247 Matching Annotations
  1. Nov 2024
  2. Oct 2024
    1. Guanidinoacetate Methyltransferase Deficiency: The First InbornError of Creatine Metabolism in Man

      PMID: 8651275

      Gene: GAMT

      Disease: GAMT deficiency

      Inheritance: Autosomal Recessive

    1. In order to give the reader some chance of havinga good Collection of Headings, and less chance ofomitting the important Headings, I have offered (e.g.on pp. 83, 92) a few General Lists, which are not quitecomplete but yet approach to completeness ; two ofthese Lists will be found sufficient for most purposes.One of these is called the List of Period- Headings,such as Geography, Religion, Education, Commerce,War, etc. (see p. 83); the other is called the List ofGeneral Headings, and includes Instances, Causes andHindrances, Effects, Aims, etc. : this latter List will befound on p. 92.
    2. pages 83 and 92. Ihave called theni 'General Lists'
  3. Sep 2024
    1. Résumé de la vidéo [00:00:04][^1^][1] - [00:24:55][^2^][2]:

      Cette vidéo est une réunion d'information pour les parents d'élèves de terminale générale au lycée Louis Vincent. Elle couvre divers aspects de la vie scolaire, du règlement intérieur, du baccalauréat et de l'orientation via Parcoursup.

      Points forts : + [00:02:48][^3^][3] Introduction et présentation * Accueil par M. Lis Grandpierre * Présentation des intervenants * Remerciements aux participants + [00:04:47][^4^][4] Règlement intérieur * Comportement dans les couloirs * Horaires et ponctualité * Utilisation des téléphones portables + [00:12:00][^5^][5] Orientation et Parcoursup * Rôle de la psychologue de l'éducation nationale * Prise de rendez-vous pour l'orientation * Importance de la réflexion sur les choix de formation + [00:16:01][^6^][6] Calendrier Parcoursup * Dates clés pour l'année scolaire 2024-2025 * Processus de formulation des vœux * Importance de la préparation en amont + [00:22:00][^7^][7] Conseils pour les parents * Suivi scolaire via le bureau numérique * Importance de la discussion avec les enfants * Utilisation de la plateforme Parcoursup pour rechercher des formations

      Résumé de la vidéo [00:24:59][^1^][1] - [00:48:31][^2^][2]:

      Cette vidéo traite de l'orientation post-bac des élèves de terminale générale au lycée Louis Vincent. Elle aborde les différentes étapes et outils pour aider les élèves à choisir leur future formation.

      Points forts : + [00:25:09][^3^][3] Cibler des formations * Importance de choisir des formations dès maintenant * Utilisation de questionnaires pour aider les élèves à se projeter * Bilan à mi-trimestre pour évaluer les résultats et le comportement + [00:26:48][^4^][4] Actions spécifiques * Participation à des salons pour poser des questions sur les formations * Immersions à l'université pour découvrir les formations * Importance de préparer ces visites pour en tirer le maximum + [00:34:01][^5^][5] Baccalauréat * Notes de contrôle continu comptent pour le bac * Importance de bien préparer les épreuves écrites et orales * Organisation de bacs blancs pour habituer les élèves aux conditions d'examen + [00:39:02][^6^][6] Grand oral * Importance du grand oral pour obtenir le bac * Préparation tout au long de l'année * Organisation d'oraux blancs pour s'entraîner + [00:45:00][^7^][7] Parcoursup * Importance d'avoir un bon dossier pour être sélectionné * Conseils pour améliorer les remarques des enseignants * Encouragement à faire des efforts tout au long de l'année

      Résumé de la vidéo [00:48:33][^1^][1] - [01:11:53][^2^][2]:

      Cette vidéo traite des examens et des procédures administratives pour les élèves de terminale au lycée Louis Vincent. Elle aborde les absences, les devoirs, les fraudes, et les certifications numériques.

      Temps forts: + [00:48:33][^3^][3] Absences et rattrapages * Gestion des absences codifiée par les professeurs * Importance des certificats médicaux pour éviter les zéros * Épreuves de rattrapage en fin d'année scolaire + [00:49:47][^4^][4] Devoirs communs et bacs blancs * Devoirs communs le samedi matin * Bac blanc de philosophie et épreuves de spécialité en avril * Préparation de sujets différents pour chaque jour d'examen + [00:52:00][^5^][5] Grand oral * Validation des questions par les enseignants * Importance de l'exercice à l'oral pour la confiance * Exemples de réussite grâce à une bonne préparation + [00:55:00][^6^][6] Fraudes et tentatives de fraude * Règlement strict sur les téléphones portables * Conséquences sévères en cas de fraude avérée * Importance de l'équité entre les candidats + [01:03:00][^7^][7] Certifications et bourses * Certification PIX des compétences numériques * Démarches pour les bourses scolaires et du supérieur * Importance de respecter les échéances administratives

      Résumé de la vidéo [01:11:55][^1^][1] - [01:19:04][^2^][2]:

      Cette vidéo traite de divers aspects de la gestion des emplois du temps, des préparations aux concours, et de l'importance de la présence en classe pour les élèves de terminale.

      Points forts : + [01:11:55][^3^][3] Gestion des emplois du temps * Contraintes de salle * Ajustements finaux en cours * Défis de planification + [01:12:42][^4^][4] Préparations aux concours * Importance des cours réguliers * Heures supplémentaires de préparation * Rôle des enseignants + [01:13:11][^5^][5] Présence en classe * Absences en fin d'année * Importance de la présence des enseignants * Responsabilité des parents + [01:14:26][^6^][6] Fiche Avenir * Moyennes et classements * Critères de sélection pour le supérieur * Importance des appréciations des enseignants + [01:17:00][^7^][7] Rôle du chef d'établissement * Avis sur la capacité à réussir * Critères de classement * Importance de la motivation des élèves

    1. Der neue französische Premierminister Michel Barnier hat in seiner Zeit als Umweltminister wesentlich dazu beigetragen, das Vorsorgeprinzip und die finanzielle Verantwortung der Verschmutzenden für Schäden im Umweltrecht zu verankern. Obwohl er zu Amtsbeginn auch von der „ökologischen Schuld" gesprochen hat, erwarten NGOs und Thinktanks, deren Vertreter:innen die Libération befragt hat, allenfalls vorsichtige umweltpolitische Schritte und eine insgesamt restriktive Ausgabenpolitik von ihm.https://www.liberation.fr/environnement/le-premier-ministre-michel-barnier-est-il-vraiment-decide-a-payer-la-dette-ecologique-de-la-france-20240906_7BYVDVAUSJD2VN6M4V7DAI2N2E/

  4. Aug 2024
    1. 101st CONGRESS 1st Session H. CON. RES. 180 Commending the outstanding efforts of aviators and the Flying Tigers for valued and competent service to the United States. IN THE HOUSE OF REPRESENTATIVES July 31, 1989

      resolution; which was referred to the Committee on Post Office and Civil Service.

