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  1. Last 7 days
    1. 16:30 "But the only fatwa that has, in fact, said that no images of Mohammed are permitted, and that includes Islamic paintings, not just the cartoons, came out in 2013 in Saudi Arabia by a Salafi cleric whose name is Al-Munajid. And there are other fatwas like Asistani, the Shi'i cleric, who says these images are perfectly fine, as long as they're respectful."

      20:00 Fatwas can be issued (like the above) in a vacuum without any real conversation within the Islamic community. Few years back even building a snowman fatwa as haram. Animals are decapitated in Saudi textbooks. People in 20th century having 14th century book that depicts a head, decapitating it (al-ras).

    1. The 'polycrisis' is real enough. But it’s a surface level symptom of multiple, simultaneous phase transitions at the core of the ‘hardware’ and ‘software’ systems that define human civilisation – which together can be understood as a planetary phase shift. But if all we see and respond to is the polycrisis – the symptoms of this process as it weakens industrial structures – that will derail the planetary phase shift to a new life cycle.

      for - comparison - to - book - The Ascent of Humanity - chapter 8 - The Gaian Birthing - Charles Eisenstein - quote - making sense of the polycrisis - a symptom of multiple phase transitions - (see below) - The 'polycrisis' is real enough. - But it’s a surface level symptom - of multiple, simultaneous phase transitions at the core of the ‘hardware’ and ‘software’ systems that define human civilisation - which together can be understood as a planetary phase shift. - But if all we see and respond to is the polycrisis - the symptoms of this process as it weakens industrial structures - that will derail the planetary phase shift to a new life cycle.

      comparison - to - book - The Ascent of Humanity - chapter 8 - The Gaian Birthing - Charles Eisenstein - Ahmed's writing about the polycrisis masking the planetary phase shift is very reminiscent of Charles Eisenstein's writing in the Ascent of Humanity in which he compares the great transition we are undergoing to - the perilous journey a neonate takes as it leaves the womb and enters the greater space awaiting

      to - book - The Ascent of Humanity - Chapter 8 - The Gaian Birthing - Charles Eisenstein - https://hyp.is/r8scTpG_Ee-gLTujlli5hQ/charleseisenstein.org/books/the-ascent-of-humanity/eng/the-gaian-birthing/

    2. the emergence of greater vulnerability because of the increasing number of interconnections that link that wealth, and those who control it, in efforts to sustain it

      for - quote / insight - decreased resiliency due to tight network of elites - From Complex Regions to Complex Worlds Crawford Stanley Holling - 2004 - creative alternatives - liminal spaces - rapid whole system change

      quote / insight - decreased resiliency due to tight network of elites - (see quote below) - The front-loop phase is more predictable, - with higher degrees of certainty. - In both the natural and social worlds, - it maximizes production and accumulation. - We have been in that mode since World War II. - The consequence of this is not only an accumulation and concentration of wealth, - but also the emergence of greater vulnerability because of - the increasing number of interconnections that link that wealth, and - those who control it, - in efforts to sustain it. - Little time and few resources are available for alternatives that explore different visions or opportunities. - Emergence and novelty is inhibited. - This growing connectedness leads to increasing rigidity in its goal to retain control, - and the system becomes ever more tightly bound together. - This reduces resilience and the capacity of the system to absorb change, - thus increasing the threat of abrupt change. - We can recognize the need for change but become politically stifled in our capacity to act effectively.

      to - quote - we are now in a back-loop of a planetary adaptive cycle - From Complex Regions to Complex Worlds - Crawford Stanley Holling - 2004 - https://hyp.is/FTRDoJFuEe-rsvdKeYjr0g/www.ecologyandsociety.org/vol9/iss1/art11/main.html?ref=ageoftransformation.org

      comment - These ideas are quite important for those change actors working to emerge creative alternatives - liminal spaces - rapid whole system change

    1. Ein internationales Team von Forschenden kommt in einer zusammenfassenden Arbeit zu dem Ergebnis, dass das Erdsystem in die neue Epoche des Anthropozän eingetreten ist. Dafür sei vor allem das Energieungleichgewicht durch Treibhausgase verantwortlich. Das Anthropzän werde wesentlich länger dauern als.das. Holozän, in dem stabile.Umweltbedingungen die.Entwicklung der menschlichen Zivilisation begünstigten https://science.orf.at/stories/3227245/

      Paper: https://www.sciencedirect.com/science/article/pii/S0921818124002157?via%3Dihub

    1. The front-loop phase is more predictable, with higher degrees of certainty. In both the natural and social worlds, it maximizes production and accumulation. We have been in that mode since World War II. The consequence of this is not only an accumulation and concentration of wealth, but also the emergence of greater vulnerability because of the increasing number of interconnections that link that wealth, and those who control it, in efforts to sustain it. Little time and few resources are available for alternatives that explore different visions or opportunities. Emergence and novelty is inhibited. This growing connectedness leads to increasing rigidity in its goal to retain control, and the system becomes ever more tightly bound together. This reduces resilience and the capacity of the system to absorb change, thus increasing the threat of abrupt change. We can recognize the need for change but become politically stifled in our capacity to act effectively.

      for - quote - we are in a back-loop phase - From Complex Regions to Complex Worlds - Crawford Stanley Holling - 2004 - creative alternatives - liminal spaces - rapid whole system change

      comment - This is important for discussion for change actors working in liminal spaces attempting to give birth to creative alternatives

    1. Die von Waldbränden außerhalb der Tropen verursachten Emissionen haben sich seit 2001 fast verdreifacht. Weltweit haben die Emissionen durch Waldbrände in dieser Zeit um 60% zugenommen. Ursache dafür ist die Kombination von heißerem und trockenerem Wetter mit dem schnelleren Wachstum der Wälder durch die höheren Temperaturen. Die Wälder können durch die Brände jahrzehntelang zu Emittenten werden. Damit ist die Funktion der Wälder als Kohlenstoffsenken gefährdet. Das bedeutet auch, dass sie andere anthropogene Emissionen weniger kompensieren und die Fähigkeit verlieren, nach einem Überschreiten der 1,5°-Grenze C0<sub>2</sub> aus der Atmosphäre zu entfernen. Außerdem müssten diese von Menschen verursachten Emissonen den C0<sub>2</sub>-Budgets der Nationalstaaten zugeordnet werden.

      https://theconversation.com/forest-fires-are-shifting-north-and-intensifying-heres-what-that-means-for-the-planet-241337

  2. Oct 2024
    1. I think from the video I watched, I think they said it could be a for profit too. I think if I'm correct, did not have to specifically be a non-profit.

      YEs Kauffman will fund a company that is NOT a not for profit if its terms of assocaition say it has a charitable function. 501c3 for kauffman is all about TAX ANd yes, we can set up an LLC with an FSC bye laws just as easily

    2. Then there are, for example, in the United States, you have to do a a lot more scrutiny of dollars you receive because they don't get taxed.

      Tapping to the MMT theory, if a 501c3 is not taxed, then why does it need dollars??? We are close to some understanding some fundamental incoherencies

    3. Why should we have philanthropy?

      We aslo see philantropy as a parasite We are attuned to Dan Palatto's work in Unchariotable and his TED talk

    4. I've got a lot and we can even have a dialogue between us to ask me anything.

      Thank you Marie. You embody the SPIRIT of a 555 FSC

    5. One of the advantages of an institution is that it says you're hired by us. We're going to take care of all the rest.

      This is why we are raising the money - to offer this benign parenting support of helping us all to pay for what we need so that we do what we love For now, I am using thew term Universal Learning Income

    1. Is "Scoping the subject" a counter-Zettelkasten approach?

      Sounds like you're doing what Mortimer J. Adler and Charles van Doren would call "inspectional reading" and outlining the space of your topic. This is both fine and expected. You have to start somewhere. You're scaffolding some basic information in a new space and that's worthwhile. You're learning the basics.

      Eventually you may come back and do a more analytical read and/or cross reference your first sources with other sources in a syntopical read. It's at these later two levels of reading where doing zettelkasten work is much more profitable, particularly for discerning differences, creating new insights, and expanding knowledge.

      If you want to think of it this way, what would a kindergartner's zettelkasten contain? a high school senior? a Ph.D. researcher? 30 year seasoned academic researcher? Are the levels of knowledge all the same? Is the kindergartner material really useful to the high school senior? Probably not at all, it's very basic. As a result, putting in hundreds of atomic notes as you're scaffolding your early learning can be counter-productive. Read some things, highlight them, annotate them. You'll have lots of fleeting notes, but most of them will seem stupidly basic after a month or two. What you really want as main notes are the truly interesting advanced stuff. When you're entering a new area, certainly index ideas, but don't stress about capturing absolutely everything until you have a better understanding of what's going on. Then bring your zettelkasten in to leverage yourself up to the next level.

      • Adler, Mortimer J. “How to Mark a Book.” Saturday Review of Literature, July 6, 1940. https://www.unz.com/print/SaturdayRev-1940jul06-00011/
      • Adler, Mortimer J., and Charles Van Doren. How to Read a Book: The Classical Guide to Intelligent Reading. Revised and Updated edition. 1940. Reprint, Touchstone, 2011.

      reply to u/jack_hanson_c at https://old.reddit.com/r/Zettelkasten/comments/1g9dv9b/is_scoping_the_subject_a_counterzettelkasten/

    1. 2023 haben Böden und Landpflanzen fast kein CO2 absorbiert. Dieser Kollaps der Landsenken vor allem durch Dürren und Waldbrände wurde in diesem Ausmaß kaum vorausgesehen, und es ist nicht klar, ob auf ihn eine Regeneration folgt. Er stellt Klimamodelle ebenso in Frage wie die meisten nationalen Pläne zum Erreichen von CO2-Neutralität, weil sie auf natürlichen Senken an Land beruhen. Es gibt Anzeichen dafür, dass die steigenden Temperaturen inzwischen auch die CO2-Aufnahmefähigkeit der Meere schwächen. Überblicksartikel mit Links zu Studien https://www.theguardian.com/environment/2024/oct/14/nature-carbon-sink-collapse-global-heating-models-emissions-targets-evidence-aoe

    1. Noch nie ist die CO2-Konzentration in der Atmosphäre so stark gestiegen wie im vergangenen Jahr, nämlich um 3,37 parts per million (PPM). Die Konzentration liegt jetzt bei 422 PPM. Vor allem die sehr geringe CO2-Aufnahme durch Ozean- und Landsenken hat diese Steigerung verursacht https://taz.de/Hiobsbotschaft-fuers-Klima/!6040258/

    1. beyond our power to alter, and therefore to be accepted and made the best of. It is a waste of time to criticize the inevitable.

      for - quote / critique - it is upon us, beyond our power to alter, and therefore to be accepted and made the best of. It is a waste of time to criticize the inevitable. - Andrew Carnegie - The Gospel of Wealth - alternatives - to - mainstream companies - cooperatives - Peer to Peer - Decentralized Autonomous Organization (DAO) - Fair Share Commons - B Corporations - Worker owned companies

      quote / critique - it is upon us, beyond our power to alter, and therefore to be accepted and made the best of. It is a waste of time to criticize the inevitable. - Andrew Carnegie - The Gospel of Wealth - This is a defeatist attitude that does not look for a condition where both enormous inequality AND universal squalor can both eliminated - Today, there are a growing number of alternative ideas which can challenge this claim such as: - Cooperatives - example - Mondragon corporation with 70,000 employees - B Corporations - Fair Share Commons - Peer to Peer - Worker owned companies - Cosmolocal organizations - Decentralized Autonomous Organization (DAO)

    2. Thus is the problem of Rich and Poor to be solved. The laws of accumulation will be left free; the laws of distribution free. Individualism will continue, but the millionaire will be but a trustee for the poor; intrusted for a season with a great part of the increased wealth of the community, but administering it for the community far better than it could or would have done for itself.

      for - quote / critique / question - Thus is the problem of Rich and Poor to be solved. The laws of accumulation will be left free; the laws of distribution free. Individualism will continue, but the millionaire will be but a trustee for the poor; intrusted for a season with a great part of the increased wealth of the community, but administering it for the community far better than it could or would have done for itself. - The Gospel of Wealth - Andrew Carnegie

      quote / critique / question - Thus is the problem of Rich and Poor to be solved. The laws of accumulation will be left free; the laws of distribution free. Individualism will continue, but the millionaire will be but a trustee for the poor; intrusted for a season with a great part of the increased wealth of the community, but administering it for the community far better than it could or would have done for itself. - The Gospel of Wealth - Andrew Carnegie - The problem with this reasoning is that it is circular - By rewarding oneself an extreme and unfettered amount of wealth for one's entrepreneurship skills creates inequality in the first place - Competition that destroys other corporations ends up reducing jobs - At the end of life, the rich entrepreneur desires to give back to society the wealth that (s)he originally stole - If one had reasonable amounts of rewarding innovation instead of unreasonable amounts, the problem of inequality can be largely mitigated in the first place whilst still recognizing and rewarding individual effort and ingenuity

    3. That this talent for organization and management is rare among men is proved by the fact that it invariably secures for its possessor enormous rewards, no matter where or under what laws or conditions.

