574 Matching Annotations
  1. Aug 2020
    1. Sherrard-Smith, E., Hogan, A. B., Hamlet, A., Watson, O. J., Whittaker, C., Winskill, P., Ali, F., Mohammad, A. B., Uhomoibhi, P., Maikore, I., Ogbulafor, N., Nikau, J., Kont, M. D., Challenger, J. D., Verity, R., Lambert, B., Cairns, M., Rao, B., Baguelin, M., … Churcher, T. S. (2020). The potential public health consequences of COVID-19 on malaria in Africa. Nature Medicine, 1–6. https://doi.org/10.1038/s41591-020-1025-y

    1. Hewitt, J., Carter, B., Vilches-Moraga, A., Quinn, T. J., Braude, P., Verduri, A., Pearce, L., Stechman, M., Short, R., Price, A., Collins, J. T., Bruce, E., Einarsson, A., Rickard, F., Mitchell, E., Holloway, M., Hesford, J., Barlow-Pay, F., Clini, E., … Guaraldi, G. (2020). The effect of frailty on survival in patients with COVID-19 (COPE): A multicentre, European, observational cohort study. The Lancet Public Health, 5(8), e444–e451. https://doi.org/10.1016/S2468-2667(20)30146-8

    1. Horby, P., Mafham, M., Linsell, L., Bell, J. L., Staplin, N., Emberson, J. R., Wiselka, M., Ustianowski, A., Elmahi, E., Prudon, B., Whitehouse, A., Felton, T., Williams, J., Faccenda, J., Underwood, J., Baillie, J. K., Chappell, L., Faust, S. N., Jaki, T., … Landray, M. J. (2020). Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial. MedRxiv, 2020.07.15.20151852. https://doi.org/10.1101/2020.07.15.20151852

  2. Jul 2020
    1. Lavezzo, E., Franchin, E., Ciavarella, C., Cuomo-Dannenburg, G., Barzon, L., Del Vecchio, C., Rossi, L., Manganelli, R., Loregian, A., Navarin, N., Abate, D., Sciro, M., Merigliano, S., De Canale, E., Vanuzzo, M. C., Besutti, V., Saluzzo, F., Onelia, F., Pacenti, M., … Crisanti, A. (2020). Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’. Nature, 1–1. https://doi.org/10.1038/s41586-020-2488-1

  3. Jun 2020
    1. Sbidian, E., Josse, J., Lemaitre, G., Mayer, I., Bernaux, M., Gramfort, A., Lapidus, N., Paris, N., Neuraz, A., Lerner, I., Garcelon, N., Rance, B., Grisel, O., Moreau, T., Bellamine, A., Wolkenstein, P., Varoquaux, G., Caumes, E., Lavielle, M., … Audureau, E. (2020). Hydroxychloroquine with or without azithromycin and in-hospital mortality or discharge in patients hospitalized for COVID-19 infection: A cohort study of 4,642 in-patients in France. MedRxiv, 2020.06.16.20132597. https://doi.org/10.1101/2020.06.16.20132597

    1. Ferguson, N., Laydon, D., Nedjati Gilani, G., Imai, N., Ainslie, K., Baguelin, M., Bhatia, S., Boonyasiri, A., Cucunuba Perez, Z., Cuomo-Dannenburg, G., Dighe, A., Dorigatti, I., Fu, H., Gaythorpe, K., Green, W., Hamlet, A., Hinsley, W., Okell, L., Van Elsland, S., … Ghani, A. (2020). Report 9: Impact of non-pharmaceutical interventions (NPIs) to reduce COVID19 mortality and healthcare demand. Imperial College London. https://doi.org/10.25561/77482

    2. Ferguson, N., Laydon, D., Nedjati Gilani, G., Imai, N., Ainslie, K., Baguelin, M., Bhatia, S., Boonyasiri, A., Cucunuba Perez, Z., Cuomo-Dannenburg, G., Dighe, A., Dorigatti, I., Fu, H., Gaythorpe, K., Green, W., Hamlet, A., Hinsley, W., Okell, L., Van Elsland, S., … Ghani, A. (2020). Report 9: Impact of non-pharmaceutical interventions (NPIs) to reduce COVID19 mortality and healthcare demand. In 20 [Report]. https://doi.org/10.25561/77482