      • Whereas aviators have had a distinguished record as volunteers in emergency and rescue missions;

      • Whereas the Flying Tigers originated in the jungles of Burma nearly 50 years ago with the United States volunteer group of General Clair Chennault;

      • Whereas the tradition of proud and distinguished service of the Flying Tigers to the United States began under the direction of Robert W. Prescott;

      • Whereas this proud and distinguished group of aviators has steadfastly served the specialized air transportation needs of the United States for more than 4 decades;

      • Whereas the Flying Tigers has provided assistance with rescue efforts in Korea, Hungary, Vietnam, Cambodia, and Ethiopia, as well as many other humanitarian missions; and

      • Whereas the Flying Tigers are representative of countless aviators that deserve recognition for service to the Nation and to thousands of individuals throughout the world:

      Now, therefore, be it Resolved by the House of Representatives (the Senate concurring), That the Congress commends the outstanding efforts of aviators and the Flying Tigers for valued and competent service to the United States.

  5. Jun 2024
    1. Résumé de la vidéo [00:00:01][^1^][1] - [04:15:35][^2^][2]:

      La vidéo aborde la gouvernance des données et l'intelligence artificielle (IA) dans le contexte de l'intérêt général. Elle souligne l'importance de développer des critères de progrès précis pour orienter vers les bons usages de l'IA, tout en évitant les dangers potentiels. Les discussions portent sur des sujets variés, notamment la santé, le climat, la justice, et l'égalité, et comment l'IA peut contribuer positivement à ces domaines.

      Points forts: + [00:00:01][^3^][3] Gouvernance des données et IA * Importance de l'IA dans le développement et la recherche * Nécessité de critères de progrès précis pour l'IA * Impact de l'IA sur la société et les citoyens + [00:36:42][^4^][4] Confiance et partage des données * Défis liés à la dépossession et au manque de confiance * Conséquences de l'utilisation commerciale des données personnelles * Importance de la régulation pour protéger les données + [01:18:50][^5^][5] Marché des données et intérêt général * Coût et moyens technologiques nécessaires pour collecter des données * Contrôle et bénéfice des données pour les individus et la société * Débat sur l'utilisation lucrative des données et son impact + [01:55:09][^6^][6] Coût énergétique de l'IA * Augmentation de la consommation énergétique pour l'entraînement des modèles d'IA * Utilisation massive des modèles et leur impact environnemental * Comparaison des coûts énergétiques entre l'IA et d'autres secteurs + [03:02:39][^7^][7] Données multimodales dans le domaine de la santé * Utilisation des données du dossier patient pour la recherche * Avantages des données multimodales sur les données structurées * Progrès possible sans surcharger les médecins avec la saisie de données + [04:03:23][^8^][8] Empreinte énergétique et technologie numérique * Relation entre puissance informatique et consommation énergétique * Besoin de réseaux plus puissants pour les nouveaux usages * Débat sur l'empreinte énergétique du numérique par rapport à d'autres secteurs

  6. May 2024
    1. Ivan papov

      for - key insight - geopolitics - arrest of General Ivan Papov - suppress uprising

      key insight - geopolitics - Russia - arrest of general Papov - The arrest sends a signal to all the generals - do not try to overthrow Putin

    1. This intuition is generally more useful, but is more difficult to explain, precisely because it is so general.
  7. Apr 2024
    1. The small article does reflect however one very general feature 79in modern activity i.e. to treat the specific rather than thegeneral.
  8. Mar 2024
  9. Feb 2024
    1. if (( ${#} == 0 )) ; then while read -r __my_function ; do my_function "${__my_function}" done else target_utility "${@}" fi

      I like it pretty well, in many ways more than G-Man's answer. I like the use of while read. I'd probably prefer non-recursive solution most of the time though, esp. if instead of a function we would be spawning a subshell (script) to achieve the recursion, like in ...

    2. Also unclear why the answer is criticized for providing a "more general case" since the OP said "You are right, this [base64] was just used as an example, though.
    3. (It seems reasonable to assume users are often expected to occasionally adapt answers rather than expect to use them verbatim.)
    4. This answer is one of various possible solutions for a "Bash function that accepts input from parameter or pipe" since the OP indicated [in a comment] that base64 was not the actual problem domain. As such, it makes no attempt to assure input is able to be directly read from a file.
    5. but in a different situation target_utility "${@}" could represent more complex code
    6. Though the OP's issue may not present a problem ideally resolved through use of recursion, other reader's problems may benefit from using it, or, from considering use of an wrapper function:
    7. The title of the question is what triggered the process of finding this Q/A for material that aided development of the above to solve a real life problem described by the title. The OP declared that base64 decode was not the "real" problem; pedantic constraint of answers to a particular "example" seems less helpful. When this question and its answers were key to helping solve real problems, alternate answers can be gifts to the community in recognition of the fact that many more people will use this Q/A to solve problems. Since the answer is on-topic per the title, I feel it is "game on".
    1. Résumé de la vidéo [00:00:00][^1^][1] - [01:48:19][^2^][2]:

      Cette vidéo est une conférence sur les biens communs pour partager la connaissance, organisée par le Collège de France en 2023. Elle réunit trois intervenants qui sont des experts dans le domaine des données numériques et de leur diffusion. Ils abordent les enjeux, les opportunités et les limites de l'ouverture des données, notamment dans les domaines de la recherche, de la géographie, du climat et du patrimoine. Ils illustrent leurs propos par des exemples concrets de projets et de plateformes qui visent à créer des communs numériques, c'est-à-dire des ressources partagées et accessibles à tous.

      Points clés: + [00:08:31][^3^][3] Les données sont au centre de l'innovation économique et sociale * Elles sont nécessaires pour le progrès de la connaissance et la résolution des problèmes * Elles doivent être de qualité, non biaisées, représentatives et interopérables * Elles posent des questions de protection, de régulation et d'éthique + [00:34:00][^4^][4] L'IGN a développé une stratégie de géocommuns pour coproduire et partager les données géographiques * Il s'agit de passer d'un modèle de producteur unique à un modèle de collaboration avec les acteurs du territoire * Il s'agit de créer des tables communes où chacun peut déposer et utiliser des données * Il s'agit de soutenir et de valoriser des initiatives innovantes dans le domaine de la géographie + [00:54:40][^5^][5] Le Haut Conseil pour le climat utilise les données pour évaluer et orienter les politiques climatiques * Il s'agit de mesurer les émissions de gaz à effet de serre, l'empreinte carbone, la vulnérabilité et l'adaptation des territoires * Il s'agit de comparer les scénarios et les trajectoires possibles pour atteindre la neutralité carbone * Il s'agit de sensibiliser et de mobiliser les acteurs et les citoyens sur les enjeux du changement climatique + [01:14:00][^6^][6] Le Collège de France a lancé une plateforme de données ouvertes sur le patrimoine culturel * Il s'agit de mettre à disposition des chercheurs et du public des données issues des collections et des archives du Collège * Il s'agit de favoriser la diffusion et la valorisation des savoirs et des œuvres * Il s'agit de créer des passerelles entre les disciplines et les époques à travers les données

    1. Les entretiens du contentieux sont l’occasion de remettre en lumière ce principe, dans un contexte à la fois d’affirmation des intérêts individuels et d’émergence de nouveaux enjeux, notamment environnementaux ou numériques.

