Ball, P. (2022, February 26). Will we get a single, variant-proof vaccine for Covid? The Observer. https://www.theguardian.com/society/2022/feb/26/will-we-get-a-single-variant-proof-vaccine-for-covid
115 Matching Annotations
- Aug 2022
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www.theguardian.com www.theguardian.com
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www.biorxiv.org www.biorxiv.org
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Iketani, S., Liu, L., Guo, Y., Liu, L., Huang, Y., Wang, M., Luo, Y., Yu, J., Yin, M. T., Sobieszczyk, M. E., Huang, Y., Wang, H. H., Sheng, Z., & Ho, D. D. (2022). Antibody Evasion Properties of SARS-CoV-2 Omicron Sublineages (p. 2022.02.07.479306). bioRxiv. https://doi.org/10.1101/2022.02.07.479306
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Varmus, H. (2021, August 31). Covid has revealed the need for genomic sequencing around the world. Financial Times. https://www.ft.com/content/342fd3c3-5a22-49a0-9cef-135f2ccd8700
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plus.tagesspiegel.de plus.tagesspiegel.de
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Karberg, S., & Friebe, R. (2022, January 18). Virologe Drosten im Interview: „Wie lange geht diese Quälerei noch weiter?“. https://plus.tagesspiegel.de/wissen/virologe-drosten-im-interview-wie-lange-geht-diese-qualerei-noch-weiter-361636.html
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www.nature.com www.nature.com
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Meng, B., Abdullahi, A., Ferreira, I. A. T. M., Goonawardane, N., Saito, A., Kimura, I., Yamasoba, D., Gerber, P. P., Fatihi, S., Rathore, S., Zepeda, S. K., Papa, G., Kemp, S. A., Ikeda, T., Toyoda, M., Tan, T. S., Kuramochi, J., Mitsunaga, S., Ueno, T., … Gupta, R. K. (2022). Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity. Nature, 1–1. https://doi.org/10.1038/s41586-022-04474-x
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twitter.com twitter.com
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ReconfigBehSci. (2021, December 12). RT @ryan_landay: > A new diverse genome has appeared within the B.1.1.529 lineage that has all of the shared mutations of B.1.1.529, some o… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1470066521615605766
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twitter.com twitter.com
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ReconfigBehSci on Twitter: “RT @chrischirp: As well as Tom’s new one (B.1.1.529), C.1.2 seems to be spreading in S Africa—C.1.2 was the one with lots of worrying mut…” / Twitter. (n.d.). Retrieved December 23, 2021, from https://twitter.com/SciBeh/status/1463597407082532864
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www.washingtonpost.com www.washingtonpost.com
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Perspective | Even the best-case scenario with omicron will still be bad. (n.d.). Washington Post. Retrieved December 23, 2021, from https://www.washingtonpost.com/outlook/2021/12/21/omicron-mild-cases-numbers/
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- Apr 2022
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twitter.com twitter.com
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ReconfigBehSci on Twitter: “RT @COGUK_ME: The @CovidGenomicsUK Mutation Explorer https://t.co/x2zsrhKj8Y is now tracking the combinations of spike substitutions known…” / Twitter. (n.d.). Retrieved April 29, 2022, from https://twitter.com/SciBeh/status/1462782003787542529
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twitter.com twitter.com
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Ravi K Gupta [@ravgup33_ravi]. (2021, November 24). This one is worrying and I’ve not said that since delta. Please get vaccinated and boosted and mask up in public as the mutations in this virus likely result in high level escape from neutralising antibodies [Tweet]. Twitter. https://twitter.com/ravgup33_ravi/status/1463626745651806208
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twitter.com twitter.com
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Prof. Christina Pagel 🇺🇦 [@chrischirp]. (2021, November 24). As well as Tom’s new one (B.1.1.529), C.1.2 seems to be spreading in S Africa—C.1.2 was the one with lots of worrying mutations first reported in August... Plus cases in S Africa suddenly increasing again in the middle of their summer. Https://t.co/fCqfOMcO83 [Tweet]. Twitter. https://twitter.com/chrischirp/status/1463504890530086917
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www.who.int www.who.int
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Update on Omicron. (n.d.). Retrieved April 22, 2022, from https://www.who.int/news/item/28-11-2021-update-on-omicron
