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  1. Jul 2024
    1. propofol,have also been demonstrated to act at extrasynaptic receptors and enhance tonicinhibition in hippocampus

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  2. May 2024
  3. Nov 2023
  4. Sep 2022
    1. What is N64 emulator iPhone? N64 emulator iPhone is a free tool for iOS devices to play classic N64 games on iPhone devices. Some restrictions imposed by Apple are not to install old classic game emulators on iOS devices. That’s where the N64 emulator iPhone comes into action.  Not only Nintendo games, but the Delta emulator is also available to play Gameboy and Sega Genesis games. Delta is the successor of GBA4iOS, which was repeated for emulating old video games on iOS devices. This Delta version is far more flexible than the previous version even though there is Delta iOS 16 version available too. Make sure to read the entire guide to get the best knowledge of Delta emulator iOS. We will make sure to share accurate information on the Delta N64 emulator iPhone.

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  5. Aug 2022
    1. Lauring, A. S., Tenforde, M. W., Chappell, J. D., Gaglani, M., Ginde, A. A., McNeal, T., Ghamande, S., Douin, D. J., Talbot, H. K., Casey, J. D., Mohr, N. M., Zepeski, A., Shapiro, N. I., Gibbs, K. W., Files, D. C., Hager, D. N., Shehu, A., Prekker, M. E., Erickson, H. L., … Self, W. H. (2022). Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: Prospective observational study. BMJ, 376, e069761. https://doi.org/10.1136/bmj-2021-069761

    1. Krause, P. R., Fleming, T. R., Peto, R., Longini, I. M., Figueroa, J. P., Sterne, J. A. C., Cravioto, A., Rees, H., Higgins, J. P. T., Boutron, I., Pan, H., Gruber, M. F., Arora, N., Kazi, F., Gaspar, R., Swaminathan, S., Ryan, M. J., & Henao-Restrepo, A.-M. (2021). Considerations in boosting COVID-19 vaccine immune responses. The Lancet, 4. https://doi.org/10.1016/S0140-6736(21)02046-8

    1. Sandra Ciesek. (2021, December 8). Unsere ersten Daten zur Neutralisation von Omicron versus Delta sind fertig: 2x Biontech, 2x Moderna, 1xAZ/1x Biontech nach 6 Monaten 0% Neutralisation bei Omicron, auch 3x Biontech 3 Monate nach Booster nur 25% NT versus 95% bei Delta. Bis zu 37fache Reduktion Delta vs. Omicron https://t.co/w0gHww26sg [Tweet]. @CiesekSandra. https://twitter.com/CiesekSandra/status/1468465347519041539

    1. Collier, A. Y., Brown, C. M., Mcmahan, K., Yu, J., Liu, J., Jacob-Dolan, C., Chandrashekar, A., Tierney, D., Ansel, J. L., Rowe, M., Sellers, D., Ahmad, K., Aguayo, R., Anioke, T., Gardner, S., Siamatu, M., Rivera, L. B., Hacker, M. R., Madoff, L. C., & Barouch, D. H. (2021). Immune Responses in Fully Vaccinated Individuals Following Breakthrough Infection with the SARS-CoV-2 Delta Variant in Provincetown, Massachusetts (p. 2021.10.18.21265113). https://doi.org/10.1101/2021.10.18.21265113

    1. Meng, B., Abdullahi, A., Ferreira, I. A. T. M., Goonawardane, N., Saito, A., Kimura, I., Yamasoba, D., Gerber, P. P., Fatihi, S., Rathore, S., Zepeda, S. K., Papa, G., Kemp, S. A., Ikeda, T., Toyoda, M., Tan, T. S., Kuramochi, J., Mitsunaga, S., Ueno, T., … Gupta, R. K. (2022). Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity. Nature, 1–1. https://doi.org/10.1038/s41586-022-04474-x