      Colloque organisé dans le cadre des Entretiens du contentieux, le mardi 28 novembre 2023

      12:25 : Ouverture - Didier-Roland TABUTEAU, vice-président du Conseil d'État 46:36 : TR1 – Intérêt général et action publique 50:58: Pierre DELVOLVE, membre de l'académie des sciences morales et politiques. Professeur émérite de l'Université de Paris II 1:04:01: Frédéric VEAUX, directeur général de la police nationale 1:22:39: Murielle FABRE, secrétaire générale de l'AMF, vice-présidente de l'Eurométropole de Strasbourg, maire de la commune de Lampertheim (67) 1:44:34: Marie-Amandine STEVENIN, présidente de UFC-QUE CHOISIR

      2:17:20 : TR2 – Les différentes formes de l’intérêt général 2:24:45: Benoît COEURE, présidente de la 1ère chambre de la section du contentieux, Conseil d'État 2:46:18: Gaelle DUMORTIER, présidente de la 1ère chambre de la section du contentieux, Conseil d'Etat 3:01:51: Me Denis DE LA BURGADE, avocat aux Conseils

      3:32:54 : Questions/ réponses 3:47:32 : Clôture

  10. Jan 2024
    1. Another example are issue boards. They represent elegant use of a good infrastructure ­— it is all just a smart use of labels. It would be very complex feature without the use of labels.
    2. Issue relations are meant to be the basic infrastructure to build on (at least that is how I meant it when I posted the original feature request). Just like the labels are just a binary relation between a issue and a "label", the relations should be just a ternary relation between two issues and a "label". Then you can build issue task lists on top of the relations like you've built issue boards on top of the labels.
    3. We already have a very nice example of such tool and its great use: the Board, where labels are used to store metadata and the Board is built above this storage. Do the same with the relations -- simple metadata storage to build on.
    4. Such a generic approach will allow the Relations to fit any reasonable workflow, because possible relations are defined by users, just like the Labels are.
  11. Dec 2023
    1. on sait que le principe d'égalité ne s'oppose pas à ce que des situations différentes soi traité différemment on sait aussi que lorsque les situations ne sont pas 00:09:42 différentes le traitement ne peut normalement pas être différencié sauf si un intérêt général justifie de favoriser certains par rapport à d'autres et il 00:09:53 faut alors sauf à justifier n'importe quelle discrimination que l'intérêt général invoque soit en rapport avec l'objet de la mesure là aussi il ne suffit pas de trouver un intérêt général 00:10:06 quelconque il faut trouver l'intérêt général pertinent
    2. elle conduisait très directement l'administration à faire usage de ses pouvoirs dans un but autre que celui pour lesquel ces pouvoirs lui avaient été confiés agir dans un but d'intérêt général alors que cet intérêt 00:09:18 général n'est pas pertinent et constitutif d'un détournement de pouvoir
  12. Oct 2023
  13. Aug 2023
    1. Was Ronald Reagan's shift in politics an example of “It is difficult to get a man to understand something, when his salary depends upon his not understanding it!” (Upton Sinclair)? (see also: https://quoteinvestigator.com/2017/11/30/salary/)

      Link to https://hypothes.is/a/Kft7kDOrEe6TQKcW-dREwQ in The Big Myth on Regan's shift in political views while working for General Electric.

    1. Most Americans know that before becoming a politician Reaganwas an actor, but fewer are aware that Reagan’s flagging screencareer was revived by a job with the General Electric Corporation(GE). Reagan hosted the popular television show General ElectricTheater, where each week his voice and face reached into tens ofmillions of homes, promoting didactic stories of individualism andfree enterprise. At the same time, he traveled across the country onbehalf of GE—visiting factories, making speeches at schools, anddoing the dinner circuit in communities where GE had a presence—promoting the corporation’s stridently individualist antiunion andantigovernment vision.

      From a philosophical viewpoint, Reagan grew up in Dixon, Illinois a small town (surrounded by farmland) in North West-ish Illinois roughly on the border of the political borders of what Colin Woodard calls The Midlands and Greater Appalachia. He seems to have been a Midlander for the first half of his life, but obviously had an easy time moving to a more Greater Appalachia viewpoint when working for GE.

  14. Jul 2023
    1. Q: What is global namespace? The global namespace is the namespace that contains namespaces and types that aren't declared inside a named namespace

      Q: How to use? ::global

      Ref: https://learn.microsoft.com/vi-vn/dotnet/csharp/language-reference/operators/namespace-alias-qualifier

    2. In C# 9.0 and later versions, when you use top-level statements in a Program.cs file, there is no default namespace defined.

      IF "there is no default namespace defined" = "without any namespace declaration" -> the code in Program.cs belongs to the global namespace since there is no default or explicit namespace specified in the file

  15. Jun 2023
  16. May 2023
  17. Feb 2023
    1. Et les arrêts de la Cour de cassation commencent à suivre ce mouvement moins rigoriste pour ceux qui écrivent et publient ; en particulier en considérant que «  la bonne foi doit être appréciée   en tenant compte notamment du caractère d’intérêt général  ». En 2011, les Arènes et Denis Robert ont pu bénéficier de ce fléchissement. Les conditions restent difficiles à remplir pour exciper des exceptions de vérité comme de bonne foi ; mais « l’intérêt général », à défaut de pousser à une refonte de la loi, incite les juges à plus de modération.
    2. En outre, ces dernières années, plusieurs décisions rendues par la Cour Européenne des Droits de l’Homme se réfèrent à la notion d’intérêt général, qu’il s‘agisse d’admettre plus aisément la bonne foi comme, dans quelques cas, de permettre d’user de l’exception de vérité (en contournant notamment la fameuse règle des dix ans). Il ressort de cette jurisprudence que les restrictions à la liberté d’expression sont forcément d‘interprétation stricte.
  18. Dec 2022
    1. Inborn errors of creatine metabolism and epilepsy: clinical features, diagnosis, and treatment

      PMID: 12597058

      Gene: GAMT

      Disease:GAMT deficiency

      Inheritance:Autosomal Recessive

    1. Biochemical and clinical characteristics of creatine deficiency syndromes

      PMID: 15625559

      Gene:GAMT

      Disease:GAMT deficiency

      Inheritance: Autosomal Recessive

    1. Diagnostic enzyme assay that uses stable-isotope-labeled substrates to detect L-arginine:glycine amidinotransferase deficiency

      PMID: 12709373

      Gene: GAMT

      Disease:GAMT deficiency

      Inheritance: Autosomal Recessive

    1. l-arginine:glycine amidinotransferase (AGAT) deficiency: clinical presentation and response to treatment in two patients with a novel mutation

      PMID: 20682460 Gene: GAMT Disease: GAMT deficiency Inheritance: X-linked

  19. Nov 2022
    1. Presence of guanidinoacetate may compensate creatine absence and account for less statin-induced muscle damage in GAMT-deficient compared to AGAT-deficient mice

