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Craig Spencer MD MPH. (2021, August 6). Even with Delta, the likelihood of severe illness if you’re fully immunized is still a small fraction of the likelihood for the unvaccinated. In other words, nearly every COVID-19-related death right now is preventable with vaccination. [Tweet]. @Craig_A_Spencer. https://twitter.com/Craig_A_Spencer/status/1423674337089949710
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Facebook, Twitter, options, S. more sharing, Facebook, Twitter, LinkedIn, Email, URLCopied!, C. L., & Print. (2021, July 19). Vaccines are incredibly effective against Delta variant. So why do we need to wear masks indoors? Los Angeles Times. https://www.latimes.com/california/story/2021-07-19/covid-vaccines-work-why-is-la-mask-mandate-necessary
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Justin Baragona on Twitter: “There seems to be a concerted effort today by Fox’s daytime news shows to promote the vaccines to its audience. Dr. Marc Siegel says ‘the Delta variant needs to be a wake-up call to get vaccinated.’ Anchor John Roberts then directs viewers to the government vaccine website. Https://t.co/T5b21nXCfe” / Twitter. (n.d.). Retrieved August 4, 2021, from https://twitter.com/justinbaragona/status/1417178420950220811
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John Burn-Murdoch. (2021, May 27). NEW: B.1617.2 is fuelling a third wave in the UK, with not only cases but also hospital admissions rising. Vaccines will make this wave different to those that have come before, but it remains a concern, and one that other countries will soon face. Thread on everything we know: Https://t.co/4825qOqgrl [Tweet]. @jburnmurdoch. https://twitter.com/jburnmurdoch/status/1397995388267810818
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- Jul 2021
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Carl T. Bergstrom. (2021, May 27). An update on the B.1.617.2 lineage. I’m concerned. Not because of reduced vaccine efficacy, but simply because a further increase in transmissibility above B.1.1.7 would be quite bad news for countries where vaccination is low and for hopes of near-elimination everywhere. [Tweet]. @CT_Bergstrom. https://twitter.com/CT_Bergstrom/status/1398029743954432005
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Meaghan Kall 🏳️🌈 on Twitter: “The updated cumulative growth curves showing continued exponential growth of B.1.617.2.. Https://t.co/3fmEwU7cP3” / Twitter. (n.d.). Retrieved July 2, 2021, from https://twitter.com/kallmemeg/status/1397981951907217411
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Juliet Pulliam, PhD. (2021, June 28). My take (3/4): The last 15 months have been brutal for those of us in SA, as in most of the world. The next few months will continue to try us. Vaccination brings our best hope of making COVID manageable. [Tweet]. @SACEMAdirector. https://twitter.com/SACEMAdirector/status/1409392605901864962
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Elisabeth Mahase. (2021, July 26). At least 6 weeks between Pfizer vaccine doses = higher neutralising antibody levels (than a 3-4 wk interval) For those with the delta variant, antibody levels were 2.3-fold higher with the longer interval Preprint from @pitchstudy @bmjlatest https://t.co/E3yOTqNgpa [Tweet]. @emahase. https://twitter.com/emahase_/status/1419604658344112130
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Staff, Fox News. “McEnany Encourages People to Get COVID Vaccine: It Reduces Your Risk of Transmitting the Virus.” Text.Article. Fox News. Fox News, July 21, 2021. https://www.foxnews.com/media/mcenany-encourages-people-to-get-covid-vaccine-variant.