    1. Vöhringer, H. S., Sanderson, T., Sinnott, M., De Maio, N., Nguyen, T., Goater, R., Schwach, F., Harrison, I., Hellewell, J., Ariani, C. V., Gonçalves, S., Jackson, D. K., Johnston, I., Jung, A. W., Saint, C., Sillitoe, J., Suciu, M., Goldman, N., Panovska-Griffiths, J., … Gerstung, M. (2021). Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature, 1–11. https://doi.org/10.1038/s41586-021-04069-y

    1. John Burn-Murdoch. (2021, November 25). Five quick tweets on the new variant B.1.1.529 Caveat first: Data here is very preliminary, so everything could change. Nonetheless, better safe than sorry. 1) Based on the data we have, this variant is out-competing others far faster than Beta and even Delta did 🚩🚩 https://t.co/R2Ac4e4N6s [Tweet]. @jburnmurdoch. https://twitter.com/jburnmurdoch/status/1463956686075580421

  6. Apr 2022
    1. (((Howard Forman))) [@thehowie]. (2021, December 26). South Africa Hospitalizations⬆️15% week over week⬆️0.3% from yesterday Gauteng Province⬆️2.4% week over week⬆️0.7% Long plateau: Ventilators are last to peak (17% of Delta peak) Should see meaningful declines later this week. Https://t.co/qNv1l5hNcv [Tweet]. Twitter. https://twitter.com/thehowie/status/1475095305297268740

    1. Shalin Naik [@shalinhnaik]. (2021, October 14). 📢The first episode of the @thejabgab http://thejabgab.com is LIVE!! 🎙 Join me and the fabulous comedians @nazeem_hussain and @calbo as they chat about the Delta variant, vaccines …. And cows? With experts @DrKGregorevic and @BedouiSammy! Search your fav platform or... Https://t.co/bo4HiRfqF6 [Tweet]. Twitter. https://twitter.com/shalinhnaik/status/1448510610837159939

    2. Shalin Naik. (2021, October 14). 📢The first episode of the @thejabgab http://thejabgab.com is LIVE!! 🎙 Join me and the fabulous comedians @nazeem_hussain and @calbo as they chat about the Delta variant, vaccines …. And cows? With experts @DrKGregorevic and @BedouiSammy! Search your fav platform or... Https://t.co/bo4HiRfqF6 [Tweet]. @shalinhnaik. https://twitter.com/shalinhnaik/status/1448510610837159939

    1. Ravi K Gupta [@ravgup33_ravi]. (2021, November 24). This one is worrying and I’ve not said that since delta. Please get vaccinated and boosted and mask up in public as the mutations in this virus likely result in high level escape from neutralising antibodies [Tweet]. Twitter. https://twitter.com/ravgup33_ravi/status/1463626745651806208

    1. Dr Dominic Pimenta [@DrDomPimenta]. (2021, December 15). An illustration of communicating risk with “less severe” variants: [Thread] Assume Omicron is 4x more transmissible than Delta. [1] Assume Omicron leads to 1/3 less admissions than Delta. [Figure below] Assume 1 in 100 cases of Delta are admitted to hospital. Https://t.co/XtnVwoOrUo [Tweet]. Twitter. https://twitter.com/DrDomPimenta/status/1471094002808242177

    1. Pérez-Then, E., Lucas, C., Monteiro, V. S., Miric, M., Brache, V., Cochon, L., Vogels, C. B. F., Cruz, E. D. la, Jorge, A., Santos, M. D. los, Leon, P., Breban, M. I., Billig, K., Yildirim, I., Pearson, C., Downing, R., Gagnon, E., Muyombwe, A., Razeq, J., … Iwasaki, A. (2021). Immunogenicity of heterologous BNT162b2 booster in fully vaccinated individuals with CoronaVac against SARS-CoV-2 variants Delta and Omicron: The Dominican Republic Experience (p. 2021.12.27.21268459). medRxiv. https://doi.org/10.1101/2021.12.27.21268459