      for - critique - extreme wealth a reward for rare management skills - Andrew Carnegie - The Gospel of Wealth - Mondragon counterexample - to - stats - Mondragon pay difference between highest and lowest paid - article - In this Spanish town, capitalism actually works for the workers - Christian Science Monitor - Erika Page - 2024, June 7

      critique - extreme wealth a reward for rare management skills - Andrew Carnegie - The Gospel of Wealth - Mondragon counterexample - This is invalidated today by large successful cooperatives such as Mondragon

      to - stats - Mondragon corporation - comparison of pay difference between highest paid and lowest paid - https://hyp.is/QAxx-o14Ee-_HvN5y8aMiQ/www.csmonitor.com/Business/2024/0513/income-inequality-capitalism-mondragon-corporation

    4. for - from - MSN article - How a poor boy from Scotland became the richest man on Earth - The life of Andrew Carnegie - Daniel Coughlin - essay - The Gospel of Wealth - Andrew Carnegie - philanthropy adjacency - Carnegie - The Gospel of Wealth - Anthropocene - critique

      summary - It is interesting to read this article from the perspectives of a commons activist - The link to the MSN article that led me to Carnegie's essay is below and it provides a good summary of his life. - He came from a very challenging life of poverty, growing up in a family and in circumstances where they were constantly struggling to make ends meet - His is the story of the deep imprint of poverty providing him with motivation to escape it - Having risen to become the world's richest man, and then giving his fortune away due to the deep imprint of poverty experienced in childhood, - he formed an opinion on inequality and capitalist material production that was borne out of his experience as a successful entrepreneur and the contrast of quality of life between: - a pre-industralized society in which he was familiar from childhood experiences and - the profound material improvements accessible to all due to mass production that he helped to pioneer - In the essay, he sees the inequality found in society to be the price that needed to be paid for everyone to have access to a higher standard of living - This is where critical analysis from a modern post-Marxist, post-Capitalist perspective might provide an interesting critique, - especially from the anthropocene perspective, where the epitome of the system Carnegie praised has led to a state of environmental destruction so vast that Carnegie could never have foreseen it - A question: would Carnegie have written his essay differently were he alive to witness the environmental destruction of the Anthropocene?

      from - MSN article - How a poor boy from Scotland became the richest man on Earth - The life of Andrew Carnegie - Daniel Coughlin - https://hyp.is/urXCfo1hEe-OdSMr4kqwyg/www.lovemoney.com/news/135656/the-astonishing-rags-to-riches-story-of-andrew-carnegie

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    1. Reporter John Dickerson talking about his notebook.

      While he doesn't mention it, he's capturing the spirit of the commonplace book and the zettelkasten.

      [...] I see my job as basically helping people see and to grab ahold of what's going on.

      You can decide to do that the minute you sit down to start writing or you can just do it all the time. And by the time you get to writing you have a notebook full of stuff that can be used.

      And it's not just about the thing you're writing about at that moment or the question you're going to ask that has to do with that week's event on Face the Nation on Sunday.

      If you've been collecting all week long and wondering why a thing happens or making an observation about something and using that as a piece of color to explain the political process to somebody, then you've been doing your work before you ever sat down to do your work.

      <div style="padding:56.25% 0 0 0;position:relative;"><iframe src="https://player.vimeo.com/video/169725470?h=778a09c06f&title=0&byline=0&portrait=0" style="position:absolute;top:0;left:0;width:100%;height:100%;" frameborder="0" allow="autoplay; fullscreen; picture-in-picture" allowfullscreen></iframe></div> <script src="https://player.vimeo.com/api/player.js"></script>

      Field Notes: Reporter's Notebook from Coudal Partners on Vimeo.

    1. for - article - Why Human (Contributive) Labor remains the creative principle of human society - Michael Bauwens - PhD thesis - From Modes of Production to the Resurrection of the Body: A Labor Theory of Revolutionary Subjectivity & Religious Ideas (2016) - Benjamin Suriano - to - P2P Foundation - more detailed presentation of Benjamin Suriano's PhD paper

      Summary - This is a review and high recommendation of the PhD dissertation of Benjamin Suriano by Michael Bauwens - The subject is the historical analysis of labour in medieval times, and - how Christian monasticism provided a third perspective on labour that was an important alternative to the false dichotomy of - cleric - warrior - that was inclusive of the alienated within class majority - a proposal for revival the spirit of this spiritual view of labour - as a means to mitigate modernity's meaning crisis as it relates to the lack of purpose usually associated with work in contemporary society

      to - P2P Foundation - more detailed presentation of Benjamin Suriano's PhD paper - https://hyp.is/7PeMMIxtEe-NOmuU08T3jg/wiki.p2pfoundation.net/From_Modes_of_Production_to_the_Resurrection_of_the_Body

    1. what really I was really interested in was the idea that Marx wasn't really Keen or was sort of hostile to the idea of equality which I'm guessing will come as a surprise to many people

      for - interesting perspective - Karl Marx - He wasn't principally interested in equality - book - Capitalism: the word and the thing - perspectival knowledge of - Michael Sonenscher - misunderstanding - modern capitalists - misunderstand Karl Marx's work - Michael Sonenscher - Karl Marx and Capitalism - Maximizing each individual's freedom while not trampling on the same aspiration of other individuals within a society

      Interesting perspective - Karl Marx wasn't principally interested in equality - Sonenscher offers an interesting interpretation and perspectival knowledge of Karl Marx's motivation in his principal work paraphrase - Marx's thought centered on is interest in individuality and the degree to which in certain respects being somebody who is free and able to make choices about his or her lives and future activities is going to depend on each person's: - qualities - capabilities - capacities - preoccupations - values, etc - For Marx, freedom is in the final analysis something to do with something - particular - specific and - individual w - What matters to me may not matter entirely in the same sort of way to you because ultimately - in an ideal State of Affairs, my kinds of concerns and your kinds of concerns will be simply specific to you and to me respectively - For Marx, the problems begin as is also the case with Rosseau - when these kinds of absolute qualities are displaced by - relative qualities that apply equally to us both - For Marx, things like - markets - prices - commodities and - things that connect people - are the hallmarks of equality because they put people on the same kind of footing prices and productivity - Whereas the things that REALLY SHOULD COUNT are - the things that separate and distinguish people that make each individual fully and and entirely him or herself and - the idea for Marx is that capitalism - which is not a term that Marx used, - puts people on a kind of spurious footing of equality - Getting beyond capitalism means getting beyond equality to a state of effect in which - difference , - particularity, - individuality and - uniqueness - in a certain kind of sense will prevail

      comment - This perspective is quite enlightening on Marx's motivations on this part of his work and is likely misconstrued by those mainstream "capitalists" who vilify his work without critical analysis - Of course freedom - within a social context - is never an absolute term. - It is not possible to live in a society in which everyone is able to actualize their full imaginations, something pointed out in the work of two other famous thought leaders of modern history: - Thomas Hobbes observed in his famous work, Leviathan, and - Sigmund Freud also made a primary subject of his ID, Ego and Superego framework. - Total freedom would lead - first to anarchy and then - the emergence within that anarchy of those which possess the most charisma, influence, self-seeking manipulative skills and brutality - surfacing rule by authority - Historically, as democracy attempts to surface from a history of authoritarian, patriarchal governance, - democracy is far from ubiquitous and authoritarian governance is still alive and well in many parts of the world - The battle between - authoritarian governments among themselves and - authoritarian and democratic governments - results in war, violence and trauma that creates the breeding ground for the next generation of authoritarian leaders - Marx's main intent seems to be to enable the individual existing within a society to live the fullest life possible, - by way of enabling and maximizing their unique expression, - while not constraining the same aspiration in other individuals who belong to the same society

    1. Successful Secretary Presented by Royal Office Typewriters. A Thomas Craven Film Corporation Production, 1966. https://www.youtube.com/watch?v=If5b2FiDaLk.

      Script: Lee Thuna<br /> Educational Consultant: Catharine Stevens<br /> Assistant Director: Willis F. Briley<br /> Design: Francisco Reynders<br /> Director & Producer: Carl A. Carbone<br /> A Thomas Craven Film Corporation Production

      "Mother the mail"

      gendered subservience

      "coding boobytraps"


      "I think you'll like the half sheet better. It is faster." —Mr. Typewriter, timestamp

      A little bit of the tone of "HAL" from 2001: A Space Odyssey (1968). This is particularly suggestive as H.A.L. was a one letter increment from I.B.M. and the 1966 Royal 660 was designed to compete with IBM's Selectric

      This calm voice makes suggestions to a secretary while H.A.L. does it for a male astronaut (a heroic figure of the time period). Suddenly the populace feels the computer might be a bad actor.

      "We're living in an electric world, more speed and less effort."—Mr. Typewriter<br /> (techno-utopianism)

    1. What is a Certified Translation? Understand the common uses and requirements of a certified translation and download sample statements. Home / Client Assistance / What is a Certified Translation?

      What is a Certified Translation?

      Understand the common uses and requirements of a certified translation and download sample statements.

      Home / Client Assistance / What is a Certified Translation?

      What are the basics of a certified translation?

      In the United States, anyone can certify a translation. A translator does not need to be certified in order to provide a certified translation. The individual translator can certify their translations, as can an employee of a translation company.

      A translator may also certify someone else's translation—as long as the translator has fully reviewed the translation for accuracy and completeness and the translation will not be changed after being certified. That is why translation companies can certify translations provided by their employees or freelance translators.

      The certification statement must specify whether the signer has translated or reviewed the translation.

    1. Derailed climate action: Mr. Trump will almost certainly withdraw again from the 2015Paris Climate Agreement, dismantle domestic climate and environmental regulations(particularly those seen to hamper the fossil fuel industry), and actively oppose atransition to green energy.

      for - question - Study on 2024 Trump win on polycrisis - Cascade Institute - why is there such a small analysis on the environment and especially planetary tipping points whilst climate clock is ticking?

    1. 1:27:32 A Community Bill of Rights

    2. 1:26:14 Marlborough can become a Commons

    3. 1:25:22 First comes an AGREEMENT by members of the neighbourhood to co-operate and then they agree to use a mechanism called money to mobilise resources

    4. 1:24:34 Money is not the scare resource. Money is the organising tool that mobilises people and tangible resources to manifest a vision

    5. 1:23:30 How can a neighbourhood become a local food PRODUCER evolving into a PROSUMER

    6. 1:23:06 How can we get a neighbourhood to operate at full capacity (strengths) while minimising to its collective shadows

    7. 1:22:36 Could A community Association get a Community Banking Licence? 1:22:38 Could a local Credit Union be a consortium partner and issue more money into the system to develop the entire wealth of the Neighbourhood

    8. 1:21:54 If a community moved to a WELLNESS model rather than an ILLNESS model, it would generate millions of dollars in saved resources 1:21:54 If a community moved to a PREVENTION model rather than a CURE Model, it would generate millions of dollars in resources

    9. 1:14;46 Our greatest existential threat is not CLIMATE CHANGE it is MIND CHANGE which leads to a CHANGE IN LANGUAGE

    10. 1:10:56 Your checking account is your bank's I.O.U. It is their liability that they owe you. 1:11:08 When you repay a loan, THE MONEY DISAPPEARS

    11. 1:09:52 A Bank LOAN is an interest attached to your own ability to pay back something that did not exist before you borrowed it

      1:09:59 A bank officer ACQUIRES the loan in order to charge interest on it

    12. 1:08:50 Using BANK MONEY to create a mutual fund at low interest rates to pay off PREDATORY LOANS at high interest rates

    13. 1:05:36 Instead of asking DONORS for money, a community can make its own money and donors can contribute to a healthy local economy as a participant rather than a funder

    14. 1:02:29 The national debt is a historical record of the cumulative money that a government spent dollars than it took out which were transformed into US Treasuries

    15. 53:36 A community can set up a CONTRIBUTION which everyone agrees to pay in the currency issued by the community issuer 53:48 Therefore a Debt Free Currency System really means a COMMUNITY TRIBUTE money system where the debt is a contribution to the community, payable in the currency of the issuer 55:45 A community can set up its own CENTRAL BANK that sets the interest rate at zero for the money in the community

    16. 50:32 Currency is the governments I.O.U. 52:04 When the government gets its tax, it no longer has the debt so it burns the currency which was an I.O.U.

    17. 48:52 Example of a Community Currency

    18. 40:40 UMKC created its own currency - the Buckaroo 40:42 Students had to pay buckaroos to get their grades

    19. 39:59 DEFICIT is a word designed to shock and frighten

    20. 37:34 A government DEFICIT is that a government is putting IN more than it is taking out

    21. 36:10 If a government can create money, why is it in DEBT?

    22. 34:59 A government does not need money. It needs citizens to need money so that they can pay taxes

      Governments FORCE PEOPLE TO NEED MONEY

    23. 34:47 Taxes drive demand for a currency

    24. 34:12 taxes are imposed by a government that is only payable in their currency and they make a law that puts you in jail if you do not pay their tax

    25. 32:12 Money is not a REAL resource. Money is a too invented by political authorities to organise and mobilise real resources

    26. 30:38 Money is not a physical object. It is a UNIT OF MEASURE

    27. 23:10 MMT is not a new system or theory. It simply explains what happens today.