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twitter.com twitter.com
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Dr Emma Hodcroft [@firefoxx66]. (2021, November 26). We now have B.1.1.529 sequences (designed at @nextstrain clade 21K) up in our Africa build. You can check them out below. These are from South Africa & Botswana—You can see the high number of mutations. CoVariants focal build & updates will come ASAP. https://t.co/fqBldneF5U [Tweet]. Twitter. https://twitter.com/firefoxx66/status/1464145615571623938
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twitter.com twitter.com
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Nathan Grubaugh [@NathanGrubaugh]. (2021, September 24). Hi @Newsweek 👋. I understand that #variant news has been slow recently with the near-complete dominance of Delta, but do you really need to go and make things up? Lineage R.1 is not a concern. Let me briefly explain why. (1/4) https://t.co/OD46PsXZEu [Tweet]. Twitter. https://twitter.com/NathanGrubaugh/status/1441522760832933888
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twitter.com twitter.com
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ReconfigBehSci. (2022, January 28). RT @chrischirp: BA.2 & BA.1.1 (Omicron variants) are growing in many countries. Quite what this means in terms of cases, hospitalisation… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1487066966363934720
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www.nature.com www.nature.com
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Tao, K., Tzou, P. L., Nouhin, J., Gupta, R. K., de Oliveira, T., Kosakovsky Pond, S. L., Fera, D., & Shafer, R. W. (2021). The biological and clinical significance of emerging SARS-CoV-2 variants. Nature Reviews Genetics, 1–17. https://doi.org/10.1038/s41576-021-00408-x
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twitter.com twitter.com
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nature. (2021, April 16). Coronavirus variants: Where do they come from? How do we spot them? What do they mean for COVID vaccines, and future of the pandemic? Https://t.co/NRbORu2hoF [Tweet]. @Nature. https://twitter.com/Nature/status/1383093697374474240
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Callaway, E. (2021). Heavily mutated Omicron variant puts scientists on alert. Nature, 600(7887), 21–21. https://doi.org/10.1038/d41586-021-03552-w
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twitter.com twitter.com
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Trevor Bedford on Twitter. (n.d.). Twitter. Retrieved 1 April 2022, from https://twitter.com/trvrb/status/1447566558973231104
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- Mar 2022
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twitter.com twitter.com
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ReconfigBehSci. (2022, February 21). RT @Mike_Honey_: Here’s a look at the frequency of BA.2 (Omicron) samples with an unusual mutation: ORF1a:M85del (NSP1:M85del). It was fir… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1497864547880902656
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twitter.com twitter.com
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Mia Malan. (2021, November 25). [Thread] What is the potential impact of the new B.1.1.529 #COVID19 variant? @rjlessells: 1. It’s relatively simple to detect some B.1.1.529 cases, as it’s possible to use PCR tests to do this in some cases 2. B.1.1.529 = has many mutations across different parts of the virus https://t.co/ytktqLzJUi [Tweet]. @miamalan. https://twitter.com/miamalan/status/1463846528578109444
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- Feb 2022
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www.mercurynews.com www.mercurynews.com
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Living with COVID-19: How the virus could turn into the common cold, or something far worse. (2022, January 9). The Mercury News. https://www.mercurynews.com/2022/01/09/living-with-covid-19-how-the-virus-could-turn-into-the-common-cold-or-something-far-worse
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www.sciencedirect.com www.sciencedirect.com
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Chatterjee, D., Tauzin, A., Marchitto, L., Gong, S. Y., Boutin, M., Bourassa, C., Beaudoin-Bussières, G., Bo, Y., Ding, S., Laumaea, A., Vézina, D., Perreault, J., Gokool, L., Morrisseau, C., Arlotto, P., Fournier, É., Guilbault, A., Delisle, B., Levade, I., … Finzi, A. (2022). SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-weeks interval between doses. Cell Reports, 0(0). https://doi.org/10.1016/j.celrep.2022.110429
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theconversation.com theconversation.com