    1. 🇺🇦 Meaghan Kall [@kallmemeg]. (2021, December 23). VACCINES Speaking of boosters, it’s not great news I’m afraid. Updated vaccine effectiveness analysis shows mRNA boosters beginning to wane from one month (week 5-9) for Omicron, and as low as 30-50% effective from 10 weeks post-booster. This effect is not seen with Delta. Https://t.co/g0tLxH3vLR [Tweet]. Twitter. https://twitter.com/kallmemeg/status/1474072056878804992

    1. Nathan Grubaugh [@NathanGrubaugh]. (2021, September 24). Hi @Newsweek 👋. I understand that #variant news has been slow recently with the near-complete dominance of Delta, but do you really need to go and make things up? Lineage R.1 is not a concern. Let me briefly explain why. (1/4) https://t.co/OD46PsXZEu [Tweet]. Twitter. https://twitter.com/NathanGrubaugh/status/1441522760832933888

    1. Carl T. Bergstrom. (2021, August 18). 1. There has been lots of talk about recent data from Israel that seem to suggest a decline in vaccine efficacy against severe disease due to Delta, waning protection, or both. This may have even been a motivation for Biden’s announcement that the US would be adopting boosters. [Tweet]. @CT_Bergstrom. https://twitter.com/CT_Bergstrom/status/1427767356600688646

    1. Eric Topol. (2021, June 9). Despite increasing incentives, the US vaccination campaign is really struggling. Notably, the top 5 states are approaching 60% total population fully vaccinated which should provide strong protection vs the delta variant. A different story for the bottom 5 states @OurWorldInData https://t.co/boqk3Khhuc [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1402413221667954690

    1. Marc Lipsitch. (2021, July 20). At the risk of boiling down too much and certainly losing some detail, one way to summarize this wonderful thread is that when we think about vaccine effectiveness, we should think of 4 key variables: 1 which vaccine, 2 age of the person, 3 how long after vax, 4 vs what outcome. [Tweet]. @mlipsitch. https://twitter.com/mlipsitch/status/1417595538632060931

  7. Mar 2022
  8. Feb 2022
    1. Kok, K.-H., Wong, S.-C., Chan, W.-M., Lei, W., Chu, A. W.-H., Ip, J. D., Lee, L.-K., Wong, I. T.-F., Lo, H. W.-H., Cheng, V. C.-C., Ho, A. Y.-M., Lam, B. H.-S., Tse, H., Lung, D., Ng, K. H.-L., Au, A. K.-W., Siu, G. K.-H., & Yuen, K.-Y. (2022). Cocirculation of two SARS-CoV-2 variant strains within imported pet hamsters in Hong Kong. Emerging Microbes & Infections, 1–39. https://doi.org/10.1080/22221751.2022.2040922

    1. Tseng, H. F., Ackerson, B. K., Luo, Y., Sy, L. S., Talarico, C. A., Tian, Y., Bruxvoort, K. J., Tubert, J. E., Florea, A., Ku, J. H., Lee, G. S., Choi, S. K., Takhar, H. S., Aragones, M., & Qian, L. (2022). Effectiveness of mRNA-1273 against SARS-CoV-2 Omicron and Delta variants. Nature Medicine, 1–1. https://doi.org/10.1038/s41591-022-01753-y

    1. ReconfigBehSci on Twitter: “RT @Gab_H_R: Effectiveness of mRNA-1273 against-Omicron and Delta variants ⚠️ The 3dose VE was 71.6% and 47.4% against Omicron infection (…” / Twitter. (n.d.). Retrieved February 22, 2022, from https://twitter.com/SciBeh/status/1496032262177136642

    1. Cornelius Roemer. (2022, February 12). Fantastic work by @UKHSA comparing serial intervals of BA.1, BA.2 and Delta as published in the most recent technical briefing. BA.2 seems to have even shorter serial interval than BA.1 This could help explain different relative growth rates of BA.2 vs BA.1 in different countries https://t.co/Gch94Ew8CX [Tweet]. @CorneliusRoemer. https://twitter.com/CorneliusRoemer/status/1492434232664375304