    28. 18:59 Warren Mosler 19:49 Government does not need dollars, citizens need dollars 20:18 Warren is not an economist - he is not trying to defend economic theory - he is a financial trader watching the operation of money

    29. 18:17 A government who creates a currency does not need to tax its citizens to get dollars. 18:25 Currency issuers spend first before they tax - they do not use tax to spend

    30. 11:42 For a currency issuer, funding the money is NEVER the problem

    31. 9:16 Why are we borrowing in a currency that we print ourselves?

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    1. fter the Letter has been done it should beread through, and should (if possible) be read out loud,and you should ask yourself, as you read it, whetherit is clear, whether it is fair and true, and (last but notleast) whether it is kind. Putting it in another way,you might ask yourself, ' What will the person feel andthink on reading this ? ' or, * Should I eventually besorry to have received such a Letter myself? ' or, again,'Should I be sorry to have written it, say a yearhe

      Recall: Abraham Lincoln's angry letter - put it in a drawer

    2. The third reading should again be a slow reading,

      relationship to Adler's levels of reading?

    1. Kurz vor der COP16 zur Biodiversität geht die EU immer deutlicher von ihrer bisherigem Politik zum Schutz der Biodiversität ab. Man nimmt Rücksicht auf konventionelle Landwirt:innen, rechtsradikale und auch zunehmend antiökologisch agierende konservative Parteien. An die Stelle des Green Deal tritt das Bestreben, die Unternehmen im globalen Wettbewerb konkurrenzfähiger zu machen und die Wirtschaft wachsen zu lassen. Ajit Niranjan berichtet zusammenhängend über diese Entwicklungen und verweist auf wichtiger Meilensteine in der Geschichte von Abkommen zum Schutz der Biodiversität. https://www.theguardian.com/environment/2024/oct/09/europe-eu-green-deal-backsliding-nature-biodiversity-farmers-far-right-cop16-aoe

  3. docdrop.org docdrop.org
    1. With an income of more than $300,000, Alexander's family was able to spend far more money on Alexander's education, lessons, and other enrichment activities than Anthony's parents could devote to their son's needs.

      When it comes to education, one's socioeconomic status plays a big influence in their educational journey. Education is an area where the government cannot control equal opportunities because people will always be looking for the "best ways" for their children to learn. Even with public schools, living in richer areas will raise a students chances of going to college based on the facilities being offered.

    1. truly, become a chalice.

      Symbolism of becoming a chalice (metaphor): Connects to the previous image of Handmaid's needing to empty themselves of all to become a perfect vessel. Being nothing but a container, the chalice symbolises this as it is formally used religiously to hold sacramental/holy wine -- just as Offred is allowing herself to be emptied, mind and body, to carry something sacred (a child) and none more.

      Also, because of the communion, it also means that she is turning herself over to God (drinking the blood).

      Also, the shape of the chalice is like one of a woman's uterus.

    2. I wish this story were different. I wish it were more civilized. I wish itshowed me in a better light, if not happier, then at least more active, lesshesitant, less distracted by trivia. I wish it had more shape. I wish it wereabout love, or about sudden realizations important to one's life, or even aboutsunsets, birds, rainstorms, or snow.

      Anaphora of "I wish", kind of like asking a genie for three wishes, a childlike wonder. Her constant reflection on what happens in her life shows her control over the retelling of what is being told us in the story -- shows her power as the narrator.

    3. I tell,therefore you are

      Reference to Descartes : I think therefore I am. Shows her power as a narrator, as a creator, as a reconstructor. She created her audience, which represents her power

      This is a intertextual reference.

    4. All I can hope for is a reconstruction: The way love feels is alwaysonly approximate

      Shows that words and language cannot fully express -- Most happened detailed and not a reconstruction in other scenes, but her sex with Nick is similar to all other Night scenes, all other scenes with herself.

    1. Case: patient is named case #2, male

      Disease Assertion: UCD/OTCD

      Family Info:

      Case Presenting HPOs: Hyperammonemia (HP:0001987), oriticaciduria (HP:0003218), low plasma citrulline (HP:0003572), neonatal onset(HP:0003623), Hyperglutaminemia (HP:0003217)

      Case HPO FreeText:

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: GDNA was isolated from lymphocytes. To examine the small mutations in the coding region of the OTC gene, all 10 exons and their flanking intron regions were amplified using PCR, and the nucleotide sequences of the amplified products were determined. To determine the intron 5 sequence of case 2, PCR was performed using primers OTCex5F and OTCint5R, and primers OTCint5F and OTCex6R (Table 1, Fig. 3). The amplified products were subcloned into the pT7 vector and the inserted DNA was sequenced using an automated DNA sequencer. Allopurinol test

      Supplemental Data: TABLE 1, Notes:

      Variant: NM_000531.6: c.540+265G>A

      ClinVarID: NA

      CAID: CA658658977

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    1. term spectacle refers to

      for - definition - the spectacle - context - the society of the spectacle - cacooning - the spectacle - social media - the spectacle

      definition - the spectacle - context - the society of the spectacle - A society where images presented by mass media / mass entertainment not only dominate - but replaces real experiences with a superficial reality that is - focused on appearances designed primarily to distract people from reality - This ultimately disconnects them from - themselves and - those around them

      comment - How much does our interaction with virtual reality of - written symbols - audio - video - two dimensional images - derived from our screens both large and small affect our direct experience of life? - When people are distracted by such manufactured entertainment, they have less time to devote to important issues and connecting with real people - We can sit for hours in social isolation, ignoring our bodies need for exercise and our emotional need for real social connection - We can ignore the real crisis going on in the world and instead numb ourselves out with contrived entertainment

    1. To understand how SAIDs work

      Little confused... this is telling me about how "SAIDs" work... I thought I already learned that... the #1 below seems very CESR related... are SAIDs and CESR tightly coupled? or are they independent concepts? Making an ID with an eye toward how it will be serialized seems... unnecessarily coupled.

  4. Sep 2024
    1. Notice how bad, as of this writing, the typography is on this page.

      Use this as an example of the weirdness of the difference in creator agency and consumer expectations about presentation of the written word when it comes to print vs Web.

    1. Résumé de la vidéo [00:00:00][^1^][1] - [00:22:07][^2^][2]:

      Cette vidéo aborde la gestion des classes agitées et comment les enseignants peuvent préserver leur santé mentale face à ce défi. Caroline, une professeure d'histoire-géographie, partage ses expériences et ses stratégies pour gérer l'agitation en classe.

      Moments forts: + [00:00:00][^3^][3] Définition de l'agitation * L'agitation est liée aux mouvements et aux émotions visibles * Les élèves agités peuvent troubler le climat de la classe * Les écrans et le COVID ont accentué l'agitation + [00:02:02][^4^][4] Impact sur les élèves et les enseignants * L'agitation affecte la concentration et l'apprentissage des élèves * Les enseignants doivent comprendre leurs propres limites * Importance de fixer des règles claires et universelles + [00:08:11][^5^][5] Stratégies pour gérer l'agitation * Adapter les techniques pédagogiques selon les classes * Tester différentes méthodes pour trouver ce qui fonctionne * Importance de la communication et de l'explication aux élèves + [00:16:00][^6^][6] Santé mentale des enseignants * L'épuisement mental causé par des classes difficiles * La nécessité de trouver un équilibre pour préserver sa santé mentale * Reconnaître que certaines classes peuvent être plus difficiles à gérer que d'autres

    1. Résumé de la vidéo [00:00:00][^1^][1] - [00:22:52][^2^][2]:

      Cette vidéo explore les causes de l'échec scolaire et les solutions possibles pour aider les élèves en difficulté. Elle met en avant l'importance d'une approche globale et d'une évaluation approfondie pour identifier les besoins des élèves et trouver des solutions adaptées.

      Moments forts: + [00:00:00][^3^][3] Importance de l'évaluation * Approche solutionniste * Évaluation des besoins * Recherche de solutions + [00:01:00][^4^][4] Expertise et diagnostic * Danger du sur-diagnostic * Approche globale * Rôle des enseignants + [00:04:32][^5^][5] Difficulté scolaire * Sujet central pour les enseignants * Importance de la formation * Recherche de solutions pratiques + [00:06:00][^6^][6] Approche pyramidale * 80% des élèves réussissent sans différenciation * 15% nécessitent une différenciation * 5-8% nécessitent des approches alternatives + [00:10:00][^7^][7] Exemple concret * Cas de l'élève Léo * Importance de comprendre le contexte familial * Identification du point nodal

    1. Résumé de la vidéo [00:00:06][^1^][1] - [00:23:55][^2^][2]:

      Noémie Le Donné présente les recherches de l'OCDE sur les compétences scolaires et les contextes d'apprentissage. Elle aborde les résultats de l'enquête PISA, les facteurs influençant les compétences des élèves, et les pratiques enseignantes efficaces.

      Points forts: + [00:00:06][^3^][3] Introduction et contexte * Présentation de l'OCDE et de ses objectifs * Importance des enquêtes auprès des élèves et enseignants * Public cible de la présentation + [00:02:03][^4^][4] Résultats de l'enquête PISA * Performance des élèves français en lecture, maths et sciences * Comparaison internationale des résultats * Inégalités socio-économiques et leurs impacts + [00:07:01][^5^][5] Facteurs influençant les compétences * Effets des enseignants sur les performances des élèves * Importance des pratiques enseignantes et de l'environnement de travail * Rôle des pairs et de la composition de la classe + [00:14:01][^6^][6] Pratiques enseignantes efficaces * Utilisation du temps de classe et correction des copies * Engagement dans des activités extra-scolaires * Satisfaction des enseignants et réussite des élèves

    1. Résumé de la vidéo [00:00:01][^1^][1] - [00:24:21][^2^][2]:

      La vidéo explore comment rendre les élèves plus enthousiastes à l'enseignement explicite, en mettant l'accent sur la métacognition et l'autorégulation. Jonathan Fernandez partage des stratégies pour améliorer la compréhension et l'autonomie des élèves.

      Moments forts: + [00:00:01][^3^][3] Début de l'entretien * Série d'affirmations sur l'enseignement explicite * Importance de la formation pour enseigner explicitement * Réduction des inégalités grâce à l'enseignement explicite + [00:02:08][^4^][4] Exemple de situation de classe * Enseignement des habiletés de rédaction * Utilisation d'organisateurs graphiques * Importance de la structuration des idées + [00:10:05][^5^][5] Métacognition et stratégies de mémorisation * Différences d'activités mentales entre élèves * Importance des stratégies de mémorisation * Enseignement explicite des stratégies efficaces + [00:18:01][^6^][6] Vérification de la compréhension * Importance de la vérification régulière * Stratégies pour améliorer la compréhension * Impact sur la réussite scolaire + [00:22:26][^7^][7] Définition de l'autonomie * Compétences d'autorégulation * Processus d'apprentissage et d'évaluation * Importance de l'enseignement explicite pour l'autonomie

      J'espère que cela vous aide ! Si vous avez d'autres questions, n'hésitez pas.

    1. What is needed, and what I attempt to think through within this dissertation, is then a return to labor as a self-transcending activity. This is nothing short of resurrecting a revolutionary sense of labor as itself an act of resurrection, a fundamentally social and creative activity whose final cause is to raise humanity into a new historical body beyond any reduction to the merely mortal flesh prescribed by the present.

      for - quote - reviving the view of labour as a spiritual activity - to counter the meaning crisis of modernity - Benjamin Suriano - question - how do we find the eternal in labour? quote - reviving the view of labour as a spiritual activity - to counter the meaning crisis of modernity - Benjamin Suriano - (see below) - What is needed, - and what I attempt to think through within this dissertation, - is then a return to labor as a self-transcending activity. - This is nothing short of resurrecting a revolutionary sense of labor as itself an act of resurrection, - a fundamentally social and creative activity - whose final cause is to raise humanity into a new historical body - beyond any reduction to the merely mortal flesh prescribed by the present. - Thus, the laboring body qua labor - always already harbors all the seeds for its immortality, - for producing the perfection of life for itself, - which is the qualitative perfection of eternal life. - The task, then, - is not to eliminate its religious consciousness, - but to develop it from the true rationalization of labor - according to its own ratio of perfection, - i.e. to therein find its corresponding religious forms of thought - that illuminate and reinvest in its capacities - for the infinite and eternal."

    2. From Modes of Production to the Resurrection of the Body: A Labor Theory of Revolutionary Subjectivity & Religious Ideas

      for - PhD thesis - Benjamin Suriano - From Modes of Production to the Resurrection of the Body: A Labor Theory of Revolutionary Subjectivity & Religious Ideas" (2016).

    1. se voirappliquer le tarif maximal pour les prestationsservies [avant la rectification], mesure quiconstituait une sanction pécuniaire au sensdes dispositions de l’article L. 123-1 du codedes relations entre le public etl’administration62 ».
    1. Dans un lycée en banlieue parisienne, une douzaine d’adolescent-e-s, en classe de seconde générale ou professionnelle, se retrouvent dans une salle, pour assister à un cours pas comme les autres… Option éducation sexuelle! Ils-elles ont 15 ans et ont été sélectionnée-e-s pour participer à 5 ateliers d’éducation à la sexualité, animés par Thomas Guiheneuc.

