448 Matching Annotations
  1. Aug 2021
  2. Jul 2021
    1. Kraemer, M. U. G., Hill, V., Ruis, C., Dellicour, S., Bajaj, S., McCrone, J. T., Baele, G., Parag, K. V., Battle, A. L., Gutierrez, B., Jackson, B., Colquhoun, R., O’Toole, Á., Klein, B., Vespignani, A., Consortium‡, T. C.-19 G. U. (CoG-U., Volz, E., Faria, N. R., Aanensen, D., … Pybus, O. G. (2021). Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence. Science. https://doi.org/10.1126/science.abj0113

    1. Regev-Yochay, G., Amit, S., Bergwerk, M., Lipsitch, M., Leshem, E., Kahn, R., Lustig, Y., Cohen, C., Doolman, R., Ziv, A., Novikov, I., Rubin, C., Gimpelevich, I., Huppert, A., Rahav, G., Afek, A., & Kreiss, Y. (2021). Decreased infectivity following BNT162b2 vaccination: A prospective cohort study in Israel. The Lancet Regional Health - Europe, 7, 100150. https://doi.org/10.1016/j.lanepe.2021.100150

    1. David Fisman. (2021, July 8). Fascinating new preprint on delta vs older variants in well-investigated outbreaks in China. Viral load for delta is 3 log higher, and latent period is shorter too (estimate is 4 days vs 6 days). This may explain much higher R estimates which may be due to elevated viral load [Tweet]. @DFisman. https://twitter.com/DFisman/status/1413126886570536963

    1. Youyang Gu. (2021, June 30). South Dakota has a vaccination rate of 50% (1+ dose). Maine is at 66%. So is Maine better protected? Not quite. If you factor in immunity from natural infection, SD has a total population immunity of ~70%, while ME is at ~62%. I created a calculator: Https://t.co/j4tMI2zN2K [Tweet]. @youyanggu. https://twitter.com/youyanggu/status/1410264061900726283

    1. Lemey, P., Ruktanonchai, N., Hong, S. L., Colizza, V., Poletto, C., Van den Broeck, F., Gill, M. S., Ji, X., Levasseur, A., Oude Munnink, B. B., Koopmans, M., Sadilek, A., Lai, S., Tatem, A. J., Baele, G., Suchard, M. A., & Dellicour, S. (2021). Untangling introductions and persistence in COVID-19 resurgence in Europe. Nature, 1–8. https://doi.org/10.1038/s41586-021-03754-2

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  3. Jun 2021
    1. Regev-Yochay, G., Amit, S., Bergwerk, M., Lipsitch, M., Leshem, E., Kahn, R., Lustig, Y., Cohen, C., Doolman, R., Ziv, A., Novikov, I., Rubin, C., Gimpelevich, I., Huppert, A., Rahav, G., Afek, A., & Kreiss, Y. (2021). Decreased Infectivity Following BNT162b2 Vaccination. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3815668

    1. Knock, E. S., Whittles, L. K., Lees, J. A., Perez-Guzman, P. N., Verity, R., FitzJohn, R. G., Gaythorpe, K. A. M., Imai, N., Hinsley, W., Okell, L. C., Rosello, A., Kantas, N., Walters, C. E., Bhatia, S., Watson, O. J., Whittaker, C., Cattarino, L., Boonyasiri, A., Djaafara, B. A., … Baguelin, M. (2021). Key epidemiological drivers and impact of interventions in the 2020 SARS-CoV-2 epidemic in England. Science Translational Medicine, eabg4262. https://doi.org/10.1126/scitranslmed.abg4262

    1. Thompson, M. G., Burgess, J. L., Naleway, A. L., Tyner, H. L., Yoon, S. K., Meece, J., Olsho, L. E. W., Caban-Martinez, A. J., Fowlkes, A., Lutrick, K., Kuntz, J. L., Dunnigan, K., Odean, M. J., Hegmann, K. T., Stefanski, E., Edwards, L. J., Schaefer-Solle, N., Grant, L., Ellingson, K., … Gaglani, M. (2021). Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers—Eight U.S. Locations, December 2020–March 2021. MMWR. Morbidity and Mortality Weekly Report, 70(13), 495–500. https://doi.org/10.15585/mmwr.mm7013e3