      PMID: 32172372 Gene: GAMT Disease: GAMT deficiency Inheritance: X-linked

    1. LC-MS/MS measurements of urinary guanidinoacetic acid and creatine: Method optimization by deleting derivatization step

      PMID: 30858092 Gene: GAMT Disease: GAMT deficiency Inheritance: X-linked

    1. Case Study for the Evaluation of Current Treatment Recommendations of Guanidinoacetate Methyltransferase Deficiency: Ineffectiveness of Sodium Benzoate

      PMID: 24766785

      Gene: GAMT

      Disease: GAMT deficiency

      Inheritance: X-linked

  20. Oct 2022
    1. Arginine:Glycine Amidinotransferase Deficiency: The Third Inborn Error of Creatine Metabolism in Humans

      PMID: 11555793

      Gene: GATM

      Disease: AGAT deficiency

      Inheritance: Autosomal Recessive

    1. X-Linked Creatine-Transporter Gene (SLC6A8) Defect: A New Creatine-Deficiency Syndrome

      PMID: 11326334

      Gene: SLC6A8

      Disease: creatine transporter deficiency

      Inheritance: X-linked

    1. Inborn errors of creatine metabolism and epilepsy

      PMID: 23157605

      Gene: SLC6A8

      Disease: Creatine transporter deficiency

      Inheritance: X-linked

    1. Title annotation

      PMID: 21308988

      Gene: SLC6A8

      Disease: Creatine transporter deficiency

      Inheritance: X-linked

      Case annotation

      Case#: N/A

      DiseaseAssertion: AGAT Deficiency

      FamilyInfo: N/A

      CasePresentingHPOs: HP:0000729, HP:0001249, HP:0002373, HP:0001252

      CaseHPOFreeText: mental retardation, autistic behavior, febrile seizures, hypotonia

      CaseNotHPOs: N/A

      CaseNotHPOFreeText: Developmental Delays, slow somatic growth

      Biochemical analyte testing: Plasma Creatine: low/normal and Urine Creatine: low/normal

      Brain Magnetic Resonance Spectroscopy (MRS): N/A

      Creatine uptake assay:

      Variant:

      ClinVarID:

      CAID:

      gnomAD:

      Zygosity:

      MaternalGenotype:

      AdditionalParentalTesting:

      AlsoPublished:

    1. Adult GAMT deficiency: A literature review and report of two siblings

      PMID: 33996490

      Gene: GAMT

      Disease: GAMT deficiency

      Inheritance: Autosomal Recessive

    1. Pre-symptomatic treatment of creatine biosynthesis defects

      PMID: 18652077 Gene: GAMT Disease:GAMT deficiency Inheritance:Autosomal Recessive

      Not accessible

    1. Increased creatine demand during pregnancy in Arginine: Glycine Amidino-Transferase deficiency: a case report

      PMID: 32883247 Gene: GAMT Disease: GAMT deficiency Inheritance: X-linked

    1. Guanidinoacetic acid deficiency: a new entity in clinical medicine?

      PMID: 33029096 Gene: GAMT Disease: GAMT deficiency Inheritance: X-linked

  21. Sep 2022
    1. Maria Kozhevnikov, a neuroscientist at the National University of Singapore and Massachusetts General Hospital

      !- reference : Maria Kozhevnikov - neuroscientist at National University of Singapore, Massachusetts General Hospital - Nangchen tow, Amdo region of Tibet - testing if g-tummo vase breathing technique could raise core body temperature. One monk raised body temp to that normally associated with a fever - published results in PLOS One

  22. Aug 2022
    1. The template for what personal computing could become was really obvious by the end of the 1970s. If you look at Engelbart, it was obvious in 1968. But it did take quite a while for the computer chips to be powerful enough and inexpensive enough to make the kinds of things that billions of people use today.

      Ideas ahead of their time in the mainstream (not in the niches). Compare to Lernout and Hauspie wrt early natural language processing 1987-1998 and GPT-3 now.

  23. Jul 2022
    1. mutations in the α-sarcoglycan gene (SGCA)

      PMID: 30989758

      Gene: SGCA

      HGNCID: 10805

      Case: 8 year old boy, Chinese.

      DiseaseAssertion: LGMD

      FamilyInfo: Family members denied relevant family history

      CasePresentingHPOs: HP:0006785, HP:0003551, HP:0003391, HP:0003560

      MotorAchievement: Noticed around 7 years old that he had trouble climbing stairs and standing up when crouching and had slower activity than other peers.

      CreatineKinase: Creatine kinase CK 15550U/L, MB fraction 276 U/L

      CasePreviousTesting:430 genes associated with muscular dystrophy were captured with a liquid catch kit.

      GenotypingMethod: NGS

      PreviouslyPublished: NA

      SupplementalData: NA

      Variant: NM_000023c.218 C>T

      ClinVarID: Unregistered varient

      CAID: Unregistered varient

      gnomAD: https://gnomad.broadinstitute.org/variant/17-48245003-C-T?dataset=gnomad_r2_1

      "0.000 Allele Frequency - East Asian

  24. May 2022
  25. Apr 2022
    1. This would work if your transaction only wraps a single model's save operation. I need to wrap at least Node + Version + Attachment

      looking for a callback that you can register to happen after current transaction is committed, not just after_commit of model -- though actually, that might fire precisely when current transaction is committed, too (except that it might only get triggered for nested transactions, not the top-most transaction), so it could maybe go there ... but I think the problem is just that it doesn't belong there, because it's not specific to the model...

      I guess the OP said it best:

      I am not looking for model based after commits on update/create/etc, I want to be able to dynamically define a block that will be executed only if the current (top-most) transaction passes:

  26. Mar 2022
    1. Capybara can get us part of the way there. It allows us to work with an API rather than manipulating the HTML directly, but what it provides isn't an application specific API. It gives us low-level API methods like find, fill_in, and click_button, but it doesn't provide us with high-level methods to do things like "sign in to the app" or "click the Dashboard item in the navigation bar".
  27. Jan 2022
  28. Dec 2021
    1. shinydoc. (2021, December 12). I love how I, an actual GP...who was involved in the initial covid vaccination programme ...has to tune in at 8pm with the public to find out that apparently we are vaccinating the entire adult population with boosters by the end of the year [Tweet]. @irishayesha. https://twitter.com/irishayesha/status/1470123478221303810

  29. Nov 2021
    1. Striketober

      I am just realizing that I was not listening to The New York Times about the strikes spreading across the United States of America. Of course, the editors would not want to be causing this mass panic or a labour movement.

      I was learning about this from Democracy Now!

    1. Striketober is the labor strike wave in October 2021 by workers in the United States in the context of strikes during the COVID-19 pandemic. During the month, more than 100,000 workers in the United States either participated in or prepared for strikes in one of the largest increases of organized labor in the twenty-first century.

      Perhaps people have finally had a chance to read Debt by David Graeber or Temp by Louis Hyman or Winners Take All by Anand Giridharadas.

      This is the great disillusionment in capitalism that Forbes will not talk about. What have we been building this whole time? Colonization, slavery, and genocide on steroids enabled by big tech and big business? Maybe people just want their self-respect back.

