8,832 Matching Annotations
  1. Nov 2021
    1. organization and experiences of teaching and learningduring this time are described based on representative surveys conducted during andafter the spring 2020 distance teaching period.

      organization and experiences of teaching and learning during this time are described based on representative surveys conducted during and after the spring 2020 distance teaching period.

    1. our fourth point is that for something like eukaryotes and others where there is no immediate major system 00:25:30 transition we're really sort of saying is that they perhaps are critical to such a transition but not at the time necessarily that they have evolved so in essence we want to amp we want to bring in a new 00:25:43 term which we call facilitating evolutionary transition so it makes it is part of a major system transition but it clearly needs other 00:25:55 evolutionary events to go along with it and the final sort of point is that there are perhaps catalysts that are involved in this process and one of the major catalysts that may 00:26:12 have had effects throughout evolutionary history are viruses so viruses may have been key actors to help the transition from 00:26:23 rna to dna they may have uh produced or helped produce the nucleus in eukaryotes and we'll talk about a little bit later about the key role that viral genes play 00:26:36 in making sexual reproduction possible and even in placental mammals the evolution of a placenta so without viral genes being moved across 00:26:47 horizontally species some of these major transitions could never have happened so now we have sort of the complete integrated process of of our diagram and again the question 00:27:02 that we're really focusing on oftentimes is that last one yes when how and why do we get to a major system transition and how do nets mechs uh 00:27:15 fets and catalysts all play a role in these various transitions

      Viruses have played a key role in a number of different METs. This is an important insight that can contextualize the covid-19 pandemic.

    1. ReconfigBehSci. (2021, November 4). RT @DrTedros: We continue to hear excuses about why low-income countries have only received 0.4% of #COVID19 vaccines: 1. They can’t absorb… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1456588731155165189

    1. Dhar, M. S., Marwal, R., VS, R., Ponnusamy, K., Jolly, B., Bhoyar, R. C., Sardana, V., Naushin, S., Rophina, M., Mellan, T. A., Mishra, S., Whittaker, C., Fatihi, S., Datta, M., Singh, P., Sharma, U., Ujjainiya, R., Bhatheja, N., Divakar, M. K., … Rakshit, P. (n.d.). Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India. Science, 0(0), eabj9932. https://doi.org/10.1126/science.abj9932

    1. Vaccine effectiveness against laboratory-confirmed symptomatic infection is never higher than 50 to 60%, and in some years it is much lower.

      Vaccine effectiveness for influenza vaccines for symptomatic infection is never higher than 50-60% and some years it is much slower.

    2. Eliminating Covid-19 seemed theoretically possible, because the original 2002 SARS virus ultimately disappeared.

      Eliminating SARS-CoV-2 was deemed plausible, because SARS-CoV-1 had been eliminated.

    3. The effect on asymptomatic infections was a welcome surprise, because it has been thought that most vaccines for respiratory illnesses, including influenza, are “leaky” — that is, they allow some degree of asymptomatic infection and are better at preventing symptomatic infection.

      Most vaccines for respiratory illnesses are leaky.

      The efficacy the mRNA vaccines showed in preventing asymptomatic transmission was therefore a welcome surprise.

    1. The findings add to growing evidence that most people immunized with the mRNA vaccines may not need boosters, so long as the virus and its variants do not evolve much beyond their current forms — which is not guaranteed. People who recovered from Covid-19 before being vaccinated may not need boosters even if the virus does make a significant transformation.
    1. Leana Wen, M.D. (2021, November 4). Covid-19 has claimed the lives of over 750,000 Americans. That’s more than the populations of Alaska, Vermont, Washington DC, or Wyoming. Please, let’s not become numb to this tremendous and tragic loss. Https://t.co/urdZgTg2hV [Tweet]. @DrLeanaWen. https://twitter.com/DrLeanaWen/status/1456274565164724227

    1. Dr Nisreen Alwan 🌻. (2021, October 30). Mass infection of kids with a virus less than 2 years old is not ethical, not moral, not scientifically evidenced, not socially just & medically risky. There’s no good argument for this. And no, boosting population immunity to protect the adults is not a valid argument. #Childism [Tweet]. @Dr2NisreenAlwan. https://twitter.com/Dr2NisreenAlwan/status/1454498829403922440

