133 Matching Annotations
  1. Sep 2021
    1. c. 19, s. 700

      Jobs, Growth and Long-term Prosperity Act, SC 2012, c 19, s. 700:

      • removed the previous s. 2(2)
      • replaced it with: "(2) Unless otherwise indicated, references in this Act to “this Act” include regulations made under it and instructions given under subsection 14.1(1)."
    1. Since about 70% of water delivered from the Colorado River goes to growing crops, not to people in cities, the next step will likely be to demand large-scale reductions for farmers and ranchers across millions of acres of land, forcing wrenching choices about which crops to grow and for whom — an omen that many of America’s food-generating regions might ultimately have to shift someplace else as the climate warms.

      Deep Concept: The US Government, in the 1960's/70's provided a crystal ball glimpse into the future by defining climate change (man-made global warming) as a national security concern. Various reports warned of "exponential" growth (population) and related man-made factors (technology etc.) that would contribute to climate change and specifically discussed the possibility of irreconcilable damage to "finite" natural resources.

  2. Aug 2021
    1. A baby grows to adult size, after which growth goes to maintaining stability, homeostasis, balance. Growth much beyond that leads to obesity. For a baby to grow endlessly bigger would be first monstrous, then fatal.

      Growth has a limit dependent on the nature of the system

    1. According to Brian Balfour, "The fastest growing products are better represented as a system of loops, not funnels. Loops are closed systems where the inputs through some process generates more of an output that can be reinvested in the input. There are growth loops that serve different value creation including new users, returning users, defensibility, or efficiency."

      Treat product growth as loops not funnels.

  3. Jul 2021
  4. Jun 2021
    1. Bolze, A., Cirulli, E. T., Luo, S., White, S., Cassens, T., Jacobs, S., Nguyen, J., Ramirez, J. M., Sandoval, E., Wang, X., Wong, D., Becker, D., Laurent, M., Lu, J. T., Isaksson, M., Washington, N. L., & Lee, W. (2021). Rapid displacement of SARS-CoV-2 variant B.1.1.7 by B.1.617.2 and P.1 in the United States [Preprint]. Infectious Diseases (except HIV/AIDS). https://doi.org/10.1101/2021.06.20.21259195

  5. May 2021
  6. Apr 2021
  7. Mar 2021
  8. Feb 2021
    1. So which seems likelier: that we're no better off than we were a quarter century ago, or that Shadow Stats is total bunk?

      Great Question

      This is an easy question to answer from my perspective. For me (age 62) and most of my peers, their kids and their peers, we are NO better off than we were a quarter century ago! A large part is the change from Industrial/Manufacturing to Technology and the outsourced labor and manufacturing. America has changed, this is FACT

    1. A second trap is thinking that you just need to work on yourself in order to grow your career. For example, "To progress, I just need to get better at [insert skill.]" But you are only one part of the equation.There is a whole other part of the equation, which is your environment. Your environment either limits or amplifies your own ability to get better at a skill.
      • Trap: "I just need to work on myself more"
      • Assumption: You need to focus on improving X
      • Impact: You need to consider the environment. if you don't, you could end up in a place that limits your ability to work on that skill instead of amplify it.
    2. "Should I leave my current role?""How do I compare or choose between two or more opportunities?""What is preventing me from moving forward?"
      • do we switch projects?
      • teams?
      • career paths?
      • what projects do we take on, vs not, and why?
    1. Il s’agit en fait plu­tôt d’une inca­pa­ci­té de pen­ser vrai­ment avec cette pos­si­bi­li­té que quelque chose vienne enrayer la nor­ma­li­té des choses, la rou­tine de la crois­sance…
  9. Jan 2021
    1. “Different from natural science and social science, Dataology and Data Science takes data in cyberspace as its research object. It is a new science.”

      Computer engineering and coding has been rapidly growing at this point and the internet is becoming more available to everyone which helps keep the innovation driving and is a large reason in the expansion of data science.