    1. The NetherlandsSchools in primary, secondary, vocational and higher education have been closed since March16 with the exception of children of parents with “essential jobs”(e.g. health care, education,public transport) (Rijksoverheid, 2020). It is anticipated that K-12 schools will have resumedorganising activities in schools before the start of the summer holidays, albeit in a customisedmanner in keeping with regulations issued by the National Institute for Public Health and theEnvironment (Algemene Vereniging Schoolleiders, 2020). It is expected that universities willorganise distance and online education until the end of the academic year, although somefacilities and buildings (library, research labs) are still accessible.As a result of the measures schools and universities faced decisions about how to continueteaching and learning and mandated that teachers and faculty move education online within amatter of days, requiring not only an enormous effort and flexibility from teachers andeducational support staff but also from students and their respective home-situation.The Netherlands has an advanced digital economy and the extent to which the internet isavailable to everyone is high (De Heij, 2019). The use of technology for teaching and learningis widely adopted in Dutch education (ten Brummelhuis and Binda, 2017; Bijleveld andHeuzels, 2020; SURF, Vereniging van Universiteiten and Vereniging van Hogescholen, 2018)Education inprecarioustimes
      1. Общ контекст и описание на ситуацията в началото на пандемията, включително готовност за преминаване към електронно обучение.
  30. Sep 2021
  31. Aug 2021
    1. Normally, thousands of rabbits and guinea pigs are used andkilled, in scientific laboratories, for experiments which yieldgreat and tangible benefits to humanity. This war butcheredmillions of people and ruined the health and lives of tens ofmillions. Is this climax of the pre-war civilization to be passedunnoticed, except for the poetry and the manuring of the battlefields, that the“poppies blow”stronger and better fed? Or is thedeath of ten men on the battle field to be of as much worth inknowledge gained as is the life of one rabbit killed for experi-ment? Is the great sacrifice worth analysing? There can be onlyone answer—yes. But, if truth be desired, the analysis must bescientific.

      Idea: Neural net parameter analysis but with society as the 'neural net' and the 'training examples' things like industrial accidents, etc. How many 'training examples' does it take to 'learn' a lesson, and what can we infer about the rate of learning from these statistics?

    2. What we call progressconsists in coordinating ideas with realities

      "The map is not the territory" is there as a basic sentiment long before General Semantics

    3. What is the defining or characteristic mark of humanity?To this question two answers and only two have been given in thecourse of the ages, and they are both of them current to-day. Oneof the answers is biological—man is an animal, a certain kind ofanimal; the other answer is a mixture partly biological and partlymythological or partly biological and partly philosophical—manis a combination orunionof animal with something supernatural.An important part of my task will be to show that both of theseanswers are radically wrong and that, beyond all things else, theyare primarily responsible for what is dismal in the life and historyof humankind. This done, the question remains: What is Man? Ihope to show clearly and convincingly that the answer is to befound in the patent fact that human beings possess in varyingdegrees a certain natural faculty or power or capacity whichserves at once to give them their appropriate dignity as humanbeings and to discriminate them, not only from the minerals andthe plants but also from the world of animals, this peculiar orcharacteristic human faculty or power or capacity I shall call[004]

      Here Korzybski defines how he thinks his thinking diverges from previous work, what in his thought is novel. It is very specifically the idea that the spirit-animal and the animal conception of man are inadequate and that the time-binding posterity man is his nature(?).

    4. It is useless to argue if electricity be“natural”or“supernatu-ral,”of“material”or of“spiritual”origin. As a matter of fact wedo not ask these questions in studying electricity; we endeavorto find out the natural laws governing it and in handling livewires we do not argue or speculate about them—we use rubber[xi]gloves, etc. It will be the same with Man and the great affairs ofMan—we have, first of all, to know what Man is.

      This basically materialist approach, believing that Man has a specific nature which can be described and planned around accords with the zeitgeist of the 1920's, and it's of course correct. Its declining popularity in the ensuing decades points more to a declining society than to any essential incorrectness.

  32. Jul 2021
  33. Jun 2021
    1. "Many North American music education programs exclude in vast numbers students who do not embody Euroamerican ideals. One way to begin making music education programs more socially just is to make them more inclusive. For that to happen, we need to develop programs that actively take the standpoint of the least advantaged, and work toward a common good that seeks to undermine hierarchies of advantage and disadvantage. And that, inturn, requires the ability to discuss race directly and meaningfully. Such discussions afford valuable opportunities to confront and evaluate the practical consequences of our actions as music educators. It is only through such conversations, Connell argues, that we come to understand “the real relationships and processes that generate advantage and disadvantage”(p. 125). Unfortunately, these are also conversations many white educators find uncomfortable and prefer to avoid."

    1. There were attempts to simplify this setup by building specific browsers (such as capybara-webkit and PhantomJS) providing such APIs out-of-box, but none of them survived the compatibility race with real browsers.
  34. May 2021
    1. Darren Dahly. (2021, February 24). @SciBeh One thought is that we generally don’t ‘press’ strangers or even colleagues in face to face conversations, and when we do, it’s usually perceived as pretty aggressive. Not sure why anyone would expect it to work better on twitter. Https://t.co/r94i22mP9Q [Tweet]. @statsepi. https://twitter.com/statsepi/status/1364482411803906048

    1. ReconfigBehSci on Twitter: ‘the SciBeh initiative is about bringing knowledge to policy makers and the general public, but I have to say this advert I just came across worries me: Where are the preceding data integrity and data analysis classes? Https://t.co/5LwkC1SVyF’ / Twitter. (n.d.). Retrieved 18 February 2021, from https://twitter.com/SciBeh/status/1362344945697308674

  35. Apr 2021
    1. An example of this would be a button that looks clickable but isn’t, underlined text that doesn’t contain a link, or a TV remote that turns on your lights but not the TV. False affordances are often present by mistake or occur due to lack of effective design techniques.
  36. Mar 2021
    1. xdg-open should do the same thing - actually, it will call gnome-open, or kde-open, or whatever, depending on your desktop environment. Thus it's more portable.
    2. The advantage is that you can use gnome-open for almost all file-types, URIs and directories. It's one command to learn, instead of trying to remember about obscure commands like sensible-browser
    1. There are myriads of platformers around, it's an oversaturated market, and just like industrial designer Karim Rashid said about there being no excuse by this point to make an uncomfortable chair, there's no excuse by this point to make a boring patformer.
    1. There are plenty of words and acronyms you can put in front of “Designer”. Product, Web, Graphic, UX, UI, IA, etc. The lines between each are blurry, and the titles go in and out of fashion. Depending on the project and team I’m working alongside, I practice them all to varying degrees. I prefer to call myself; “A Designer.”
  37. Feb 2021
    1. 3)(A) The warning shall also contain any article or articles requested by a petition signed by at least five percent of the voters of the municipality and filed with the municipal clerk not less than 47 days before the day of the meeting. (B) The clerk receiving the petitions shall immediately proceed to examine them to ascertain whether they contain the required number of signatures of registered voters set forth in subdivision (A) of this subdivision (3). If found not to conform, he or she shall state in writing on the petition why it cannot be accepted, and within 24 hours from receipt, he or she shall return it to the petitioners. In this case, supplementary petitions may be filed not later than 48 hours after the petition was returned to the petitioners by the clerk or the filing deadline set forth in subdivision (A) of this subdivision (3), whichever is later. However, supplementary petitions shall not be accepted if petitions with signatures of different persons totaling at least the number specified in subdivision (A) of this subdivision (3) were not filed by the filing deadline. (C) A petition submitted under this subdivision (3): (i) may include more than one proposed article; (ii) shall contain the petition language on each page on which signatures are collected; and (iii) shall include the printed name, signature, and street address of each voter who signed the petition. (D) A voter may withdraw his or her name from a petitioned article at any time prior to the signing of the warning by a majority of the legislative body.