      Le film raconte cette expérience pilote et suit le quotidien du groupe d’adolescent-e-s volon-taires pendant plusieurs semaines.

      A travers des exercices sur les représentations genrées, sur les forces et influences des normes et stéréotypes, sur le souci du plaisir de soi et de l’autre, sur la compréhension de l’égalité et du consentement, ces lycéen-ne-s se dévoilent et se racontent.

      La transcription fournie est celle d'un documentaire sur l'éducation sexuelle dans un lycée en banlieue parisienne. Voici les moments clés de la transcription, organisés par thème :

      1. Représentations du corps et stéréotypes de genre (5:11 - 5:49):

      ● Suite à un exercice de représentation du sexe masculin et féminin avec de la pâte à modeler, une analyse des mots choisis par les garçons et les filles pour décrire la sexualité révèle des différences notables.

      ● Les filles se concentrent davantage sur leur corps et expriment des sentiments négatifs tels que l'insécurité et le complexe, tandis que les garçons se focalisent sur leurs propres désirs et ne mentionnent pas explicitement leur corps.

      1. Le plaisir féminin et la représentation du clitoris (14:50 - 17:39) :

      ● L'intervenant souligne que le clitoris est souvent réduit à un point dans les représentations anatomiques, ce qui reflète une méconnaissance et une minimisation du plaisir féminin dans la société.

      ● Plusieurs filles admettent ne pas savoir à quoi ressemble un clitoris ni comment le trouver sur leur propre corps, soulignant le manque d'éducation sexuelle complète.

      1. Identité de genre et difficultés d'acceptation (38:41 - 43:37):

      ● Une mise en situation met en scène le rejet violent d'un adolescent par ses camarades lorsqu'il révèle se sentir femme dans un corps d'homme.

      ● Les réactions des élèves face à ce jeu de rôle révèlent la difficulté d'accepter la différence et le poids des normes sociales.

      1. L'homosexualité et l'homophobie (46:09 - 52:03):

      ● Des élèves partagent leurs expériences personnelles de harcèlement et d'insultes homophobes.

      ● Un échange met en lumière la difficulté de certains à accepter l'homosexualité, la considérant comme "non naturelle", tandis que d'autres défendent la liberté d'aimer qui l'on veut.

      1. Le consentement et les violences sexuelles (56:11 - 1:03:25):

      ● La définition des violences sexuelles est abordée, incluant tout acte sexuel commis par violence, contrainte, menace ou surprise.

      ● Plusieurs élèves témoignent de situations d'agressions sexuelles vécues dans leur enfance ou adolescence, soulignant l'importance du consentement et la difficulté de parler de ces expériences.

      1. L'importance de l'éducation sexuelle (1:04:07 - 1:06:15):

      ● Le documentaire se conclut par un appel à la parole et à l'éducation sexuelle complète et inclusive pour lutter contre les stéréotypes, les violences et favoriser le respect de soi et des autres. Ces temps forts permettent de comprendre les principaux thèmes abordés dans le documentaire et les enjeux liés à l'éducation à la sexualité chez les adolescents.

      Résumé de la vidéo [00:50:12][^1^][1] - [01:06:17][^2^][2]:

      Cette vidéo aborde les thèmes de l'homophobie, de la transphobie, et des violences sexuelles à travers des témoignages et des discussions en classe.

      Temps forts: le debut de la transcription est censuré par l'IA... + [00:50:12][^3^][3] Homophobie et transphobie * Insultes et attitudes de rejet * Impact émotionnel sur les victimes * Importance de la loi contre ces discriminations + [00:51:00][^4^][4] Témoignages personnels * Expériences de rejet et de harcèlement * Difficulté de vivre son orientation sexuelle * Souffrance liée à l'isolement social + [00:56:17][^5^][5] Violences sexuelles * Définition et exemples de violences sexuelles * Témoignages de victimes * Importance du consentement + [01:00:00][^6^][6] Réactions et soutien * Réactions des témoins et des proches * Importance de l'écoute et du soutien * Difficulté de parler des expériences traumatisantes + [01:04:07][^7^][7] Discussion en classe * Importance de l'éducation sur la sexualité * Déconstruction des tabous * Encouragement à parler ouvertement des sujets difficiles

    1. for - The projected timing of climate departure from recent variability - Camilo Mora et al. - 6th mass extinction - biodiversity loss - question - 2024 - Sept 13 - how do we reconcile climate departure with quantification of earth system boundary biodiversity safe and just limit? - to - climate departure map - map of major cities - 2013 - to - researchgate paper - The projected timing of climate departure from recent variability - 2013 - Camilo Mora et al

      paper details - title: The projected timing of climate departure from recent variability - author: - Camilo Mora, - Abby G. Frazier, - Ryan J. Longman, - Rachel S. Dacks, - Maya M. Walton, - Eric J. Tong, - Joseph J. Sanchez, - Lauren R. Kaiser, - Yuko O. Stender, - James M. Anderson, - Christine M. Ambrosino, - Iria Fernandez-Silva, - Louise M. Giuseffi, - Thomas W. Giambelluca - date - 9 October, 2013 - publication Nature 502, 183-187 (2013) - https://doi.org/10.1038/nature12540 - https://www.nature.com/articles/nature12540

      to - https://hyp.is/0BdCglsHEe-2CteEQbOBfw/www.researchgate.net/publication/257598710_The_projected_timing_of_climate_departure_from_recent_variability

      Summary - This is an extremely important paper with a startling conclusion of the magnitude of the social and economic impacts of the biodiversity disruption coming down the pipeline - It is likely that very few governments are prepared to adapt to these levels of ecosystemic disruption - Climate departure is defined as an index of the year when: - The projected mean climate of a given location moves to a state that is - continuously outside the bounds of historical variability - Climate departure is projected to happen regardless of how aggressive our climate mitigation pathway - The business-as-usual (BAU) scenario in the study is RCP85 and leads to a global climate departure mean of 2047 (+/- 14 years s.d.) while - The more aggressive RCP45 scenario (which we are currently far from) leads to a global climate departure mean of 2069 (+/- 18 years s.d.) - So regardless of how aggressive we mitigate, we cannot avoid climate departure. - What consequences will this have on economies around the world? How will we adapt? - The world is not prepared for the vast ecosystem changes, which will reshape our entire economy all around the globe.

      question - 2024 - Sept 13 - how do we reconcile climate departure with quantification of earth system boundary biodiversity safe and just limit? - Annotating the Sept 11, 2024 published Earth Commission paper in Lancet, the question arises: - How do we reconcile climate departure dates with the earth system boundary quantification of safe limits for biodiversity? - There, it is claimed that: - 50 to 60 % of intact nature is required<br /> - https://hyp.is/Mt8ocnIEEe-C0dNSJFTjyQ/www.thelancet.com/journals/lanplh/article/PIIS2542-5196(24)00042-1/fulltext - a minimum of 20 to 25% of human modified ecosystems is required - https://hyp.is/AKwa4nIHEe-U1oNQDdFqlA/www.thelancet.com/journals/lanplh/article/PIIS2542-5196(24)00042-1/fulltext - in order to mitigate major species extinction and social disruption crisis - And yet, Mora et al.'s research and subsequent climate departure map shows climate departure is likely to take place everywhere on the globe, with - aggressive RCP decarbonization pathway only delaying climate departure from - Business-As-Usual RCP pathway - by a few decades at most - And this was a 2011 result. 13 years later in 2024, I expect climate departure dates have likely gotten worse and moved closer to the present

      from - Gupta, Joyeeta et al.(2024). A just world on a safe planet: a Lancet Planetary Health–Earth Commission report on Earth-system boundaries, translations, and transformations. The Lancet Planetary Health, Volume 0, Issue 0 - https://hyp.is/go?url=https%3A%2F%2Fwww.thelancet.com%2Fjournals%2Flanplh%2Farticle%2FPIIS2542-5196(24)00042-1%2Ffulltext&group=world

      to - climate departure map - of major cities of the world - 2013 - https://hyp.is/tV1UOFsKEe-HFQ-jL-6-cw/www.hawaii.edu/news/2013/10/09/study-in-nature-reveals-urgent-new-time-frame-for-climate-change/ - full research paper - researchgate

    1. 54% of Wikipedia pages contain at least one link in their “References” section that points to a page that no longer exists.

      for - stats - digital stats - 54% of Wikipedia pages contain at least one link in their “References” section that points to a page that no longer exists.

    1. Humanity in general is to develop tools to identify detect and communicate with all kinds of intelligences and very unconventional embodiments that we are not good at

      for - proposal - future conversations - Earth Species Project & Michael Levin could be a good future conversation!

    2. Ben lions in particular uh is uh someone who's who's been pointing out this so so he and I are actually um writing a paper on um the price system as a kind of cognitive glue

      for - Michael Levin & economist Ben Lyon collaboration on price in marketplace as cognitive glue

      to - Michael Levin & economist Ben Lyon conversation on Price in the marketplace as a cognitive glue for human social superorganism - https://hyp.is/X-yNJnczEe-Nd6N02kiSVQ/www.youtube.com/watch?v=0Oo4ng6dWrQ

    3. what would happen if I begin to self-referentially and try to embody a part of a collective intelligence including the three of us in such a fashion that we were actually leveraging that qualitatively distinct um mind to inform the conversation we're having to get us there

      for - Jordan Hall - gedanken - collective intelligence of a group - Michael Levin & Jordan Hall conversation

    4. I think it's really important for us to develop a science of that like CR like critically important

      for - answer - Micheal Levin - adjacency - hyperobject - cognitive light cone - critically important to develop a science of this

      adjacency - between - multi scale competency architecture - cognitive light cone - hyperobject - awakening / enlightenment - adjacency relationship - At every stage of the multi scale competency architecture, - the living entities at a particular stage may maintain - feedback and - feedforward signals - with any - higher or - lower level systems. - Human INTERbeCOMings and other consciousness are no different - We exist at one level but are both - composed of lower level living parts and - compose larger social superorganism - Indeed, the spiritual acts variously described as - awakening - enlightenment - can be interpreted as transcending level cognitive light cone

    1. On many occasions, I've opened up requests for support in the form of a Github pull request. This way, I am telling the author: I have found a potential problem with your library, here is how I fixed it for my circumstance, here is the code I used for reference. You get extra internet points if you open the pull request with: "I don't expect this pull request to get merged, but I wanted to you show you what I did".
    2. Don't assume that because you opened up a pull request, that the author will accept it. There are many reasons that a maintainer might choose to not merge in your specific patch, many of which have nothing to do with you. If your patch isn't accepted, try to assume it's for a valid technical reason and not because the author hates you.
    3. Don't get upset, rejection is normal
    1. Both biosphere boundaries

      for - question - earth system boundaries - biodiversity - how do we reconcile these boundaries with climate departure?

      question - earth system boundaries - biodiversity - how do we reconcile these boundaries with climate departure? - Does the term "functional integrity" imply autonomy from climate feedbacks? Obviously, climate feedback plays a huge role in determining biodiversity health - In 2013, Mora et al. found that climate departure, the year in which a climate variable moves out of the historical bounds will occur everywhere on the planet, regardless of an aggressive RCP pathway being taken. In this study, climate departure was found to take place (relative to 2013) - 37.5 years in the future under RCP45, or - 22.5 years in the future under RCP85 - It would seem that the biodiversity boundaries should take into consideration climate departure as species extinction and ecological system disruption is projected to occur, regardless of whether RCP45 or RCP85 is adopted. - Currently, we are still on a Business-As-Usual trajectory, but since 2013, scientific research has moved the danger threshold even lower so climate departure dates are likely even sooner than those calculated in the 2013 Mora paper

      to - Mora, C., Frazier, A., Longman, R. et al. (2013). The projected timing of climate departure from recent variability. Nature 502, 183–187. https://doi.org/10.1038/nature12540 - https://hyp.is/3wZrokX9Ee-XrSvMGWEN2g/www.nature.com/articles/nature12540 - Researchgate copy - https://hyp.is/go?url=https%3A%2F%2Fwww.researchgate.net%2Fpublication%2F257598710_The_projected_timing_of_climate_departure_from_recent_variability&group=world

    2. system transformations that could move humanity into a safe and just corridor

      for - rapid whole system change - to move humanity to a safe and just corridor

    1. Seit 2023 herrscht im Amazonasgebiet eine extreme Dürre, deren Ursachen die Erhitzung der Ozeane und ein durch die globale Erhitzung verstärkter El Niño sind. Sie begünstigt die extrem zahlreichen Waldbrände, deren Rauch gerade die Luft über 60% des brasilianischen Territoriums verschmutzt. 97% der Brände werden aber von Menschen entzündet, vor allem im Interesse der Agrarindustrie. Auch aufgrund der Entwaldung ist der Kipppunkt, von dem an der Wald Kohlenstoff emittiert statt absorbiert, näher als bisher angenommen. Ausführlicher Bericht anlässlich einer neuen Studie und des Aufrufs zum Boykott von.Agrarprodukten aus dem Gebiet. https://www.liberation.fr/environnement/ravagee-par-les-feux-lamazonie-au-bord-du-basculement-le-climat-est-devenu-un-allie-de-la-destruction-de-la-foret-20240911_HEMGMQI7WZCYHAWC6E24ZJCTIU/

      Studie: https://www.nature.com/articles/s41586-023-06970-0

    1. Der neue französische Premierminister Michel Barnier hat in seiner Zeit als Umweltminister wesentlich dazu beigetragen, das Vorsorgeprinzip und die finanzielle Verantwortung der Verschmutzenden für Schäden im Umweltrecht zu verankern. Obwohl er zu Amtsbeginn auch von der „ökologischen Schuld" gesprochen hat, erwarten NGOs und Thinktanks, deren Vertreter:innen die Libération befragt hat, allenfalls vorsichtige umweltpolitische Schritte und eine insgesamt restriktive Ausgabenpolitik von ihm.https://www.liberation.fr/environnement/le-premier-ministre-michel-barnier-est-il-vraiment-decide-a-payer-la-dette-ecologique-de-la-france-20240906_7BYVDVAUSJD2VN6M4V7DAI2N2E/

    1. Die Fossilindustrie finanziert seit Jahrzehten Universitäten und fördert damit Publikationen in ihrem Interesse, z.B. zu false solutions wie #CCS. Hintergrundbericht anlässlich einer neuen Studie: https://www.theguardian.com/business/article/2024/sep/05/universities-fossil-fuel-funding-green-energy

      Studie: https://doi.org/10.1002/wcc.904

    1. not to act in such a case would be the egoic response would be there it would be a response that came from the fear of an individual that it would be cowardice it would be it would be refusing to act washing a veneer of of non-violence over one's egoic fea

      for - nonduality - not acting against violence in such a case (as Ukraine war) is an egoic response - acting out of cowardice - Rupert Spira

      comment - One can act egoically both to take action AND to not take action.