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Alan McNally 💙. (2021, February 5). Our latest lab data for B.1.1.7 prevalence in Pillar 2 samples, as determined by SGTF. Clearly now plateauing at 80-90%. Which to me suggests there are other lineages as transmissible as B.1.1.7......... Https://t.co/toA0GyVsZz [Tweet]. @alanmcn1. https://twitter.com/alanmcn1/status/1357701944027004929
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World Health Organization (WHO). (2021, May 31). Today WHO has announced a new naming system for key #COVID19 variants. The labels are based on the Greek alphabet (i.e. Alpha, Beta, Gamma, etc), making them simple, easy to say and remember. 👉 https://t.co/aYCZfspZyb https://t.co/Gxt14fwVqF [Tweet]. @WHO. https://twitter.com/WHO/status/1399432092333883393
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ReconfigBehSci. (2021, April 8). RT @EricTopol: The variants of concern/interest fall into a spectrum of immune evasiveness, w/ B.1.351 being most; B.1.1.7, B.1.429 least.… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1397697142769152001
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Seth Trueger. (2021, May 3). Https://t.co/mKCwcjQfe3 [Tweet]. @MDaware. https://twitter.com/MDaware/status/1389244959757373441
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Nick Holliman. (2021, May 30). @anthonybmasters @d_spiegel A quick visual summary of data on this week’s article by @anthonybmasters & @d_spiegel The outlook is uncertain, although we have survived a variant once already (B.1.1.7). The data on the effect of variants is analysed as fast as it (reliably) arrives. Https://t.co/vOKmCxYMGT https://t.co/3ZeJJTdRs3 [Tweet]. @binocularity. https://twitter.com/binocularity/status/1398957348492918784
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Eric Topol. (2021, June 9). Here’s the updated, comprehensive list of #SARSCoV2 variants that are resistant to vaccines https://t.co/JnOz3T7L28 [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1402752521970458628
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ReconfigBehSci on Twitter: ‘RT @EricTopol: Summed up well by @MollyJongFast, especially for delta, the most challenging one so far https://t.co/cSGekr2q2S’ / Twitter. (n.d.). Retrieved 11 June 2021, from https://twitter.com/SciBeh/status/1403057875254054914
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Adam Kucharski on Twitter: “Useful data 👇– quick look suggests odds ratio for detection of B.1.617.2 relative to non-B.1.617.2 in vaccinated group compared to controls is 2.7 (95% CI: 0.7-10) after one dose and 1.2 (0.4-3.6) after two...” / Twitter. (n.d.). Retrieved July 2, 2021, from https://twitter.com/AdamJKucharski/status/1400443351908892675?s=20
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A Marm Kilpatrick on Twitter: “How effective are vaccines vs severe & all disease, death, infection, & transmission? Very nice collection of studies assessing different aspects of vaccine protection by Julia Shapiro (on twitter?) @nataliexdean @betzhallo @ilongini & 2 others. Thread https://t.co/mhe0DufVtH” / Twitter. (n.d.). Retrieved June 28, 2021, from https://twitter.com/DiseaseEcology/status/1395848357461954563
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Why most people who now die with Covid in England have had a vaccination | David Spiegelhalter and Anthony Masters | The Guardian. (n.d.). Retrieved June 28, 2021, from https://www.theguardian.com/theobserver/commentisfree/2021/jun/27/why-most-people-who-now-die-with-covid-have-been-vaccinated?CMP=Share_iOSApp_Other
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Systematic gaslighting by dangerous ideologies. (n.d.). Retrieved June 28, 2021, from https://vip.politicsmeanspolitics.com/2021/06/15/systematic-gaslighting-by-dangerous-ideologies/
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Jeffrey Ely on Twitter: “The base-rate fallacy is about to become a daily nuisance when it comes to processing outbreak data in highly vaccinated societies. Here’s a cautionary tale.” / Twitter. (n.d.). Retrieved June 28, 2021, from https://twitter.com/Jeffely/status/1408500890999328770
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Just give us the vaccines, WHO pleads, as poor countries go wanting | Reuters. (n.d.). Retrieved June 28, 2021, from https://www.reuters.com/world/just-give-us-vaccines-who-pleads-poor-countries-go-wanting-2021-06-25/
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twitter.com twitter.com
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Eric Topol on Twitter: “As the Delta variant (B.1.617.2) becomes dominant throughout the world, there are 2 patterns emerging: —Countries w/ low vaccination rates are seeing both case and fatality rates increase—Countries w/ high vaccination rate: Some case increase and minimal to no fatality increase https://t.co/sSE4RlSeUJ” / Twitter. (n.d.). Retrieved June 28, 2021, from https://twitter.com/EricTopol/status/1408195243279667204
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Darby, Alistair C., and Julian A. Hiscox. ‘Covid-19: Variants and Vaccination’. BMJ 372 (23 March 2021): n771. https://doi.org/10.1136/bmj.n771.