    1. Marshall, J. C., Murthy, S., Diaz, J., Adhikari, N., Angus, D. C., Arabi, Y. M., Baillie, K., Bauer, M., Berry, S., Blackwood, B., Bonten, M., Bozza, F., Brunkhorst, F., Cheng, A., Clarke, M., Dat, V. Q., de Jong, M., Denholm, J., Derde, L., … Zhang, J. (2020). A minimal common outcome measure set for COVID-19 clinical research. The Lancet Infectious Diseases, S1473309920304837. https://doi.org/10.1016/S1473-3099(20)30483-7

    1. Barry, D., Buchanan, L., Cargill, C., Daniel, A., Delaquérière, A., Gamio, L., Gianordoli, G., Harris, R., Harvey, B., Haskins, J., Huang, J., Landon, S., Love, J., Maalouf, G., Matthews, A., Mohamed, F., Moity, S., Royal, D.-C., Ruby, M., & Weingart, E. (2020, May 27). Remembering the 100,000 Lives Lost to Coronavirus in America. The New York Times. https://www.nytimes.com/interactive/2020/05/24/us/us-coronavirus-deaths-100000.html

    1. (((Howard Forman))) on Twitter: “#Italy remains one of the worst outbreaks & one of the best & most consistent responses to lockdown/NPI measures. 0.6% positive rate; STILL testing at rate of greater than 1/1000 each day. The US is NOT currently on this path. (some regions are). 33K fatalities. https://t.co/5lWdXMdlEf” / Twitter. (n.d.). Twitter. Retrieved June 2, 2020, from https://twitter.com/thehowie/status/1266873463681298433

    1. Snyder-Mackler, N., Burger, J. R., Gaydosh, L., Belsky, D. W., Noppert, G. A., Campos, F. A., Bartolomucci, A., Yang, Y. C., Aiello, A. E., O’Rand, A., Harris, K. M., Shively, C. A., Alberts, S. C., & Tung, J. (2020). Social determinants of health and survival in humans and other animals. Science, 368(6493). https://doi.org/10.1126/science.aax9553

  4. May 2020
  5. Apr 2020
    1. Verity, R., Okell, L. C., Dorigatti, I., Winskill, P., Whittaker, C., Imai, N., Cuomo-Dannenburg, G., Thompson, H., Walker, P. G. T., Fu, H., Dighe, A., Griffin, J. T., Baguelin, M., Bhatia, S., Boonyasiri, A., Cori, A., Cucunubá, Z., FitzJohn, R., Gaythorpe, K., … Ferguson, N. M. (2020). Estimates of the severity of coronavirus disease 2019: A model-based analysis. The Lancet Infectious Diseases, S1473309920302437. https://doi.org/10.1016/S1473-3099(20)30243-7

    1. Consistently, our study also found 19.7% of patients with cardiac injury and first demonstrated that cardiac injury was independently associated with an increased risk of mortality in patients with COVID-19.
    2. After adjusting for age, preexisting cardiovascular diseases (hypertension, coronary heart disease, and chronic heart failure), cerebrovascular diseases, diabetes mellitus, chronic obstructive pulmonary disease, renal failure, cancer, ARDS, creatinine levels greater than 133 μmol/L, and NT-proBNP levels greater than 900 pg/mL, the multivariable adjusted Cox proportional hazard regression model showed a significantly higher risk of death in patients with cardiac injury than in those without cardiac injury, either during time from symptom onset (hazard ratio [HR], 4.26 [95% CI, 1.92-9.49]) or time from admission to study end point (HR, 3.41 [95% CI, 1.62-7.16]) (Table 3).
    3. The mortality rate was higher among patients with vs without cardiac injury (42 [51.2%] vs 15 [4.5%]; P < .001) as shown in Table 2 and the Kaplan-Meier survival curves in Figure 2. The mortality rate increased in association with the magnitude of the reference value of hs-TNI
  6. Sep 2018
  7. Dec 2017
    1. This degree of medical information is such as the mass of scientific students would wish to possess, as enabling them, in their course thro life, to estimate with satisfaction the extent & limits of the aid to human life & health, which they may understandingly expect from that art: and it constitutes such a foundation for those intended for the profession, that the finishing course of practice at the bedsides of the sick, and at the operations of surgery in a hospital, can neither be long nor expensive.