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Willett, J. D. S. (n.d.). Omicron: Vaccines remain the best defence against this COVID-19 variant and others. The Conversation. Retrieved February 8, 2022, from http://theconversation.com/omicron-vaccines-remain-the-best-defence-against-this-covid-19-variant-and-others-174195
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twitter.com twitter.com
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Yaneer Bar-Yam on Twitter. (n.d.). Twitter. Retrieved February 7, 2022, from https://twitter.com/yaneerbaryam/status/1474091037861761026
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twitter.com twitter.com
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Trisha Greenhalgh. (2022, January 8). Apart from (e.g.): 1. Severe disease in clinically vulnerable (they are people too); 2. Long covid in many; 3. Strokes / heart attacks / kidney failure from micro-clots; 4. New-onset diabetes and MIS-C in children; 5. High potential for recombinant mutations. [Tweet]. @trishgreenhalgh. https://twitter.com/trishgreenhalgh/status/1479738523511136258
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twitter.com twitter.com
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Ulrich Elling. (2022, January 12). While #Omicron BA.1 leads the race, the little sister BA.2 is catching up in numbers. They are rather different with likely functional implications. BA.2 might be more immune evasive in RBD, less in NTD. And due to reduced mutation load in NTD maybe different fusion properties? Https://t.co/kEACjzQDs3 [Tweet]. @EllingUlrich. https://twitter.com/EllingUlrich/status/1481214901997682692
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twitter.com twitter.com
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Jonathan Li on Twitter: “There’s a lineage of Omicron that’s gained the R346K mutation (BA.1.1). This one could spell some trouble for the AZ mAb (tixagevimab/cilgavimab, Evusheld) that’s being used for pre-exposure prophylaxis. If you want to learn about tix/cil vs Omicron, read on 1/7” / Twitter. (n.d.). Retrieved February 6, 2022, from https://twitter.com/DrJLi/status/1487479972293853188
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twitter.com twitter.com
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Trevor Bedford. (2022, January 28). Omicron viruses can be divided into two major groups, referred to as PANGO lineages BA.1 and BA.2 or @nextstrain clades 21K and 21L. The vast majority of globally sequenced Omicron have been 21K (~630k) compared a small minority of 21L (~18k), but 21L is gaining ground. 1/15 [Tweet]. @trvrb. https://twitter.com/trvrb/status/1487105396879679488
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twitter.com twitter.com
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Prof. Christina Pagel. (2022, January 26). here is BA.2 growth in Denmark. Https://t.co/stake8vHvq [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1486300603735330816
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- Jan 2022
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www.nejm.org www.nejm.org
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Pajon, R., Doria-Rose, N. A., Shen, X., Schmidt, S. D., O’Dell, S., McDanal, C., Feng, W., Tong, J., Eaton, A., Maglinao, M., Tang, H., Manning, K. E., Edara, V.-V., Lai, L., Ellis, M., Moore, K. M., Floyd, K., Foster, S. L., Posavad, C. M., … Montefiori, D. C. (2022). SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination. New England Journal of Medicine, 0(0), null. https://doi.org/10.1056/NEJMc2119912
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twitter.com twitter.com
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Cornelius Roemer. (2021, December 22). @mccarthy_kr I took a look at all these NY sequences. I don’t think these point mutations S:681H are real. Why? Because they appear all over the Omicron diversity. Some sequences have S:346K, some S:701V, most miss S679K, a few have it. That’s the signature of contamination/co-infection. Https://t.co/DcJD4q44EM [Tweet]. @CorneliusRoemer. https://twitter.com/CorneliusRoemer/status/1473507369455923203
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www.niid.go.jp www.niid.go.jp
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Active epidemiological investigation on SARS-CoV-2 infection caused by Omicron variant (Pango lineage B.1.1.529) in Japan: Preliminary report on infectious period. (n.d.). Retrieved January 14, 2022, from https://www.niid.go.jp/niid/en/2019-ncov-e/10884-covid19-66-en.html
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- Dec 2021
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twitter.com twitter.com
