39 Matching Annotations
  1. Oct 2019
  2. Sep 2019
    1. Hereditary protein C deficiency caused by compound heterozygousmutants in two independent Chinese families

      PMID: 25393254

      Gene: PROC

      Disease: Thrombophilia due to protein C deficiency

      MonDO: 0012860

      InheritancePattern: Autosomal Recessive

  3. Jul 2019
  4. Apr 2019
    1. The consensus reception holds that the visual composition of the structures lack a unified voice due to the heavy handedness of the individual star-architects who were commissioned to design its various structures.Most critics write from the lens of art criticism and therefor focus on the aesthetics of structures as though they were sculptures in a museum. For decades, critics from this tradition have failed to understand or assimilate the principles of urban design that make cities vibrant and walkable.

      This struck me as very interesting, as it frames the article as a rejection of accepted criticism of many respected voices in the field. Instead, the author conducts a potential use study of the space for future users, from the perspective of walkability. It is written not for other scholars of the field but for a general audience, New Yorkers in particular.

    2. The primary benefit of this would be to make the Hudson River and Public Square park areas more easily accessible to everyone who lives and works east of Hudson Yards. Opening 10th avenue to street facing retail, turning the six lane street two-way, and adding bike lanes would also make it more forgiving.

      Concluding appeal and explanation of the author's call to action. Considering the lack of walkability and limited potential use, they suggest a new design that will maximize access. This also has the benefit of altering the public's sense of that the space is exclusive.

    3. It's important to note here that between the posh region of Chelsea and Hudson Yards are seven blocks of unglamorous project style developments and warehouses. The High Line provides a convenient bridge over this region, and the canyon of quirky residential developments that flank it obscures the true nature of the surrounding neighborhood, which is mostly black, latino and poor.

      Briefly discusses underserved populations that would likely not benefit from the space and go mainly unnoticed by art critics and star architects. Members of the general public.

    4. Much has been made over the symbolism of the Public Square’s corporate aesthetic, its ‘gaudy’ stairway monument, and the exclusive luxury of its mall. I believe this is overstated; New York has plenty of examples of luxury developments and amenities which also contribute to the fabric of the city, including Rockefeller Center, the World Trade Center memorial site, and Fifth Avenue. With time, these markers of status will ebb and a new development will claim the hyper-lux mantle.

      This is another example of the author rejecting popular criticism by leaders of the field. He tempers his comments towards the design of the space by mentioning other historic examples in the city.

      This may also be a connection to the general public who have embraced (as a novelty) the Hudson Yards. It gives the author a sense of reliability, compared to the highbrow disdain of art critics.

    5. But over time, they become numb to the novelty of art, and other considerations exert a far greater influence on their experience of the building: things like who uses the space, when the space is used, how the space forms community and how it integrates the the community that surrounds it.

      His argument is user-orientated, criticizing experts in the field who work separately to build components of a shared urban ecosystem. Each architect was chosen for their fame, not their ability to work as part of a team, and spare little consideration about those who will live, work, and move through the space. Most importantly, the question of fostering community is addressed.

      Similar to scholars at the top of their field, these architects place little consideration towards the mass consumption of their work and its context.

  5. Mar 2019
  6. Feb 2019
    1. Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome

      PMID: 28132690

      Gene: EXTL3

      Disease: Neuro-immuno-skeletal Dysplasia Syndrome

      MonDO: 0010668

      Inheritance Pattern: autosomal-recessive (maybe, check me on this, found 1st paragraph of results, but was unclear)

    1. abstraction is in itself but a dull and inert thing

      That "in itself" is an important qualifier. My initial thought was how this idea contrasts with Hume's discussion of the uses of general concepts, but the "in itself" poses abstractions by themselves, when not employed to a particular use. When abstractions are put to work, do they do something similar to Hume's generalities? (How closely related are abstractions and general principles?)