      VT Constitution

      Petitions for Ballot Question

      Rules governing petitions

    1. One way to alleviate this configuration fatigue is by making configuration consistent and composable. That’s what Sprocket’s new “manifest.js” seeks to do.
    1. Not all cases can be covered and easily restored. And sometimes when we will reuse this function for different use-cases we will find out that it requires different restore logic.
    2. But why do we return 0? Why not 1? Why not None? And while None in most cases is as bad (or even worse) than the exceptions, turns out we should heavily rely on business logic and use-cases of this function.
    3. So, the sad conclusion is: all problems must be resolved individually depending on a specific usage context. There’s no silver bullet to resolve all ZeroDivisionErrors once and for all. And again, I am not even covering complex IO flows with retry policies and expotential timeouts.
    1. while ActiveForm currently fits 99% of my use cases, I do sometimes make modifications based on the product requirements
    2. I will continue to use form objects and push changes into the repo when I feel they are universally relevant and valuable.

      new tag?:

      • code that is universally relevant/valuable
      • non - _-specific logic
  38. Jan 2021
    1. A Svelte component that monitors an element enters or leaves the viewport/parent element. Performant and efficient thanks to using Intersection Observer under the hood. Can be used in multiple projects including lazy loading images, infinite scrolling, playing/pausing the video when in the viewport, tracking user behaviour firing link pre-fetching and animations and many many more.
    1. § 2661. Reconsideration or rescission of vote (a) A warned article voted on at an annual or special meeting of a municipality shall not be submitted to the voters for reconsideration or rescission at the same meeting after the assembly has begun consideration of another article. If the voters have begun consideration of another article, the original article may only be submitted to the voters at a subsequent annual or special meeting duly warned for the purpose and called by the legislative body on its own motion or pursuant to a petition requesting such reconsideration or rescission signed and submitted in accordance with subsection (b) of this section. A vote taken at an annual or special meeting shall remain in effect unless rescinded or amended. (b) If a petition requesting reconsideration or rescission of a question considered or voted on at a previous annual or special meeting is filed with the clerk of the municipality within 30 days following the date of that meeting, the legislative body shall provide for a vote by the municipality in accordance with the petition within 60 days of the submission at an annual or special meeting duly warned for that purpose. The number of signatures required for a petition for reconsideration or rescission shall be not less than five percent of the registered voters unless the voters of the municipality increase that percentage pursuant to the following: (1) At a meeting duly warned for the purpose, the voters of a municipality may require that a petition for reconsideration be signed by a percentage of registered voters that is not less than five percent nor greater than 20 percent. (2) A vote to increase the percentage of voters required to sign a petition for reconsideration or rescission to up to 20 percent shall be in substantially the following form: "Shall the (name of municipality) increase the percentage of voters required on a petition for reconsideration or rescission from five to (up to 20) percent?" (3) Once the voters of a municipality have voted to require a new percentage, that percentage shall remain in effect until the voters of the municipality vote to change the percentage. (c) A question voted on shall not be presented for reconsideration or rescission at more than one subsequent meeting within a one-year period, except with the approval of the legislative body. (d) For a vote by Australian ballot: (1) The form of the ballot shall be as follows: "Article 1: [cite the article to be reconsidered as lastly voted]." (2) Absentee ballots for the reconsideration or rescission vote shall be sent to any voter who requested an absentee ballot for the initial vote on the article to be reconsidered or rescinded, whether or not a separate request for an absentee ballot for the reconsideration or rescission vote is submitted by the voter. (e) A majority vote in favor of reconsideration or rescission of a question voted on by paper or Australian ballot shall not be effective unless the number of votes cast in favor of reconsideration or rescission exceeds two-thirds of the number of votes cast for the prevailing side at the original meeting unless the voters of the municipality approve a different percentage pursuant to the following: (1) At a meeting duly warned for the purpose, the voters of a municipality may require that a vote in favor of reconsideration or rescission shall not be effective unless the number of votes cast in favor of reconsideration or rescission exceeds a certain percentage of the number of votes cast for the prevailing side at the original meeting. (2) A vote to increase or decrease the percentage shall be in substantially the following form: "Shall the (name of municipality) change the percentage of votes cast in favor of reconsideration or rescission required for a vote to reconsider or rescind a question considered or voted on at a previous annual or special meeting to be effective to (percentage)?" (3) Once the voters of a municipality have voted to require a new percentage, that percentage shall remain in effect until the voters of the municipality vote to change the percentage. (f) A municipality shall not reconsider a vote to elect a local officer. (g) This section shall not apply to nonbinding advisory articles, which shall not be subject to reconsideration or rescission. (Added 1977, No. 269 (Adj. Sess.), § 1; amended 1979, No. 200 (Adj. Sess.), § 105; 1991, No. 235 (Adj. Sess.); 2007, No. 36, § 1; 2013, No. 161 (Adj. Sess.), § 50; 2017, No. 50, § 52.)