    1. Parry, H. M., Tut, G., Faustini, S., Stephens, C., Saunders, P., Bentley, C., Hilyard, K., Brown, K., Amirthalingam, G., Charlton, S., Leung, S., Chiplin, E., Coombes, N. S., Bewley, K. R., Penn, E. J., Rowe, C., Otter, A., Watts, R., D’Arcangelo, S., … Moss, P. (2021). BNT162b2 Vaccination in People Over 80 Years of Age Induces Strong Humoral Immune Responses with Cross Neutralisation of P.1 Brazilian Variant. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3816840

  4. May 2021
    1. Eric Topol. (2021, May 1). Downgrading the concern on B.1.617, the poorly named ‘double mutant’—98% effectiveness of mRNA vaccine in an Israeli outbreak @CT_Bergstrom https://t.co/tGbuwPUmAL —Lab studies: Minimal immune evasion, expected full protection from vaccine @GuptaR_lab https://t.co/AIp24G0ROK https://t.co/AK20UWlDBD [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1388539223230140422

    1. Temoka, E. (2013). Becoming a vaccine champion: Evidence-based interventions to address the challenges of vaccination. South Dakota Medicine: The Journal of the South Dakota State Medical Association, Spec no, 68–72.

    1. Aleta, A., Martín-Corral, D., Pastore y Piontti, A., Ajelli, M., Litvinova, M., Chinazzi, M., Dean, N. E., Halloran, M. E., Longini Jr, I. M., Merler, S., Pentland, A., Vespignani, A., Moro, E., & Moreno, Y. (2020). Modelling the impact of testing, contact tracing and household quarantine on second waves of COVID-19. Nature Human Behaviour, 1–8. https://doi.org/10.1038/s41562-020-0931-9

  5. Apr 2021
    1. ReconfigBehSci on Twitter: “There is a Twitter account for the Great Barrington Declaration. It is totally silent on what is presently unfolding in India. Is it really possible to watch the surge there and in Brazil and not feel challenged in your beliefs about herd immunity? For otherwise smart people?” / Twitter. (n.d.). Retrieved April 25, 2021, from https://twitter.com/SciBeh/status/1384794607997890560

  6. Mar 2021
    1. O’Driscoll, M., Santos, G. R. D., Wang, L., Cummings, D. A. T., Azman, A. S., Paireau, J., Fontanet, A., Cauchemez, S., & Salje, H. (2020). Age-specific mortality and immunity patterns of SARS-CoV-2 infection in 45 countries. MedRxiv, 2020.08.24.20180851. https://doi.org/10.1101/2020.08.24.20180851

    1. Decerf, B., Ferreira, F. H. G., Mahler, D. G., & Sterck, O. (2020). Lives and Livelihoods: Estimates of the Global Mortality and Poverty Effects of the COVID-19 Pandemic. IZA Discussion Paper, 13549.

    1. López, J. A. M., Arregui-Garcĺa, B., Bentkowski, P., Bioglio, L., Pinotti, F., Boëlle, P.-Y., Barrat, A., Colizza, V., & Poletto, C. (2020). Anatomy of digital contact tracing: Role of age, transmission setting, adoption and case detection. MedRxiv, 2020.07.22.20158352. https://doi.org/10.1101/2020.07.22.20158352

    1. Prof. Devi Sridhar. (2020, March 25). We will be stuck in an endless cycle of lockdown/release for next 18 months, if we do not start mass testing, tracing, & isolating those who are carriers of the virus while pursuing rapid research for antiviral treatment or vaccine. This is the message the public needs to hear. [Tweet]. @devisridhar. https://twitter.com/devisridhar/status/1242743618986745861