    1. Lyngse, F. P., Mortensen, L. H., Denwood, M. J., Christiansen, L. E., Møller, C. H., Skov, R. L., Spiess, K., Fomsgaard, A., Lassaunière, M. M., Rasmussen, M., Stegger, M., Nielsen, C., Sieber, R. N., Cohen, A. S., Møller, F. T., Overvad, M., Mølbak, K., Krause, T. G., & Kirkeby, C. T. (2021). SARS-CoV-2 Omicron VOC Transmission in Danish Households (p. 2021.12.27.21268278). medRxiv. https://doi.org/10.1101/2021.12.27.21268278

    1. Peña-Hernández, M. A., Klein, J., Malik, A. A., Coppi, A., Kalinich, C., Vogels, C. B. F., Silva, J., Initiative, Y. S.-C.-2 G. S., Peaper, D. R., Landry, M.-L., Wilen, C., Grubaugh, N. D., Schulz, W., Omer, S. B., & Iwasaki, A. (2022). Comparison of infectious SARS-CoV-2 from the nasopharynx of vaccinated and unvaccinated individuals (p. 2021.12.28.21268460). medRxiv. https://doi.org/10.1101/2021.12.28.21268460

    1. Krutika Kuppalli, MD FIDSA. (2022, January 14). If you had #COVID19 once you can get it again (and again). Risk of reinfection in England with #Omicron was ~5.4 fold higher compared to #Delta The relative risk were 6.36 & 5.02 for unvaxxd & vaxxd cases—Implies protection against reinfection by Omicron may be as low as 19% [Tweet]. @KrutikaKuppalli. https://twitter.com/KrutikaKuppalli/status/1482074117742288898

    1. Trevor Bedford. (2022, January 28). Omicron viruses can be divided into two major groups, referred to as PANGO lineages BA.1 and BA.2 or @nextstrain clades 21K and 21L. The vast majority of globally sequenced Omicron have been 21K (~630k) compared a small minority of 21L (~18k), but 21L is gaining ground. 1/15 [Tweet]. @trvrb. https://twitter.com/trvrb/status/1487105396879679488

  9. Jan 2022
    1. Elliott, P., Eales, O., Bodinier, B., Tang, D., Wang, H., Jonnerby, J., Haw, D., Elliott, J., Whitaker, M., Walters, C., Atchison, C., Diggle, P., Page, A., Trotter, A., Ashby, D., Barclay, W., Taylor, G., Ward, H., Darzi, A., … Donnelly, C. (2022). Post-peak dynamics of a national Omicron SARS-CoV-2 epidemic during January 2022 [Working Paper]. http://spiral.imperial.ac.uk/handle/10044/1/93887

    1. Helen Branswell. (2022, January 11). 1. #Omicron’s takeover was stunningly rapid and is now nearly complete, at least in the U.S. The latest “Nowcast” from @CDCgov (which uses recent data to model what’s happen now) suggests most of what is circulating here now is omicron. Https://t.co/6w3e8Ut5NW [Tweet]. @HelenBranswell. https://twitter.com/HelenBranswell/status/1480970453313277954

    1. Carreño, J. M., Alshammary, H., Tcheou, J., Singh, G., Raskin, A., Kawabata, H., Sominsky, L., Clark, J., Adelsberg, D. C., Bielak, D., Gonzalez-Reiche, A. S., Dambrauskas, N., Vigdorovich, V., Group, P. S., Srivastava, K., Sather, D. N., Sordillo, E. M., Bajic, G., van Bakel, H., … Krammer, F. (2021). Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron. Nature. https://doi.org/10.1038/d41586-021-03846-z

  10. Dec 2021
    1. Seth Trueger. (2021, June 26). friendly reminder that “more transmissible” is by itself REALLY BAD for a pandemic. Even small increases in R₀ mean more potential for spread, more cases, more deaths etc please get your vax & help others get theirs https://t.co/mlojYmp71j [Tweet]. @MDaware. https://twitter.com/MDaware/status/1408811800108355586