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Lewis Spurgin on Twitter: “Perhaps an under appreciated point with the B.1.617.2 variant is that regional PHE teams and local authorities across the country are putting in heroic amounts of effort to break chains of transmission. (1/2)” / Twitter. (n.d.). Retrieved June 27, 2021, from https://twitter.com/LewisSpurgin/status/1395827267297759234
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twitter.com twitter.com
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Deepti Gurdasani on Twitter: “I’m still utterly stunned by yesterday’s events—Let me go over this in chronological order & why I’m shocked. - First, in the morning yesterday, we saw a ‘leaked’ report to FT which reported on @PHE_uk data that was not public at the time🧵” / Twitter. (n.d.). Retrieved June 27, 2021, from https://twitter.com/dgurdasani1/status/1396373990986375171
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UK is with EU. (2021, January 18). ..The reason we are in this third lockdown is because of the anti lockdowners like Lord Sumption ..We are going in circles, countries who have done well controlled the virus and now have an economic recovery ..And every life matters #GMB @devisridhar speaking truth to power https://t.co/U3BBV0uUSb [Tweet]. @ukiswitheu. https://twitter.com/ukiswitheu/status/1351089812799950850
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Challen, R., Dyson, L., Overton, C., Guzman-Rincon, L., Danon, L., & Gog, J. (n.d.). Briefing note: Potential community transmission of B.1.617.2 inferred by S-gene positivity. 18.
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ReconfigBehSci. (2021, June 14). RT @AdamJKucharski: Compare relationship between R and proportion of sequences consistent with the B.1.1.7 variant in autumn 2020 (below le… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1404604886117797888
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Two vaccine doses needed for strong protection against variant found in India, data show | Financial Times. (n.d.). Retrieved June 14, 2021, from https://www.ft.com/content/a70d423a-7d7c-4736-8828-0a485d7c3a8e
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Cirillo, Nicola, and Richard Doan. “Bell’s Palsy and SARS-CoV-2 Vaccines—an Unfolding Story.” The Lancet Infectious Diseases 0, no. 0 (June 7, 2021). https://doi.org/10.1016/S1473-3099(21)00273-5.
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More transmissible variant makes vaccinations more crucial, experts say. (2021, June 10). STAT. https://www.statnews.com/2021/06/10/more-transmissible-variant-covid-19-vaccinations-even-more-crucial/
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Covid variants: How much protection do the different vaccines offer? (2021, June 3). The Guardian. http://www.theguardian.com/world/2021/jun/03/covid-variants-delta-alpha-how-much-protection-vaccines
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Liverpool, M. L. P., Clare Wilson, Jessica Hamzelou, Sam Wong, Graham Lawton, Adam Vaughan, Conrad Quilty-Harper and Layal. (n.d.). Covid-19 news: Delta variant now causing 91 per cent of UK cases. New Scientist. Retrieved 11 June 2021, from https://www.newscientist.com/article/2237475-covid-19-news-delta-variant-now-causing-91-per-cent-of-uk-cases/
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Michaelsen, Thomas Y., Marc Bennedbæk, Lasse E. Christiansen, Mia S. F. Jørgensen, Camilla H. Møller, Emil A. Sørensen, Simon Knutsson, et al. “Introduction and Transmission of SARS-CoV-2 B.1.1.7 in Denmark.” MedRxiv, June 7, 2021, 2021.06.04.21258333. https://doi.org/10.1101/2021.06.04.21258333.
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Daniels, Curt J., Saurabh Rajpal, Joel T. Greenshields, Geoffrey L. Rosenthal, Eugene H. Chung, Michael Terrin, Jean Jeudy, et al. “Prevalence of Clinical and Subclinical Myocarditis in Competitive Athletes With Recent SARS-CoV-2 Infection: Results From the Big Ten COVID-19 Cardiac Registry.” JAMA Cardiology, May 27, 2021. https://doi.org/10.1001/jamacardio.2021.2065.