    1. Damialis, A., Gilles, S., Sofiev, M., Sofieva, V., Kolek, F., Bayr, D., Plaza, M. P., Leier-Wirtz, V., Kaschuba, S., Ziska, L. H., Bielory, L., Makra, L., Trigo, M. del M., Group, C.-19/POLLEN study, & Traidl-Hoffmann, C. (2021). Higher airborne pollen concentrations correlated with increased SARS-CoV-2 infection rates, as evidenced from 31 countries across the globe. Proceedings of the National Academy of Sciences, 118(12). https://doi.org/10.1073/pnas.2019034118

    1. Stefan Simanowitz. (2020, November 14). “Sweden hoped herd immunity would curb #COVID19. Don’t do what we did” write 25 leading Swedish scientists “Sweden’s approach to COVID has led to death, grief & suffering. The only example we’re setting is how not to deal with a deadly infectious disease” https://t.co/azOg6AxSYH https://t.co/u2IqU5iwEn [Tweet]. @StefSimanowitz. https://twitter.com/StefSimanowitz/status/1327670787617198087

    1. Kenneth Fordyce. (2020, November 3). @devisridhar @georgeeaton Yet another article packed full of wise words: E.g., ‘in some ways, the people pushing for “herd immunity” are forcing us into these lockdown-release cycles because you end up in a reactive position by underestimating the spread of the virus and the hospitalisation rate’ [Tweet]. @FordyceKenneth. https://twitter.com/FordyceKenneth/status/1323544552112852992

  7. Feb 2021
    1. Youyang Gu. (2021, February 24). When can we return to normal? Forget about ‘herd immunity’. Below is my estimate for the number of susceptible individuals over time, as a proportion of the US population. Looking at this graph, what is the best point to go back to normal? Christmas? Fall? Or Summer? 🧵 https://t.co/V4uiFk5YcP [Tweet]. @youyanggu. https://twitter.com/youyanggu/status/1364627872233750543

    1. Yale SOM. (2020, October 27). Herd immunity is the end goal of developing a vaccine, @thehowie explains. But when government officials talk about relying on “herd immunity” as a strategy for slowing or stopping the Covid-19 pandemic without a vaccine, it’s a more dangerous approach. Https://t.co/aJ8VXos7zh [Tweet]. @YaleSOM. https://twitter.com/YaleSOM/status/1321150247503101956

  8. Jan 2021
  9. Dec 2020
    1. As immunity builds in the population, the risk of infection to all – including the vulnerable – falls. We know that all populations will eventually reach herd immunity – i.e.  the point at which the rate of new infections is stable – and that this can be assisted by (but is not dependent upon) a vaccine. Our goal should therefore be to minimize mortality and social harm until we reach herd immunity. 

      In case anyone is wondering vaccines provide herd immunity.

  10. Nov 2020
    1. The Swedish Public Health authority has never admitted that the goal of their chosen strategy is to reach herd immunity. However, from an epidemiological stand point, all strategies depend on reaching herd immunity in one way or another. A vaccination based strategy also builds on getting to herd immunity, it just chooses a different way to reach it. At some point in the relatively near future, every country on Earth will have developed herd immunity to covid, either by letting the disease spread until that point is reached, or by vaccinating enough people to reach that point.

      All pandemic strategies end up reaching herd immunity.

  11. Oct 2020
    1. The working class must utilize the next four weeks and beyond to unify and coordinate its struggles against the ruling class’s policy of “herd immunity,” social devastation, war, police violence and authoritarianism into an independent and revolutionary movement for socialism.
    1. t’s not clear why the sequence of the vaccines only mattered in girls, partly because there has been very little research into how male and female immune systems are different. “Somehow immunology has been blind to sex,” says Aaby. “If you read research about mortality in low income countries, there is no such thing as boys and girls – there are children. So we perceive that they have to be the same, and they are definitely not the same.”

      Take away: "Immune training" or bystander effects from other vaccinations may help to fight off Covid-19 or other infections, in spite of not being specific to that pathogen. Some of these effects are sex-specific.