    1. McNamara, L. A., Wiegand, R. E., Burke, R. M., Sharma, A. J., Sheppard, M., Adjemian, J., Ahmad, F. B., Anderson, R. N., Barbour, K. E., Binder, A. M., Dasgupta, S., Dee, D. L., Jones, E. S., Kriss, J. L., Lyons, B. C., McMorrow, M., Payne, D. C., Reses, H. E., Rodgers, L. E., … Schrag, S. J. (2021). Estimating the early impact of the US COVID-19 vaccination programme on COVID-19 cases, emergency department visits, hospital admissions, and deaths among adults aged 65 years and older: An ecological analysis of national surveillance data. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(21)02226-1

    1. Benjamin Veness. (2021, November 2). Singapore’s 🇸🇬 Senior Minister of State for Health, Dr Janil Puthucheary, told Parliament on 1 November: “I hope my explanation has helped members understand why although we say we are living with COVID-19, we cannot just open up, and risk having the number of cases shoot up.” [Tweet]. @venessb. https://twitter.com/venessb/status/1455396047765733376

    1. ReconfigBehSci. (2021, November 2). interestingly the Singapore Health Minister also mentions “boosting through mild infections”—A concept that is currently generating much furore in the UK in the wake of the release of the JCVI minutes on child vaxx decisions 1/n [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1455445587910922240

    1. Dr Daya Sharma 😷🥽💨🧼💉💉. (2021, October 30). Some of the UK JCVI deliberations are deeply disturbing, eg arguing against childhood vax so that they can get infected & boost immunity in adults. Also imply that vax doesn’t have an individual benefit! 🤯 How much of this warped thinking is present in Australia? #COVID19Aus https://t.co/o887d2etcW [Tweet]. @DrDayaSharma. https://twitter.com/DrDayaSharma/status/1454418003429183492

    1. Prof. Gavin Yamey MD MPH. (2021, October 30). “Circulation of COVID-19 in childhood could therefore periodically boost immunity in adults through exposure” When I say childhood vax ALSO benefits adults, folx say “you can’t use benefits to adults in your argument!” JCVI uses benefits to adults of letting kids get infected 👀 [Tweet]. @GYamey. https://twitter.com/GYamey/status/1454433823085715461

    1. ReconfigBehSci. (2021, October 30). Does there maybe need to be more distinction between points raised for discussion and any actual decision? Without knowing about votes etc., it’s maybe a bit strong to say ‘JCVI wanted x...’? I’ve sat on many bodies with minutes documenting positions I disagreed with [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1454488759785897987

    1. ReconfigBehSci. (2021, October 30). as the fallout from the JCVI minutes build, it’s worth considering that the corresponding U.S. body ACIP has been live streaming its meetings on YouTube... Transparency helps reduce faulty reasoning...we should have learned that lesson with the very first lockdown, no? [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1454502337368764421

    1. 𝚃𝚘𝚖 𝙻𝚊𝚠𝚝𝚘𝚗 💙. (2021, October 30). From the paper—Ventilation makes a big difference further away, but below 1-1.5m then you’d have to be in a gale to be safe! ✅DISTANCE if you can ✅VENTILATE - works even within 2m, but sadly not so much within 1-1.5m ✅PPE if you have to get close #COVIDisAirborne https://t.co/wYuWdG47He [Tweet]. @LawtonTri. https://twitter.com/LawtonTri/status/1454355692593328132

    1. Richard Sever. (2021, October 30). The article is on ivermectin but the sunk intellectual cost fallacy has lessons for us all: "Publicly backtracking when the results refute your idea requires a very large dose of humility” Such humility has been notably lacking among Nobels and other COVID inexperts [Tweet]. @cshperspectives. https://twitter.com/cshperspectives/status/1454483988031152137