      Vermont Constitution

      Repeal Referendum

    2. § 2645. Charters; adoption, repeal, or amendment; procedure (a) A municipality may propose to the General Assembly to adopt, repeal, or amend its charter by majority vote of the legal voters of the municipality present and voting at any annual or special meeting warned for that purpose in accordance with the following procedure: (1) A proposal to adopt, repeal, or amend a municipal charter (charter proposal) may be made by the legislative body of the municipality or by petition of five percent of the voters of the municipality. (2) An official copy of the charter proposal shall be filed as a public record in the office of the clerk of the municipality at least 10 days before the first public hearing. The clerk shall certify the date on which he or she received the official copy, and the dated copies thereof shall be made available to members of the public upon request. (3)(A) The legislative body of the municipality shall hold at least two public hearings prior to the meeting to vote on the charter proposal. (B) The first public hearing shall be held in accordance with subdivision (a)(2) of this section and at least 30 days before the vote. (4)(A) If the charter proposal is made by the legislative body, the legislative body may revise the proposal as a result of suggestions and recommendations made at a public hearing, but in no event shall such revisions be made less than 20 days before the date of the meeting to vote on the charter proposal. (B) If revisions are made, the legislative body shall post a notice of these revisions in the same places as the warning for the meeting not less than 20 days before the date of the meeting and shall attach such revisions to the official copy kept on file for public inspection in the office of the clerk of the municipality. (5)(A) If the charter proposal is made by petition, the second public hearing shall be held no later than 10 days after the first public hearing. The legislative body shall not have the authority to revise a charter proposal made by petition. (B) After the warning and hearing requirements of this section are satisfied, the petitioned charter proposal shall be submitted to the voters at the next annual meeting, primary, or general election in the form in which it was filed, except that the legislative body may make technical corrections. (6)(A) Notice of each public hearing and of the annual or special meeting shall be given in accordance with section 2641 of this chapter. (B)(i) Each notice shall specify the charter sections to be adopted, repealed, or amended, setting out those sections in the amended form, with deleted matter struck through and new matter underlined. (ii) If the legislative body of the municipality determines that the charter proposal is too long or unwieldy to set out in amended form, the notice shall include a concise summary of the charter proposal and shall state that an official copy of the charter proposal is on file for public inspection in the office of the clerk of the municipality and that copies thereof shall be made available to members of the public upon request. (7)(A) Voting on a charter proposal shall be by Australian ballot. (B)(i) The ballot shall show each charter section to be adopted, repealed, or amended in the amended form, with deleted matter struck through and new matter underlined, and shall permit the voter to vote on each separate proposal contained within the charter proposal. (ii) If the legislative body determines that the charter proposal is too long or unwieldy to be shown in the amended form, voters shall be permitted to vote upon each separate proposal in its entirety in the form of a yes or no proposition. (C) An official copy of the charter proposal shall be posted conspicuously in each ballot booth for inspection by the voters during the balloting. (b)(1) The clerk of the municipality, under the direction of the legislative body, shall announce and post the results of the vote immediately after the vote is counted. (2) The clerk, within 10 days after the day of the meeting, shall certify to the Secretary of State each separate proposal contained within the charter proposal, showing the facts as to its origin and the procedure followed, which shall include: (A)(i) If the charter proposal was made by the legislative body, the minutes recorded by the legislative body that detail the origins and intent of each separate proposal; (ii) If the charter proposal was made by voter petition, the body of the petition and evidence of the required number of petition signatures; (B) A copy of the official certified copy of the charter proposal filed with the clerk of the municipality pursuant to subdivision (a)(2) of this section; (C) Copies of the warnings and published notices for each of the public hearings held pursuant to subdivision (a)(3) of this section; (D) Minutes recorded by the legislative body that detail each of the public hearings held pursuant to subdivision (a)(3) of this section; (E) Copies of warnings and published notices for the meeting to vote on the charter proposal; and (F) A copy of the ballot and the results of the vote or votes on the charter proposal. (c) After confirming that the clerk of the municipality has certified each of the documents listed in subdivision (b)(2) of this section, the Secretary of State shall file the certificate and deliver copies of it to the Attorney General, the Clerk of the House, the Secretary of the Senate, and the chairs of the committees concerned with municipal charters of both houses of the General Assembly. (d) The charter proposal shall become effective upon affirmative enactment of the proposal, either as proposed or as amended by the General Assembly. (Added 1977, No. 269 (Adj. Sess.), § 1; amended 1979, No. 200 (Adj. Sess.), § 100; 1981, No. 239 (Adj. Sess.), § 22, eff. May 4, 1982; 1983, No. 161 (Adj. Sess.); 1987, No. 63; 2017, No. M-7, § 2A, eff. May 22, 2017.)

      Vermont Constitution

      Charter Change

      either by council OR by petition

  39. Nov 2020
  40. Oct 2020
    1. In the many projects I have maintained so far, sooner or later I always run into the same issue: circular module dependencies. Although there are many strategies and best practices on how to avoid circular dependencies. There is very little on how to fix them in a consistent and predictable way.
    2. This is how I solve circular dependency issues nowadays.
    1. One of the primary tasks of engineers is to minimize complexity. JSX changes such a fundamental part (syntax and semantics of the language) that the complexity bubbles up to everything it touches. Pretty much every pipeline tool I've had to work with has become far more complex than necessary because of JSX. It affects AST parsers, it affects linters, it affects code coverage, it affects build systems. That tons and tons of additional code that I now need to wade through and mentally parse and ignore whenever I need to debug or want to contribute to a library that adds JSX support.
    1. As we've briefly seen already, you can listen to any event on an element with the on: directive:
    1. Il faut rappeler que même des associations d’intérêt général ne peuvent imposer la neutralité générale et absolue. En effet, il s’agit d’un critère obligatoire mais non suffisant pour qualifier une mission de mission de service public
  41. Sep 2020
    1. Web developers are well aware of the mess you can get into with global CSS, and the action of writing <Child class="foo"/> and <div class={_class}>` (or similar) in the child component is an explicit indication that, while taking advantage of all the greatness of style encapsulation by default, in this case you have decided that you want a very specific and controlled "leak", of one class, from one component instance to one component instance.
    1. COVID-19 Can Wreck Your Heart, Even if You Haven’t Had Any Symptoms

      Take Away: SARS-CoV-2 infection has been clearly linked to heart muscle injury in those with severe COVID-19 illness. However, at present, there is insufficient data to determine the impact of mild or asymptomatic COVID-19 on the hearts of previously healthy individuals.

      The Claim: COVID-19 can wreck your heart, even if you haven’t had any symptoms.

      The Evidence: Several articles, including this August 31st piece (1), have raised the alarm about dangerous effects of mild or even asymptomatic cases of COVID-19 on the heart of infected individuals.

      In support of this argument, there have been numerous reports, some of which are cited in the article above, documenting severe heart inflammation (myocarditis) and injury (e.g. cardiomyopathy and/or heart failure) in patients with COVID-19. However, most of these documented cases were in individuals with severe cases of COVID-19. At present, the evidence for clinically significant heart injury (requiring treatment or special precautions) from mild or asymptomatic COVID-19, is much less clear, especially in those with no prior evidence of heart disease.

      One recent study reported that 78% of patients from an unselected cohort (including patients with asymptomatic, mild, and severe cases) had evidence of myocarditis (via MRI or blood testing) following COVID-19 infection (2). This study clearly demonstrated the link between COVID-19 and myocarditis by examining tissue from biopsies of the heart (the gold standard definitive diagnosis of myocarditis) of patients with the most severe cases. The study went on to show that, on average, patients who were treated for COVID-19 at the hospital (presumably more severe cases) and patients who were treated at home (presumably asymptomatic to moderate cases) both had blood test levels or MRI findings suggesting elevated myocarditis compared to non-COVID-19 infected patients with similar health profiles.

      A key limitation here is “average”. The study was not designed or powered to look for the rate of myocarditis in only previously healthy patients with mild or asymptomatic COVID-19. This study included asymptomatic patients in the analysis, but without knowing their prior health or comparing their findings to other healthy non-COVID patients, it is not possible to infer the risk of myocarditis to this population. To their credit, the authors of the study discuss this limitation in their conclusions.

      Despite this, the study was widely covered as evidence that ”COVID-19 can wreck your heart, even if you haven’t had any symptoms.“ In order to answer that question, we need research looking selectively healthy patients with mild or asymptomatic COVID-19 as outlined above.