      Claim: "Somehow immunology has been blind to sex"

      The evidence: This is not entirely true- there is actually a LOT of research into sex differences in the immune response, and it is well-known that women can generally mount stronger Th1-type immune responses against viral infections than men. This is thought to be partially linked to estrogen cycling, and partly due to the fact that women have 2 active copies of genes associated with immunity because those are encoded on the X chromosomes. Men only have 1 copy, and thus they don't generally mount as strong an inflammatory response. However, women are also more prone to autoimmune diseases as a consequence of having stronger inflammatory responses than men, which is seen in diseases such as multiple sclerosis, rheumatoid arthritis, and lupus.

      Sources: (https://www.nature.com/articles/nri.2016.90).

  12. Sep 2020
    1. Le Bert, N., Tan, A. T., Kunasegaran, K., Tham, C. Y. L., Hafezi, M., Chia, A., Chng, M. H. Y., Lin, M., Tan, N., Linster, M., Chia, W. N., Chen, M. I.-C., Wang, L.-F., Ooi, E. E., Kalimuddin, S., Tambyah, P. A., Low, J. G.-H., Tan, Y.-J., & Bertoletti, A. (2020). SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. Nature, 584(7821), 457–462. https://doi.org/10.1038/s41586-020-2550-z

  13. Aug 2020
    1. Ferretti, A. P., Kula, T., Wang, Y., Nguyen, D. M., Weinheimer, A., Dunlap, G. S., Xu, Q., Nabilsi, N., Perullo, C. R., Cristofaro, A. W., Whitton, H. J., Virbasius, A., Olivier, K. J., Baiamonte, L. B., Alistar, A. T., Whitman, E. D., Bertino, S. A., Chattopadhyay, S., & MacBeath, G. (2020). COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2. MedRxiv, 2020.07.24.20161653. https://doi.org/10.1101/2020.07.24.20161653

    1. Walls, A. C., Fiala, B., Schäfer, A., Wrenn, S., Pham, M. N., Murphy, M., Tse, L. V., Shehata, L., O’Connor, M. A., Chen, C., Navarro, M. J., Miranda, M. C., Pettie, D., Ravichandran, R., Kraft, J. C., Ogohara, C., Palser, A., Chalk, S., Lee, E.-C., … King, N. P. (2020). Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2. BioRxiv, 2020.08.11.247395. https://doi.org/10.1101/2020.08.11.247395

    1. Consiglio, C. R., Cotugno, N., Sardh, F., Pou, C., Amodio, D., Zicari, S., Ruggiero, A., Pascucci, G. R., Rodriguez, L., Santilli, V., Tan, Z., Eriksson, D., Wang, J., Lakshmikanth, T., Marchesi, A., Lakshmikanth, T., Campana, A., Villani, A., Rossi, P., … Brodin, P. (2020). The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19. MedRxiv, 2020.07.08.20148353. https://doi.org/10.1101/2020.07.08.20148353

    1. Rodda, L. B., Netland, J., Shehata, L., Pruner, K. B., Morawski, P. M., Thouvenel, C., Takehara, K. K., Eggenberger, J., Hemann, E. A., Waterman, H. R., Fahning, M. L., Chen, Y., Rathe, J., Stokes, C., Wrenn, S., Fiala, B., Carter, L. P., Hamerman, J. A., King, N. P., … Pepper, M. (2020). Functional SARS-CoV-2-specific immune memory persists after mild COVID-19. MedRxiv, 2020.08.11.20171843. https://doi.org/10.1101/2020.08.11.20171843

  14. Jul 2020
    1. Seow, J., Graham, C., Merrick, B., Acors, S., Steel, K. J. A., Hemmings, O., O’Bryne, A., Kouphou, N., Pickering, S., Galao, R., Betancor, G., Wilson, H. D., Signell, A. W., Winstone, H., Kerridge, C., Temperton, N., Snell, L., Bisnauthsing, K., Moore, A., … Doores, K. (2020). Longitudinal evaluation and decline of antibody responses in SARS-CoV-2 infection. MedRxiv, 2020.07.09.20148429. https://doi.org/10.1101/2020.07.09.20148429