    1. Dr. Thomas Wilckens. (2021, October 31). JCVI facing calls from within for greater transparency over decision-making https://buff.ly/3GwVqCZ JCVI has been criticised for failing to publish detailed minutes, modelling and analysis behind its decision to advise vaccinating all over-16s in Britain #covid19 #coronavirus https://t.co/nWbnvci7LI [Tweet]. @Thomas_Wilckens. https://twitter.com/Thomas_Wilckens/status/1454798820156530689

    1. ReconfigBehSci. (2021, November 1). 2/2 from the paper ‘We speculate that the extraordinarily high antibody titers observed in vaccinated individuals who develop breakthrough infections may lead to subsequent long-term protection in those individuals.’ [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1455104597454954497

    1. Deepti Gurdasani. (2021, November 1). No- the statement explicitly talks about infection in children being a ‘booster’ to adults i.e. Children infecting adults to protect them against... Infection!🤔 I don’t think there’s any level of cognitive gymnastics that could justify this or make sense of it. [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1455106192112500736

  2. Oct 2021
    1. Singanayagam, A., Hakki, S., Dunning, J., Madon, K. J., Crone, M. A., Koycheva, A., Derqui-Fernandez, N., Barnett, J. L., Whitfield, M. G., Varro, R., Charlett, A., Kundu, R., Fenn, J., Cutajar, J., Quinn, V., Conibear, E., Barclay, W., Freemont, P. S., Taylor, G. P., … Lackenby, A. (2021). Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: A prospective, longitudinal, cohort study. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00648-4

    1. Sun, W., Liu, Y., Amanat, F., González-Domínguez, I., McCroskery, S., Slamanig, S., Coughlan, L., Rosado, V., Lemus, N., Jangra, S., Rathnasinghe, R., Schotsaert, M., Martinez, J. L., Sano, K., Mena, I., Innis, B. L., Wirachwong, P., Thai, D. H., Oliveira, R. D. N., … Palese, P. (2021). A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses. Nature Communications, 12(1), 6197. https://doi.org/10.1038/s41467-021-26499-y

    1. Kenneth Baillie. (2021, October 27). When a healthcare system fails, increasing numbers of people suffer and die needlessly. That’s all. If you aren’t a patient or staff, you don’t see it. But this is happening, now, all over the UK. 2/n [Tweet]. @kennethbaillie. https://twitter.com/kennethbaillie/status/1453422360795680769

    1. Jeong, M., Ocwieja, K. E., Han, D., Wackym, P. A., Zhang, Y., Brown, A., Moncada, C., Vambutas, A., Kanne, T., Crain, R., Siegel, N., Leger, V., Santos, F., Welling, D. B., Gehrke, L., & Stankovic, K. M. (2021). Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction. Communications Medicine, 1(1), 1–14. https://doi.org/10.1038/s43856-021-00044-w

    1. Gil Feldman. (2021, October 26). @EricTopol Updated data from Israel. The booster works, without any doubt! Red (empty battery): Un-vax Light green (half battery): 2nd dose without the booster Green (full battery): With the booster https://t.co/HbZBvDMQs6 [Tweet]. @feldman_gil. https://twitter.com/feldman_gil/status/1452845319251767299

    1. Andreano, E., Paciello, I., Piccini, G., Manganaro, N., Pileri, P., Hyseni, I., Leonardi, M., Pantano, E., Abbiento, V., Benincasa, L., Giglioli, G., De Santi, C., Fabbiani, M., Rancan, I., Tumbarello, M., Montagnani, F., Sala, C., Montomoli, E., & Rappuoli, R. (2021). Hybrid immunity improves B cells and antibodies against SARS-CoV-2 variants. Nature, 1–7. https://doi.org/10.1038/s41586-021-04117-7

    1. Tartof, S. Y., Slezak, J. M., Fischer, H., Hong, V., Ackerson, B. K., Ranasinghe, O. N., Frankland, T. B., Ogun, O. A., Zamparo, J. M., Gray, S., Valluri, S. R., Pan, K., Angulo, F. J., Jodar, L., & McLaughlin, J. M. (2021). Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: A retrospective cohort study. The Lancet, 398(10309), 1407–1416. https://doi.org/10.1016/S0140-6736(21)02183-8