      Until that research is conducted, we might look at COVID within the same context as a number of other well studied viruses, many of which generally cause mild illness, that have also been shown to lead to heart injury and inflammation (3).

      Disclaimer: This content is not intended as a substitute for professional medical advice. Always seek the advice of a qualified health provider with any questions regarding a medical condition.

      Sources:

      1. https://www.scientificamerican.com/article/covid-19-can-wreck-your-heart-even-if-you-havent-had-any-symptoms/
      2. https://jamanetwork.com/journals/jamacardiology/fullarticle/2768916
      3. https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.108.766022
    1. Take away: People are infectious for only part of the time they test positive. The tests for COVID-19 were granted emergency status by the FDA so some debate concerning the most ideal number of cycles is to be expected. It is worth noting that the FDA has the disclaimer "Negative results do not preclude 2019-nCoV infection and should not be used as the sole basis for treatment or other patient management decisions. Negative results must be combined with clinical observations, patient history, and epidemiological information (2)."

      The claim: Up to 90 percent of people diagnosed with coronavirus may not be carrying enough of it to infect anyone else

      The evidence: Per Walsh et al. (1), SARS-CoV-2 virus (COVID-19) is most likely infectious if the number of PCR cycles is <24 and the symptom onset to test is <8 days. RT-PCR detects the RNA, not the infectious virus. Therefore, setting the cycle threshold at 37-40 cycles will most likely result in detecting some samples with virus which is not infectious. As the PCR tests were granted emergency use by the FDA (samples include 2-9), it is not surprising that some debate exists currently about where the cycle threshold should be. Thresholds need to be set and validated for dozens of PCR tests currently in use. If identifying only infectious individuals is the goal, a lower cycle number may be justified. If detection of as many cases as possible to get closer to the most accurate death rate is the goal, setting the cycle threshold at 37-40 makes sense. A lower threshold will result in fewer COVID-19 positive samples being identified. It is worth noting that the emergency use approval granted by the FDA includes the disclaimer that a negative test does not guarantee that a person is not infected with COVID-19. RNA degrades easily. If samples are not kept cold or properly processed, the virus can degrade and result in a false negative result.

      Source: 1 https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa638/5842165

      2 https://www.fda.gov/media/134922/download

      3 https://www.fda.gov/media/138150/download

      4 https://www.fda.gov/media/137120/download

      5 https://www.fda.gov/media/136231/download

      6 https://www.fda.gov/media/136472/download

      7 https://www.fda.gov/media/139279/download

      8 https://www.fda.gov/media/136314/download

      9 https://www.fda.gov/media/140776/download

    1. Afin de mieux promouvoir en télévision un certain nombre de causes sociales, humanitaires et d’intérêt général tout au long de l’année, le Syndicat National de la Publicité TéléVisée (SNPTV) a mis en place pour les associations, ONG et/ou leurs intermédiaires (agences de publicité, agences média) une procédure de traitement de l’ensemble des demandes d’espaces gracieux faites aux grandes chaînes nationales et à leur régie publicitaire.
  42. Aug 2020
    1. As a web designer, I hate that "log in" creates a visual space between the words. If you line up "Log In Register" - is that three links or two? This creates a Gestalt problem, meaning you have to really fiddle with spacing to get the word groupings right, without using pipe characters.

      Sure, you can try to solve that problem by using a one-word alternative for any multi-word phrase, but that's not always possible: there isn't always a single word that can be used for every possible phrase you may have.

      Adjusting the letter-spacing and margin between items in your list isn't that hard and would be better in the long run since it gives you a scalable, general solution.

      "Log in" is the only correct way to spell the verb, and the only way to be consistent with 1000s of other phrasal verbs that are spelled with a space in them.

      We don't need nor want an exception to the general rule just for "login" just because so many people have made that mistake.

    1. This is twitter. What is its purpose? It is a general-purpose electronic communication medium on the Internet, accessible via web and apps, comprising a high-volume global stream of written thoughts of people, attached with pics, gifs, links and audio- & video-embeds.

  43. Jul 2020
    1. Oh, but there’s so much more to see than just where our current Drops are located.  Below, you’ll find maps showing where our delivery routes go.  If you live along one of these routes (even if no Drop already exists in your area of the route), you can get an Azure delivery
  44. May 2020
    1. Gobbi, S., Plomecka, M., Ashraf, Z., Radziński, P., Neckels, R., Lazzeri, S., Dedić, A., Bakalović, A., Hrustić, L., Skórko, B., Es haghi, S., Almazidou, K., Rodríguez-Pino, L., Alp, A. B., Jabeen, H., Waller, V., Shibli, D., AghiliBehnam, M., Strutt, A. M., … Jawaid, A. (2020). Worsening of pre-existing psychiatric conditions during the COVID-19 pandemic [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/x6cyg

    1. Don’t go to code academy, go to design academy. Be advocates of the user & consumer. It’s not about learning how to code, it’s about translating real-world needs to technological specifications in just ways that give end users agency and equity in design, development and delivery. Be a champion of user-centric design. Learn how to steward data and offer your help.

      The importance of learning to design, and interpreting/translating real-world needs.

    1. « Survivre c’est résister »

      Après lecture de votre article, le comité éditorial recommande la publication après modifications mineures.

  45. Apr 2020
  46. Mar 2020
    1. Alert: New office locations are now accepting reservations for license and permit transactions at the Adam Clayton Powell Jr. State Office Building in Harlem, Empire State College in Selden, and Shirley A. Chisholm State Office Building in Brooklyn.

      General information types of products Location of service

  47. Jan 2020
    1. I understand this is a relational division type problem, involving having and count. These posts describe what I want to do, but I can't figure out how to apply the examples to the particular case above:
    1. HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth

      PMID: 26160855

      Gene: HACD1

      Disease: Congenital Myopathy

  48. Dec 2019
    1. All cannabis byproduct, scrap, and harvested cannabis not intended for distribution to a dispensing organization must be destroyed and disposed of under rules adopted by the Department of Agriculture under this Act. Documentation of destruction and disposal shall be retained at the cultivation center, craft grower, infuser organization, transporter, or testing facility as applicable for a period of not less than 5 years.    (b) A cultivation center, craft grower, or infuser organization shall, before destruction, notify the Department of Agriculture and the Department of State Police. A dispensing organization shall, before destruction, notify the Department of Financial and Professional Regulation and the Department of State Police. The Department of Agriculture may by rule require that an employee of the Department of Agriculture or the Department of Financial and Professional Regulation be present during the destruction of any cannabis byproduct, scrap, and harvested cannabis, as applicable.     (c) The cultivation center, craft grower, infuser organization, or dispensing organization shall keep a record of the date of destruction and how much was destroyed.     (d) A dispensing organization shall destroy all cannabis, including cannabis-infused products, not sold to purchasers. Documentation of destruction and disposal shall be retained at the dispensing organization for a period of not less than 5 years.

      This section covers destruction of cannabis. All products not intended to be sold by a dispensary must be destroyed and exposed of. Documentation of destruction including the amount destroyed must be kept for at least 5 years.