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Hotez, P. J., & Ko, A. I. (2021, June 4). Opinion | Why Are So Many Children in Brazil Dying From Covid-19? The New York Times. https://www.nytimes.com/2021/06/04/opinion/Brazil-covid-children.html
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Page, Michael Le. “How Effective Are the Different Vaccines against Covid-19 Variants?” New Scientist. Accessed June 8, 2021. https://institutions.newscientist.com/article/mg25033363-500-how-effective-are-the-different-vaccines-against-covid-19-variants/?utm_campaign=echobox&utm_medium=social&utm_source=Twitter.
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Wall, E. C., Wu, M., Harvey, R., Kelly, G., Warchal, S., Sawyer, C., Daniels, R., Hobson, P., Hatipoglu, E., Ngai, Y., Hussain, S., Nicod, J., Goldstone, R., Ambrose, K., Hindmarsh, S., Beale, R., Riddell, A., Gamblin, S., Howell, M., … Bauer, D. L. (2021). Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(21)01290-3
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Callaway, E. (2021). ‘The perfect storm’: Lax social distancing fuelled a coronavirus variant’s Brazilian surge. Nature. https://doi.org/10.1038/d41586-021-01480-3
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ReconfigBehSci. (2021, May 9). RT @Tuliodna: Confirmed Detection of B.1.617.2 and B.1.1.7 in South Africa by NGS-SA This report was sent to our Health Minister @DrZweliM… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1391416831156514817
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Eric Topol on Twitter: “New reports on transmissibility and immune evasiveness for delta (B.1.617.2) lead to an update of this Table of the variants and key properties https://t.co/nGzEa39eF4” / Twitter. (n.d.). Retrieved June 5, 2021, from https://twitter.com/EricTopol/status/1400590583274426370
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Prof. Christina Pagel on Twitter: “So Hancock confirms that B.1.617.2 (‘India’ variant) is now dominant in England. Harries says we must remain ‘vigilant’. What does vigilant even mean? That we watch very carefully as a new, more dangerous, variant takes over cos it was so fun last time? Yeah, I’m pissed off” / Twitter. (n.d.). Retrieved May 28, 2021, from https://twitter.com/chrischirp/status/1397951741283405825
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Richardson, H. (2021). How waste water is helping South Africa fight COVID-19. Nature, 593(7860), 616–617. https://doi.org/10.1038/d41586-021-01399-9
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No 10 ‘tried to block’ data on spread of new Covid variant in English schools | Coronavirus | The Guardian. (n.d.). Retrieved May 24, 2021, from https://www.theguardian.com/world/2021/may/22/no-10-tried-to-block-data-on-spread-of-new-covid-variant-in-english-schools
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Ministers ‘failed to act on Bedford Covid variant surge for two weeks’ | Coronavirus | The Guardian. (n.d.). Retrieved May 24, 2021, from https://www.theguardian.com/world/2021/may/23/ministers-failed-to-act-on-bedford-covid-variant-surge-for-two-weeks
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Covid: India tells social media firms to remove ‘India variant’ from content. (2021, May 22). BBC News. https://www.bbc.com/news/world-asia-india-57213046
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Ramanathan, M., Ferguson, I. D., Miao, W., & Khavari, P. A. (2021). SARS-CoV-2 B.1.1.7 and B.1.351 spike variants bind human ACE2 with increased affinity. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00262-0
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Israelow, B., Mao, T., Klein, J., Song, E., Menasche, B., Omer, S. B., & Iwasaki, A. (2021). Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2. BioRxiv, 2021.05.19.444825. https://doi.org/10.1101/2021.05.19.444825
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John Burn-Murdoch. (2021, May 7). NEW: time for a proper thread on B.1.617.2, the subtype of the Indian variant that has been moved to ‘variant of concern’ today by Public Health England. First, it’s clear case numbers from this lineage are growing faster than other imported variants have done in the UK. https://t.co/hUUzBvCsY1 [Tweet]. @jburnmurdoch. https://twitter.com/jburnmurdoch/status/1390666071724765185