      The authors of the Rockfish Gap Report recognized the need to create curriculum that focused on the moral/ethical implications of medical practice. The fact that the "extent & limits" of the practice is emphasized here demonstrates that there is more to care than simply repairing the body on an anatomical level, thus prompting the need for a more compassionate kind of care. The initial purpose of UVA's medical curriculum was to create a more compassionate pool of health-providers, and this vision persists today in programs like the nursing school's Compassionate Care initiative. This fully aligns with Jefferson's belief that students should focus on their area of study from a micro and macro level, synthesizing knowledge of the hard sciences with philosophical and ethical inquiry.

    2. John Robinson of Rockbridge County, has executed a deed to the President & Directors of the Literary fund, to take effect at his death for the following tracts of Land, to wit

      The development of the University was an incredible feat that I am sure many wanted to be a part of. John Robinson likely hoped to do some good in death by having his final legacy be contributing his land and slaves for the university's use. Though Lexington was not chosen as the site for the University, Robinson's willingness to donate the wealth he accumulated throughout his lifetime to UVA demonstrates the human tendency to be a part of a cause greater than who they are individually, thus in a sense defying death.

  8. Oct 2017
    1. To give to every citizen the information he needs for the transaction of his own business. To enable him to calculate for himself, and to express & preserve his ideas, his contracts & accounts in writing.

      This part of the text makes it known that everyone who was to be involved in the University's establishment should have the right of knowing what goes on with his own transactions. While reading this, i was constantly reminded of how my engagement constantly talks about people having the right to control what goes on to their bodies. Some people choose to stay ignorant to the problems going on in their body while others care to know what is going on and what indeed is the best way to proceed forward. It is all a right and in no way, shape, or form should this right be violated and/or questioned. I believe that while, several other aspects of the document were designed for failure, this section provided some sort of hope for equality and self awareness. - Kayla Thomas

    2. Education, in like manner engrafts a new man on the native stock, & improves what in his nature was vicious & perverse

      This section reminded me of the philosophy of Thomas Hobbes who believed the nature of man is inherently bad and the purpose of government and education is to control man's selfish desires. In my opinion, I side more with John Locke's philosophy that the nature of man is inherently good but society is corrupted by certain negative people. Education's purpose should be to remind people of their virtuous nature and not become distracted by the inequalities and failures of society.

    3. To understand his duties to his neighbours, & country, and to discharge with competence the functions confided to him by either.

      This idea seems to be really important in being a conscious and involved member of society in our time. In light of recent events, we can look to interpret the "duties to [our] neighbors" to mean that we need to care for and support each other, regardless of differences.

  9. Sep 2017
    1. that to secure Ourselves where we are, we must tread with awfull reverence in the footsteps of Our fathers.

      The word "secure" demonstrates a need for status and purpose. This seems interesting in reflecting on the document as a whole, which is essentially a declaration of establishment and is securing the meaning of the university. "Tread with awful reverence" prompts a reflection upon what is considered a good and valuable life in this situation. Do we need to keep this reverence in mind with all decisions that come with the progression of the school? Tana Mardian

    2. Districts of such extent as that every parent should be within a days journey of his son at school, would be desirable in cases of sickness

      In my Mortality and Morality engagement class, we often times talk about the role of family in the event that someone does become sick and how their presence can make a huge impact on how a situation is carried out. Family is often time seen as an extra layer of protection over any individual, especially for children. We assume that children are not old enough or mature enough to make major decisions for themselves, so it is ideal to keep them within reach in case of emergency. Therefore, if a school can supply resources that could be beneficial in times of need many parents would view that as a plus. - Kayla Thomas

  10. Sep 2013
    1. no friends so dear and sweet, But with death's parting blow is sure to meet.

      It is not surprising that Bradstreet would mention death as a fast approaching certainty. In the colonies, although more so in the Chesapeake rather than New England where she is from, the mortality rate was very high and it was rare for people to live well into their adulthood. Yet, she mentions friends that are close to her, which is also a characteristic of the New England colonies because they lived very close to one another and created a culture centered around the fellowship of the community, especially among the women.