  7. Nov 2018
    1. The debate over the role of hospitalists is takingplace against the backdrop of the larger controversyover whether generalists or specialists should pro-vide care for relatively ill patients.11
    2. HE explosive growth of managed care has led toan increased role for general internists and otherprimary care physicians in the American health caresystem.
  8. Oct 2018
    1. To test this hypothesis we conducted a detailed study on the root architecture of these crops using SimRoot (Postma and Lynch, 2011a, b), a functional–structural plant model, and estimated competition for nitrate, potassium and phosphorus among roots of maize, bean and squash plants grown in monoculture or polyculture.
    1. In this study we examine how the water transport and photosynthetic carbon assimilation rates of leaves are related to the spatial arrangement of veins in the leaf mesophyll.
  9. Sep 2018
    1. cash crops

      A cash crop or profit crop is an agricultural crop which is grown to sell for profit. It is typically purchased by parties separate from a farm. The term is used to differentiate marketed crops from subsistence crops, which are those fed to the producer's own livestock or grown as food for the producer's family.

  10. Aug 2018
    1. in an effort to more firmly ascertain the influence of climate on leaf physiognomy within species, we report results from a large data set that includes two North American woody plants (A. rubrum and Q. kelloggii) whose native ranges span large MAT gradients and are not closely related to each other.
  11. Jul 2018
    1. 2
      1. You will need a Flat-Head screwdriver and a Phillips-Head screwdriver.
      2. Working alone may not be the most efficient or safe, we recommending having a helper for the task.
      3. To avoid damage to the product, place the product on soft surfaces like a rug.
      4. Whenever you encounter difficulties or have any concerns about the product, do not hesitate to contact IKEA customer service.

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  12. Apr 2018
    1. General Advertizer

      The General Advertiser was an eighteenth-century newspaper. It was originally known as the London Daily Post and General Advertiser, and then became the General Advertiser. Printer Henry Woodfall took over the paper in 1713, renaming it the Public Advertiser. He operated it until his nineteen-year-old son, Henry Sampson Woodfall, took over the paper in 1769. relaunched as the Public Advertiser with much more news content. In 1758, the printer's nineteen-year-old son, Henry Sampson Woodfall took it over. During this time, The anonymous polemicist Junius sent his letters to the Public Advertiser. Henry Sampson Woodfall sold his interest in the Public Advertiser in November 1793. N. Byrne took it over and printed it as the Political and Literary Diary, but it went out of business by 1795.

    1. the scalar curvatureRofds2is given byR= (1−u−2)Rρ+u−2n−1∑i,jR0ijij+ 2n−1∑i=1Rnini= (1−u−2)Rρ+u−2R0−2u−1∆ρu+ 2u−3∂u∂ρH0whereR0is the scalar curvature ofNwith respect tods20andRρis the scalar curvatureof Σρwith the induced metric.
  13. Mar 2018
    1. ObjetivogeneralRecuperar el níquel (II) y otros metales disuelto en aguas residuales mediante electro coagulaciónpara su uso en industria metalúrgica.

      Tiene la estructura del objetivo general, sin embargo no queda muy claro el qué (Niquel y, ¿cuáles otros metales?)

    1. Objetivo general del proyecto

      Sigue la forma "verbo+qué+cómo+para qué" pero deja vago el "cómo" ya que, no especifica el por cual método lo hará.

    1. Obtener alginatode sodioa partir de las Sargassum liebmanniirecolectadas de las costas Jalisco y de Nayarit; mediante tratamiento con soluciones alcalinas acuosas (NAOH) evaluando los temas relacionados para la posible producción a escala industrial.

      El objetivo generar se ve completo, en una sola frase presenta el verbo "obtener" el cual es correcto, seguido de la materia de estudio "alginato de sodio", la metodología y la posible aplicación aparecen con coherencia. esencialmente este objetivo general resume de manera correcta las intenciones del proyecto.

