live memory, free of holes.

If we’re in that situation when new memory is allocated then the “high water mark” is bumped up, eating up some of the previously “free” portion of the block. The newly-reserved memory is then usable for the reference type instance that has just been allocated. That is extremely cheap; just a single pointer move, plus zeroing out the newly reserved memory if necessary.

The idea is that there is a large block of memory reserved for instances of reference types. This block of memory can have “holes” – some of the memory is associated with “live” objects, and some of the memory is free for use by newly created objects. Ideally though we want to have all the allocated memory bunched together and a large section of “free” memory at the top.

I blogged a while back about how “references” are often described as “addresses” when describing the semantics of the C# memory model. Though that’s arguably correct, it’s also arguably an implementation detail rather than an important eternal truth. Another memory-model implementation detail I often see presented as a fact is “value types are allocated on the stack”. I often see it because of course, that’s what our documentation says.

It is only by means of forgetfulness that man can ever reach the point of fancying himself to possess a "truth" of the grade just indicated.

Quintilian decrees that there are five parts to the art of rhetoric - I shall talk about these afterwards - invention, arrangement, style, memory, and delivery.

Better than either of these, however, is the man who, when he wishes, can repeat the words, and at the same time correctly apprehends their meaning.

Memory (as I shall show in its proper place) is most necessary to an orator and is eminently strengthened and nourished by exercise; and, at the age of which we are now speaking, and which cannot, as yet, produce anything of itself, it is almost the only faculty that can be improved by the aid of teachers.

The remembrance of such admonitions will attend him to old age and will be of use even for the formation of his character. It is possible for him, also, to learn the sayings of eminent men, and select passages, chiefly from the poets (for the reading of poets is more pleasing to the young), in his play-time. Memory (as I shall show in its proper place) is most necessary to an orator and is eminently strengthened and nourished by exercise; and, at the age of which we are now speaking, and which cannot, as yet, produce anything of itself, it is almost the only faculty that can be improved by the aid of teachers.

Memory (as I shall show in its proper place) is most necessary to an orator and is eminently strengthened and nourished by exercise; and, at the age of which we are now speaking, and which cannot, as yet, produce anything of itself, it is almost the only faculty that can be improved by the aid of teachers.

The chief symptom of ability in children is memory, the excellence of which is twofold: to receive with ease and retain with fidelity

and therefore people think that, if his name is mentioned many times, many things have been said about him. So that Homer, by means of this illusion, has made a great deal of though he has mentioned him only in this one passage, and has preserved his memory, though he nowhere says a word about him afterwards.

hence it is not now easy to remember the past or consider the present or foretell the future; so that most people on most subjects furnish themselves with opinion as advisor to the soul.

For if all people possessed memory concerning all things past, and awareness of all things present, and foreknowledge of all things to come