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Eric Topol. (2021, November 27). View of key mutations of Omicron’s 50, with 30 in the spike protein, 15 in its receptor binding domain https://ft.com/content/42c5ff3d-e676-4076-9b9f-7243a00cba5e http://covariants.org @EllingUlrich @_b_meyer https://t.co/onMoNFVLFJ [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1464452102382448643
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www.medrxiv.org www.medrxiv.org
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Wilhelm, A., Widera, M., Grikscheit, K., Toptan, T., Schenk, B., Pallas, C., Metzler, M., Kohmer, N., Hoehl, S., Helfritz, F. A., Wolf, T., Goetsch, U., & Ciesek, S. (2021). Reduced Neutralization of SARS-CoV-2 Omicron Variant by Vaccine Sera and monoclonal antibodies (p. 2021.12.07.21267432). https://doi.org/10.1101/2021.12.07.21267432
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github.com github.com
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Proposal to split B.1.1.529 to incorporate a newly characterised sibling lineage · Issue #361 · cov-lineages/pango-designation. (n.d.). GitHub. Retrieved 17 December 2021, from https://github.com/cov-lineages/pango-designation/issues/361
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www.medrxiv.org www.medrxiv.org11779531
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Garcia-Beltran, W. F., Denis, K. J. S., Hoelzemer, A., Lam, E. C., Nitido, A. D., Sheehan, M. L., Berrios, C., Ofoman, O., Chang, C. C., Hauser, B. M., Feldman, J., Gregory, D. J., Poznansky, M. C., Schmidt, A. G., Iafrate, A. J., Naranbhai, V., & Balazs, A. B. (2021). MRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant (p. 2021.12.14.21267755). https://doi.org/10.1101/2021.12.14.21267755
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twitter.com twitter.com
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Carl T. Bergstrom. (2021, November 26). I’d be careful not to overinterpret the following graph from @jburnmurdoch. Yes, the fraction of B.1.1.529 is increasing faster. But I think that is that is largely due to different denominators. Https://t.co/NDhSqJpLlw [Tweet]. @CT_Bergstrom. https://twitter.com/CT_Bergstrom/status/1464061037292883970
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Mahase, E. (2021). Covid-19: Do vaccines work against omicron—and other questions answered. BMJ, 375, n3062. https://doi.org/10.1136/bmj.n3062
Tags
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www.gavi.org www.gavi.org
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What do we know about the new B.1.1.529 coronavirus variant and should we be worried? (n.d.). Retrieved 10 December 2021, from https://www.gavi.org/vaccineswork/what-we-know-about-new-b11529-coronavirus-variant-so-far
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inews.co.uk inews.co.uk
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Omicron cases may be far higher than currently confirmed, variant marker analysis reveals. (2021, December 8). Inews.Co.Uk. https://inews.co.uk/news/health/omicron-covid-cases-may-be-seven-times-higher-than-confirmed-1341156
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www.bbc.co.uk www.bbc.co.uk
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New Covid variant: How worried should we be? (2021, November 25). BBC News. https://www.bbc.com/news/health-59418127
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www.theguardian.com www.theguardian.com
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Devlin, H., & Kollewe, J. (2021, November 26). BioNTech says it could tweak Covid vaccine in 100 days if needed. The Guardian. https://www.theguardian.com/society/2021/nov/26/biontech-says-it-could-tweak-covid-vaccine-in-100-days-if-needed
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Annotators
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theguardian.com/society/2021/nov/26/biontech-says-it-could-tweak-covid-vaccine-in-100-days-if-needed -
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Cotterill, J. (2021, November 26). South African anger over ‘rushed’ Covid travel restrictions. Financial Times. https://www.ft.com/content/6a177732-4faf-4ecb-adc1-667c22248e0f
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www.abbott.com www.abbott.com
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Evaluating Omicron and Other COVID Variants to Ensure Test Effectiveness. (n.d.). Abbott. Retrieved December 3, 2021, from https://www.abbott.com/corpnewsroom/diagnostics-testing/monitoring-covid-variants-to-ensure-test-effectiveness.html
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www.statnews.com www.statnews.com