    1. Long before there was the Internet, there was the commonplace book — a creative and intellectual ledger of fragmentary inspirations, which a writer would collect from other books and copy into a notebook, often alongside his or her reflections and riffs. These borrowed ideas are in dialogue with the writer’s own imagination and foment it into original thinking. Over long enough a period of time — years, decades, often a lifetime — the commonplace book, while composed primarily of copied passages, comes to radiate the singular sensibility of its keeper: beliefs are refined, ideas incubated, intellectual fixations fleshed out, and the outlines of a personhood revealed. (Brain Pickings is, in an unshakable sense, a commonplace book.)
  10. Dec 2020
  11. Nov 2020
    1. V. natriegens grows rapidly in BHIN complex medium with a μ of up to 4.43 h−1 (doubling time of 9.4 min) as well as in minimal medium supplemented with various industrially relevant substrates.
  12. Oct 2020
    1. ​Institutions that were primarily online before the pandemic are also doing well. At colleges where more than 90 percent of students took courses solely online pre-pandemic, enrollments are growing for both undergraduate (6.8 percent) and graduate students (7.2 percent).
    1. Learning & Development Best Practices from the Top Silicon Valley Companies

      Interesting read about what top tech companies are doing to promote a growth mindset within their company. From Google to Amazon each company has a different approach that is working for them.

      7/10

  13. Aug 2020
    1. moving from emissions to concentrations in the context of forecasting long-term economic growth, the likelihood that CO2 concentrations will exceed those assumed in RCP8.5 by 2100 is at least 35%

      This means that the CO2 emissions caused by use of fossile fuels should be understood as a component of all emissions caused by continued economic growth.

    1. Altig, D., Baker, S. R., Barrero, J. M., Bloom, N., Bunn, P., Chen, S., Davis, S. J., Leather, J., Meyer, B. H., Mihaylov, E., Mizen, P., Parker, N. B., Renault, T., Smietanka, P., & Thwaites, G. (2020). Economic Uncertainty Before and During the COVID-19 Pandemic (Working Paper No. 27418; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27418

    1. Dave, D. M., Friedson, A. I., Matsuzawa, K., Sabia, J. J., & Safford, S. (2020). Were Urban Cowboys Enough to Control COVID-19? Local Shelter-in-Place Orders and Coronavirus Case Growth (Working Paper No. 27229; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27229

  14. Jul 2020
  15. Jun 2020
  16. May 2020
  17. Apr 2020
    1. Chronic wounds, in general, behave differently in relation to bacterial growth when compared to acute wounds. Chronic wounds develop bacterial growth that is resistant to invasion by antibiotics and is protected from the host immune defenses.
    2. Disappointingly, a recent meta-analysis failed to demonstrate any value for autologous platelet-rich plasma in the treatment of chronic wounds
    3. This approach allows treatment with patient-specific factors at an apparently physiologic ratio of growth factor concentrations.
    4. Autologous growth factors are harvested from the patient’s own platelets, yielding an unpredictable combination and concentration of factors, which are then applied to the wound.
    5. Fibroblasts stimulated by growth factors can produce type I collagen and glycosaminoglycans (e.g., chondroitin sulfates), which adhere to the wound surface to permit epithelial cell migration, as well as adhesive ligands (e.g., the matrix protein fibronectin), which promote cell adhesion.
  18. Dec 2019
    1. “death phase,” where at least 99% of the cells in the culture lose viability

      So the 'death' in death phase is only loss of viability?

      I thought the cells lyse and are eaten up by neighbours; while reducing the OD (due to cell lysis)

  19. Nov 2019
    1. An emotional intelligence course initiated by Google became a tool to improve mindfulness, productivity, and emotional IQ. The course has since expanded into other businesses which report that employees are coping better with stressors and challenges. Rating: 7/10 Key questions...what is the format of the course, tools etc?