    2. at least some of my audience sometimes misunderstand this position um they say well you know to express evil is also part of nature it's also part of the universal mind which is correct um but it is also part of you of the universal mind also part of nature to strive against evil to stop evil and sometimes forcefully if need be because you're not just going to wait for evil to come and barbarize your loved ones and violate truth left and right i think what this understand understanding calls for is not the complete cessation of the use of force when force is the last resort that we have at our at our hands what it calls for is the the end of the notion that the use of force is a form of vengeance

      for - question - nilhism - nondualism - is fighting evil a contradiction? - Rupert Spira - Bernado Kastrup - question - nilhism - how do we prevent falling into?

      question - nondualism - is fighting evil a contradiction? - Pondering this idea raises the question: - Is fighting evil a contradiction? - Do we fall into duality if we fight evil? - Does nonduality imply not creating categories of morality of good and evil? - This question has no answer because - If you understand the question, you are already - a language user - applying some morality - We are already post category and post linguistic - we can never undo this and get back to pre-category and pre-linguistic - Fighting evil cannot conquer it because - in fighting evil, this implies using (deadly) force - deadly force results in death, the most extreme form of suffering - It is tantamount to abuse and justifying death is the greatest act of separation, causing great suffering to the other - In effect, we have the same result as the abuser and this can create a new generation of abused

      question - nilhism - how do we prevent falling into? - Rather, what is needed is to PENETRATE moral relativism / dualism altogether to re-discover the common sacred ground both moral categories are based upon - The use of force as a form of vengeance - is the perpetuation of the abused-abuser cycle

    1. So there has to be a reality, deeper reality, out of which these spacetime reality that we call reality emerges. So so therefore the model to think of the model in your following way, consciousness is a quantum field.

      for - quote - consciousness - model of - as a quantum field - Federico Faggin - question - about Federico Faggin's quantum field theory of consciousness - Is it neo-dualistic?

      quote - consciousness - model of - as a quantum field - Federico Faggin - (see below) - Think of the body as a structure in space and time - It is both - classical - cells are made of particles, atoms and molecules that interact quantumly in space and time - AND fields - The body is a bridge between consciousness and the classical (objective spacetime) world - The body reports to the conscious field - and creates quantum states inside the cell

      potential future dialogue - Michael Levin and Federico Faggin - To unpack quantum states at cellular or subcellular level, it would be good to see a dialogue between Michael Levin and Federico Faggin

    2. Now we understand why there has to be an inner reality which is made of qualia and an outer reality which is made a lot of symbols, shareable symbols, what we call matter.

      for - unpack - key insight - with the postulate of consciousness as the foundation, it makes sense that this is - an inner reality made of qualia - and an outer reality made of shareable symbols we call matter - Federico Faggin - question - about Federico Faggin's ideas - in what way is matter a symbol? - adjacency - poverty mentality - I am the universe who wants to know itself question - in what way is matter a symbol? - Matter is a symbol in the sense that it - we describe reality using language, both - ordinary words as well as - mathematics - It is those symbolic descriptions that DIRECT US to jump from one phenomena to another related phenomena. - After all, WHO is the knower of the symbolic descriptions? - WHAT is it that knows? Is it not, as FF points out, the universe itself - as expressed uniquely through all the MEs of the world, that knows? - Hence, the true nature of all authentic spiritual practices is that - the reality outside of us is intrinsically the same as - the reality within us - our lebenswelt of qualia

    3. it has to be taken as a postulate

      for - answer - It has to be taken as a postulate - Federico Faggin - to question - how can we test that consciousness is the foundation of reality?

  5. Aug 2024
    1. we can reverse engineer practices for people that help them to do uh the recovery and also the development of the cognitive light cone of right of a recovery of a lot of of what is lost for people in the meaning crisis

      for - STOP - intervention - integration of cognitive science and wisdom traditions to - provide a praxis to address the meaning crisis - John Verveake

    2. a model of the self that is inherently Collective and flowing

      for - quote - model of a Self that is flowing and collective - John Vervaeke - similiarity to - Deep Humanity foundations on emptiness

      quote - model of a Self that is flowing and collective - John Vervaeke - This is equivalent to Stop Reset Go Deep Humanity foundation on the two pillars of emptiness - change and intertwingledness

    1. this localization process enables consciousness to perceive itself as the universe because infinite consciousness cannot perceive its own activity directly because it would have to do so from if infinite consciousness were to perceive the universe directly it would have to do so from every single point of view in the universe it would be the deepest darkest black image you could imagine so in order to perceive an object consciousness must localize itself as an apparently separate subject so this localization of the apparent localization of our self or the dissociation of ourselves as finite minds out of infinite consciousness enables um perception

      for - adjacency - key insight - quote - localization enables (infinite or universal consciousness) to perceive itself - Rupert Spira - discerning single voice at a busy party metaphor - existential isolation - umwelt

      adjacency - between - key insight - quote - localization enables (infinite or universal consciousness) to perceive itself - Rupert Spira - discerning single voice at a busy party metaphor - existential isolation - adjacency relationship - quote - localization enables (infinite or universal consciousness) to perceive itself - Rupert Spira - This localization process enables (infinite) consciousness to perceive itself as the universe because - infinite consciousness cannot perceive its own activity directly - because if infinite consciousness were to perceive the universe directly - it would have to do so from every single point of view in the universe - It would be the deepest, darkest black image you could imagine - So in order to perceive an object - (infinite) consciousness must localize itself as an apparently separate subject so - the apparent localization of our self or - the dissociation of ourselves - as finite minds out of infinite consciousness enables - perception and - thought

      • There is a metaphor that applies here:
        • At a busy dinner party, many people are talking at the same time
        • As the number of people approach infinite, the signal becomes more difficult to detect
        • In the same manner, as the activities of the universe are seemingly unbounded, how could infinite consciousness possibly observe its own infinite entirety?
        • Existential isolation is deemed depressing because it makes us feel intrinsically separated and disconnected from others, yet
          • it may be very necessary
        • Can you imagine hearing and understanding the voices of every human being, much less every living being?
        • An individual human does not have the capacity to process all that information
        • In the same manner, the body of every living organism is fine tuned for only one specific set of unwelts
        • How would we process the unbound amounts of information if we had an infinite number of different detectors?
    1. is DNA in engram or not yeah I think so yeah okay yeah yeah I think so but now now again that that requires that requires a real shift I think most biologists would say no but I think it is because I think that um all memories are just messages from your past self and that what's happening with DNA is that previous previous basically there's this giant lineage agent that's the scale of an evolutionary lineage and the DNA are its engrams where that information is is being passed on the way that any memory would

      for - adjacency - DNA - as an engram - as a memory - Micheal Levin

      adjacency - between - DNA - as an engram - as a memory - adjacency relationship - Very interesting n way to see DNA

    1. Today on AirTalk:<br /> - California announces new deal with tech to fund journalism, AI research - How to help your LGBTQ+ student deal with the anxiety of going back to school - Anthology television and its place in mid century American society - Digital driver's licenses are here. Does that mean convenience, privacy headache or both? - Tribute to jazz legends The Mizell Brothers kicks off ‘Jazz Is Dead’ concert series at The Ford - TV Talk: ‘Homicide’ streaming release, ‘City of God,’ ‘Solar Opposites’ and more

      https://laist.com/shows/airtalk/california-announces-new-deal-with-tech-to-fund-journalism-ai-research

    1. Conclusión

      Propusimos una herramienta basada en IA que podría motivar a las mujeres de América Latina a participar en proyectos de ciencia ciudadana.

    1. International cooperation and an approach to ADM and machine learning grounded in human rights.

      Llamado a la acción

      Una revisión a nivel de agencias de la ONU sobre la aplicación de las leyes y estándares internacionales de derechos humanos existentes para la gestión de los datos automatizados, el aprendizaje automático y el género: esto puede guiar y provocar el pensamiento creativo para un enfoque basado en los derechos humanos que sea adecuado para el propósito en la era digital que cambia rápidamente.

      Desarrollo de un conjunto de métricas para la inclusión digital: debe acordarse urgentemente, medirse en todo el mundo y detallarse con datos desagregados por sexo en los informes anuales de instituciones como la ONU, el Fondo Monetario Internacional, la Unión Internacional de Telecomunicaciones, el Banco Mundial y otros bancos multilaterales de desarrollo, y la OCDE.

    2. Take clear proactive steps to include an intersectional variety and equal numbers of women and girls in the creation, design, and coding of ADM.

      Llamado a la acción

      Equilibrio de género en la toma de decisiones de IA: el equilibrio de género en la toma de decisiones debe incluirse en la agenda oficial de todos los involucrados en la financiación, el diseño, la adopción y la evaluación de ADM.

      Equilibrio de género en los equipos de diseño: empleo de una gama sólida de feministas interseccionales en el diseño de sistemas ADM que desencadenarán y ayudarán a una mayor innovación y creatividad, así como la detección y mitigación de sesgos y efectos nocivos en mujeres, niñas y personas tradicionalmente excluidas.

      Exigir a las empresas que divulguen e informen de manera proactiva sobre el equilibrio de género en los equipos de investigación y diseño, incluso en la fase inicial cuando soliciten subvenciones. Incentivar equipos equilibrados y multidisciplinarios.

      Fondo de investigación: crear un fondo de investigación para explorar los impactos del género y la IA, el aprendizaje automático, el sesgo y la equidad, con un enfoque multidisciplinario más allá de la informática y la perspectiva económica para incluir nuevas formas de incorporar la alfabetización digital y estudiar los efectos económicos, políticos y sociales de ADM en las vidas de las mujeres y las personas tradicionalmente excluidas de la elaboración de reglas y la toma de decisiones.

    3. Advocate for and adopt guidelines that establish accountability and transparency for algorithmic decision making (ADM) in both the public and private sectors.

      Llamado a la acción

      Acciones algorítmicas equitativas para corregir los sesgos y barreras de la vida real que impiden que las mujeres y las niñas logren la participación plena y el disfrute igualitario de los derechos.

      Instituciones públicas para pilotar y liderar: Acción afirmativa para algoritmos implementados cuando las instituciones públicas pilotan ADM. Basar los pilotos en investigaciones de ciencias sociales nuevas y de larga data que asignan incentivos sociales, subsidios o becas donde las mujeres tradicionalmente han sido dejadas atrás en sistemas anteriores. Esta es una agenda positiva para promover los valores de igualdad que hemos adoptado durante mucho tiempo, para corregir la visibilidad, la calidad y la influencia de las mujeres proporcionales a la población.

      Adopción por parte del sector público y privado de evaluaciones de impacto algorítmico (AIA): un marco de autoevaluación diseñado para respetar el derecho del público a conocer los sistemas de IA que impactan sus vidas en términos de principios de responsabilidad y equidad.

      Pruebas rigurosas a lo largo del ciclo de vida de los sistemas de IA: las pruebas deben tener en cuenta los orígenes y el uso de los datos de entrenamiento, los datos de prueba, los modelos, la interfaz de programación de aplicaciones (API) y otros componentes a lo largo del ciclo de vida de un producto. Las pruebas deben cubrir ensayos previos al lanzamiento, auditorías independientes, certificación y monitoreo continuo para detectar sesgos y otros daños. La ADM debe mejorar la calidad de la experiencia humana, no controlarla.