    1. Thiruvengadam, R., Awasthi, A., Medigeshi, G., Bhattacharya, S., Mani, S., Sivasubbu, S., Shrivastava, T., Samal, S., Rathna Murugesan, D., Koundinya Desiraju, B., Kshetrapal, P., Pandey, R., Scaria, V., Kumar Malik, P., Taneja, J., Binayke, A., Vohra, T., Zaheer, A., Rathore, D., … Garg, P. K. (2021). Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: A test-negative, case-control study and a mechanistic study of post-vaccination immune responses. The Lancet Infectious Diseases, S1473309921006800. https://doi.org/10.1016/S1473-3099(21)00680-0

  11. Nov 2021
    1. Thiruvengadam, R., Awasthi, A., Medigeshi, G., Bhattacharya, S., Mani, S., Sivasubbu, S., Shrivastava, T., Samal, S., Murugesan, D. R., Desiraju, B. K., Kshetrapal, P., Pandey, R., Scaria, V., Malik, P. K., Taneja, J., Binayke, A., Vohra, T., Zaheer, A., Rathore, D., … Garg, P. K. (2021). Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: A test-negative, case-control study and a mechanistic study of post-vaccination immune responses. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00680-0

    1. Dhar, M. S., Marwal, R., VS, R., Ponnusamy, K., Jolly, B., Bhoyar, R. C., Sardana, V., Naushin, S., Rophina, M., Mellan, T. A., Mishra, S., Whittaker, C., Fatihi, S., Datta, M., Singh, P., Sharma, U., Ujjainiya, R., Bhatheja, N., Divakar, M. K., … Rakshit, P. (n.d.). Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India. Science, 0(0), eabj9932. https://doi.org/10.1126/science.abj9932

  12. Oct 2021
    1. Singanayagam, A., Hakki, S., Dunning, J., Madon, K. J., Crone, M. A., Koycheva, A., Derqui-Fernandez, N., Barnett, J. L., Whitfield, M. G., Varro, R., Charlett, A., Kundu, R., Fenn, J., Cutajar, J., Quinn, V., Conibear, E., Barclay, W., Freemont, P. S., Taylor, G. P., … Lackenby, A. (2021). Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: A prospective, longitudinal, cohort study. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00648-4

    1. Andreano, E., Paciello, I., Piccini, G., Manganaro, N., Pileri, P., Hyseni, I., Leonardi, M., Pantano, E., Abbiento, V., Benincasa, L., Giglioli, G., De Santi, C., Fabbiani, M., Rancan, I., Tumbarello, M., Montagnani, F., Sala, C., Montomoli, E., & Rappuoli, R. (2021). Hybrid immunity improves B cells and antibodies against SARS-CoV-2 variants. Nature, 1–7. https://doi.org/10.1038/s41586-021-04117-7

    1. Tartof, S. Y., Slezak, J. M., Fischer, H., Hong, V., Ackerson, B. K., Ranasinghe, O. N., Frankland, T. B., Ogun, O. A., Zamparo, J. M., Gray, S., Valluri, S. R., Pan, K., Angulo, F. J., Jodar, L., & McLaughlin, J. M. (2021). Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: A retrospective cohort study. The Lancet, 398(10309), 1407–1416. https://doi.org/10.1016/S0140-6736(21)02183-8

    1. Siddle, K. J., Krasilnikova, L. A., Moreno, G. K., Schaffner, S. F., Vostok, J., Fitzgerald, N. A., Lemieux, J. E., Barkas, N., Loreth, C., Specht, I., Tomkins-Tinch, C. H., Silbert, J., Schaeffer, B., Taylor, B. P., Loftness, B., Johnson, H., Schubert, P. L., Shephard, H. M., Doucette, M., … Sabeti, P. C. (2021). Evidence of transmission from fully vaccinated individuals in a large outbreak of the SARS-CoV-2 Delta variant in Provincetown, Massachusetts (p. 2021.10.20.21265137). https://doi.org/10.1101/2021.10.20.21265137