  20. Oct 2019
    1. Cengage’s own research forecast that the use of OER as primary courseware was poised to triple within five years.

      Useful info, which I'm not above using.

    1. Being a brand it is essential to design reliable Instagram growth strategy that would help grow followers, attract right customers and support the system of sales.

      Being a brand it is essential to design reliable Instagram growth strategy that would help grow followers, attract right customers and support the system of sales.

  21. Jul 2019
    1. Given a dataset of transactions, the first step of FP-growth is to calculate item frequencies and identify frequent items. Different from Apriori-like algorithms designed for the same purpose, the second step of FP-growth uses a suffix tree (FP-tree) structure to encode transactions without generating candidate sets explicitly, which are usually expensive to generate. After the second step, the frequent itemsets can be extracted from the FP-tree.
    1. The state’s population grew by 14.4 percent over the past eight years, faster than any other state, according to Census Bureau population estimates. And that’s increasingly because of migration, which contributed 43 percent to the state’s population growth between 2015 and 2018, compared to 16 percent in the previous four-year period

      Utah's highest population growth across the nation is one factor that contributes to housing shortage. The drastic increase in migration over the past 4 years indicates there is a great chance that this trend will continue which can worsen the current housing crisis in Utah.

  22. Apr 2019
    1. Personality development, if done right, inevitably sets us on a collision course with the unjust world in which we live, and with everything that is primitive, unevolved and destructive within ourselves.  One of the major developmental dynamisms—i.e, the internal forces guiding our individual growth as described in TPD—is positive maladjustment: a lack of adjustment to the world as is, guided by our vision of what ought to be which turns us into eternal misfits, “guests of reality,” to use the title of Par Lagerkvist’s story. Positive maladjustment is always rooted in universal human values embedded in our conscience and gives rise to our protest, internal and external, against the inhumane status quo. Sometimes this protest can take a form of non-cooperation or silence, or even mental illness, but it is still positive and expressive of better mental health than unreflective adjustment to what is. Jiddu Krishnamurti reminded us that “[i]t is no measure of health to be well adjusted to a profoundly sick society.”  This maladjustment in turn awakens other developmental dynamisms such as guilt, shame, astonishment with oneself, disquietude with oneself, subject-object in oneself, and others that create the basis for transcending our biological and social limitations through personality growth.
    2. His clinical experience led him to develop the theory of positive disintegration (TPD), which posits that, far from being destructive and undesirable, many forms of psychological suffering—anxiety, depression, doubts, inner conflicts, even psychosis—are positive and necessary for emotional and personality development. More often than not, they are expressive of the emerging understanding of the multilevel nature of reality, inner and external, and, related, an objectively existing hierarchy of human values. This understanding becomes a basis of personality growth through positive disintegration
    1. “The primary goal of our recommendation systems today is to create a trusted and positive experience for our users,” the document reads. “The YouTube company-wide goal is framed not just as ‘Growth’, but as ‘Responsible Growth.’”
    1. Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of Klotho in mice extends lifespan. Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the systemic circulation. Circulating levels of soluble Klotho decrease with age, and the klotho gene is associated with increased risk of age-related diseases. The three forms of Klotho protein have distinct functions. Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of Pi and vitamin D metabolism. Secreted Klotho functions as a humoral factor with pleiotropic activities including regulation of oxidative stress, growth factor signaling, and ion homeostasis. Secreted Klotho is also involved in organ protection. The intracellular form of Klotho suppresses inflammation-mediated cellular senescence and mineral metabolism. Herein we provide a brief overview of the structure and function and recent research about Klotho.
  23. Feb 2019
    1. Work with what you have, to support the people around you and together you'll create a community that has a defined shape and form only in hindsight. Instead of worrying about having enough onboarding ramps, I say we make a future space that is so exciting, so fun, that is such a cool party with lights so bright that everyone wants to build their own methods to get here and join in. And I thought: what's the coolest, most party thing in the world? Reading.
    1. The summation of human experience is being expanded at a prodigious rate

      The prodigious rate itself is expanding, is it a scale even conceivable at this time? (insert the usual stats of YouTube content growing at 300 hours a minute).