    1. Meuris, C., Kremer, C., Geerinck, A., Locquet, M., Bruyère, O., Defêche, J., Meex, C., Hayette, M.-P., Duchene, L., Dellot, P., Azarzar, S., Maréchal, N., Sauvage, A.-S., Frippiat, F., Giot, J.-B., Léonard, P., Fombellida, K., Moutschen, M., Durkin, K., … Darcis, G. (2021). Transmission of SARS-CoV-2 After COVID-19 Screening and Mitigation Measures for Primary School Children Attending School in Liège, Belgium. JAMA Network Open, 4(10), e2128757. https://doi.org/10.1001/jamanetworkopen.2021.28757

    1. Professor Lucy Easthope. (2021, October 20). WFH really is only for a very privileged few now. Not sure how that can stay a “thing” as an NPI. Too many harms being done by a fractured society where people are thriving by getting other people to bring them stuff/ make them things/ look after their family members for them [Tweet]. @LucyGoBag. https://twitter.com/LucyGoBag/status/1450842213613772802

    1. Hulme, W. J., Williamson, E. J., Green, A., Bhaskaran, K., McDonald, H. I., Rentsch, C. T., Schultze, A., Tazare, J., Curtis, H. J., Walker, A. J., Tomlinson, L., Palmer, T., Horne, E., MacKenna, B., Morton, C. E., Mehrkar, A., Fisher, L., Bacon, S., Evans, D., … Goldacre, B. (2021). Comparative effectiveness of ChAdOx1 versus BNT162b2 COVID-19 vaccines in Health and Social Care workers in England: A cohort study using OpenSAFELY [Preprint]. Epidemiology. https://doi.org/10.1101/2021.10.13.21264937

    1. Prof. Akiko Iwasaki. (2021, September 23). Thankfully, we have not seen any evidence of antibody-dependent enhancement of infection or disease by any COVID vaccines to date. Vaccine are not making infections worse, and are very effective in preventing disease. [Tweet]. @VirusesImmunity. https://twitter.com/VirusesImmunity/status/1441074260534075392

    1. UCL Centre for Behaviour Change. (2021, October 12). The CBC Conference 2021 programme has just been released and is packed with thought-provoking talks, international keynote speakers, symposia, and plenty of networking opportunities and social exchanges for delegates. Register now! Http://tinyurl.com/5xwa7c27 #cbcconf2021 https://t.co/9iZqPjEEY6 [Tweet]. @UCLBehaveChange. https://twitter.com/UCLBehaveChange/status/1447860878511157252

    1. Wenzel, J., Lampe, J., Müller-Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M., Körbelin, J., Zhang, L., Özorhan, Ü., Neve, V., Wagner, J. U. G., Bojkova, D., Shumliakivska, M., Jiang, Y., Fähnrich, A., Ott, F., Sencio, V., Robil, C., … Schwaninger, M. (2021). The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nature Neuroscience, 1–12. https://doi.org/10.1038/s41593-021-00926-1

    1. Siddle, K. J., Krasilnikova, L. A., Moreno, G. K., Schaffner, S. F., Vostok, J., Fitzgerald, N. A., Lemieux, J. E., Barkas, N., Loreth, C., Specht, I., Tomkins-Tinch, C. H., Silbert, J., Schaeffer, B., Taylor, B. P., Loftness, B., Johnson, H., Schubert, P. L., Shephard, H. M., Doucette, M., … Sabeti, P. C. (2021). Evidence of transmission from fully vaccinated individuals in a large outbreak of the SARS-CoV-2 Delta variant in Provincetown, Massachusetts (p. 2021.10.20.21265137). https://doi.org/10.1101/2021.10.20.21265137

    1. Mlcochova, P., Kemp, S. A., Dhar, M. S., Papa, G., Meng, B., Ferreira, I. A. T. M., Datir, R., Collier, D. A., Albecka, A., Singh, S., Pandey, R., Brown, J., Zhou, J., Goonawardane, N., Mishra, S., Whittaker, C., Mellan, T., Marwal, R., Datta, M., … Gupta, R. K. (2021). SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion. Nature, 1–6. https://doi.org/10.1038/s41586-021-03944-y