  14. Nov 2017
    1. General Assembly The General Assembly is the main deliberative, policymaking and representative organ of the UN. All 193 Member States of the UN are represented in the General Assembly, making it the only UN body with universal representation.  Each year, in September, the full UN membership meets in the General Assembly Hall in New York for the annual General Assembly session, and general debate, which many heads of state attend and address. Decisions on important questions, such as those on peace and security, admission of new members and budgetary matters, require a two-thirds majority of the General Assembly. Decisions on other questions are by simple majority.  The General Assembly, each year, elects a GA President to serve a one-year term of office.

      General Assembly

  15. Oct 2017
    1. We report results from randomized, placebo-controlled, double-blind trials of antibiotic therapy inseropositive and seronegative patients who had chron-ic symptoms after treatment for Lyme disease.

      Experimental study with correct experimental design.

  16. Sep 2017
    1. Let Σ0be a compact strictly convex hypersurface inRn,Xbe the position vector ofa point on Σ0, and letNbe the unit outward normal of Σ0atX. Let Σrbe the convexhypersurface described byY=X+rN, withr≥0. The Euclidean space outside Σ0canbe represented by(Σ0×(0,∞),dr2+gr)wheregris the induced metric on Σr. Consider the following initial value problem(2.1)2H0∂u∂r= 2u2∆ru+ (u−u3)Rron Σ0×[0,∞)u(x,0) =u0(x)whereu0(x)>0 is a smooth function on Σ0,H0andRrare the mean curvature and scalarcurvature of Σrrespectively, and ∆ris the Laplacian operator on Σr.

      Note que de agora em diante o autor se detém a estudar esse caso particular, onde estão inteiramente determinadas as geometrias intrínseca e extrínseca das folhas do semi cilindro, obtido folheando-se pelas paralelas o exterior da hipersuperfície estritamente convexa dada a priori.

    2. Given a functionRonN, we want to find the equation forusuch that(1.2)ds2=u2dρ2+gρhas scalar curvatureR.

      O papel da aplicação \( u: N \longrightarrow \mathbb{R} \) é distorcer as fibras do semi cilindro \( N \), por dilatações e torções, deixando a geometria intrínseca das folhas invariante, de tal forma que o resultado seja um semi cilindro com a curvatura escalar prescrita \( \mathcal{R} \).

    3. Let Σ be a smooth compact manifold without boundary with dimensionn−1 and letN= [a,∞)×Σ equipped with a Riemannian metric of the form(1.1)ds20=dρ2+gρfor a point (ρ,x)∈N. Heregρis the induced metric on Σρwhich is the level surfaceρ=constant

      Isso significa que a construção a seguir é feita a partir de um semi cilindro em que a geometria das folhas é dada a priori.

      Esse artigo não trata da construção desse semi cilindro inicial.

  17. May 2017
    1. Canol Pipeline
      Designed during the first months of World War II, the Canol Pipeline brought oil from Norman Wells near the Mackenzie River to Whitehorse, Yukon Territory. Once the oil was refined, it would be sent to Alaska via pipeline to ensure that the Japanese navy could not intercept any transport. The oil deposits at Norman Wells were discovered by the explorer Alexander Mackenzie during the 18th century. In January of 1942, Lieutenant General Brehon Somervell, commanding general of the Army Service Forces, ordered James H. Graham, former dean of engineering at the University of Kentucky, to investigate the possibility of harvesting oil from Norman Wells. On April 29, 1942, General Somervell immediately approved the recommendation of Dean Graham to implement a pipeline from Norman Wells to Whitehorse (O'Brien, 1970). The construction began in 1942 and was completed in 1944 by the United States Army. A road was also constructed alongside the Canol pipeline during this time. In 1945, soon after the completion of the Canol Pipeline, the volume of crude oil that was able to be transported compared to the cost of operating the pipeline could not be justified. The Canol Pipeline was shut down and abandoned in 1945 (Wilson, 1991). 
      

      References

      O'Brien, C. F. (1970). The Canol Project: A Study in Emergency Military Planning. The Pacific Northwest Quarterly, 101-108.

