2,377 Matching Annotations
  1. Jun 2021
    1. Ryan Struyk. (2021, June 2). WHO Director General: ‘Of the 1.8 billion vaccines administered globally, just 0.4% have been administered in low-income countries. This is ethically, epidemiologically and economically unacceptable.’ [Tweet]. @ryanstruyk. https://twitter.com/ryanstruyk/status/1400114783882461190

  2. May 2021
    1. Gobeil, P., Pillet, S., Séguin, A., Boulay, I., Mahmood, A., Vinh, D. C., Charland, N., Boutet, P., Roman, F., Most, R. V. D., Perez, M. de los A. C., Ward, B. J., & Landry, N. (2021). Interim Report of a Phase 2 Randomized Trial of a Plant-Produced Virus-Like Particle Vaccine for Covid-19 in Healthy Adults Aged 18-64 and Older Adults Aged 65 and Older. MedRxiv, 2021.05.14.21257248. https://doi.org/10.1101/2021.05.14.21257248

    1. Prof. Azeem Majeed. (2021, May 20). 1/ Our new article in @bmj_latest discusses vaccine hesitancy and how health professionals can collaborate with patients to improve confidence in vaccines. WHO has identified vaccine hesitancy as one of the top threats to global health. Https://t.co/V9nwAKbm8Z @MohammadRazai [Tweet]. @Azeem_Majeed. https://twitter.com/Azeem_Majeed/status/1395356264390135820

    1. Current injectable vaccines induce a systemic immune response by generating circulating IgG antibodies that neutralize pathogens before they can cause severe tissue damage. But IgG is not very good at controlling viral entry into the body. To do that, the mucosal immune system is needed. It produces secretory IgA at the site of viral entry, and in larger quantities than any other type of immunoglobulin in the body.

      Why nasal vaccinew would be superior?

    1. Reducing pain at the time of vaccination: WHO Position Paper – September 2015. Weekly epidemiological record. 2015;90(39):505–16 (www.who.int /immunization/policy/position_papers /reducing_pain_vaccination/en/)

    1. Taddio, A., McMurtry, C. M., Shah, V., Riddell, R. P., Chambers, C. T., Noel, M., MacDonald, N. E., Rogers, J., Bucci, L. M., Mousmanis, P., Lang, E., Halperin, S. A., Bowles, S., Halpert, C., Ipp, M., Asmundson, G. J. G., Rieder, M. J., Robson, K., Uleryk, E., … Bleeker, E. V. (2015). Reducing pain during vaccine injections: Clinical practice guideline. CMAJ : Canadian Medical Association Journal, 187(13), 975–982. https://doi.org/10.1503/cmaj.150391

    1. Prof. Christina Pagel. (2021, April 15). THREAD on VACCINATION & EQUITY in ENGLAND: I know I’ve tweeted about this before, but now we can look at how gaps by deprivation and ethnicity change with age groups and what that might mean... TLDR: widening gaps but access and communication will be key I suspect 1/5 [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1382725119773134848

    2. Ben Wakana. (2021, April 14). NEW POLL: The J&J pause makes people more confident in vaccines, not less. M-O-R-E C-O-N-F-I-D-E-N-T https://t.co/bqe6bTBwiR [Tweet]. @benwakana46. https://twitter.com/benwakana46/status/1382436908689657867

    1. Lawrence Gostin. (2021, April 30). Insightful talk by @doctorsoumya @P4HR webinar on #VaccinePassports @WHO is developing smart Int’l Vaccine Certificates Proof of vac Confidential & Secure Open Access Interoperable But @WHO doesn’t support requiring vacs for int’l travel until the world is more equal [Tweet]. @lawrencegostin. https://twitter.com/lawrencegostin/status/1388215713328943104

    1. ReconfigBehSci on Twitter: ‘am I the only one discomfited by the fact that US teenagers are being vaccinated while an out of control pandemic rages in India and Nepal? I would have expected more discussion of this!’ / Twitter. (n.d.). Retrieved 14 May 2021, from https://twitter.com/SciBeh/status/1392852883410849796

    1. The Astra-Zeneca shot uses a modified chimpanzee adenovirus as vector. These viruses use the CD46 receptor instead of the usual CAR receptor for infecting cells. “We found that human umbilical vein and brain microvascular endothelial cells (HUVECs and HBMECs) were CD46-positive”

      On AstraZeneca and brain damage.

    2. The Hsieh et al, Science, 2020 paper on HexaPro also notes that the HexaPro mod and the S-2P mod have the same ACE2 affinity (although they don’t make the comparison to wild-type). (Note that the conformational change upon binding is all about assisting viral entry into the cell, not binding the ACE2 receptor.)