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Prof. Christina Pagel on Twitter: “SHORT THREAD: I was on Sky News earlier where I explained why I thought test 4 (new variant test) for the next stage of the roadmap had not been met, because of B.1.617.2 (the so called ‘Indian’ variant of concern). 1/5 https://t.co/0O3dL2saOR” / Twitter. (n.d.). Retrieved May 17, 2021, from https://twitter.com/chrischirp/status/1392927819504701441
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Eric Topol. (2021, May 1). Downgrading the concern on B.1.617, the poorly named ‘double mutant’—98% effectiveness of mRNA vaccine in an Israeli outbreak @CT_Bergstrom https://t.co/tGbuwPUmAL —Lab studies: Minimal immune evasion, expected full protection from vaccine @GuptaR_lab https://t.co/AIp24G0ROK https://t.co/AK20UWlDBD [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1388539223230140422
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Dr. Tom Frieden. (2021, April 30). Globally, the end of the pandemic isn’t near. More than a million lives depend on improving our response quickly. Don’t be blinded by the light at the end of the tunnel. There isn’t enough vaccine and the virus is gathering strength & speed. Global cooperation is crucial. 1/ [Tweet]. @DrTomFrieden. https://twitter.com/DrTomFrieden/status/1388172436999376899
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ReconfigBehSci. (2021, May 1). RT @GuptaR_lab: Given the dire situation in India and questions regarding the new variant B.1.617, the so called ‘Double Mutant’ we are sha… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1388915829383720961
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Kissler, S., Fauver, J. R., Mack, C., Tai, C. G., Breban, M. I., Watkins, A. E., Samant, R. M., Anderson, D. J., Ho, D. D., Grubaugh, N. D., & Grad, Y. (2021). Densely sampled viral trajectories suggest longer duration of acute infection with B.1.1.7 variant relative to non-B.1.1.7 SARS-CoV-2. https://dash.harvard.edu/handle/1/37366884
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Eric Topol. (2021, February 17). New reports @NEJM today confirming some immune evasion of the B.1.351 variant (identified in South Africa) to both the mRNA vaccines, in vitro data @BioNTech_Group/@Pfizer and @moderna_tx. Less vaccine efficacy vs B.1.351 has been confirmed in clinical trials for 3 vaccines https://t.co/2N7eKDllso [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1362160675913568256
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Roy, A. (2021, April 29). ‘We are witnessing a crime against humanity’: Arundhati Roy on India’s Covid catastrophe. The Guardian. https://www.theguardian.com/news/2021/apr/28/crime-against-humanity-arundhati-roy-india-covid-catastrophe
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Eric Topol on Twitter: “The variants of concern/interest fall into a spectrum of immune evasiveness, w/ B.1.351 being most; B.1.1.7, B.1.429 least. This property pertains to potential for reinfection & some reduction in vaccine efficacy My prelim estimates based on publications/preprints, subject to Δ https://t.co/fQZwBCUEGS” / Twitter. (n.d.). Retrieved April 28, 2021, from https://twitter.com/EricTopol/status/1380203664317456385
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ReconfigBehSci. (2021, April 13). RT @JoshBiostats: Important comment by @_nickdavies here: New studies are compatible with B.1.1.7 having higher severity because new studie… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1381927390633410562
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Moderna Provides Clinical and Supply Updates on COVID-19 Vaccine Program Ahead of 2nd Annual Vaccines Day. (2021, April 13). Moderna, Inc. https://investors.modernatx.com/news-releases/news-release-details/moderna-provides-clinical-and-supply-updates-covid-19-vaccine
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Chen, C. (2021, April 14). A Tiny Number of People Will Be Hospitalized Despite Being Vaccinated. We Have to Learn Why. ProPublica. https://www.propublica.org/article/a-tiny-number-of-people-will-be-hospitalized-despite-being-vaccinated-we-have-to-learn-why?token=4HsRcuNGpEdmAeWz4oEu5Cr56zj5_5OE
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Tan, Steph H., Orchid Allicock, Mari Armstrong-Hough, and Anne L. Wyllie. ‘Saliva as a Gold-Standard Sample for SARS-CoV-2 Detection’. The Lancet Respiratory Medicine 0, no. 0 (19 April 2021). https://doi.org/10.1016/S2213-2600(21)00178-8.