      Marcos legales sólidos para promover la rendición de cuentas: incluida la posible expansión de poderes para agencias sectoriales específicas o la creación de nuevos términos de referencia para supervisar, auditar y monitorear los sistemas de ADM para la supervisión regulatoria y la responsabilidad legal en el sector privado y público.

      Directrices de adquisiciones con perspectiva de género: las organizaciones y todos los niveles de gobierno deben desarrollar directrices de adquisiciones de igualdad de género de ADM con objetivos estrictos; y describir los roles y responsabilidades de aquellas organizaciones requeridas para aplicar estos principios.

      Mejorar los conjuntos de datos: datos abiertos desagregados por género, recopilación de datos y conjuntos de datos de calidad inclusivos: producir activamente conjuntos de datos abiertos desagregados por género; Esto permite comprender mejor las fuentes de sesgo en la IA y, en última instancia, mejorar el rendimiento de los sistemas de aprendizaje automático. Invertir en controles para supervisar los procesos de recopilación de datos y la verificación humana en el circuito, de modo que los datos no se recopilen a expensas de las mujeres y otros grupos tradicionalmente excluidos. Participar en procesos de recopilación de datos más inclusivos que se centren no solo en la cantidad sino también en la calidad de los conjuntos de datos.

    1. how do you know if, if, and when you are part of a larger cognitive system, right?

      for - question - how do you know when you are part of a larger cognitive system? - answer - adjacency - synchronicity - lower level example - two neurons talking to each other - Michael Levin - Mark Solms foundation theory of affect

      question - how do you know when you are part of a larger cognitive system? - answer - adjacency - synchronicity - lower level example - two neurons talking to each other - Michael Levin - Mark Solms foundation theory of affect

      adjacency - between - answer - synchronicity - lower level example - two neurons talking to each other - Michael Levin - Mark Solms foundational theory of affect - adjacency relationship - This is a very interesting question and Michael Levin provides a very interesting answer - First, it is very interesting that Mark Solms points out that affect is foundational to cognition - This is evident once we begin to think of the fundamental goals of any individual of any species is to optimize survival - The positive or negative affects that we feel are a feedback signal that measures how successful we are in our efforts to survive - Hence, it is more accurate to ask: - How do you know if and when you are part of a larger affective-cognitive system? - Levin illustrates the multi-level nature of simultaneous consciousness by looking at two neurons "in dialogue" with each other, and potentially speculating about a "higher level of consciousness", which is in fact, the level you and I operate at and take for granted - This speculative question is very important for it also can be generalized to the next layer up, - Do collectives of humans, each one experiencing itself a unified, cohesive inner perspective, constitute a higher level "collective consciousness"? - If we humans experience feelings and thinking whilst we have a well defined physical body, then - what does a society feel and think whilst not having such a well defined physical body?

    1. I want to figure out find out help find out ways in which we can have things where maybe at the most you need to dedicate a week of your life you know because you need to be in a special environment in order to have the the sort of the the conditions in which this can happen and can have those experiences and if say 30% of the people that claim to be ready actually have one of those experien that would be a marvelous objective to reach so that's what I'm thinking right now

      for - Federico Faggin - high priority objective - find and implement ways to catalyze authentic awakening experiences in a short time - ie - one week

    1. for - Dr. Donna Thomas - book - Children's unexplained experiences in a post materialistic world - analytic idealism - children perspective of reality - adjacency - children as natural philosophers - Deep Humanity as reminder of our philosophical nature

      adjacency - between - Children as natural philosophers - Deep Humanity - adjacency relationship - At time 59 minute of that interview, Dr Thomas makes a very insightful observation that - children are naturally philosophers - and ask deeply philosophical questions - Another way to look at Deep Humanity is that it is reminding us of these deeply philosophical questions the see all had when we were children - but we stopped asking then as we grew out of childhood because nobody could answer them for us

    1. Fear, thereby, acts a fulcrum tonegotiate his identity in context of his relationships.

      Fear is the deciding factor on how Elio and Oliver decide who they are in the context of their relationships there and then. Their identity is directly based on the social mirror due to fear.

    Tags

    Annotators

    1. the number one issue is to get world leaders  immediately to sit down together and, recognize that we need to urgently get back  into the safe space of planetary boundaries.

      for - planetary emergency - top priority task - get world leaders to meet and develop a plan to return to the safe operating space

    2. So either you're back into the future  in a dead end, and you hit the wall, and it gets dark. or you transition  towards this more attractive future. And I think we need to start talking  about that attractive future

      for - planetary emergency - narrative shift required - from lack to building a better world

    3. even if we were successful in phasing out fossil fuels, we would still fail. on  the climate boundary. We would still breach the 1. 5 degree Celsius boundary if we do not come back  into the safe space on the biosphere boundaries. Because biodiversity, freshwater, land, and  nutrients will determine the ability of the planet to buffer

      for - quote - Johan Rockstrom - successful phase of of fossil fuels - is a necessary but not sufficient condition for station under 1.5 degree Celsius

    1. before puberty before let's say 30 and 14 years of age um we know that the Restriction of those devices is beneficial for the development of the brain because children learn to to think in a three-dimensional world

      for - neuroscience - education of children - recommend no digital devices before puberty - allows learning in a 3 dimensional world

    2. children for instance ask 500 2 000 questions a day and as you are grown up it's maybe 10 or 20 Questions per day

      for - neuroscience - importance of maintaining curiosity - 1000 questions a day for children - 20 questions a day for adults

    1. Case: Patient Proband SS, Female, Caucasian

      DiseaseAssertion: UCD/OTCD

      FamilyInfo: De novo inheritance, no family history of disease

      CasePresentingHPOs: Hyperammonemia (HP:0001987), oroticaciduria (HP:0003218), Childhood onset (HP:0011463)

      CaseHPOFreeText:

      CaseNOTHPOs: Positive allopurinol test

      CaseNOTHPOFreeText:

      CasePreviousTesting: Genomic DNA isolated from peripheral blood leukocytes or cultured skin fibroblasts. Amplification by PCR used. SSCP analysis performed. Sequencing of both free and immobilized single strands carried out by dideoxy chain termination method.

      SupplementalData: Table 1: Mutations in the Ornithine Transcarbamylase Gene of 17 Females

      Variant: NM_000531.6:c.77+1G>A

      ClinVarID: 97313

      CAID: CA224773

      gnomAD:

    1. the more stuff happened I'm going to think retrospectively oh this was a very long time because there were so so many new things and so much experience in retrospectively

      for - time sense - more new events gives a longer sense of time

    2. the best way to have a very long life is that you have a lot of new stuff around you

      for - neuroscience - how to - create perception of a long life - increase new activities

    1. Case: Patient #50, Male

      DiseaseAssertion: UCD/OTCD

      FamilyInfo: N/A

      CasePresentingHPOs: Neonatal onset (HP:0003623), Hyperammonemia (HP:0001987)

      CaseHPOFreeText:

      CaseNOTHPOs:

      CaseNOTHPOFreeText:

      CasePreviousTesting: N/A

      Variant: NM_000531.6: c.174G>A (p.Trp58*)

      ClinVarID: 97127

      CAID: CA224490

      gnomAD:

    2. Case: Patient #15, Female

      DiseaseAssertion: UCD/OTCD

      FamilyInfo: N/A

      CasePresentingHPOs: N/A

      CaseHPOFreeText:

      CaseNOTHPOs:

      CaseNOTHPOFreeText:

      CasePreviousTesting:

      Variant: NM_000531.6: c.77+1G>A

      ClinVarID: 97313

      CAID: CA224773

      gnomAD:

  6. Jul 2024
    1. Case: patient #10, Male, Argentine

      Disease Assertion: UCD/OTCD

      Family Info: family history of the disease,

      Case Presenting HPOs: Neonatal onset(HP:0003623), Hyperammonemia HP:0001987

      Case HPO FreeText:

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: The OTC gene mutations were identified using PCR amplification, classical sequencing (Sanger), and multiplex ligation-dependent probe amplification.10,11 Mutations were identified by comparison with the GenBank reference sequence for human OTC (GenBank entries: NG_008471.1, NP 000522.3, NM 000531.5, NC 000023.11) Missense mutations were analyzed using different computational algorithms: CLUSTALW2 (http://www.clustal.org/clustal2/), SIFT (http://blocks.fhcrc.org/sift/SIFT.html),Polyphen2(http://genetics.bwh.harvard.edu/pph/),PoPMuSiC(http://babylone.ulb.ac.be/popmusic/), and SIFT Indel(http://siftdna.org/www/SIFT_indels2.html).

      Supplemental Data: Table 1 Notes: died at 6 months and had 2 brothers that died a neonatal stage

      Variant: NM_000531.6: c.540+1G>A

      ClinVarID: 1458773

      CAID: CA412724226

      gnomAD: X-38381340-A-T

      Gene Name: OTC (ornithine transcarbamylase)

    1. for - search - google - high resolution addressing of disaggregated text corpus mapped to graph - search results of interest - high resolution addressing of disaggregated text corpus mapped to graph

      search - google - high resolution addressing of disaggregated text corpus mapped to graph - https://www.google.com/search?q=high+resolution+addressing+of+disaggregated+text+corpus+mapped+to+graph&oq=high+resolution+addressing+of+disaggregated+text+corpus+mapped+to+graph&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIHCAEQIRigATIHCAIQIRigAdIBCTMzNjEzajBqN6gCALACAA&sourceid=chrome&ie=UTF-8

      to - search results of interest - high resolution addressing of disaggregated text corpus mapped to graph - A New Method for Graph-Based Representation of Text in - The use of a new text representation method to predict book categories based on the analysis of its content resulted in accuracy, precision, recall and an F1- ... - https://hyp.is/H9UAbk46Ee-PT_vokcnTqA/www.mdpi.com/2076-3417/10/12/4081 - Encoding Text Information with Graph Convolutional Networks - According to our understanding, this is the first personality recognition study to model the entire user text information corpus as a heterogeneous graph and ... - https://hyp.is/H9UAbk46Ee-PT_vokcnTqA/www.mdpi.com/2076-3417/10/12/4081

    1. Case: patient #11, female, 35yo, slovenian

      Disease Assertion: UCD/OTCD

      Family Info: family history of the disease,

      Case Presenting HPOs: Adult onset(HP:0003581), hyperammonemia(HP:0001987), protein avoidance (HP:0002038)

      Case HPO FreeText:

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: Sequencing was performed at a 3rd-party sequencing center using a standardized seq of procedures following PCR-free WGS library preparation protocol Illumina TrueSeq DNA Nano and sequenced on Illumina NovaSeq 6000 platform with a mean autosomal depth greater than 30×. Variants were interpreted by a medical doctor specialized in the NGS sequencing data analysis and those classified as likely pathogenic or pathogenic according to the ACMG/AMP standards and guidelines were considered for reporting, while variants of uncertain clinical significance, were not considered. Likely pathogenic and pathogenic variants were further evaluated by the referring clinical geneticist and were considered and reported if they were classified as both a likely diagnostic finding and if they were compatible with the clinical presentation of referral.

      Supplemental Data: Table 4 and section 3.1(Case description) Notes:

      Variant: NM_000531.6: c.540+265G>A

      ClinVarID: 449382

      CAID: CA658658977

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    1. Case: patient #113, Male

      Disease Assertion: UCD/OTCD

      Family Info:

      Case Presenting HPOs: Neonatal onset(HP:0003623), Hyperammonemia HP:0001987

      Case HPO FreeText:

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: GDNA from blood, cultured skin fibroblasts, liver from patients suspected for otc deficiency was used to amplify all 10 exons and exon/intron boundaries using primers listed in Table 1. The amplified DNA fragments were then screened by single-strand conformational polymorphism (SSCP) and the abnormally migrating DNA fragments were sequenced directly from PCR products (w/o subcloning) to identify the mutation. The amino acid residue substitution created by the mutation is examined using an alignment of 26 OTCase sequences from 23 species.