    1. Mlcochova, P., Kemp, S. A., Dhar, M. S., Papa, G., Meng, B., Ferreira, I. A. T. M., Datir, R., Collier, D. A., Albecka, A., Singh, S., Pandey, R., Brown, J., Zhou, J., Goonawardane, N., Mishra, S., Whittaker, C., Mellan, T., Marwal, R., Datta, M., … Gupta, R. K. (2021). SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion. Nature, 1–6. https://doi.org/10.1038/s41586-021-03944-y

  13. Sep 2021
    1. Twohig, K. A., Nyberg, T., Zaidi, A., Thelwall, S., Sinnathamby, M. A., Aliabadi, S., Seaman, S. R., Harris, R. J., Hope, R., Lopez-Bernal, J., Gallagher, E., Charlett, A., Angelis, D. D., Presanis, A. M., Dabrera, G., Koshy, C., Ash, A., Wise, E., Moore, N., … Gunson, R. (2021). Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: A cohort study. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00475-8

    1. David Dowdy on Twitter: “@NEJM joining the waning immunity debate. I’m going to push back a bit. Data from @UCSDHealth of vax effectiveness in health workers: 94% in June, 65% in July. Interpreted as ‘likely to be due to...delta and waning immunity over time, compounded by end of masking requirements.’ https://t.co/flDOfBbTs7” / Twitter. (n.d.). Retrieved September 2, 2021, from https://twitter.com/davidwdowdy/status/1433254675915157504?s=20

  14. Aug 2021
    1. Tim Plante, MD MHS on Twitter: “Just reported: About half of recent ICU patients with #Covid19 in #Vermont are vaccinated. Sounds like the vaccines aren’t working, right? WRONG. Vaccines are working and here’s why. But first, let’s talk a bit about unprotected sex. A thread. (Refs at the end.) 1/n https://t.co/iyQcfCDAfh” / Twitter. (n.d.). Retrieved August 27, 2021, from https://twitter.com/tbplante/status/1430222978961317896

    1. Liu, Y., Arase, N., Kishikawa, J., Hirose, M., Li, S., Tada, A., Matsuoka, S., Arakawa, A., Akamatsu, K., Ono, C., Jin, H., Kishida, K., Nakai, W., Kohyama, M., Nakagawa, A., Yamagishi, Y., Nakagami, H., Kumanogoh, A., Matsuura, Y., … Arase, H. (2021). The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines (p. 2021.08.22.457114). https://doi.org/10.1101/2021.08.22.457114

    1. Prof. Christina Pagel on Twitter: “THREAD latest on B.1.617.2 variant in England: B.1.617.2 (1st discovered in India) is now dominant in England. Here is a thread summarising latest PHE report and Sanger local data. TLDR: it is NOT good news. 1/7” / Twitter. (n.d.). Retrieved August 24, 2021, from https://twitter.com/chrischirp/status/1399333330286415876

    1. André Picard on Twitter: “Most of those numbers are in the column, which focuses on a) the risk of the Delta variant to children under 12 and b) the 29% of Canadians who are not fully vaccinated. Brace yourself for more COVID-19 nastiness https://t.co/V0agVYvKRx” / Twitter. (n.d.). Retrieved August 13, 2021, from https://twitter.com/picardonhealth/status/1425316861176995840

    1. Craig Spencer MD MPH. (2021, August 6). Even with Delta, the likelihood of severe illness if you’re fully immunized is still a small fraction of the likelihood for the unvaccinated. In other words, nearly every COVID-19-related death right now is preventable with vaccination. [Tweet]. @Craig_A_Spencer. https://twitter.com/Craig_A_Spencer/status/1423674337089949710

    1. Rafael Irizarry. (2021, August 8). Vaccines work in a gif update: COVID19 cases versus vaccination rates in US states through time. The Delta variant effect can be seen clearly starting in July. States with lower vaccination rates are affected much worse. Https://t.co/e0SQpa8Qg0 [Tweet]. @rafalab. https://twitter.com/rafalab/status/1424440520361787392