      I'm anxious to read if he anticipates the notion of turning to automation to try and handle this organization- it always seemed that Bush's vision was human focused.

  24. Jan 2019
    1. This central focus meant that the arcs were perpetually shifting position and overlapping one another. Such shifting is what Ramus hated the most: "For arts ought to consist of subjects that are constant, perpetual, and unchanging, and they should consider only those concepts which Plato says are archetypal and eternal" (99).

      Although uniformity within a discipline can be beneficial, "shifting" and "overlapping" combat stagnation. Without this constant movement, would disciplines be able to grow and develop?

  25. Nov 2018
    1. Hospitalists need to continue to take C-suite positions at hospitals and policy roles at think tanks and governmental agencies. They need to continue to master technology, clinical care, and the ever-growing importance of where those two intersect. Most of all, the field can’t get lazy. Otherwise, the “better mousetrap” of HM might one day be replaced by the next group of physicians willing to work harder to implement their great idea. “If we continue to be the vanguard of innovation, the vanguard of making the system work better than it ever has before,” Dr. Wachter says, “the field that creates new models of care, that integrates technology in new ways, and that has this can-do attitude and optimism, then the sky is the limit.”
    2. At a time of once-in-a-generation reform to healthcare in this country, the leaders of HM can’t afford to rest on their laurels, says Dr. Goldman. Three years ago, he wrote a paper for the Journal of Hospital Medicine titled “An Intellectual Agenda for Hospitalists.” In short, Dr. Goldman would like to see hospitalists move more into advancing science themselves rather than implementing the scientific discoveries of others. He cautions anyone against taking that as criticism of the field. “If hospitalists are going to be the people who implement what other people have found, they run the risk of being the ones who make sure everybody gets perioperative beta-blockers even if they don’t really work,” he says. “If you want to take it to the illogical extreme, you could have people who were experts in how most efficiently to do bloodletting. “The future for hospitalists, if they’re going to get to the next level—I think they can and will—is that they have to be in the discovery zone as well as the implementation zone.” Dr. Wachter says it’s about staying ahead of the curve. For 20 years, the field has been on the cutting edge of how hospitals treat patients. To grow even more, it will be crucial to keep that focus.

      Hospitalists can learn these skills through residency and fellowship training. In addition, through mentorship models that create evergrowing

    3. 2003 amid the push for quality and safety. And while the specialty’s early adoption of those initiatives clearly was a major reason for the exponential growth of hospitalists, Dr. Gorman doesn’t want people to forget that the cost of care was what motivated community facilities.
    4. Hospitalists were seen as people to lead the charge for safety because they were already taking care of patients, already focused on reducing LOS and improving care delivery—and never to be underestimated, they were omnipresent, Dr. Gandhi says of her experience with hospitalists around 2000 at Brigham and Women’s Hospital in Boston. “At least where I was, hospitalists truly were leaders in the quality and safety space, and it was just a really good fit for the kind of mindset and personality of a hospitalist because they’re very much … integrators of care across hospitals,” she says. “They interface with so many different areas of the hospital and then try to make all of that work better.”