      Stable spike protein ALSO binds to ACE2 receptors, after all. Stability

    3. Inadvertent injection into blood vessels has been raised in the comments here previously

      Injections accidentally hitting a vein are there cause for blood clots!??

    1. Eric Topol. (2021, May 1). Downgrading the concern on B.1.617, the poorly named ‘double mutant’—98% effectiveness of mRNA vaccine in an Israeli outbreak @CT_Bergstrom https://t.co/tGbuwPUmAL —Lab studies: Minimal immune evasion, expected full protection from vaccine @GuptaR_lab https://t.co/AIp24G0ROK https://t.co/AK20UWlDBD [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1388539223230140422

    1. Dr. Tom Frieden. (2021, April 30). Globally, the end of the pandemic isn’t near. More than a million lives depend on improving our response quickly. Don’t be blinded by the light at the end of the tunnel. There isn’t enough vaccine and the virus is gathering strength & speed. Global cooperation is crucial. 1/ [Tweet]. @DrTomFrieden. https://twitter.com/DrTomFrieden/status/1388172436999376899

    1. Prof. Gavin Yamey MD MPH. (2021, April 20). I was very pleased to see Levitt resign yesterday from the science advisory board of the anti-vaxx group PANDA. Previously Sikora had resigned. This press release mentions other resignations. Anyone know if the 3 GBD authors finally resigned? Here’s PANDA’s views on vaccines: Https://t.co/wVZX7XujZ3 [Tweet]. @GYamey. https://twitter.com/GYamey/status/1384476491317227525

    1. Adam Kucharski. (2021, April 14). If populations are highly vaccinated, we’d expect a higher proportion of future cases to have been previously vaccinated (because by definition, there aren’t as many non-vaccinated people around to be infected). But what sort of numbers should we expect? A short thread... 1/ [Tweet]. @AdamJKucharski. https://twitter.com/AdamJKucharski/status/1382242089673617417

    1. Temoka, E. (2013). Becoming a vaccine champion: Evidence-based interventions to address the challenges of vaccination. South Dakota Medicine: The Journal of the South Dakota State Medical Association, Spec no, 68–72.

    1. Ian bremmer on Twitter: “Seychelles is most vaccinated country in the world...but right now has more COVID cases per capita than India (!). How is that possible? Most vaccines used are Sinopharm. Which significantly reduces serious illness/death...but doesn’t do much to reduce transmission.” / Twitter. (n.d.). Retrieved May 11, 2021, from https://twitter.com/ianbremmer/status/1391751797770006534

    1. Cameron, R. L., Kavanagh, K., Watt, D. C., Robertson, C., Cuschieri, K., Ahmed, S., & Pollock, K. G. (2017). The impact of bivalent HPV vaccine on cervical intraepithelial neoplasia by deprivation in Scotland: Reducing the gap. J Epidemiol Community Health, 71(10), 954–960. https://doi.org/10.1136/jech-2017-209113

    1. David Benkeser. (2020, November 9). Another view on uncertainty associated based on Pfizer’s results. Even if you were highly skeptical about MRNA vaccines (many are [were?]) with 50% prior belief that VE ~ 0, based on an 8:86 vax:placebo case split, the posterior probability that VE > 75% is ~ 1. Https://t.co/xtBONtGHmT [Tweet]. @biosbenk. https://twitter.com/biosbenk/status/1325856366225993729

    1. Robert Colvile. (2021, February 16). The vaccine passports debate is a perfect illustration of my new working theory: That the most important part of modern government, and its most important limitation, is database management. Please stick with me on this—It’s much more interesting than it sounds. (1/?) [Tweet]. @rcolvile. https://twitter.com/rcolvile/status/1361673425140543490

    1. Eric Topol. (2021, February 17). New reports @NEJM today confirming some immune evasion of the B.1.351 variant (identified in South Africa) to both the mRNA vaccines, in vitro data @BioNTech_Group/@Pfizer and @moderna_tx. Less vaccine efficacy vs B.1.351 has been confirmed in clinical trials for 3 vaccines https://t.co/2N7eKDllso [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1362160675913568256

    1. Jonathan Rothberg 🦋. (2021, March 2). Testing works. I test daily. Insist on HOME testing. @michaelmina_lab @JoeBiden Research suggests B.1.526 needs to be closely watched “for its ability to evade both monoclonal antibody and, to a certain extent, the vaccine-induced antibody,” said Fauci [Tweet]. @JMRothberg. https://twitter.com/JMRothberg/status/1366755339912306688