      Wilson, W. H. (1991). Review: A Walk on teh Canol Road: Exploring the First Major Northern Pipeline. The Pacific Northwest Quarterly, 114.

  18. Jan 2017
    1. The lady of such a professor, on being questioned by a company of ladies as to her husband's emotions at the prospect of such an enlargement of the field of science, excited a strong feeling of displeasure against herself. She could not say that he believed it, and would gladly have said nothing about it; but her inquisitive companions first cross-examined her, and then were angry at her skepticism

      Angry at Skepticism

      The Great Moon Hoax of 1835 was widely believed (see General Credulity). Similar to today, skeptics were not well liked, and the reaction to them was often anger.

    2. "The credulity was general. All New York rang with the wonderful discoveries of Sir John Herschell... There were, indeed, a few sceptics; but to venture to express a doubt of the genuineness of the great lunar discoveries, was considered almost as heinous a sin as to question the truth of revelation."

      General Credulity

      Most people truly believed the hoax.

  19. Dec 2015
    1. Lemma 2.3.(2.1) has a unique solutionufor allrwhich satisfies the estimates in Lemma2.2.
    2. Let Σ0be a smooth compact strictly convex hypersurface inRn. Letrbe the distance function from Σ0. Then the metric on the exteriorNof Σ0is given bydr2+gr, wheregris the induced metric on Σr, which is the hypersurface with distancerfrom Σ0. The functionuwith prescribed scalar curvatureR= 0 is given by2H0∂u∂r= 2u2∆ru+ (u−u3)RrwhereH0is the mean curvature of Σr,Rris the scalar curvature of ΣrandR0is the scalarcurvature of Σrwith the induced metric fromRnand ∆ris the Laplacian on Σr.
  20. Mar 2015
    1. θ dμ ≥ p 16 π | Σ |

      Qual a relação dessa desigualdade com a dita desigualdade de Penrose Riemanniana provada por Huisken-Ilmanen e Bray?

    2. GIBBONS-PENROSE INEQUALITY

      Qual a relação dessa desigualdade com a dita desigualdade de Penrose Riemanniana provada por Huisken-Ilmanen e Bray?

  21. Feb 2015
    1. The New York State attorney general’s office accused four major retailers on Monday of selling fraudulent and potentially dangerous herbal supplements and demanded that they remove the products from their shelves.

      As early as the opening, we can see issues with the handling of the subject matter that give ample room to herbal supplement apologists.

      The apologist could start with the semantic objection, "What is an herbal supplement that does not contain the ingredients on the label -- it is just a filler pill." He will go on to establish that this constitutes supplement fraud for sure. But the author seeks to smuggle the idea of danger into the idea of herbal medicine and would not be able to do that if the products were more carefully engineered. In other words, these fraudulent herbal supplements only present dangers because they're fraudulent; if they contained what they were supposed to they would be safe.

      The apologist would be deeply mistaken.

      Sadly, even though this is just one little paragraph, the problems do not stop there. The 4 major retailers targeted by the investigation are being set-up (through the use of that "major" label) as giants in the industry. While this may be true by the numbers, it's also a very easy point for an apologist to knock down. One can almost imagine the smaller scale "herbal remedy" operation -- "Is it really any surprise big corporations fail to provide a quality herbal product? They care about you. They only care about their bottom line."

      Suffice it to say, the handling oo the reporting, as well as the circumstances of the investigation look like they're going to leave much to be desired. If thee early presentation fails persist throughout the article, it would have the effect of turning this should-be exposé into little more than a flash the pan.

      We'll see this is exactly what happens.

  22. Nov 2013
    1. The whole of the following sixth book is taken up with the arts for stirring the emotions and causing delight; here nothing is the property of dialectic or of rhetoric. Since rhetoric and di-alectic are general arts, they should therefore be explained in a general fashion, the one in respect to style and delivery, the other in respect to in-vention and arrangement.

      I disagree. The arts of "stirring the emotions" show how to produce this effect in style and delivery. In the end, good rhetoric should "stir the emotions," no matter what the subject or emotion.