      role of hospitalists in safety and quality

    5. Two years later, IOM followed up its safety push with “Crossing the Quality Chasm: A New Health System for the 21st Century.” The sequel study laid out focus areas and guidelines to start reducing the spate of medical mistakes that “To Err Is Human” lay bare.
    6. “When the IOM report came out, it gave us a focus and a language that we didn’t have before,” says Dr. Wachter, who served as president of SHM’s Board of Directors and to this day lectures at SHM annual meetings. “But I think the general sensibility that hospitalists are about improving quality and safety and patients’ experience and efficiency—I think that was baked in from the start.”
    7. The federal Agency for Health Care Policy and Research was renamed the Agency for Healthcare Research and Quality (ARHQ) to indicate the change in focus.
    8. Dr. Wachter and other early leaders pushed the field to become involved in systems-improvement work. This turned out to be prophetic in December 1999, when patient safety zoomed to the national forefront with the publication of the Institute of Medicine (IOM) report “To Err Is Human.” Its conclusions, by now, are well-known. It showed between 44,000 and 98,000 people a year die from preventable medical errors, the equivalent of a jumbo jet a day crashing. The impact was profound, and safety initiatives became a focal point of hospitals.
    9. “My feeling at the time was this was a good idea,” Dr. Wachter says. “The trend toward our system being pushed to deliver better, more efficient care was going to be enduring, and the old model of the primary-care doc being your hospital doc … couldn’t possibly achieve the goal of producing the highest value.”

      How can care be made further efficient? E.g., integration, cost-sharing, payment-sharing, parent partners, nurse partners

    1. The nutritional supplement ingestion for 3 weeks was found to increase serum GH levels with 70% relatively to placebo, whereas circulating IGF-I levels did not change.

      Niacin does not appear to elevate IGF-1.

    1. The field’s rapid growth has both ref lected and contributed to the evolution of clinical practice over the past two decades.
    1. The Deck

      A powerful framework for breaking down acquisition, engagement and growth metrics. This will allow you to understand the feedback loops and reinforcing systems that can help predict a companies trajectory.

    1. Instructional Design Strategies for Intensive Online Courses: An Objectivist-Constructivist Blended Approach

      This was an excellent article Chen (2007) in defining and laying out how a blended learning approach of objectivist and constructivist instructional strategies work well in online instruction and the use of an actual online course as a study example.

      RATING: 4/5 (rating based upon a score system 1 to 5, 1= lowest 5=highest in terms of content, veracity, easiness of use etc.)

    1. Online Options Give Adults Access, but Outcomes Lag

      In this article, drivers that increase and improve online learning success in adults are explored. State by state data along with federal stats contribute to the conclusions presented.

      Roughly 13% of all undergraduates are full-time online students and between 2012 and 2017 online students grew y 11 percent, about 2.25 million. The article presents a map showing state by state stats and the information provided can assist in growing individual school needs.

      RATING: 4/5 (rating based upon a score system 1 to 5, 1= lowest 5=highest in terms of content, veracity, easiness of use etc.)

  26. Oct 2018
    1. we needed to think six to 12 months ahead and work backwards to design the processes that would get us to the scale to handle this growth.”

      How does this apply in an agency environment?