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Cause for optimism on Omicron: Our immune systems aren’t blank slates. (2021, December 1). STAT. https://www.statnews.com/2021/12/01/a-reason-for-optimism-on-omicron-our-immune-systems-are-not-blank-slates/
Tags
- immunology
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Annotators
URL
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twitter.com twitter.comTwitter1
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Kristian G. Andersen on Twitter. (n.d.). Twitter. Retrieved 3 December 2021, from https://twitter.com/K_G_Andersen/status/1465822536629821442
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news.sky.com news.sky.com
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COVID-19: Most Omicron cases are “mild” and there’s no evidence to suggest vaccines may be less effective against the variant, says WHO official. (n.d.). Sky News. Retrieved December 2, 2021, from https://news.sky.com/story/covid-19-most-omicron-cases-are-mild-and-theres-no-evidence-to-suggest-vaccines-may-be-less-effective-against-the-variant-says-who-12483729
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twitter.com twitter.com
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nference. (2021, November 27). Here is how B.1.1.529 (#Omicron #B11529) compares to Alpha, Beta, Gamma, Delta variants. Omicron has highest novel Spike mutations including striking cluster on the “crown” suggesting significant selection pressure & antigenic distinction from prior strains (Credits: Nference) https://t.co/4oZQbjhbG8 [Tweet]. @_nference. https://twitter.com/_nference/status/1464404770098229250
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- Nov 2021
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www.npr.org www.npr.org
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N, P, & R. (2021, November 27). Does omicron pose a risk to the vaccinated? Too early to tell, epidemiologist says. NPR. https://www.npr.org/2021/11/27/1059539509/too-early-to-tell-whether-omicron-poses-a-threat-to-vaccinated-epidemiologist-sa
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twitter.com twitter.com
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Meaghan Kall. (2021, November 26). B.1.1.529 in the UK • Designated a Variant Under Investigation (VUI) VUI-21NOV-01 • No cases in the UK 🇬🇧 to date • Enhanced case finding & rapid assessment is underway https://t.co/0DGvlgvdPR [Tweet]. @kallmemeg. https://twitter.com/kallmemeg/status/1464210457795907588
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- Oct 2021
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www.dailymail.co.uk www.dailymail.co.uk
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UK’s daily Covid deaths hit SEVEN-MONTH high of 223 while cases jump 13% in a week to 43,738 | Daily Mail Online. (n.d.). Retrieved October 25, 2021, from https://www.dailymail.co.uk/news/article-10108203/UKs-daily-Covid-deaths-hit-SEVEN-MONTH-high-223-cases-jump-13-week-43-738.html
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www.theguardian.com www.theguardian.com
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Davis, N. (2021, October 19). Offshoot of Covid Delta variant on the rise in England. The Guardian. https://www.theguardian.com/world/2021/oct/19/fears-grow-in-england-over-rise-of-new-covid-delta-variant
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www.biorxiv.org www.biorxiv.org
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Rono, E. K. (2021). Covid-19 genomic analysis reveals clusters of emerging sublineages within the delta variant [Preprint]. Genomics. https://doi.org/10.1101/2021.10.08.463334
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Mlcochova, P., Kemp, S. A., Dhar, M. S., Papa, G., Meng, B., Ferreira, I. A. T. M., Datir, R., Collier, D. A., Albecka, A., Singh, S., Pandey, R., Brown, J., Zhou, J., Goonawardane, N., Mishra, S., Whittaker, C., Mellan, T., Marwal, R., Datta, M., … Gupta, R. K. (2021). SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion. Nature, 1–6. https://doi.org/10.1038/s41586-021-03944-y
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twitter.com twitter.com
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Pablo Tsukayama on Twitter. (n.d.). Twitter. Retrieved 4 October 2021, from https://twitter.com/pablotsukayama/status/1435725621599027202
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- Sep 2021
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www.nytimes.com www.nytimes.com
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Zimmer, C., Corum, J., & Wee, S.-L. (2020, June 10). Coronavirus Vaccine Tracker. The New York Times. https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.html
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twitter.com twitter.com