      Supplemental Data: Table 4 Notes:

      Variant: NM_000531.6: c.867+1G>A

      ClinVarID: 97342

      CAID: CA224813

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    1. for - paper review - building a system-based Theory of Change using Participatory Systems Mapping - participatory systems mapping - SRG / Indyweb dev - system mapping - participatory approach

      summary - I'm reviewing this paper because the title seems salient for the development of our own participatory Stop Reset Go system mapping tool within Indyweb ecosystem. - The building of - a systems-based Theory of Change using - Participatory Systems Mapping - is salient to our own project and aligns to it with different language: - Theory of Change with uses theory to perform an evaluation and propose an intervention - The Stop Reset Go framework focuses on the specific type of process called "improvement", or - transforming a process to make it "better" in some way

      to - Indyweb project info page - https://hyp.is/RRevQk0UEe-xwP-i8Ywwqg/opencollective.com/open-learning-commons/projects/indy-learning-commons

    1. Ccile Barrois sarigné adjoint 00:12:17 du Défenseur des droits en matière de simplification du langage en langage plus clair plus compréhensible vous pouvez nous poser les les enjeux de votre côté comment vous vous saisissez de de C cette problématique essentielle 00:12:30 on l'a vu oui euh je vous remercie de m'avoir convié à ce rendez-vous donc en qualité d'adjointe de clireedon défenseur des droits une institution qui est saisie de de plus de 2 2000000 réclamations enfin sollicitations par an 00:12:42 donc qui Crète un volume important et qui porte sur la question qui nous occupe aujourd'hui je crois un double regard tout d'abord celui d'une institution dont la mission de de de contrôle et de d'observation des 00:12:54 relations usagers services public est au cœur finalement des missions euh et dans ce cadre évidemment nous sommes confrontés à la question de la complexité de de du langage administratif complexité des procédures 00:13:07 qui nous reviennent qui nous reviennent à travers les réclamations qui sont transmises notamment à nos délégués du Défenseur des droits et et qui nous ont fait fait prendre conscience de de grandes difficultés notamment sur 00:13:19 l'accès à des prestations donc l'accès au droit
    2. Ccile Barrois sarigné adjoint 00:12:17 du Défenseur des droits en matière de simplification du langage en langage plus clair plus compréhensible vous pouvez nous poser les les enjeux de votre côté comment vous vous saisissez de de C cette problématique essentielle 00:12:30 on l'a vu oui euh je vous remercie de m'avoir convié à ce rendez-vous donc en qualité d'adjointe de clireedon défenseur des droits une institution qui est saisie de de plus de 2 2000000 réclamations enfin sollicitations par an 00:12:42 donc qui Crète un volume important et qui porte sur la question qui nous occupe aujourd'hui je crois un double regard tout d'abord celui d'une institution dont la mission de de de contrôle et de d'observation des 00:12:54 relations usagers services public est au cœur finalement des missions euh et dans ce cadre évidemment nous sommes confrontés à la question de la complexité de de du langage administratif complexité des procédures 00:13:07 qui nous reviennent qui nous reviennent à travers les réclamations qui sont transmises notamment à nos délégués du Défenseur des droits et et qui nous ont fait fait prendre conscience de de grandes difficultés notamment sur 00:13:19 l'accès à des prestations donc l'accès au droit
    1. Case: no patient #ID, male Disease Assertion: UCD/OTCD

      Family Info: NA

      Case Presenting HPOs: NA

      Case HPO FreeText:

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: NA

      Supplemental Data: TABLE 1, Notes: NA

      Variant: NM_000531.6: c.663+1G>A

      ClinVarID: 97283

      CAID: CA224730

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    1. Despite this panoply of stories, we are in fact living in a time between stories, because the d

      for - paradigm shift - we need a new story quote - a time between stories

      quote - a time between stories - Despite this panoply of stories, we are in fact living in a time between stories, because - the dominant narrative remains the same: - progressing within the modern paradigm is the best way to create and maintain a good quality of life, and the only way societies can do this is through - Western-style industrial development, - corporate capitalism, and - representative democracy. - While many people recognise that this narrative needs to be replaced, - we haven’t yet found a new narrative that’s powerful enough to replace it.

    2. for - paradigm shift - we need a new story

      article details - title - Finding our place in the human story - author - Paddy Le Flufy - date - 14 July, 2024 - publication - substack - self link - https://paddyleflufy.substack.com/p/finding-our-place-in-the-human-story

    1. I like to call it inverse vandalism (when vandalism is destroying things just because one can, then inverse vandalism is making things because one can).
    1. 26:30 Brings up progress traps of this new technology

      26:48

      question How do we shift our (human being's) relationship with the rest of nature

      27:00

      metaphor - interspecies communications - AI can be compared to a new scientific instrument that extends our ability to see - We may discover that humanity is not the center of the universe

      32:54

      Question - Dr Doolittle question - Will we be able to talk to the animals? - Wittgenstein said no - Human Umwelt is different from others - but it may very well happen

      34:54

      species have culture - Marine mammals enact behavior similar to humans

      • Unknown unknowns will likely move to known unknowns and to some known knowns

      36:29

      citizen science bioacoustic projects - audio moth - sound invisible to humans - ultrasonic sound - intrasonic sound - example - Amazonian river turtles have been found to have hundreds of unique vocalizations to call their baby turtles to safety out in the ocean

      41:56

      ocean habitat for whales - they can communicate across the entire ocean of the earth - They tell of a story of a whale in Bermuda can communicate with a whale in Ireland

      43:00

      progress trap - AI for interspecies communications - examples - examples - poachers or eco tourism can misuse

      44:08

      progress trap - AI for interspecies communications - policy

      45:16

      whale protection technology - Kim Davies - University of New Brunswick - aquatic drones - drones triangulate whales - ships must not get near 1,000 km of whales to avoid collision - Canadian government fines are up to 250,000 dollars for violating

      50:35

      environmental regulation - overhaul for the next century - instead of - treatment, we now have the data tools for - prevention

      56:40 - ecological relationship - pollinators and plants have co-evolved

      1:00:26

      AI for interspecies communication - example - human cultural evolution controlling evolution of life on earth

    1. Two "5" keys (?!?) (SC Poweriter)

      reply to u/Deep-Seaworthiness48 at https://www.reddit.com/r/typewriters/comments/1e5gh4p/two_5_keys_sc_poweriter/

      SMC Typewriter from late 60s/early 70s with a pound/5 key in the !/1 position whose 5 is duplicated in the usual %/5 position

      Things like that happened on alternate language/region typewriters. I've got a Dutch keyboard layout that repeats a % symbol twice.

      It's likely that the pound symbol was needed/required so they pulled one from a pre-existing typeslug and key cap on a keyboard where the £/5 key was common and replaced the 1/! which in the era was widely known could be done by alternate means (aka lower case 'l' and '.' backspace '''.

      The value of the £ was more important to the typist and because of typeface manufacture was probably easier to do in the £/5 existing combination from something like the English No. 1028, International No. 1060 keyboard, the Brazilian No. 1065, or the Danish No. 1047 all of which paired the £/5. See also: https://munk.org/typecast/2023/02/03/1954-smith-corona-scm-typewriter-type-styles-and-keyboards-catalog/

      Off hand, I don't see another S-C keyboard combination from that time period that had a £ paired with any other glyph/character. In the "change-a-type" time period they likely wouldn't have done a custom black key for the £/5 when they were already manufacturing one in a matching white. If they didn't also swap out the key at the far right end of that bank, I would expect it to be a standard black '+/=' key cap and slug.

    1. "We made dissent illegal and banned controversial discourse from public spaces, why hasn't bigotry and hate stopped existing?"

      this is just a precursor to genocide.<br /> first they ban your religion, then they wipe out your families.

      go ask the armenians how their genocide went...<br /> go ask some turcs why they killed so many armenians...<br /> (spoiler: turcs absolutely hate that question, they will freak out.)

    1. Case: patient #2, male, Saudi Arabian

      Disease Assertion: UCD/OTCD

      Family Info: Family history of the disease, Variant found in mother of the patient, Brother died of hyperammonemic crisis

      Case Presenting HPOs: intellectual disability (HP:0001249), Neonatal onset (HP:0003623), seizure(HP:0001250), episodic hyperammonemia(HP:0001951), intellectual disability (HP:0001249)

      Case HPO FreeText: hyperammonemic encephalopathy

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: Liver tissues were used to extract RNA that was later used to synthesize cDNA. The products were compared to healthy controls in order to detect variants. gDNA, in order to determine the size of deletions in patient 3 and 4 , a set of intronic primers presumably flanking the deletions was used and specific primers allowed sequencing of exactly those critical regions(sequencing on paper). To estimate the relevance of the identified intronic variants in terms of their capability to induce splicing, we used a score developed by Shapiro and Senapathy. This splice score offers information about the usage of a certain splice site

      Supplemental Data: TABLE 1, Patient was severely mentally retarded after the age of 2. Low OTC activity

      Variant: NM_000531.6: c.540+265G>A(p.Gln180_Glu181insX4)

      ClinVarID: 449382

      CAID: CA658658977

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    1. Case: no patient ID#, 36yo donor , female

      Disease Assertion: UCD/OTCD

      Family Info:

      Case Presenting HPOs: adult onset (HP:0003581), oriticaciduria (HP:0003218), irritability (HP:0000737), protein avoidance

      Case HPO FreeText: hyperammonemic encephalopathy

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: N/A

      Supplemental Data: TABLE 1, She is vegeterian. The symptoms of OTCD started showing after the patient donated 60% of liver to her sibling. the information reported in this is the biochemical results during hyperammonemic episode following the transplantation. the patient became irritable and confused, and her level of consciousness deteriorated markedly. After hemodialysis the patient recovered.

      Variant: NM_000531.6: c.429T>A(p.Tyr143*)

      ClinVarID: 1072591

      CAID: CA412723166

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    1. The red curve in the right panel of Fig.3 shows a more realistic trajectory for theeconomy in the face of a steady physicalscale. In this example, non-physical activitiesare allowed to comprise 75% of the economybefore saturating. Although this upperlimit is arbitrary, its exact value does notchange the resulting saturation of the overalleconomy.

      for - steady state economy - when we hit physical constraints - a major percentage of our economy needs to be non-physical

    2. It seems ludicrous to imagine that these vitalresources incapable of further expansionwould become essentially free of charge.

      for - question - transition - from capitalism to a form of socialism?

      question - capitalism to a form of socialism? - To say it seems ludicrous is an opinion that makes sense from a traditional capitalists perspective - From a socialist perspective, it seems feasible - Nothing is free of charge, however, even in socialism, there is always some price an individual must pay, it's more about the incentive structure that differentiates the two - capitalism - polarized towards self-centric perspective - socialism -balanced self-and-other perspective

      adjacency - between - capitalism - socialism - differing perspective on self/other worldview - adjacency relationship - While capitalism relies on a self-centric perspective, socialism relies on a more balanced self/other perspective

    3. Given that assumptions of quantitativegrowth are pervasive in our society andhave been present for many generations,it is perhaps not surprising that growth isnot widely understood to be a transientphenomenon. Early thinkers on the physicaleconomy, such as Adam Smith, ThomasMalthus, David Ricardo and John Stuart Millsaw the growth phase as just that: a phase9

      for - quote - economic growth - pioneering economists saw growth not as permanent, but as just a temporary phase

      quote - economic growth - pioneering economists saw growth not as permanent, but as just a temporary phase - (see below) - Given that - assumptions of quantitative growth are pervasive in our society and - have been present for many generations, - it is perhaps not surprising that growth is not widely understood to be a transient phenomenon. - Early thinkers on the physical economy, such as - Adam Smith, <br /> - Thomas Malthus, - David Ricardo and - John Stuart Mill - saw the growth phase as just that: a phase

    1. I keep the possibility that um things will look different in the next few decades that I vasate between optimism and pessimism because there's there's plenty of reasons for the latter 00:40:37 but I'm I'm trying to hold space for the the former

      for - climate crisis - we are in a pivotal moment

    2. I don't think humans are going extinct anytime soon um but I do think 00:36:25 the global Industrial you know networked societies might be a lot more fragile

      for - Climate change impacts - human extinction - don't think so - paleontological evidence shows that humans are a resilient species

      Climate change impacts - human extinction - don't think so - paleontological evidence shows that humans are a resilient species - ice ages are really extreme events that humans have survived - Before entering the holocene interglacial period we have been in for the past 10,000 years, the exit from the previous Ice Age took approximately 10,000 years and - there was 400 feet of sea level rise - North America was covered with an Antarctica's equivalence of ice thickness - there was a quarter less vegetation a on the planet - it was dusty and miserable living conditions - There have been dozens of these natural climate oscillations over the past two and a half million years and humans are about 5 to 6 million years old, so have survived all of these - Sometimes in really particularly harsh climate swings,<br /> - speciations of new hominids will appear along with - new tools in the record or - evidence that there's been better control over fire - Humans are resilient and super adaptable - We've lived and adapted to the conditions on all the continents - We will make it through, but modern, industrialized, global society likely won't

    1. If warming reaches or exceeds 2 °C this century, mainly richer humans will be responsible for killing roughly 1 billion mainly poorer humans through anthropogenic global warming, which is comparable with involuntary or negligent manslaughter.

      for - quote - exceeding 2 Deg C may result in a billion deaths - Joshua Pearce

      quote - exceeding 2 Deg C may result in a billion deaths - Joshua Pearce - (see below) - If warming reaches or exceeds 2 °C this century, - mainly richer humans will be responsible for killing roughly 1 billion mainly poorer humans - through anthropogenic global warming, - which is comparable with involuntary or negligent manslaughter.

    1. the thought has occurred to me that we need a new religion that religion is one of the few things 01:09:15 that will make people act in ways beyond their own immediate interest well i've heard a lot of people say that

      for - rapid whole system change - need for a new religion - Ronald Wright reflections

      comment - Deep Humanity is not a religion, but a deeper understanding of our own humanity, what is it to be human? - but just as important, to understand the distinction between - human nature and - nature - For if human nature is a subset of nature, - which the adjective-noun "human nature" implies - then there is something within humans that is of nature herself - Is it possible that the many fragmented spiritual paths that have emerged in different parts of the world merely reflect the different environs from which they developed, and that in fact, they all are searching for the same essence? - If so, then in perhaps the times we are in are calling us for a global recognition of our common denominators that make us ALL human, - and then the even deeper common denominator with nature herself - So what are those qualities we all have in common as human beings? - and also, what are the qualities our species has in common with nature herself? - neuroscientist David Eagleman coined the term "possibileanism". Perhaps it is that?