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Merrick, J. (2021, April 20). Covid-19 variants: South African strain is causing the most concern for UK scientists. iNews. https://inews.co.uk/news/politics/covid-19-variants-south-african-strain-is-causing-the-most-concern-for-uk-scientists-965679?utm_term=Autofeed&ito=social_itw_theipaper&utm_medium=Social&utm_source=Twitter#Echobox=1618951521
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Safi, M. (2021, April 21). India’s shocking surge in Covid cases follows baffling decline. The Guardian. https://www.theguardian.com/world/2021/apr/21/india-shocking-surge-in-covid-cases-follows-baffling-decline
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Beaumont, P. (2021, April 22). Covid-19: India’s response to second wave is warning to other countries. The Guardian. https://www.theguardian.com/world/2021/apr/22/covid-19-india-response-to-second-wave-is-warning-to-other-countries
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Nabavi, N., & Dobson, J. (2021, April 21). Covid-19 new variants—known unknowns. The BMJ Opinion. https://blogs.bmj.com/bmj/2021/04/21/covid-19-new-variants-known-unknowns/?utm_campaign=shareaholic&utm_medium=twitter&utm_source=socialnetwork
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Indian expansion of Covid vaccine drive may further strain supplies | India | The Guardian. (n.d.). Retrieved April 19, 2021, from https://www.theguardian.com/world/2021/apr/19/indian-expansion-of-covid-vaccine-drive-may-further-strain-supplies
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Gross, A. (2021, April 15). Concerns rise about spread of coronavirus variant in London. https://www.ft.com/content/d1a18cef-68ff-4f37-b5d7-ad522b2bbf68
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Trevor Bedford. (2021, January 14). After ~10 months of relative quiescence we’ve started to see some striking evolution of SARS-CoV-2 with a repeated evolutionary pattern in the SARS-CoV-2 variants of concern emerging from the UK, South Africa and Brazil. 1/19 [Tweet]. @trvrb. https://twitter.com/trvrb/status/1349774271095062528
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Graham, M. S., Sudre, C. H., May, A., Antonelli, M., Murray, B., Varsavsky, T., Kläser, K., Canas, L. S., Molteni, E., Modat, M., Drew, D. A., Nguyen, L. H., Polidori, L., Selvachandran, S., Hu, C., Capdevila, J., Koshy, C., Ash, A., Wise, E., … Ourselin, S. (2021). Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: An ecological study. The Lancet Public Health, 0(0). https://doi.org/10.1016/S2468-2667(21)00055-4
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David R Tomlinson 💙. (2021, March 5). Truth. 💙 @FreshAirNHS @theRCN @TheBMA @mancunianmedic @DrLindaDykes @Chakladar_A @KGadhok https://t.co/Ke2C84KuaT https://t.co/C469qvrSoK [Tweet]. @DRTomlinsonEP. https://twitter.com/DRTomlinsonEP/status/1367962251211202566
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).
AssayResult: 5.2
AssayResultAssertion: Normal
StandardErrorMean: 0.33
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A total of 84 PALB2 patient-derived missense variants reported in ClinVar, COSMIC, and the PALB2 LOVD database were selected
HGVS: NM_024675.3:c.1732A>G p.(Ser578Gly)
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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SUPPLEMENTARY DATA
AssayResult: 97.77
AssayResultAssertion: Not reported
PValue: > 0.9999
Comment: Exact values reported in Table S3.
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To this end, 44 missense variants found in breast cancer patients were identified in the ClinVar database (https://www.ncbi.nlm.nih.gov/clinvar) and/or selected by literature curation based on their frequency of description or amino acid substitution position in the protein (Supplemental Table S1).
HGVS: NM_024675.3:c.3049G>A p.(Ala1017Thr)
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Source Data
AssayResult: 78.2
AssayResultAssertion: Not reported
ReplicateCount: 2
StandardErrorMean: 7.31
Comment: Exact values reported in “Source Data” file.
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Source Data
AssayResult: 87.35
AssayResultAssertion: Not reported
ReplicateCount: 2
StandardDeviation: 11.94
StandardErrorMean: 8.44
Comment: Exact values reported in “Source Data” file.
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We, therefore, analyzed the effect of 48 PALB2 VUS (Fig. 2a, blue) and one synthetic missense variant (p.A1025R) (Fig. 2a, purple)29 on PALB2 function in HR.
HGVS: NM_024675.3:c.2117C>T p.(T706I)
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