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ReconfigBehSci. (2021, August 22). RT @chrischirp: Some good news from PHE’s Friday Delta tech briefing update: Two sublineages of Delta called AY.1 and AY.2 do not seem to b… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1430638002586329088
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- Aug 2021
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www.biorxiv.org www.biorxiv.org
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Liu, Y., Arase, N., Kishikawa, J., Hirose, M., Li, S., Tada, A., Matsuoka, S., Arakawa, A., Akamatsu, K., Ono, C., Jin, H., Kishida, K., Nakai, W., Kohyama, M., Nakagawa, A., Yamagishi, Y., Nakagami, H., Kumanogoh, A., Matsuura, Y., … Arase, H. (2021). The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines (p. 2021.08.22.457114). https://doi.org/10.1101/2021.08.22.457114
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www.thebulwark.com www.thebulwark.com
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What Is “Natural Immunity”? And Why Should You Get the Vaccine Even if You Already Had COVID? - The Bulwark. (n.d.). Retrieved August 11, 2021, from https://www.thebulwark.com/what-is-natural-immunity-and-why-should-you-get-the-vaccine-even-if-you-already-had-covid/
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- Jun 2021
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www.bmj.com www.bmj.com
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Darby, Alistair C., and Julian A. Hiscox. ‘Covid-19: Variants and Vaccination’. BMJ 372 (23 March 2021): n771. https://doi.org/10.1136/bmj.n771.
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news.harvard.edu news.harvard.edu
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Vaccines should end the pandemic, despite the variants, say experts – Harvard Gazette. (n.d.). Retrieved June 19, 2021, from https://news.harvard.edu/gazette/story/2021/02/vaccines-should-end-the-pandemic-despite-the-variants-say-experts/
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twitter.com twitter.com
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ReconfigBehSci. (2021, June 8). RT @TWenseleers: Across whole of England, 76% [74-78%] of all newly diagnosed infections now B.1.617.2. We see familiar pattern of combinat… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1402633076396552193
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twitter.com twitter.com
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ReconfigBehSci. (2021, June 5). RT @TWenseleers: Estimated growth rate advantage of B.1.617.2 vs B.1.1.7 is 8.3%/day [7.9-8.8%] 95% CLs and 4%/day [3-5%] for B.1.617.1 vs… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1402243029407178757
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twitter.com twitter.com
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ReconfigBehSci. (2021, June 14). RT @AdamJKucharski: Compare relationship between R and proportion of sequences consistent with the B.1.1.7 variant in autumn 2020 (below le… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1404604886117797888
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How coronavirus mutations can track its spread—And disprove conspiracies. (2020, March 26). Science. https://www.nationalgeographic.com/science/2020/03/how-coronavirus-mutations-can-track-its-spread-and-disprove-conspiracies/
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Corbett, K. S., Edwards, D., Leist, S. R., Abiona, O. M., Boyoglu-Barnum, S., Gillespie, R. A., Himansu, S., Schäfer, A., Ziwawo, C. T., DiPiazza, A. T., Dinnon, K. H., Elbashir, S. M., Shaw, C. A., Woods, A., Fritch, E. J., Martinez, D. R., Bock, K. W., Minai, M., Nagata, B. M., … Graham, B. S. (2020). SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness. BioRxiv, 2020.06.11.145920. https://doi.org/10.1101/2020.06.11.145920
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Starr, T. N., Greaney, A. J., Hilton, S. K., Crawford, K. H., Navarro, M. J., Bowen, J. E., Tortorici, M. A., Walls, A. C., Veesler, D., & Bloom, J. D. (2020). Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding [Preprint]. Microbiology. https://doi.org/10.1101/2020.06.17.157982
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Bloom Lab. (2020, June 18). "We've experimentally measured how all amino-acid mutations to the #SARSCoV2 spike RBD affect ACE2 binding and expression of folded protein in a deep mutational scanning study led by @tylernstarr & Allie Greaney:https://biorxiv.org/content/10.1101/2020.06.17.157982v1 Why is this important? (1/n)" Twitter. https://twitter.com/jbloom_lab/status/1273468539484213248
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