  27. Aug 2018
    1. Nevertheless, the evidence suggests that social capital and social institutions are significant predictors of economic growth, after controlling for the effects of human capital and initial levels of income (Knack and Keefer 1997), (Knack 2002).4 So trust is a relevant dimension of social interactions that has been connected to individual dyads, network formation, labor markets, and even economic growth.
  28. Jul 2018
  29. Jun 2018
    1. Awan: Our growth has been a  journey of constant learning, but if I were to pinpoint the principles our growth team lives by today, which I hope would help others building and growing products, they would be: Define one "North Star" metric for success that is aligned with how your users get value as well as with the success of your business, then measure everything and how it contributes to the North Star metric. Good examples of true-north metrics for growth are measures like how many users are truly engaged with your product Growth is a team sport so hire wisely and invest in your team Good product, measured by long-term retention, comes first; growth comes second Invest in multiple growth channels and identify potential channels by looking at existing user behavior, especially how they are currently discovering your product. At LinkedIn, our biggest channels are viral growth, search-engine optimization of profiles and other member-generated content and partnerships. Understand that growth requires continuous prioritization and feedback so always be testing
    2. Awan: Our growth has been a  journey of constant learning, but if I were to pinpoint the principles our growth team lives by today, which I hope would help others building and growing products, they would be: Define one "North Star" metric for success that is aligned with how your users get value as well as with the success of your business, then measure everything and how it contributes to the North Star metric. Good examples of true-north metrics for growth are measures like how many users are truly engaged with your product Growth is a team sport so hire wisely and invest in your team Good product, measured by long-term retention, comes first; growth comes second Invest in multiple growth channels and identify potential channels by looking at existing user behavior, especially how they are currently discovering your product. At LinkedIn, our biggest channels are viral growth, search-engine optimization of profiles and other member-generated content and partnerships. Understand that growth requires continuous prioritization and feedback so always be testing
    3. Awan: Here’s some advice to others as they focus on growing their own company: Make sure you have product-market fit before you invest in growth. What that means is you have validated that your product is in a market with large demand and your product is satisfying the need for users who try the product. You can measure this by retention rate which is essentially the percentage of your users who keep coming back. If your retention is not stable, you’d want to improve the product first rather than wasting resources on growth. Prioritize growth from the very beginning and build it right into the product. It’s much better for your users to bring other users to the product as they create and share photos or other content or, invite others in the course of normally using the app than to try growing through marketing that feels bolted onto the product. This is critically important if your product has network effects because the product value is limited for early users if the network doesn’t grow fast enough. As your company starts to scale, it’s important to create a dedicated multi-disciplinary growth team covering product, design, marketing, engineering, data science, and business operations. In a startup, a single person may be playing multiple of those roles (an engineer who’s also the data scientist) but as you scale, you can create dedicated functional roles.
  30. Oct 2017
    1. To develope the reasoning faculties of our youth, enlarge their minds cultivate their morals, & instil into them the precepts of virtue & order.

      I particularly enjoy this line of the report. I appreciate this emphasis on personal growth in conjunction with academic growth that is so prevalent throughout the report. Furthermore, I also appreciate that these two types of growth seem to share the same level of importance.

  31. Sep 2017
    1. The major situations for growth mindset are: When we do not know an answer When we make error When we experience failure When we are anxious.

      Moments that are prime for "Growth Mindset"

  32. Mar 2017
    1. Research proving cannabis kills cancer cells has been suppressed since 1974.

      Like so many other kids I was told that marihuana kills brain cells and to stay away from it. When I saw this article it peeked my interest. I was skeptical of its truthfulness Then, I looked up the 1974 National Institute of Health referenced in the article. In the article I found evidence that an adenocarcinoma (cancer) tumor tested on mice resulted in inhibited and or reduced size when using delta-8-tetrahydrocannabinol (THC) and cannabinol (CBN). According to the study supported by the Public Health Service grant, the National Institute on Drug Abuse, Health Services & Mental Health Administration and by other grants. “Lewis lung adenocarcinoma growth was retarded by the oral administration of delta-9-tetrahydrocannabinol”. (A.E. Munson, L.S. Harris, M.A. Friedman, W.L Dewey, and R.A Carchman) National Cancer Institute, Vol. 55, No. 3, September 1975 and also I found a Canadian review article published in Current Oncology, “a large body of evidence shows that these molecules can decrease tumour growth in animal models of cancer.” The results of these studies leave me surprised. I found references that were opposite from what I have taught. Although, I would not advise the recreational use of smoking cannabis. I can see its usefulness in inhibiting and or reducing the size of cancerous tumors. I did not, however, find evidence to support the statement that cannabis kills cancer cells. In any case this subject is definitely warrants further study.

      References A.E. Munsion, L.S. Harris, M.A. Friedman, W. Dewey, and R.A. Carchman, Jornal of the National Cancer Institute, Vol. 55, No. 3, September 1975 Research Providing Cannabis Kills Cancer Cells Safely has been Suppressed since 1974 (2016, December 24). Retrieced March 9, 2017, from http://www.realfarmacy.com/research-proving-cannabis-kills-cancer-cells-safely-suppressed-since 1974 Ware, M. (n.d.). Cannabis and cancer: towards a new understanding. Retrieved March 29, 2017,

  33. Jan 2017