    2. most of the great religions in the world have been attempts to to restrain or reform uh human nature or at least uh channel our worst impulses into something 01:10:48 more productive or higher something loftier um and in this this is exactly what we need here it's something that will create a form of altruism which doesn't only extend to people we see around us now but extends 01:11:00 to the future generations

      for - rapid whole system change - need for something that will create a new form of altruism - Ronald Wright - transition - requires an experience of re-awakening transition - need for a new religion? Deep Humanity?

      comment 10 July 2024 - Deep Humanity is our attempt at this. It is not a religion, however. It is humanity, but in the deepest sense, so it is accessible to anyone in our species. Our tagline has been - Rekindling wonder in an age of crisis - However, this morning an adjacency occurred:

      adjacency - between - familiarity - wonder - adjacency relationship - Familiarity hides wonder - Richard Dawkins said: - There is an anaesthetic of familiarity, - a sedative of ordinariness - which dulls the senses and hides the wonder of existence. - For those of us not gifted in poetry, - it is at least worth while from time to time - making an effort to shake off the anaesthetic. - What is the best way of countering the sluggish habitutation brought about by our gradual crawl from babyhood? - We can't actually fly to another planet. - But we can recapture that sense of having just tumbled out to life on a new world - by looking at our own world in unfamiliar ways. - That is, when a type of experience becomes familiar through repeated sensory episodes, - we lose the feeling of wonder we had when we initially experienced it - It's much like visiting a place for the very first time. We are struck with a sense of wonder because everything is unpredictable, in a safe way. We have no idea what's around the next corner. It's a surprise. - However, once we live there, and have traced that route hundreds of times, we have transformed that first magical experience into mundane experience. - So it is with everything that makes us human, with all the foundational things about reality that we learned from the moment we were born. - They have all become jaded. We've forgotten the awe of those first experiences in this reality: - our first experience of our basic senses - our first breath of air, instead of amniotic fluid - our first integration of multiple sensory experiences into a cohesive whole - the birth of objectification - the very first application of objectification to form the object we called mOTHER - the Most significant OTHER - our first encounter with the integration of multiple sensory stimuli associated with each object we construct - our first encounter with auditory human, speech symbols - our first experience with object continuity - how objects still exist even if they disappear from view momentarily - do we remember freaking out when mOTHER disappeared from view momentarily? - our first ability to communicate with mOTHER through speech symbols - our first encounter with ability to control our bodies through our own volition - our first encounter with gravity, the pull towards the ground - our first encounter with a large bright sphere suspended in the sky - our first encounter with perspective, how objects change size in our field of view as they get nearer or farer - etc... - What's missing now, is that we have repeated all these experiences so many times, that the feeling of awe no longer emerges with life - To generate awe, the repertoire of existing experiences is insufficient - now we have to create NEW experiences, we have to create novelty - Mortality Salience can help jolt us out of this fixation on novelty, and remind us of the sacred that is already here all the time - For, what happens at the time of death? All the constructions we have taken for granted in life disappear all at once, or perhaps some before others - Hence, we begin to re-experience them as relative, as constructions, and not absolutes - All living organisms have their own unique umwelt - These umwelts are all expressions of the sacred, sensing itself in different ways

      • What is required is a kind of awakening, or re-awakening
      • When religions do their job, it gives us a framework to engage in a shared sense of the sacred, of wonder in the mundane
      • In a sense, Deep Humanity is identifying that most vital commonality in all religions and seeing all their diverse intersectionalities in simply being deeply human
      • We awakened once, when we were born into the world
        • then we fell asleep through the dream of familiarity
      • Now, we have to collectively re-awaken to the wonder we all experienced in that initial awakening experience as newborns
    3. i think it's a near miss it's the most likely thing to save us

      for - quote - unfortunately, I think we need a near miss to wake us up - Ronald Wright

      comment - But the problem is that we can't count on that because it may very well be too late by then - Is the extreme weather events now happening regularly enough to wake us up?

    4. that calls for a new form of altruism plus a new form of asceticism

      for - rapid whole system change - a new form of asceticism - Ronald Wright - Give me liberty or give me death - degrowth challenges

      rapid whole system change - a new form of asceticism - We need something that can be higher than stripping away many of the liberties we take for granted? - This will be challenging because the American dream is based on the feeling and phrase "Give me liberty or give me death!"

    5. does agriculture become a 00:51:16 progress trap has it been a progress trap well i think i think in a sense it has

      for - progress trap - Agriculture appears to be a progress trap - Ronald Wright

      argument - progress trap - Agriculture appears to be a progress trap - Ronald Wright - The early progress traps have been comparatively small in scale - During the stone age, there were no more than a few million people alive (3 to 5 million?) and - they destroyed all the big game where humans lived - The Sumerians, with a population of around one million people salted up and destroyed the fertile land of Southern Iraq - Now we have 8 billion people and a third of them are starving - Our continuous technology development is what enables us to stave off the day of reckoning but - we are losing a Scotland-size worth of topsoil every year to - soil erosion - urban sprawl - We still face the possibility of collapse - Our species has existed for 5 to 6 million years and - civilization is an experiment that has only emerged about 10,000 years ago - It's still very possible for the experiment to fail

    6. if we fail to control our numbers and our appetites well then yes our society will start to to crash in a similar way to that of 00:35:32 easter island only on a worldwide scale and that means the whole industrial civilization will break down and 00:35:45 our descendants will essentially be uh savages to use that term very advisably and savages in the sense that they will have lost 00:35:58 the fruits of civilization and hate us

      for - progress trap - dark futures scenario - like Easter Island but on a global scale

      comment - The potential global breakdown of global industrialized society, rupturing supply chains so that our highly interdependent world becomes the very Achilles Heel that hastens its demise is chilling - It could mean a huge disruption to the most important aspect of civilization - the continuing accruing and inter-generational transmission of knowledge - It would be catastrophic to lose that, but it is entirely possible - As Wright himself famously said, to use a computer metaphor, we humans are like 50,000 year old hardware, running modern software - By that, he meant that our cognitive physiology (brain and sensory processing system) has not changed for tens of thousands of years, yet cultural evolution happens at exponentially faster rates, so much so that our biological systems are not adapted to keep up with the pace, and that spells disaster - When we no longer have the sensory or cognitive apparatus to sense danger, and we are offloading that to AI, we are in an extremely vulnerable situation

      progress trap - Gedanken - Think of our ancestors from 50,000 years ago. - What Wright is saying with his metaphor is that if that child from 50,000 years ago were transported by a time machine to modernity, (s)he would have little problem integrating into modern society - LIKEWISE, if we lose all the knowledge fruits of accumulated over so many thousands of years, it would be like being born into a human tribe 50,000 years ago. - We would likely still have language, but all our technology may have to start from scratch!

    7. one of the things i suggested in a short history of progress is that 00:30:18 one of our problems even though we're very clever as a species we're not wise

      for - key insight - progress trap - A Short History of Progress - we are clever but NOT wise!

      key insight - progress trap - A Short History of Progress - we are clever but NOT wise! - In other words - Intelligence is FAR DIFFERENT than wisdom

      new memes - We have an abundance of intelligence and a dearth of wisdom - A little knowledge is dangerous, a lot of knowledge is even more dangerous

    8. although is by no means the only place agriculture has been invented from scratch in probably at least half a dozen places around the world at least

      for - agriculture was invented in at least a dozen places around the world

    1. (1) The filing by a registered elector of a written request with a board of elections or the secretary of state, on a form prescribed by the secretary of state and signed by the elector, that the registration be canceled. The filing of such a request does not prohibit an otherwise qualified elector from reregistering to vote at any time.

      The only true protest vote.

    1. insulin resistance is actually 00:01:14 Downstream of something even more important that we will talk about called mitochondrial dysfunction

      for - health - insulin resistance - a symptom of mitochondria dysfunction

    1. we use relative risk reduction instead of absolute risk 00:26:45 reduction and it makes it look like there's a greater effect than there actually is

      for - medical deception - communicating relative risk instead of absolute risk is misleading and gives the appearance of a greater effect

    1. Case: patient #154, male

      Disease Assertion: UCD/OTCD

      Family Info: N/A

      Case Presenting HPOs: Neonatal onset (HP:0003623)

      Case HPO FreeText:

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: gDNA testing involves PCR amplification of all 10 exons and exon/intron boundaries followed by screening for mutations or sequencing of all fragments, For these patients, confirmation of the diagnosis requires enzymatic assays. No specifications about the test

      Supplemental Data: TABLE 1

      Variant: NM_000531.6: c.664-1G>A

      ClinVarID: 97288

      CAID: CA224811

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    2. Case: patient #213, male

      Disease Assertion: UCD/OTCD

      Family Info: N/A

      Case Presenting HPOs: Neonatal onset (HP:0003623)

      Case HPO FreeText:

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: gDNA testing involves PCR amplification of all 10 exons and exon/intron boundaries followed by screening for mutations or sequencing of all fragments, For these patients, confirmation of the diagnosis requires enzymatic assays. No specifications about the test

      Supplemental Data: TABLE 1

      Variant: NM_000531.6: c.962C>A(p.Ser321*)

      ClinVarID: 97373

      CAID: CA224859

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    1. Case: patient #52, female, Japanese

      Disease Assertion: UCD/OTCD

      Family Info: N/A

      Case Presenting HPOs: ,Hyperammonemia (HP:0001987)

      Case HPO FreeText: N/A

      Case NOT HPOs:

      Case NOT HPO Free Text:

      Case Previous Testing: The mRNA ref seq were, wherein the “A” nucleotide of the start codon ATG constituted as +1 numbering of the cDNA sequence. Met encoded by the start codon ATG also represented +1 for the amino acid numbering as set forth by the preprotein seq. PolyPhen-2, SIFT, and I-Mutant 3 tools were used for predicting the potential impact of an amino acid alteration in missense mutations on the function of each enzyme.

      Supplemental Data: Table 1

      Variant: NM_000531.6:c.894G>A(p.Trp298*)

      ClinVarID: N/A

      CAID: CA412725724

      gnomAD:

      Gene Name: OTC (ornithine transcarbamylase)

    1. the erosion between whiteness andgainful employment that Davidson and Saul arguedled to a cultural backlash from white Americans andhas caused them to move from the left to the far-rightas a form of retaliation against the neoliberal cosmo-politan left.

      for - key insight - gainful employment of white working class led to cultural backlash and shift from left to far-right - to - Neoliberalism and the Far-Right: A Contradictory Embrace

      key insight - gainful employment of white working class led to cultural backlash and shift from left to far-right - source - Davidson and Saul

      to - Neoliberalism and the Far-Right: A Contradictory Embrace - https://hyp.is/8Hf0lDzqEe-KM9dQxJDxsw/core.ac.uk/download/pdf/84148846.pdf

    2. Economic Policy Institute,by the year 2032 the majority of the working class willbe composed of people of colo

      for - stats - whites become minority percentage of US working class by 2032

      stats - whites become minority percentage of US working class by 2032 - From Economic Policy Institute

      to - People of color will be a majority of the American working class in 2032 -

    1. Adler, Mortimer J., and Charles Van Doren. How to Read a Book: The Classical Guide to Intelligent Reading. Revised and Updated edition. 1940. Reprint, Touchstone, 2011.

      Edmund Gröpl's concept map of Adler & Van Doren's How to Read a Book via https://forum.zettelkasten.de/discussion/comment/20668#Comment_20668:

    1. The authour gave three reason why people be;lieve in these abductions: 1.Media ? Images , troupes the romantasization of the "image of alien" 2. Time period 3.

    1. Case: Patient #20, male, Chinese

      DiseaseAssertion: UCD/OTCD

      FamilyInfo:

      CasePresentingHPOs: HP:0011463, HP:0001987, HP:0003218

      CaseHPOFreeText: childhood onset, hyperammonemia, oroticaciduria

      CaseNOTHPOs:

      CaseNOTHPOFreeText: No neurological damage

      CasePreviousTesting: gDNA extracted from peripheral blood leukocytes. PCR all coding exons and exon–intron boundaries of the OTC gene using 9 pairs of synthetic oligonucleotide primers, and the primer sequences and annealing temperature. PCR products were then purified and bidirectionally sequenced. The library was sequenced using Illumina HiSeq4000 and generated 150 bp paired-end reads. Data analysis was performed as previously described [Sun Y, Hu G, Liu H, Zhang X, Huang Z, Yan H, et al. Further delineation of the phenotype of truncating KMT2A mutations: the extended Wiedemann–Steiner syndrome. Am J Med Genet A. 2017;173:510–4.]. Multiplex ligation-dependent probe amplification analysis was performed for samples in which Sanger sequencing or WES failed to detect any disease-causing mutation.

      SupplementalData: Table 3, drug treatment (L-arginine, L-Citrulline, sodium benzoate, and sodium phenylbutyrate), deceased

      Variant: NM_000531.6:c.794G>A(p.Trp265*)

      ClinVarID: N/A

      CAID:CA412722994

      gnomAD:

      GeneName: OTC (ornithine transcarbamylase)